FINStruct

FINStruct logo

Structural Biology Finland and Instruct-ERIC Centre Finland research infrastructures

Structural Biology Finland (FINStruct)

FINStruct is a national, coordinated, multi-institution, open-access, research infrastructure network (previous Instruct Finland, Instruct-FI until 2020). It provides integrated structural biology services and training to support research and innovation in life science. FINStruct services are provided by core facilities in five universities (Helsinki, Oulu, Eastern Finland, Turku, and Åbo Academi), and coordinated by the University of Helsinki. FINStruct is included on the Finnish Research Infrastructure 2014-2020 roadmap. FINStruct is the Structural Biology Platform of Biocenter Finland, and coordinates all research infrastructure requirements of the national structural biology network.

FINStruct Coordination Hub at the University of Helsinki

  • Director, Professor Sarah Butcher
  • Coordinator, Adjunct Professor Hanna Oksanen
  • Coordinates FINStruct and Instruct-ERIC Centre Finland

FINStruct services

FINStruct spearheads international research and development in biomolecular complex purification (Biocomplex); cryo-electron microscopy (cryoEM); nuclear magnetic resonance (NMR); native mass spectrometry (native-MS); structural bioinformatics, X-ray crystallography and data management. Each unit is a core facility of the research providing organizations. FINStruct serves the entire research community, academia and industry, nationally and internationally. CryoEM, Biocomplex, NMR, SCoPE-MS, Biocenter Oulu, and Biocenter Kuopio services can be also accessed through Instruct-ERIC (see below and funding possibilities for Instruct-ERIC access).

Instruct-ERIC Centre Finland

Instruct-ERIC is one of the successful operators at the European Strategy Forum on Research Infrastructures (ESFRI) with s a landmark status on the ESFRI Roadmap (2016). Accesses are provided at the scientifically evaluated and accepted Instruct-ERIC Centres that are located across the Europe. Instruct-ERIC member states host Instruct Centres that provide infrastructure and expertise supporting the mission and objectives of the Instruct-ERIC. Instruct-ERIC provides also the following resources:

Finland became a full member of Instruct-ERIC in 2019. In February 2020, Instruct Centre Finland services were opened and are available through the Instruct-ERIC catalogue for international and national use (Instruct-ERIC News). FINStruct provides a distributed Instruct Centre Finland, which is a national node of Instruct-ERIC. Being a member of Instruct-ERIC allows scientists from Finland to access the wide catalogue of cutting-edge structural biology technologies, including funding to enable important research discoveries in molecular bioscience.

Instruct-ERIC Centre Finland services

Funding for Instruct-ERIC Access

See funded access. Who can apply?

How to acknowledge FINStruct and Instruct-ERIC

For all publication and theses of research resulting from FINStruct or Instruct-ERIC Centre Finland access and use of services, there should be acknowledgement of FINStruct and/or Instruct-ERIC. Please acknowledge, use of the service, expertise and resources using the following texts in the Acknowledgements:

Service units operating both in FINStruct  and Instruct-ERIC: CryoEM, Biocomplex, NMR, Biocenter Oulu, Biocenter Kuopio/Univ Eastern Finland units
The facilities and expertise of the “RI facility name at the University of X”, a member of Instruct-ERIC Centre Finland, FINStruct, and Biocenter Finland are gratefully acknowledged.
Example: The facilities and expertise of the CryoEM facility at the University of Helsinki, a member of Instruct-ERIC Centre Finland, FINStruct, and Biocenter Finland are gratefully acknowledged.

SCoPE-MS service unit in Instruct-ERIC
The facilities and expertise of the SCoPE-MS at the University of Helsinki, a member of Instruct-ERIC Centre Finland are gratefully acknowledged.

For projects with Instruct-ERIC access funding: see guidelines here

Service units operating in FINStruct: Protein crystallization facilities at Univ of Helsniki, Turku, and Åbo Akademi
The facilities and expertise of the “RI facility name at the University of X”, a member of FINStruct and Biocenter Finland are gratefully acknowledged.
Example: The facilities and expertise of the crystallization facility at the University of Helsinki, a member of FINStruct and Biocenter Finland are gratefully acknowledged.

