Publications

The following articles acknowledge the GBU and Biocenter Finland either as the source of clones or cloned products or in digital microscopy.

The list is not complete and we appreciate notifying us when you note an article missing or publish a new one!

Clones and cloning

Leppänen N, Kaljunen H, Takala E, Kaarijärvi R, Mäkinen PI, Ylä-Herttuala S, Paatero I, Paakinaho V, Ketola K. SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer. Nucleic Acids Res. 2024 Mar 30:gkae206. doi: 10.1093/nar/gkae206. Epub ahead of print. PMID: 38554106.
Belitškin D, Munne P, Pant SM, Anttila JM, Suleymanova I, Belitškina K, Kirchhofer D, Janetka J, Käsper T, Jalil S, Pouwels J, Tervonen TA, Klefström J. Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis. Mol Oncol. 2023 Oct 23. doi: 10.1002/1878-0261.13545. Epub ahead of print. PMID: 37872868.
Conway JRW, Isomursu A, Follain G, Härmä V, Jou-Ollé E, Pasquier N, Välimäki EPO, Rantala JK, Ivaska J. Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2304288120. doi: 10.1073/pnas.2304288120. Epub 2023 Oct 16. PMID: 37844244; PMCID: PMC10614832.
Tanjore Ramanathan J, Zárybnický T, Filppu P, Monzo HJ, Monni O, Tervonen TA, Klefström J, Kerosuo L, Kuure S, Laakkonen P. Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization. Sci Rep. 2023 Oct 11;13(1):17162. doi: 10.1038/s41598-023-44093-8. PMID: 37821496; PMCID: PMC10567708.
Giri AK, Aavikko M, Wartiovaara L, Lemmetyinen T, Karjalainen J, Mehtonen J, Palin K, Välimäki N, Tamlander M, Saikkonen R, Karhu A, Morgunova E, Sun B, Runz H, Palta P, Luo S, Joensuu H, Mäkelä TP, Kostiainen I, Schalin-Jäntti C, FinnGen, Palotie A, Aaltonen LA, Ollila S, Daly MJ. Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5. Gastroenterology. 2023 Oct;165(4):861-873. doi: 10.1053/j.gastro.2023.06.031. Epub 2023 Jul 14. PMID: 37453564.
Konovalova S, Torregrosa-Muñumer R, Manjunath P, Liu X, Baral S, Fatima K, Holopainen M, Kvist J, Rajendran J, Yang Y, Varjosalo M, Käkelä R, Somerharju P, Tyynismaa H. Small mitochondrial protein NERCLIN regulates cardiolipin homeostasis and mitochondrial ultrastructure. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2210599120. doi: 10.1073/pnas.2210599120. Epub 2023 Jul 18. PMID: 37463214; PMCID: PMC10372682.
Conway JRW, Dinç DD, Follain G, Paavolainen O, Kaivola J, Boström P, Hartiala P, Peuhu E, Ivaska J. IGFBP2 secretion by mammary adipocytes limits breast cancer invasion. Sci Adv. 2023 Jul 14;9(28):eadg1840. doi: 10.1126/sciadv.adg1840. Epub 2023 Jul 12. PMID: 37436978; PMCID: PMC10337915.
Ala-Nisula T, Sah-Teli SK, Ronkainen VP, Dimova EY, Koivunen P. Human phytanoyl-CoA dioxygenase domain-containing 1 (PHYHD1) is a putative oxygen sensor associated with RNA and carbohydrate metabolism. FEBS Lett. 2023 Jun;597(12):1651-1666. doi: 10.1002/1873-3468.14666. Epub 2023 Jun 1. PMID: 37235702.
Senju Y, Mushtaq T, Vihinen H, Manninen A, Saarikangas J, Ven K, Engel U, Varjosalo M, Jokitalo E, Lappalainen P. Actin-rich lamellipodia-like protrusions contribute to the integrity of epithelial cell-cell junctions. J Biol Chem. 2023 May;299(5):104571. doi: 10.1016/j.jbc.2023.104571. Epub 2023 Mar 3. PMID: 36871754; PMCID: PMC10173786.
Khanal P, Boskovic Z, Lahti L, Ghimire A, Minkeviciene R, Opazo P, Hotulainen P. Gas7 is a novel dendritic spine initiation factor. eNeuro. 2023 Mar 23:ENEURO.0344-22.2023. doi: 10.1523/ENEURO.0344-22.2023. PMID: 36963834.
