The following articles acknowledge the GBU and Biocenter Finland either as the source of clones or cloned products or in digital microscopy.
The list is not complete and we appreciate notifying us when you note an article missing or publish a new one!
Clones and cloning
- Conway JRW, Dinç DD, Follain G, Paavolainen O, Kaivola J, Boström P, Hartiala P, Peuhu E, Ivaska J. IGFBP2 secretion by mammary adipocytes limits breast cancer invasion. Sci Adv. 2023 Jul 14;9(28):eadg1840. doi: 10.1126/sciadv.adg1840. Epub 2023 Jul 12. PMID: 37436978; PMCID: PMC10337915.
- Khanal P, Boskovic Z, Lahti L, Ghimire A, Minkeviciene R, Opazo P, Hotulainen P. Gas7 is a novel dendritic spine initiation factor. eNeuro. 2023 Mar 23:ENEURO.0344-22.2023. doi: 10.1523/ENEURO.0344-22.2023. PMID: 36963834.
- Salokas K, Liu X, Öhman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M. Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep. 2022 Jun 7;23(6):e54041. doi: 10.15252/embr.202154041. Epub 2022 Apr 5. PMID: 35384245; PMCID: PMC9171411.
- Ahonen MA, Höring M, Nguyen VD, Qadri S, Taskinen JH, Nagaraj M, Wabitsch M, Fischer-Posovszky P, Zhou Y, Liebisch G, Haridas PAN, Yki-Järvinen H, Olkkonen VM. Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes. Mol Med. 2022 Jun 17;28(1):68. doi: 10.1186/s10020-022-00496-3. PMID: 35715726; PMCID: PMC9204892.
- Liu X, Huuskonen S, Laitinen T, Redchuk T, Bogacheva M, Salokas K, Pöhner I, Öhman T, Tonduru AK, Hassinen A, Gawriyski L, Keskitalo S, Vartiainen MK, Pietiäinen V, Poso A, Varjosalo M. SARS-CoV-2-host proteome interactions for antiviral drug discovery. Mol Syst Biol. 2021 Nov;17(11):e10396. doi: 10.15252/msb.202110396. PMID: 34709727; PMCID: PMC8552907.
- Tervonen TA, Pant SM, Belitškin D, Englund JI, Närhi K, Haglund C, Kovanen PE, Verschuren EW, Klefström J. Oncogenic Ras disrupts epithelial integrity by activating the transmembrane serine protease hepsin. Cancer Res. 2021 Mar 15;81(6):1513-1527. doi: 10.1158/0008-5472.CAN-20-1760. Epub 2021 Jan 18. PMID: 33461973.
- Moreno-Layseca P, Jäntti NZ, Godbole R, Sommer C, Jacquemet G, Al-Akhrass H, Conway JRW, Kronqvist P, Kallionpää RE, Oliveira-Ferrer L, Cervero P, Linder S, Aepfelbacher M, Zauber H, Rae J, Parton RG, Disanza A, Scita G, Mayor S, Selbach M, Veltel S, Ivaska J. Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis. Nat Cell Biol. 2021 Oct;23(10):1073-1084. doi: 10.1038/s41556-021-00767-x. Epub 2021 Oct 6. Erratum in: Nat Cell Biol. 2022 Sep;24(9):1445. PMID: 34616024.
- Myllykoski M, Sutinen A, Koski MK, Kallio JP, Raasakka A, Myllyharju J, Wierenga RK, Koivunen P. Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains. J Biol Chem. Epub 2020 Dec 17:jbc.RA120.016542. doi: 10.1074/jbc.RA120.016542. PMID: 33334883.
- Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020 Epub Oct 20:eabd2985. doi: 10.1126/science.abd2985. PMID: 33082293.
- Sahgal P, Alanko J, Icha J, Paatero I, Hamidi H, Arjonen A, Pietilä M, Rokka A, Ivaska J. GGA2 and RAB13 promote activity-dependent β1-integrin recycling. J Cell Sci. 2019 Jun 7;132(11):jcs233387. doi: 10.1242/jcs.233387. PMID: 31076515.
