Chemical compound libraries

HTB maintains a collection of about 240 000 small molecule compounds including known drugs, bioactives, and diversified sets of chemicals.
Large Compound Collections Are Ideal For Finding New Drugs
Library 
№ compounds
Content description
ChemBridge DIVERSet and CNS-Set 30 000 Combinatorial chemistry collection
ChemDiv diversity collection  50 040 Combinatorial chemistry collection
Tripos Structures collection  6 000 Combinatorial chemistry collection (old)
Specs Consortium Collection 30 000 Combinatorial chemistry collection (modern)
Sigma LOPAC1280 1 280 Library of Pharmacologically Active Compounds.  Is most commonly used to validate new drug discovery assays and characterize orphan receptors
Tocris Tocriscreen Mini 1 120 Many compounds are unique to Tocris
ChemDiv Peptidomimetic library 15 614 Peptide mimicking small compounds
EU-OpenScreen diversity collection ~100 000 European  Chemical  Biology  Library( ECBL) commercial diversity compound collection
Focused Libraries Better Suit for Biological Profiling and Drug Repositioning
Library
№ compounds
Description
FIMM oncology collections >1 000 Oncology set of approved and emerging investigational oncology drugs, compounds available also for proof-of-principle experiments
FIMM metabolic library 183 Targeting major metabolic pathways (mitochondria, energy, lipids, proteins and nucleotides)
Comprehensive anti-Cancer small-Compound Library (C3L) 620 Oncology set of approved and emerging investigational oncology drugs (max 10 uM concentration for assay plates available)
Prestwick Chemical Library 1 520 FDA-approved & EMA-approved drugs
FDA-approved drugs ENZO 640  FDA-approved drugs
SPECTRUM  MicroSource  2 000  The Drug Components (50%); The Natural Products (30%); Other Bioactive Components (20%)
NIH Clinical collection 446  The NCC consists almost entirely of experimental drugs that have been in phase I-III clinical trials and have not been represented in other arrayed collections
NCI (National Cancer Institute) collection 2 500  Cancer drug derivative collection and natural products (4.8%)
Smaller Oncology Collections for Clinical Applications
Library
№ compounds
Description
FO 528 FIMM oncology collection, a comprehensive collection of approved and emerging investigational oncology drugs in 5 concentrations each (FO6B is the latest version)
FM 142 FIMM myeloma-specific collection (5 conc.)
FA 151 FIMM AML-specific panel (5 conc.)
QA 40 AML-specific drugs in 7 concentrations for HT flow cytometry
Drug aliquots, DSRT- and custom drug plates are available on request

FIMM/HTB distributes aliquots of available chemical compounds to academic research groups in Finland for a small fee covering the actual compound costs and handling.

A list of available chemical compounds can be found here:
How to order drug aliquots and drug plates:

All compound aliquot, custom drugged plate and DSRT set reservations/orders should be done two weeks in advance via iLAB. 

For further information contact us at fimm-htb-drugging (at) helsinki.fi

Please be prepared to provide the following information:

  1. Invoicing information with the order: PI and WBS number.
  2. All preordered sets and aliquots will be charged according to the order placed in iLAB, not by use.
  3. For specific compound aliquots the name of the compound is not sufficient alone. Write also FIMM-ID and/or Supplier Reference to the order.
  4. New DSRT sets are made every other week. Sets are kept in stock for patient samples.
  5. Custom druggings are also made every other week, the weeks when DSRT sets are not made.
  6. Compound aliquots are prepared every other Tuesday and can be picked up on Wednesday. Aliquots are stored in the storage pods, and can be picked up whenever needed.

We hand out only unopened tubes/boxes of reagents (CTG, CTB, CellTox etc.) and empty assay plates (20 plates/box). We will still continue ordering big bulks for the better prices.