Publications

updated on December 5, 2019

2019

  1. Abdelkreem E, Harijan RK, Yamaguchi S, Wierenga RK, Fukao T. 2019. Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency. Hum Mutat. 40:1641-1663.
  2. Abdelnabi R, Geraets JA, Ma Y, Mirabelli C, Flatt JW, Domanska A, Delang L, Jochmans D, Jayaprakash V, Sinha BN, Leyssen P, Butcher SJ, Neyts J. 2019. A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses. PLoS Biology 17(6):e3000281
  3. Agrawal N, Lehtonen SI, Uusi-Mäkelä M, Jain P, Viitala S, Määttä JAE, Kähkönen N, Azizi L, Riihimäki TA, Kulomaa MS, Johnson MS, Hytönen VP, Airenne TT. 2019. Molecular features of steroid-binding antidins and their use for assaying serum progesterone. PLoS One. 14:e0212339.
  4. Agustin MB, Penttilä PA, Lahtinen M, Mikkonen KS. 2019. Rapid and direct preparation of lignin nanoparticles from alkaline pulping liquor by mild ultrasonication. ACS Sustainable Chem. Eng. In Press
  5. Barylski J, Enault F, Dutilh BE, Schuller MBP, Edwards RA, Gillis A, Klumpp J, Knezevic P, Krupovic M, Kuhn JH, Lavigne R, Oksanen HM, Sullivan MB, Jang HB, Simmonds P, Aiewsakun P, Wittmann J, Tolstoy I, Brister JR, Kropinski AM, Adriaenssens EM. 2019. Analysis of Spounaviruses as a case study for the overdue reclassification of tailed phages. Syst Biol. pii: syz036.
  6. Beyer HM, Mikula KM, Kudling TV, Iwaï H. 2019. Crystal structures of CDC21-1 inteins from hyperthermophilic archaea reveal the selection mechanism for the highly conserved homing endonuclease insertion site. Extremophiles. 23:669-679.
  7. Biterova EI, Isupov MN, Keegan RM, Lebedev AA, Sohail AA, Liaqat I, Alanen HI, Ruddock LW. 2019. The crystal structure of human microsomal triglyceride transfer protein. Proc Natl Acad Sci U S A. 116:17251-17260.
  8. Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P. 2019. EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology. SLAS Discov. 24:398-413.
  9. Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr. 2019. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 363:1217-1222.
  10. Chronopoulou EG, Vlachakis D, Papageorgiou AC, Ataya FS, Labrou NE. 2019. Structure-based design and application of an engineered glutathione transferase for the development of an optical biosensor for pesticides determination. Biochim Biophys Acta Gen Subj. 1863:565-576.
  11. De Colibus L, Roine E, Walter TS, Ilca SL, Wang X, Wang N, Roseman AM, Bamford D, Huiskonen JT, Stuart DI. 2019. Assembly of complex viruses exemplified by a halophilic euryarchaeal virus. Nat Commun. 10:1456.
  12. Domanska A, Flatt JW, Jukonen JJJ, Geraets JA, Butcher SJ. 2019. 2.8 Å resolution cryo-EM structure of human parechovirus 3 in complex with Fab from a neutralizing antibody. J. Virol. 93(4): e01597-18.
  13. El Omari K, Li S, Kotecha A, Walter TS, Bignon EA, Harlos K, Somerharju P, De Haas F, Clare DK, Molin M, Hurtado F, Li M, Grimes JM, Bamford DH, Tischler ND, Huiskonen JT, Stuart DI, Roine E. 2019. The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins. Nat Commun. 10:846.
  14. Eskelin K, Poranen MM, Oksanen HM. 2019. Asymmetrical flow field-flow fractionation on virus and virus-like particle applications. Microorganisms. 7:e555.
  15. Gering C, Koivisto JT, Parraga J, Leppiniemi J, Vuornos K, Hytönen VP, Miettinen S, Kellomäki M. 2019. Design of modular gellan gum hydrogel functionalized with avidin and biotinylated adhesive ligands for cell culture applications. PLoS One. 14:e0221931.
  16. Guédez G, Pothipongsa A, Sirén S, Liljeblad A, Jantaro S, Incharoensakdi A, Salminen TA. 2019. Crystal structure of dimeric Synechococcus spermidine synthase with bound polyamine substrate and product. Biochem J. 476:1009-1020.