- Zhao Z, Kesti T, Uğurlu H, Baur AS, Fagerlund R, Saksela K. Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion. Traffic. 2019 Mar;20(3):202-212. doi: 10.1111/tra.12630. Epub 2019 Jan 21. PMID: 30569492.
- Jacquemet G, Stubb A, Saup R, Miihkinen M, Kremneva E, Hamidi H, Ivaska J. Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability. Curr Biol. 2019 Jan 21;29(2):202-216.e7. doi: 10.1016/j.cub.2018.11.053. Epub 2019 Jan 10. PMID: 30639111; PMCID: PMC6345628.
- Kentala H, Koponen A, Vihinen H, Pirhonen J, Liebisch G, Pataj Z, Kivelä A, Li S, Karhinen L, Jääskeläinen E, Andrews R, Meriläinen L, Matysik S, Ikonen E, Zhou Y, Jokitalo E, Olkkonen VM. OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism. Cell Mol Life Sci. 2018 Nov;75(21):4041-4057. doi: 10.1007/s00018-018-2850-8. Epub 2018 Jun 12. PMID: 29947926.
- Hlushchenko I, Khanal P, Abouelezz A, Paavilainen VO, Hotulainen P. ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons. Front Cell Neurosci. 2018 Aug 3;12:217. doi: 10.3389/fncel.2018.00217. PMID: 30123108; PMCID: PMC6085419.
- Pehkonen H, Lento M, von Nandelstadh P, Filippou A, Grénman R, Lehti K, Monni O. Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton. Cell Commun Signal. 2018 Jul 13;16(1):41. doi: 10.1186/s12964-018-0253-y. PMID: 30005669; PMCID: PMC6045882.
- Pekkonen P, Alve S, Balistreri G, Gramolelli S, Tatti-Bugaeva O, Paatero I, Niiranen O, Tuohinto K, Perälä N, Taiwo A, Zinovkina N, Repo P, Icay K, Ivaska J, Saharinen P, Hautaniemi S, Lehti K, Ojala PM. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. Elife. 2018 May 1;7:e32490. doi: 10.7554/eLife.32490. PMID: 29712618; PMCID: PMC5929907.
- Kentala H, Koponen A, Kivelä AM, Andrews R, Li C, Zhou Y, Olkkonen VM. Analysis of ORP2-knockout hepatocytes uncovers a novel function in actin cytoskeletal regulation. FASEB J. 2018 Mar;32(3):1281-1295. doi: 10.1096/fj.201700604R. Epub 2018 Jan 3. PMID: 29092904.
- Liu Y, Mattila J, Ventelä S, Yadav L, Zhang W, Lamichane N, Sundström J, Kauko O, Grénman R, Varjosalo M, Westermarck J, Hietakangas V. PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression. Dev Cell. 2017 Oct 23;43(2):240-252.e5. doi: 10.1016/j.devcel.2017.09.022. PMID: 29065309.
Scanning
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Pikkusaari S, Tumiati M, Virtanen A, Oikkonen J, Li Y, Perez-Villatoro F, Muranen T, Salko M, Huhtinen K, Kanerva A, Koskela H, Tapper J, Koivisto-Korander R, Joutsiniemi T, Haltia UM, Lassus H, Hautaniemi S, Farkkila A, Hynninen J, Hietanen S, Carpén O, Kauppi L. Functional homologous recombination assay on FFPE specimens of advanced high-grade serous ovarian cancer predicts clinical outcomes. Clin Cancer Res. 2023 Feb 20:CCR-22-3156. doi: 10.1158/1078-0432.CCR-22-3156. Epub ahead of print. PMID: 36805632.
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Karsten L, Janson N, Le Joncour V, Alam S, Müller B, Tanjore Ramanathan J, Laakkonen P, Sewald N, Müller KM. Bivalent EGFR-Targeting DARPin-MMAE Conjugates. Int J Mol Sci. 2022 Feb 23;23(5):2468. doi: 10.3390/ijms23052468. PMID: 35269611; PMCID: PMC8909960.
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Karaman S, Paavonsalo S, Heinolainen K, Lackman MH, Ranta A, Hemanthakumar KA, Kubota Y, Alitalo K.