Englund JI, Bui H, Dinç DD, Paavolainen O, McKenna T, Laitinen S, Munne P, Klefström J, Peuhu E, Katajisto P. Laminin matrix adhesion regulates basal mammary epithelial cell identity. J Cell Sci. 2022 Dec 1;135(23):jcs260232. doi: 10.1242/jcs.260232. Epub 2022 Dec 5. PMID: 36468336.
Salokas K, Liu X, Öhman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M. Physical and functional interactome atlas of human receptor tyrosine kinases. EMBO Rep. 2022 Jun 7;23(6):e54041. doi: 10.15252/embr.202154041. Epub 2022 Apr 5. PMID: 35384245; PMCID: PMC9171411.
Arora A, Kivelä AM, Wang L, Minkeviciene R, Taskinen JH, Zhang B, Koponen A, Sun J, Shirane M, Zhou Y, Hotulainen P, Raiborg C, Olkkonen VM. Protrudin regulates FAK activation, endothelial cell migration and angiogenesis. Cell Mol Life Sci. 2022 Apr 4;79(4):220. doi: 10.1007/s00018-022-04251-z. PMID: 35368213; PMCID: PMC8977271.
Ahonen MA, Höring M, Nguyen VD, Qadri S, Taskinen JH, Nagaraj M, Wabitsch M, Fischer-Posovszky P, Zhou Y, Liebisch G, Haridas PAN, Yki-Järvinen H, Olkkonen VM. Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes. Mol Med. 2022 Jun 17;28(1):68. doi: 10.1186/s10020-022-00496-3. PMID: 35715726; PMCID: PMC9204892.
Liu X, Huuskonen S, Laitinen T, Redchuk T, Bogacheva M, Salokas K, Pöhner I, Öhman T, Tonduru AK, Hassinen A, Gawriyski L, Keskitalo S, Vartiainen MK, Pietiäinen V, Poso A, Varjosalo M. SARS-CoV-2-host proteome interactions for antiviral drug discovery. Mol Syst Biol. 2021 Nov;17(11):e10396. doi: 10.15252/msb.202110396. PMID: 34709727; PMCID: PMC8552907.
Belitškin D, Pant SM, Munne P, Suleymanova I, Belitškina K, Hongisto HA, Englund J, Raatikainen T, Klezovitch O, Vasioukhin V, Li S, Wu Q, Monni O, Kuure S, Laakkonen P, Pouwels J, Tervonen TA, Klefström J. Hepsin regulates TGFβ signaling via fibronectin proteolysis. EMBO Rep. 2021 Nov 4;22(11):e52532. doi: 10.15252/embr.202152532. Epub 2021 Sep 13. PMID: 34515392; PMCID: PMC8567232.
Mung KL, Eccleshall WB, Santio NM, Rivero-Müller A, Koskinen PJ. PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1. Cell Commun Signal. 2021 Jun 30;19(1):68. doi: 10.1186/s12964-021-00749-4. PMID: 34193159; PMCID: PMC8247201.
Tervonen TA, Pant SM, Belitškin D, Englund JI, Närhi K, Haglund C, Kovanen PE, Verschuren EW, Klefström J. Oncogenic Ras disrupts epithelial integrity by activating the transmembrane serine protease hepsin. Cancer Res. 2021 Mar 15;81(6):1513-1527. doi: 10.1158/0008-5472.CAN-20-1760. Epub 2021 Jan 18. PMID: 33461973.
Moreno-Layseca P, Jäntti NZ, Godbole R, Sommer C, Jacquemet G, Al-Akhrass H, Conway JRW, Kronqvist P, Kallionpää RE, Oliveira-Ferrer L, Cervero P, Linder S, Aepfelbacher M, Zauber H, Rae J, Parton RG, Disanza A, Scita G, Mayor S, Selbach M, Veltel S, Ivaska J. Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis. Nat Cell Biol. 2021 Oct;23(10):1073-1084. doi: 10.1038/s41556-021-00767-x. Epub 2021 Oct 6. Erratum in: Nat Cell Biol. 2022 Sep;24(9):1445. PMID: 34616024.