  17. Hankaniemi MM, Stone VM, Andrejeff T, Heinimäki S, Sioofy-Khojine AB, Marjomäki V, Hyöty H, Blazevic V, Flodström-Tullberg M, Hytönen VP, Laitinen OH. 2019. Formalin treatment increases the stability and immunogenicity of coxsackievirus B1 VLP vaccine. Antiviral Res. 171:104595.
  18. Heinimäki S, Hankaniemi MM, Sioofy-Khojine AB, Laitinen OH, Hyöty H, Hytönen VP, Vesikari T, Blazevic V. 2019. Combination of three virus-derived nanoparticles as a vaccine against enteric pathogens; enterovirus, norovirus and rotavirus. Vaccine. [Epub ahead of print]
  19. Ilca SL, Sun X, El Omari K, Kotecha A, de Haas F, DiMaio F, Grimes JM, Stuart DI, Poranen MM, Huiskonen JT. 2019. Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus. Nature. 570(7760):252-256.
  20. Karki S, Maksimainen MM, Lehtiö L, Kajander T. 2019. Inhibitor screening assay for neurexin-LRRTM adhesion protein interaction involved in synaptic maintenance and neurological disorder. Anal Biochem. 587:113463.
  21. Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. 2019Cholesterol accessibility at the ciliary membrane controls hedgehog signaling. Elife. 8:e50051.
  22. Kiema TR, Thapa CJ, Laitaoja M, Schmitz W, Maksimainen MM, Fukao T, Rouvinen J, Jänis J, Wierenga RK. 2019. The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry. Biochem J. 476:307-332.
  23. Lopes de Carvalho L, Bligt-Lindén E, Ramaiah A, Johnson MS, Salminen TA. 2019. Evolution and functional classification of mammalian copper amine oxidases. Mol Phylogenet Evol. 139:106571.
  24. Mattila A, Andsten RM, Jumppanen M, Assante M, Jokela J, Wahlsten M, Mikula KM, Sigindere C, Kwak DH, Gugger M, Koskela H, Sivonen K, Liu X, Yli-Kauhaluoma J, Iwai H, Fewer DP. 2019. Biosynthesis of the bis-prenylated alkaloids muscoride A and B. ACS Chem Biol. [Epub ahead of print].
  25. Mäntynen S, Sundberg LR, Oksanen HM, Poranen MM. 2019. Half a century of research on membrane-containing bacteriophages: bringing new concepts to modern virology. Viruses 11: e76.
  26. Li DC, Papageorgiou AC. 2019. Cellulases from thermophilic fungi: Recent insights and biotechnological potential. In: Fungi in Extreme Environments: Ecological Role and Biotechnological Significance. Eds: Tiquia-Arahiro SM, Grube M. Springer International Publishing pp. 395-417.
  27. Lyytinen OL, Starkova D, Poranen MM. 2019. Microbial production of lipid-protein vesicles using enveloped bacteriophage phi6. Microb Cell Fact. 18:29.
  28. Mikula KM, Kolodziejczyk R, Goldman A. 2019. Structure of the UspA1 protein fragment from Moraxella catarrhalis responsible for C3d binding. J Struct Biol. 208:77-85.
  29. Mizuno CM, Prajapati B, Lucas-Staat S, Sime-Ngando T, Forterre P, Bamford DH, Prangishvili D, Krupovic M, Oksanen HM. 2019. Novel haloarchaeal viruses from Lake Retba infecting Haloferax and Halorubrum species. Environ Microbiol. Environ Microbiol. 21(6):2129-2147.
  30. Mönttinen HAM, Ravantti JJ, Poranen MM. 2019. Structural comparison strengthens the higher-order classification of proteases related to chymotrypsin. PLoS One. 14(5):e0216659.
  31. Ojanen MJT, Uusi-Mäkelä MIE, Harjula SE, Saralahti AK, Oksanen KE, Kähkönen N, Määttä JAE, Hytönen VP, Pesu M, Rämet M. 2019. Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio). Sci Rep. 9:995
  32. Oksanen HM, and Abrescia NGA. 2019. Membrane-containing icosahedral bacteriophage PRD1: the dawn of viral lineages. In: Advances in Experimental Medicine and Biology - 'Physical Virology - Virus Structure and Mechanics’. Ed: Greber, U. Springer. 1140:85-109.
  33. Papageorgiou, AC. 2019. X-ray crystallography in structure-function characterization of therapeutic enzymes. Adv. Exper. Med. Biol. 1148, 81-103.