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance. J Exp Med. 2022 Mar 7;219(3):e20210565. doi: 10.1084/jem.20210565. Epub 2022 Jan 20. PMID: 35050301
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Pauliina Filppu, Jayendrakishore Tanjore Ramanathan, Kirsi J Granberg, Erika Gucciardo , Hannu Haapasalo, Kaisa Lehti, Matti Nykter, Vadim Le Joncour, Pirjo Laakkonen. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight 2021 May 10;6(9):141486. doi: 10.1172/jci.insight.141486. PMID: 33986188
- Lähde M, Heino S, Högström J, Kaijalainen S, Anisimov A, Flanagan D, Kallio P, Leppänen VM, Ristimäki A, Ritvos O, Wu K, Tammela T, Hodder M, Sansom OJ, Alitalo K. Expression of R-spondin1 in ApcMin/+ Mice Reduces Growth of Intestinal Adenomas by Altering Wnt and TGFB Signaling. Gastroenterology. 2020 Sep 14:S0016-5085(20)35148-9. doi: 10.1053/j.gastro.2020.09.011. Epub ahead of print. PMID: 32941878.
- Jurado Acosta A, Rysä J, Szabo Z, Moilanen AM, Serpi R, Ruskoaho H. Phosphorylation of GATA4 at serine 105 is required for left ventricular remodelling process in angiotensin II-induced hypertension in rats. Basic Clin Pharmacol Toxicol. 2020 Sep;127(3):178-195. doi: 10.1111/bcpt.13398. Epub 2020 Mar 9. PMID: 32060996; PMCID: PMC7496669.
- Wang H, Kuusela S, Rinnankoski-Tuikka R, Dumont V, Bouslama R, Ramadan UA, Waaler J, Linden AM, Chi NW, Krauss S, Pirinen E, Lehtonen S. Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice. Int J Obes (Lond). 2020 Aug;44(8):1691-1702. doi: 10.1038/s41366-020-0573-z. Epub 2020 Apr 21. PMID: 32317752; PMCID: PMC7381423.
- Ayo A, Figueras E, Schachtsiek T, Budak M, Sewald N, Laakkonen P. Tumor-Targeting Peptides: The Functional Screen of Glioblastoma Homing Peptides to the Target Protein FABP3 (MDGI). Cancers (Basel). 2020 Jul 8;12(7):1836. doi: 10.3390/cancers12071836. PMID: 32650473; PMCID: PMC7409020.
- Tanjore Ramanathan J, Lehtipuro S, Sihto H, Tóvári J, Reiniger L, Téglási V, Moldvay J, Nykter M, Haapasalo H, Le Joncour V, Laakkonen P. Prostate-specific membrane antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to the brain. J Cell Mol Med. 2020 Jun;24(12):6916-6927. doi: 10.1111/jcmm.15350. Epub 2020 May 11. PMID: 32390293; PMCID: PMC7299712.
- Kallio P, Jokinen E, Högström J, Das S, Heino S, Lähde M, Brodkin J, Korhonen EA, Alitalo K. Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation. Cancer Res. 2020 Jun 15;80(12):2639-2650. doi: 10.1158/0008-5472.CAN-20-0497. Epub 2020 Apr 20. PMID: 32312835.
- Turconi G, Kopra J, Võikar V, Kulesskaya N, Vilenius C, Piepponen TP, Andressoo JO. Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice. Mol Ther Methods Clin Dev. 2020 Apr 11;17:831-842. doi: 10.1016/j.omtm.2020.04.003. PMID: 32368564; PMCID: PMC7191127.
- Eriksson J, Le Joncour V, Jahkola T, Juteau S, Laakkonen P, Saksela O, Hölttä E. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls. Mol Oncol. 2020 Apr;14(4):742-762. doi: 10.1002/1878-0261.12649. Epub 2020 Feb 28. PMID: 32053263; PMCID: PMC7138405.
- Haltia UM, Pihlajoki M, Andersson N, Mäkinen L, Tapper J, Cervera A, Horlings HM, Turpeinen U, Anttonen M, Bützow R, Unkila-Kallio L, Carpén O, Wilson DB, Heikinheimo M, Färkkilä A. Functional Profiling of FSH and Estradiol in Ovarian Granulosa Cell Tumors. J Endocr Soc. 2020 Mar 16;4(4):bvaa034. doi: 10.1210/jendso/bvaa034. PMID: 32309755; PMCID: PMC7153750.