Paakinaho V, Lempiäinen JK, Sigismondo G, Niskanen EA, Malinen M, Jääskeläinen T, Varjosalo M, Krijgsveld J, Palvimo JJ. SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites. Nucleic Acids Res. 2021 Feb 26;49(4):1951-1971. doi: 10.1093/nar/gkab032. PMID: 33524141; PMCID: PMC7913686.
Myllykoski M, Sutinen A, Koski MK, Kallio JP, Raasakka A, Myllyharju J, Wierenga RK, Koivunen P. Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains. J Biol Chem. 2021 Jan-Jun;296:100197. doi: 10.1074/jbc.RA120.016542. Epub 2020 Dec 20. PMID: 33334883; PMCID: PMC7948501.
Myllykoski M, Sutinen A, Koski MK, Kallio JP, Raasakka A, Myllyharju J, Wierenga RK, Koivunen P. Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains. J Biol Chem. Epub 2020 Dec 17:jbc.RA120.016542. doi: 10.1074/jbc.RA120.016542. PMID: 33334883.
Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science. 2020 Epub Oct 20:eabd2985. doi: 10.1126/science.abd2985. PMID: 33082293.
Sahgal P, Alanko J, Icha J, Paatero I, Hamidi H, Arjonen A, Pietilä M, Rokka A, Ivaska J. GGA2 and RAB13 promote activity-dependent β1-integrin recycling. J Cell Sci. 2019 Jun 7;132(11):jcs233387. doi: 10.1242/jcs.233387. PMID: 31076515.
Zhao Z, Kesti T, Uğurlu H, Baur AS, Fagerlund R, Saksela K. Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion. Traffic. 2019 Mar;20(3):202-212. doi: 10.1111/tra.12630. Epub 2019 Jan 21. PMID: 30569492.
Jacquemet G, Stubb A, Saup R, Miihkinen M, Kremneva E, Hamidi H, Ivaska J. Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability. Curr Biol. 2019 Jan 21;29(2):202-216.e7. doi: 10.1016/j.cub.2018.11.053. Epub 2019 Jan 10. PMID: 30639111; PMCID: PMC6345628.
Kentala H, Koponen A, Vihinen H, Pirhonen J, Liebisch G, Pataj Z, Kivelä A, Li S, Karhinen L, Jääskeläinen E, Andrews R, Meriläinen L, Matysik S, Ikonen E, Zhou Y, Jokitalo E, Olkkonen VM. OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism. Cell Mol Life Sci. 2018 Nov;75(21):4041-4057. doi: 10.1007/s00018-018-2850-8. Epub 2018 Jun 12. PMID: 29947926.
Hlushchenko I, Khanal P, Abouelezz A, Paavilainen VO, Hotulainen P. ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons. Front Cell Neurosci. 2018 Aug 3;12:217. doi: 10.3389/fncel.2018.00217. PMID: 30123108; PMCID: PMC6085419.
Pehkonen H, Lento M, von Nandelstadh P, Filippou A, Grénman R, Lehti K, Monni O. Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton. Cell Commun Signal. 2018 Jul 13;16(1):41. doi: 10.1186/s12964-018-0253-y. PMID: 30005669; PMCID: PMC6045882.
Pekkonen P, Alve S, Balistreri G, Gramolelli S, Tatti-Bugaeva O, Paatero I, Niiranen O, Tuohinto K, Perälä N, Taiwo A, Zinovkina N, Repo P, Icay K, Ivaska J, Saharinen P, Hautaniemi S, Lehti K, Ojala PM. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. Elife. 2018 May 1;7:e32490. doi: 10.7554/eLife.32490. PMID: 29712618; PMCID: PMC5929907.
Kentala H, Koponen A, Kivelä AM, Andrews R, Li C, Zhou Y, Olkkonen VM. Analysis of ORP2-knockout hepatocytes uncovers a novel function in actin cytoskeletal regulation. FASEB J. 2018 Mar;32(3):1281-1295. doi: 10.1096/fj.201700604R. Epub 2018 Jan 3. PMID: 29092904.
Liu Y, Mattila J, Ventelä S, Yadav L, Zhang W, Lamichane N, Sundström J, Kauko O, Grénman R, Varjosalo M, Westermarck J, Hietakangas V. PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression. Dev Cell. 2017 Oct 23;43(2):240-252.e5. doi: 10.1016/j.devcel.2017.09.022. PMID: 29065309.