  34. Papageorgiou AC, Poudel N, Matsson J. 2019. Protein analysis with X-ray crystallography. Methods Mol. Biol. In Press
  35. Pooch F, Sliepen M, Knudsen KD, Nyström B, Tenhu H, Winnik FM. 2019. Poly(2-isopropyl-2-oxazoline)-b-poly(lactide) (PiPOx-b-PLA) nanoparticles in water: interblock van der Waals attraction opposes amphiphilic phase separation. Macromolecules. 52:1317-1326.
  36. Rehan S, Shahid S, Salminen TA, Jaakola VP, Paavilainen VO. 2019. Current progress on equilibrative nucleoside transporter function and inhibitor design. SLAS Discov. [Epub ahead of print]
  37. Richardson D, Itkonen J, Nievas J, Urtti A, Casteleijn MG. 2019. Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation. Sci Rep. 8:11967.
  38. Ruokolainen V, Domanska A, Laajala M, Pelliccia M, Butcher SJ, Marjomäki V.2019. Extracellular albumin and endosomal ions prime enterovirus particles for uncoating that can be prevented by fatty acid saturation. J.Virol. 93:e00599-19.
  39. Sah-Teli SK, Hynönen MJ, Schmitz W, Geraets JA, Seitsonen J, Pedersen JS, Butcher SJ, Wierenga RK, Venkatesan R. 2019. Complementary substrate specificity and distinct quaternary assembly of the Escherichia coli aerobic and anaerobic β-oxidation trifunctional enzyme complexes. Biochem J. 476:1975-1994.
  40. Santos-Pérez I, Charro D, Gil-Carton D, Azkargorta M, Elortza F, Bamford DH, Oksanen HM, Abrescia NGA. 2019. Structural basis for assembly of vertical single β-barrel viruses. Nat Commun. 10:1184.
  41. Sjöstedt N, Salminen TA, Kidron H. 2019. Endogenous, cholesterol-activated ATP-dependent transport in membrane vesicles from Spodoptera frugiperda cells. Eur J Pharm Sci. 137:104963.
  42. Thangaraj S, Arola H, Tullila A, Nevanen T, Rouvinen J & Jänis J. 2019. Quantitation of thyroid hormone binding to anti-thyroxine antibody Fab fragment by native mass spectrometry. ACS Omega in press.
  43. Thangaraj SK, Voutilainen S, Andberg M, Koivula A, Jänis J, Rouvinen J. 2019. Bioconjugation with aminoalkylhydrazine for efficient mass spectrometry-based detection of small carbonyl compounds. ACS Omega. 4:13447-13453.
  44. Theoharaki C, Chronopoulou E, Vlachakis D, Ataya FS, Giannopoulos P, Maurikou S, Skopelitou K, Papageorgiou AC, Labrou NE. 2019. Delineation of the functional and structural properties of the glutathione transferase family from the plant pathogen Erwinia carotovora. Funct. Integr. Gen. 19:1-12.
  45. Vidilaseris K, Kiriazis A, Turku A, Khattab A, Johansson NG, Leino TO, Kiuru PS, Boije Af Gennäs G, Meri S, Yli-Kauhaluoma J, Xhaard H, Goldman A. 2019. Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor. Sci Adv. 5:eaav7574.
  46. Valoppi F, Lahtinen MH, Bhattarai M, Kirjoranta SJ, Juntti VK, Peltonen LJ, Kilpeläinen PO, Mikkonen KS. 2019. Centrifugal fractionation of softwood extracts improves the biorefinery workflow and yields functional emulsifiers. Green Chem. 21: 4691-4705.
  47. Wang L, Ago M, Borghei M, Ishaq A, Papageorgiou AC, Lundahl M, Rojas OM. 2019. Conductive carbon microfibers derived from wet-spun lignin/nanocellulose hydrogels. ACS Sustain. Chem. Eng. 7(6):6013-6022.
  48. Wang L, Lundahl MJ, Greca LG, Papageorgiou AC, Borghei M, Rojas OJ. 2019. Effects of non-solvents and electrolytes on the formation and properties of cellulose I filaments. Sci Rep. 9:16691.
  49. Wolthers KC, Susi P, Jochmans D, Koskinen J, Landt O, Sanchez N, Palm K, Neyts J, Butcher SJ. 2019. Progress in human picornavirus research: New findings from the AIROPico consortium. Antiviral Res. 161:100-107.
  50. Åstrand M, Cuellar J, Hytönen J, Salminen TA. 2019. Predicting the ligand-binding properties of Borrelia burgdorferi s.s. Bmp proteins in light of the conserved features of related Borrelia proteins. J Theor Biol. 462:97-108.