- Minkeviciene R, Hlushchenko I, Virenque A, Lahti L, Khanal P, Rauramaa T, Koistinen A, Leinonen V, Noe FM, Hotulainen P. MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning. Front Mol Neurosci. 2019 Nov 15;12:276. doi: 10.3389/fnmol.2019.00276. PMID: 31803019; PMCID: PMC6872969.
- Le Joncour V, Filppu P, Hyvönen M, Holopainen M, Turunen SP, Sihto H, Burghardt I, Joensuu H, Tynninen O, Jääskeläinen J, Weller M, Lehti K, Käkelä R, Laakkonen P. Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization. EMBO Mol Med. 2019 Jun;11(6):e9034. doi: 10.15252/emmm.201809034. PMID: 31068339; PMCID: PMC6554674.
- Sahu MP, Nikkilä O, Lågas S, Kolehmainen S, Castrén E. Culturing primary neurons from rat hippocampus and cortex. Neuronal Signal. 2019 Apr 26;3(2):NS20180207. doi: 10.1042/NS20180207. PMID: 32714598; PMCID: PMC7363313.
- Polianskyte-Prause Z, Tolvanen TA, Lindfors S, Dumont V, Van M, Wang H, Dash SN, Berg M, Naams JB, Hautala LC, Nisen H, Mirtti T, Groop PH, Wähälä K, Tienari J, Lehtonen S. Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity. FASEB J. 2019 Feb;33(2):2858-2869. doi: 10.1096/fj.201800529RR. Epub 2018 Oct 15. PMID: 30321069; PMCID: PMC6338644.
- Danilova T, Belevich I, Li H, Palm E, Jokitalo E, Otonkoski T, Lindahl M. MANF Is Required for the Postnatal Expansion and Maintenance of Pancreatic β-Cell Mass in Mice. Diabetes. 2019 Jan;68(1):66-80. doi: 10.2337/db17-1149. Epub 2018 Oct 10. PMID: 30305368.
- Hakanpaa L, Kiss EA, Jacquemet G, Miinalainen I, Lerche M, Guzmán C, Mervaala E, Eklund L, Ivaska J, Saharinen P. Targeting β1-integrin inhibits vascular leakage in endotoxemia. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6467-E6476. doi: 10.1073/pnas.1722317115. Epub 2018 Jun 25. PMID: 29941602; PMCID: PMC6048499.
- Gramolelli S, Cheng J, Martinez-Corral I, Vähä-Koskela M, Elbasani E, Kaivanto E, Rantanen V, Tuohinto K, Hautaniemi S, Bower M, Haglund C, Alitalo K, Mäkinen T, Petrova TV, Lehti K, Ojala PM. PROX1 is a transcriptional regulator of MMP14. Sci Rep. 2018 Jun 22;8(1):9531. doi: 10.1038/s41598-018-27739-w. PMID: 29934628; PMCID: PMC6015061.
- Pekkonen P, Alve S, Balistreri G, Gramolelli S, Tatti-Bugaeva O, Paatero I, Niiranen O, Tuohinto K, Perälä N, Taiwo A, Zinovkina N, Repo P, Icay K, Ivaska J, Saharinen P, Hautaniemi S, Lehti K, Ojala PM. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. Elife. 2018 May 1;7:e32490. doi: 10.7554/eLife.32490. PMID: 29712618; PMCID: PMC5929907.
- Soini T, Pihlajoki M, Andersson N, Lohi J, Huppert KA, Rudnick DA, Huppert SS, Wilson DB, Pakarinen MP, Heikinheimo M. Transcription factor GATA6: a novel marker and putative inducer of ductal metaplasia in biliary atresia. Am J Physiol Gastrointest Liver Physiol. 2018 May 1;314(5):G547-G558. doi: 10.1152/ajpgi.00362.2017. Epub 2018 Feb 1. PMID: 29388792; PMCID: PMC6008062.