Scanning

Dillemuth P, Karskela T, Ayo A, Ponkamo J, Kunnas J, Rajander J, Tynninen O, Roivainen A, Laakkonen P, Airaksinen AJ, Li XG. Radiosynthesis, structural identification and in vitro tissue binding study of [18F]FNA-S-ACooP, a novel radiopeptide for targeted PET imaging of fatty acid binding protein 3. EJNMMI Radiopharm Chem. 2024 Feb 23;9(1):16. doi: 10.1186/s41181-024-00245-3. PMID: 38393497; PMCID: PMC10891031.
Quixabeira DCA, Jirovec E, Pakola S, Havunen R, Basnet S, Santos JM, Kudling TV, Clubb JHA, Haybout L, Arias V, Grönberg-Vähä-Koskela S, Cervera-Carrascon V, Pasanen A, Anttila M, Tapper J, Kanerva A, Hemminki A. Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine. Cancer Gene Ther. 2023 Nov;30(11):1543-1553. doi: 10.1038/s41417-023-00658-3. Epub 2023 Sep 4. PMID: 37666898; PMCID: PMC10645590.
Quixabeira DCA, Pakola S, Jirovec E, Havunen R, Basnet S, Santos JM, Kudling TV, Clubb JHA, Haybout L, Arias V, Grönberg-Vähä-Koskela S, Cervera-Carrascon V, Kerkelä E, Pasanen A, Anttila M, Tapper J, Kanerva A, Hemminki A. Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer. Cancer Gene Ther. 2023 Nov 10. doi: 10.1038/s41417-023-00674-3. Epub ahead of print. PMID: 37949944.
van Bochove B, Rongen JJ, Hannink G, Seppälä JV, Poot AA, Grijpma DW. In Vitro and In Vivo Degradation of Photo-Crosslinked Poly(Trimethylene Carbonate-co-ε-Caprolactone) Networks. Macromol Biosci. 2023 Nov 3:e2300364. doi: 10.1002/mabi.202300364. Epub ahead of print. PMID: 37923394.
Monzo HJ, Kalander K, Hyytiäinen MM, Elbasani E, Wall J, Moyano-Galceran L, Tanjore Ramanathan J, Jukonen J, Laakkonen P, Ristimäki A, Carlson JW, Lehti K, Salehi S, Puolakkainen P, Haglund C, Seppänen H, Leppä S, Ojala PM. Efficacy and Safety of Glycosphingolipid SSEA-4 Targeting CAR-T Cells in an Ovarian Carcinoma Model. Mol Cancer Ther. 2023 Nov 1;22(11):1319-1331. doi: 10.1158/1535-7163.MCT-23-0008. PMID: 37486980.
Mäenpää K, Ilves M, Zhao L, Alenius H, Sinkko H, Karisola P. Effects of Superficial Scratching and Engineered Nanomaterials on Skin Gene Profiles and Microbiota in SKH-1 Mice. Int J Mol Sci. 2023 Oct 26;24(21):15629. doi: 10.3390/ijms242115629. PMID: 37958613; PMCID: PMC10649582.
Godbole N, Kyrönlahti A, Hukkinen M, Pihlajoki M, Heikinheimo M, Pakarinen MP. Bacterial translocation markers and toll-like receptors in biliary atresia following successful portoenterostomy. Acta Paediatr. 2023 Oct;112(10):2210-2217. doi: 10.1111/apa.16893. Epub 2023 Jul 5. PMID: 37378619.
Ikonen L, Pirnes-Karhu S, Pradhan S, Jacobs HT, Szibor M, Suomalainen A. Alternative oxidase causes cell type- and tissue-specific responses in mutator mice. Life Sci Alliance. 2023 Sep 1;6(11):e202302036. doi: 10.26508/lsa.202302036. PMID: 37657934; PMCID: PMC10474302.
Koskinen MK, Laine M, Abdollahzadeh A, Gigliotta A, Mazzini G, Journée S, Alenius V, Trontti K, Tohka J, Hyytiä P, Sierra A, Hovatta I. Node of Ranvier remodeling in chronic psychosocial stress and anxiety. Neuropsychopharmacology. 2023 Sep;48(10):1532-1540. doi: 10.1038/s41386-023-01568-6. Epub 2023 Mar 22. PMID: 36949148; PMCID: PMC10425340.