2018

  1. Adriaenssens EM, Wittmann J, Kuhn JH, Turner D, Sullivan MB, Dutilh BE, Jang HB, van Zyl LJ, Klumpp J, Lobocka M, Moreno Switt AI, Rumnieks J, Edwards RA, Uchiyama J, Alfenas-Zerbini P, Petty NK, Kropinski AM, Barylski J, Gillis A, Clokie MRC, Prangishvili D, Lavigne R, Aziz RK, Duffy S, Krupovic M, Poranen MM, Knezevic P, Enault F, Tong Y, Oksanen HM, Rodney Brister J. 2018. Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee. Arch Virol. 163:1125-1129.
  2. Antenucci L, Hytönen VP, Ylänne J. 2018. Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms. J Biol Chem. 293:4591-4602.
  3. Antila CJM, Rraklli V, Blomster HA, Dahlström KM, Salminen TA, Holmberg J, Sistonen L, Cecilia Sahlgren C. 2018. Sumoylation of Notch1 represses its target gene expression during cell stress. Cell Death Differ. 25:600-615.
  4. Atanasova NS, Demina TA, Krishnam Rajan Shanthi SV, Oksanen HM, and Bamford DH. 2018. Extremely halophilic pleomorphic archaeal virus HRPV9 extends the diversity of pleolipoviruses with integrases. Res Microbiol. 169:500-504
  5. Atanasova NS, Heiniö CHE, Demina T, Bamford DH, Oksanen HM. 2018. The unexplored diversity of pleolipoviruses: the surprising case of two viruses with identical major structural modules. Genes 9:131
  6. Azinas S, Bano F, Torca I, Bamford DH, Schwartz GA, Esnaola J, Oksanen HM, Richter RP, Abrescia NG. 2018. Membrane-containing virus particles exhibit the mechanics of a composite material for genome protection. Nanoscale 10:7769-7779.
  7. Biterova E, Esmaeeli M, Alanen HI, Saaranen M, Ruddock LW. 2018. Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease. Sci Rep. 8:6752.
  8. Biterova E, Ignatyev A, Uusimaa J, Hinttala R, Ruddock LW. 2018. Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease. PLoS One 13:e0202391.
  9. Brockmann SJ, Freischmidt A, Oeckl P, Müller K, Ponna SK, Helferich AM, Paone C, Reinders J, Kojer K, Orth M, Jokela M, Auranen M, Udd B, Hermann A, Danzer KM, Lichtner P, Walther P, Ludolph AC, Andersen PM, Otto M, Kursula P, Just S, Weishaupt JH. 2018. CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency. Hum Mol Genet. 27:706-715.
  10. Carvalho LL, Elovaara H, de Ruyck J, Vergoten G, Jalkanen S, Guédez G, Salminen TA.2018. Mapping the interaction site and effect of the Siglec-9 inflammatory biomarker on human primary amine oxidase. Sci Rep. 8:2086.
  11. Chronopoulou EG, Papageorgiou AC, Ataya F, Nianiou-Obeidat I, Madesis P, Labrou NE. 2018. Expanding the plant GSTome through directed evolution: DNA shuffling for the generation of new synthetic enzymes with engineered catalytic and binding properties. Front Plant Sci. 9:1737.
  12. Duyvesteyn HME, Ginn HM, Pietilä MK, Wagner A, Hattne J, Grimes JM, Hirvonen E, Evans G, Parsy M-L, Sauter NK, Brewster AS, Huiskonen JT, Stuart DI, Sutton G, Dennis H. Bamford DH. 2018. Towards in cellulo virus crystallography. Sci. Rep. 8:3771.
  13. Eskelin K, Poranen MM. 2018. Controlled disassembly and purification of functional viral subassemblies using asymmetrical flow field-flow fractionation (AF4). Viruses 10:579
  14. Edqvist J, Blomqvist K, Nieuwland J, Salminen TA. 2018. Plant lipid transfer proteins: are we finally closing in on these enigmatic proteins. J Lipid Res. 59:1374-1382
  15. Gludovacz E, Maresch D, Lopes de Carvalho L, Puxbaum V, Baier LJ, Sützl L, Guédez G, Grünwald-Gruber C, Ulm B, Pils S, Ristl R, Altmann F, Jilma B, Salminen TA, Borth N, Boehm T. 2018. Oligomannosidic glycans at Asn-110 are essential for secretion of human diamine oxidase. J Biol Chem. 293:1070-1087.
  16. Haataja S, Verma P, Fu O, Papageorgiou AC, Pöysti S, Pieters RJ, Nilsson UJ, Finne J. 2018. Rationally designed chemically modified glycodendrimer inhibits Streptococcus suis adhesin SadP at picomolar concentrations. Chemistry 24:1905-1912.
  17. Hackenberg C, Hakanpää J, Cai F, Antonyuk S, Eigner C, Meissner S, Laitaoja M, Jänis J, Kerfeld CA, Dittmann E, Lamzin VS. 2018. Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria. Proc Natl Acad Sci U S A. 115:7141-7146.
  18. Haikarainen T, Maksimainen M. Obaji E, Lehtiö L. 2018. Development of a screening assay for mono-ADP-ribosyl hydrolyzing macrodomains using AlphaScreen technology. SLAS Disc. 23:255-263.
  19. Haining AWM, Rahikainen R, Cortes E, Lachowski D, Rice A, von Essen M, Hytönen VP, Del Río Hernández A. 2018. Mechanotransduction in talin through the interaction of the R8 domain with DLC1. PLoS Biol. 16:e2005599.
  20. Harrus D, Khoder-Agha F, Peltoniemi M, Hassinen A, Ruddock L, Kellokumpu S, Glumoff T. 2018. The dimeric structure of wild-type human glycosyltransferase B4GalT1. PLoS One. 3:e0205571.
  21. Hepojoki J, Hepojoki S, Smura T, Szirovicza L, Dervas E, Prähauser B, Nufer L, Schraner EM, Vapalahti O, Kipar A, Hetzel U. 2018. Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses-The representatives of genus hartmanivirus, family Arenaviridae. PLoS Pathog. 14:e1007415.
  22. iNEXT Consortium. 2018. iNEXT: a European facility network to stimulate translational structural biology. FEBS Lett. 592:1909-1917.
  23. Karki S, Paudel P, Sele C, Skhumatov AV, Kajander T. 2018. The structure of SALM5 suggests a dimeric assembly for the presynaptic RPTP ligand recognition. Protein Eng Des Sel. 31:147-157.
  24. Kaur I, Ruskamo S, Koivunen J, Heljasvaara R, Lackman JJ, Izzi V, Petäjä-Repo UE, Kursula P, Pihlajaniemi T. 2018. The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated. Biochem J. 475:3577-3593.
  25. King AWT, Mäkelä V, Kedzior SA, Laaksonen T, Partl GJ, Heikkinen S, Koskela H, Heikkinen HA, Holding AJ, Cranston ED, Kilpeläinen I. 2018. Liquid-state NMR analysis of nanocelluloses. Biomacromolecules. 19:2708-2720.
  26. Koskela MM, Dahlström KM, Goñi G, Lehtimäki N, Nurmi M, Velazquez-Campoy A, Hanke G, Bölter B, Salminen TA, Medina M, Mulo P. 2018. Arabidopsis FNRL protein is an NADPH-dependent chloroplast oxidoreductase resembling bacterial ferredoxin-NADP+ reductases. Physiol Plant. 162(2):177-190.
  27. Kotila T, Kogan K, Enkavi G, Guo S, Vattulainen I, Goode BL, Lappalainen P. 2018. Structural basis of actin monomer re-charging by cyclase-associated protein. Nat Commun. 9:1892.
  28. Laitinen OH, Svedin E, Kapell S, Hankaniemi MM, Larsson PG, Domsgen E, Stone VM, Määttä JAE, Hyöty H, Hytönen VP, Flodström-Tullberg M. 2018. New coxsackievirus 2Aproand 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms. J Virol Methods. 255:29-37.
  29. Lampi M, Oksanen HM, Meier F, Moldenhauer E, Poranen MM, Bamford DH, and Eskelin K. 2018. Asymmetrical flow field-flow fractionation in purification of an enveloped bacteriophage ɸ6. J Chrom B. 1095: 251-257.
  30. Laulumaa S, Nieminen T, Raasakka A, Krokengen OC, Safaryan A, Hallin EI, Brysbaert G, Lensink MF, Ruskamo S, Vattulainen I, Kursula P. 2018. Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins. BMC Struct Biol. 18:8.
  31. Leigh B, Breitbart M, Oksanen HM, Bamford DH, Dishaw L. 2018. Genome sequence of PM2-like phage Cr39582 induced from Pseudoalteromonas sp. isolated from the gut of Ciona robusta. Genome Announc. 6:e00368-18.