Nousiainen R, Eloranta K, Isoaho N, Cairo S, Wilson DB, Heikinheimo M, Pihlajoki M. UBE2C expression is elevated in hepatoblastoma and correlates with inferior patient survival. Front Genet. 2023 Jun 12;14:1170940. doi: 10.3389/fgene.2023.1170940. PMID: 37377594; PMCID: PMC10291054.
Anisimov A, Fang S, Hemanthakumar KA, Örd T, van Avondt K, Chevre R, Toropainen A, Singha P, Gilani H, Nguyen SD, Karaman S, Korhonen EA, Adams RH, Augustin HG, Öörni K, Soehnlein O, Kaikkonen MU, Alitalo K. The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium. Nat Cardiovasc Res. 2023 Mar 13;2(3):307-321. doi: 10.1038/s44161-023-00224-y. PMID: 37476204; PMCID: PMC7614785.
Zhao L, Wang S, Ilves M, Lehtonen S, Saikko L, El-Nezami H, Alenius H, Karisola P. Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs. Int J Mol Sci. 2023 Mar 8;24(6):5183. doi: 10.3390/ijms24065183. PMID: 36982257; PMCID: PMC10049322.
Pikkusaari S, Tumiati M, Virtanen A, Oikkonen J, Li Y, Perez-Villatoro F, Muranen T, Salko M, Huhtinen K, Kanerva A, Koskela H, Tapper J, Koivisto-Korander R, Joutsiniemi T, Haltia UM, Lassus H, Hautaniemi S, Farkkila A, Hynninen J, Hietanen S, Carpén O, Kauppi L. Functional homologous recombination assay on FFPE specimens of advanced high-grade serous ovarian cancer predicts clinical outcomes. Clin Cancer Res. 2023 Feb 20:CCR-22-3156. doi: 10.1158/1078-0432.CCR-22-3156. Epub ahead of print. PMID: 36805632.
Clubb JHA, Kudling TV, Girych M, Haybout L, Pakola S, Hamdan F, Cervera-Carrascon V, Hemmes A, Grönberg-Vähä-Koskela S, Santos JM, Quixabeira DCA, Basnet S, Heiniö C, Arias V, Jirovec E, Kaptan S, Havunen R, Sorsa S, Erikat A, Schwartz J, Anttila M, Aro K, Viitala T, Vattulainen I, Cerullo V, Kanerva A, Hemminki A. Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting. Front Immunol. 2023 Feb 3;14:1060540. doi: 10.3389/fimmu.2023.1060540. PMID: 36817448; PMCID: PMC9936529.
Tuohinto K, DiMaio TA, Kiss EA, Laakkonen P, Saharinen P, Karnezis T, Lagunoff M, Ojala PM. KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi's sarcoma studies. PLoS Pathog. 2023 Jan 23;19(1):e1010753. doi: 10.1371/journal.ppat.1010753. PMID: 36689549; PMCID: PMC9894539.
Lapatto HAK, Kuusela M, Heikkinen A, Muniandy M, van der Kolk BW, Gopalakrishnan S, Pöllänen N, Sandvik M, Schmidt MS, Heinonen S, Saari S, Kuula J, Hakkarainen A, Tampio J, Saarinen T, Taskinen MR, Lundbom N, Groop PH, Tiirola M, Katajisto P, Lehtonen M, Brenner C, Kaprio J, Pekkala S, Ollikainen M, Pietiläinen KH, Pirinen E. Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study. Sci Adv. 2023 Jan 13;9(2):eadd5163. doi: 10.1126/sciadv.add5163. Epub 2023 Jan 13. PMID: 36638183; PMCID: PMC9839336.
Huuska N, Netti E, Lehti S, Kovanen PT, Niemelä M, Tulamo R. Lymphatic vessels are present in human saccular intracranial aneurysms. Acta Neuropathol Commun. 2022 Sep 5;10(1):130. doi: 10.1186/s40478-022-01430-8. PMID: 36064651; PMCID: PMC9446758.
Xu M, Leskinen K, Gritti T, Groma V, Arola J, Lepistö A, Sipponen T, Saavalainen P, Söderlund-Venermo M. Prevalence, Cell Tropism, and Clinical Impact of Human Parvovirus Persistence in Adenomatous, Cancerous, Inflamed, and Healthy Intestinal Mucosa. Front Microbiol. 2022 May 24;13:914181. doi: 10.3389/fmicb.2022.914181. PMID: 35685923; PMCID: PMC9171052.