  32. Levanova A, Poranen MM. 2018. Application of steric exclusion chromatography on monoliths for separation and purification of RNA molecules. J Chrom A. 1574:50-59.
  33. Li DC, Papageorgiou AC. 2018. Cellulases from thermophilic fungus: Structural and functional insights. In 'Fungi in extreme environments: Ecological and biotechnological significance', Springer Publishers, ed. S. Tiquia-Arashiro
  34. Luhtanen AM, Eronen-Rasimus E, Oksanen HM, Tison J-L, Delille B, Dieckmann G, Rintala J-M, Bamford DH. 2018. The first known virus isolates from Antarctic sea ice have complex infection patterns. FEMS Microbiol Ecol. 94:fiy028.
  35. Medarametla P, Gatta V, Kajander T, Laitinen T, Tammela P, Poso A. 2018. Structure-based virtual screening of LsrK kinase inhibitors to target quorum sensing. ChemMedChem. 2018 13:2400-2407.
  36. Millerioux Y, Mazet M, Bouyssou G, Allmann S, Kiema TR, Bertiaux E, Fouillen, L, Thapa C, Biran M, Plazolles N, Dittrich-Domergue F, Crouzols A, Wierenga RK, Rotureau B, Moreau P, Bringaud F. 2018. De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: carbon source preferences and metabolic flux redistributions. PLoS Pathog. 14:e1007116.
  37. Mikula KM, Krumwiede L, Plückthun A, Iwaï H. 2018. Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation.  J Biomol NMR. 71:225-235.
  38. Murthy AV, Sulu R, Koski MK, Tu H, Anantharajan J, Sah-Teli SK, Myllyharju J, Wierenga RK. 2018. Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif. Protein Sci. 27:1692-1703.
  39. Murthy S, Desantis J, Verheugd P, Maksimainen MM, Venkannagari H, Massari S, Ashok Y, Obaji E, Nkizinkinko Y, Lüscher B, Tabarrini O, Lehtiö L. 2018. 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. Eur J Med Chem. 156:93-102.
  40. Myllykoski M, Eichel MA, Jung RB, Kelm S, Werner HB, Kursula P. 2018. High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1. J Neurochem. 147:764-783.
  41. Nguyen VD, Biterova E, Salin M, Wierenga RK, Ruddock LW. 2018. Crystal structure of human anterior gradient protein 3. Acta Crystallogr F Struct Biol Commun. 74(Pt 7):425-430.
  42. Niehl A, Soininen M, Poranen MM, Heinlein M. 2018. Synthetic biology approach for plant protection using dsRNA. Plant Biotechnol J. 16(9): 1679-1687.
  43. Nkizinkiko Y, Desantis J, Koivunen J, Haikarainen T, Murthy S, Sancineto L, Massari S, Ianni F, Obaji E, Loza MI, Pihlajaniemi T, Brea J, Tabarrini O, Lehtiö L. 2018. 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci. Rep. 8:1680.
  44. Norppa AJ, Kauppala TM, Heikkinen HA, Verma B, Iwai H, Frilander MJ. 2018. Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA. RNA. 24:396-409.
  45. Obaji E, Haikarainen T, Lehtiö L. 2018. Structural basis for DNA break recognition by ARTD2/PARP2. Nucleic Acids Res. 46:12154-12165.
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  47. Ojanen MJT, Uusi-Mäkelä MIE, Harjula SE, Saralahti AK, Oksanen KE, Kähkönen N, Määttä JAE, Hytönen VP, Pesu M, Rämet M. 2018. Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio). Sci Rep. 9:995
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  51. Pietilä MK, van Hemert MJ, Ahola T. 2018. Purification of highly active alphavirus replication complexes demonstrates altered fractionation of multiple cellular membranes. J Virol. 92:e01852-17.
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All Instruct-FI publications since 2013 can be found in the PDF, below.