Godbole N, Nyholm I, Hukkinen M, Davidson JR, Tyraskis A, Lohi J, Heikkilä P, Eloranta K, Pihlajoki M, Davenport M, Heikinheimo M, Kyrönlahti A, Pakarinen MP. Liver secretin receptor predicts portoenterostomy outcomes and liver injury in biliary atresia. Sci Rep. 2022 May 4;12(1):7233. doi: 10.1038/s41598-022-11140-9. PMID: 35508528; PMCID: PMC9068784.
Dienel K, Abu-Shahba A, Kornilov R, Björkstrand R, van Bochove B, Snäll J, Wilkman T, Mesimäki K, Meller A, Lindén J, Lappalainen A, Partanen J, Seppänen-Kaijansinkko R, Seppälä J, Mannerström B. Patient-Specific Bioimplants and Reconstruction Plates for Mandibular Defects: Production Workflow and In Vivo Large Animal Model Study. Macromol Biosci. 2022 Apr;22(4):e2100398. doi: 10.1002/mabi.202100398. Epub 2022 Jan 30. PMID: 35023297.
Clubb JHA, Kudling TV, Heiniö C, Basnet S, Pakola S, Cervera Carrascón V, Santos JM, Quixabeira DCA, Havunen R, Sorsa S, Zheng V, Salo T, Bäck L, Aro K, Tulokas S, Loimu V, Hemminki A. Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer. Front Immunol. 2022 Mar 7;13:794251. doi: 10.3389/fimmu.2022.794251. PMID: 35355980; PMCID: PMC8959099.
Abu-Shahba AG, Wilkman T, Kornilov R, Adam M, Salla KM, Lindén J, Lappalainen AK, Björkstrand R, Seppänen-Kaijansinkko R, Mannerström B. Periosteal Flaps Enhance Prefabricated Engineered Bone Reparative Potential. J Dent Res. 2022 Feb;101(2):166-176. doi: 10.1177/00220345211037247. Epub 2021 Sep 11. PMID: 34514892; PMCID: PMC8808084.
Karaman S, Paavonsalo S, Heinolainen K, Lackman MH, Ranta A, Hemanthakumar KA, Kubota Y, Alitalo K.
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance. J Exp Med. 2022 Mar 7;219(3):e20210565. doi: 10.1084/jem.20210565. Epub 2022 Jan 20. PMID: 35050301
Zhang K, Erkan EP, Jamalzadeh S, Dai J, Andersson N, Kaipio K, Lamminen T, Mansuri N, Huhtinen K, Carpén O, Hietanen S, Oikkonen J, Hynninen J, Virtanen A, Häkkinen A, Hautaniemi S, Vähärautio A. Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer. Sci Adv. 2022 Feb 25;8(8):eabm1831. doi: 10.1126/sciadv.abm1831. Epub 2022 Feb 23. PMID: 35196078; PMCID: PMC8865800.
Karsten L, Janson N, Le Joncour V, Alam S, Müller B, Tanjore Ramanathan J, Laakkonen P, Sewald N, Müller KM. Bivalent EGFR-Targeting DARPin-MMAE Conjugates. Int J Mol Sci. 2022 Feb 23;23(5):2468. doi: 10.3390/ijms23052468. PMID: 35269611; PMCID: PMC8909960.
Polianskyte-Prause Z, Tolvanen TA, Lindfors S, Kon K, Hautala LC, Wang H, Wada T, Tsuneki H, Sasaoka T, Lehtonen S. Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice. Int J Biol Sci. 2022 Feb 14;18(5):1852-1864. doi: 10.7150/ijbs.66314. PMID: 35342343; PMCID: PMC8935241.
Abu-Shahba AG, Wilkman T, Kornilov R, Adam M, Salla KM, Lindén J, Lappalainen AK, Björkstrand R, Seppänen-Kaijansinkko R, Mannerström B. Periosteal Flaps Enhance Prefabricated Engineered Bone Reparative Potential. J Dent Res. 2022 Feb;101(2):166-176. doi: 10.1177/00220345211037247. Epub 2021 Sep 11. PMID: 34514892; PMCID: PMC8808084.
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