About Instruct-FI

Finland is a member of the ESFRI Instruct-ERIC

Instruct is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to users.

  • Provides access to innovative equipment to industrial & academic scientists worldwide
  • Delivers training and workshops by internationally recognized experts
  • Provides funding for students - Internships of 6-month in Instruct Centres
  • Provides funding for Pilot Projects
  • Acts as a Structural Biology Hub fostering collaborative science and driving innovations

Finland is a full member of the Instruct-ERIC approved by the Instruct-ERIC Council on July 19, 2019. Instruct-ERIC  is one of the successful operators at the European Strategy Forum on Research Infrastructures (ESFRI). Instruct-ERIC is a landmark European Research Infrastructure on the ESFRI Roadmap (2016). It provides peer-reviewed access to the core structural biology technologies, develops the next generation of instrumentation in partnership with industry, and provides training for structural biologists in cutting edge techniques. Accesses are provided at the scientifically evaluated and accepted Instruct-ERIC Centres that are located across the Europe. Instruct-ERIC member states host Instruct Centres that provide infrastructure and expertise supporting the mission and objectives of the Instruct-ERIC. In Finland, Ministry of Education and Culture has requested that Instruct Centre Finland would be recognized as a distributed Instruct-ERIC Centre. After approval, the Instruct Centre Finland will open its services for the users throught Instruct-ERIC Access.

How to use Instruct-ERIC services? How to apply funded access? Please visit the Instruct-ERIC web site.

Instruct Finland (Instruct-FI) -  Integrated Structural Biology in Finland

Instruct-HiLIFE is part of the national structural biology network Instruct-FI. Instruct-FI promotes training and state-of-the-art research in protein production and purification; biomolecular complex purification (Biocomplex); high resolution cryo-electron microscopy (cryo-EM); nuclear magnetic resonance (NMR); native mass spectrometry (MS); structural bioinformatics; and X-ray crystallography (X-ray).

Instruct-FI activities are distributed in six universities (Helsinki, Oulu, Turku, Åbo Academi, Eastern Finland, and Tampere), and coordinated by the University of Helsinki (Director Professor Sarah Butcher, Coordinator Adjunct Professor Hanna Oksanen). Instruct-FI is included on the Finnish Research Infrastructure 2014-2020 roadmap.

  • Cryo-Electron Microscopy

Helsinki Institute of Life Science HiLIFE
CryoEM Core Facility (PI Sarah Butcher), Institute of Biotechnology

  • X-ray Crystallography

Helsinki Institute of Life Science HiLIFE
Protein Crystallisation Facility (PI Tommi Kajander), Institute of Biotechnology

BioCity Turku
Protein Structure and Chemistry Core Facility (PI Tassos Papageorgiou)
Structural Bioinformatics Laboratory (PI Tiina Salminen)

Biocenter Oulu
BCO Protein Crystallography Core Facility (PI Lari Lehtiö)

  • Nuclear Magnetic Resonance

Helsinki Institute of Life Science HiLIFE
Finnish Biological NMR Center (PI Hideo Iwai), Institute of Biotechnology

  • Mass Spectrometry

Biocenter Kuopio
High-resolution Mass Spectometry Facility (PI Juha Rouvinen)

  • Biomolecular Complex Purification

Helsinki Institute of Life Science HiLIFE
Biomolecular Complex Purification (Biocomplex) (PI Minna Poranen), Faculty of Biological and Environmental Sciences

  • Protein Production

Faculty of Medicine and Life Sciences
Protein Services (PI Juha Määttä), Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere

Pub­lic­a­tions 2013 on­wards where In­struct Finland (Instruct-FI) services have been utilized

2019 (updated on May 2, 2019)

  1. Abdelnabi R, Geraets JA, Ma Y, Mirabelli C, Flatt JW, Domanska A, Delang L, Jochmans D, Jayaprakash V,Sinha BN,Leyssen P, Butcher SJ, Neyts J. 2019. A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses. PLoS Biology (in press)
  2. Agrawal N, Lehtonen SI, Uusi-Mäkelä M, Jain P, Viitala S, Määttä JAE, Kähkönen N, Azizi L, Riihimäki TA, Kulomaa MS, Johnson MS, Hytönen VP, Airenne TT. 2019. Molecular features of steroid-binding antidins and their use for assaying serum progesterone. PLoS One. 14:e0212339.
  3. Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Leśnikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, Gribbon P. 2019. EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology. SLAS Discov. 24:398-413.
  4. Chronopoulou EG, Vlachakis D, Papageorgiou AC, Ataya FS, Labrou NE. 2019. Structure-based design and application of an engineered glutathione transferase for the development of an optical biosensor for pesticides determination. Biochim Biophys Acta Gen Subj. 1863:565-576.
  5. De Colibus L, Roine E, Walter TS, Ilca SL, Wang X, Wang N, Roseman AM, Bamford D, Huiskonen JT, Stuart DI. 2019. Assembly of complex viruses exemplified by a halophilic euryarchaeal virus. Nat Commun. 10:1456.
  6. Domanska A, Flatt JW, Jukonen JJJ, Geraets JA, Butcher SJ. 2019. 2.8 Å resolution cryo-EM structure of human parechovirus 3 in complex with Fab from a neutralizing antibody. J. Virol. [Epub ahead of print]
  7. El Omari K, Li S, Kotecha A, Walter TS, Bignon EA, Harlos K, Somerharju P, De Haas F, Clare DK, Molin M, Hurtado F, Li M, Grimes JM, Bamford DH, Tischler ND, Huiskonen JT, Stuart DI, Roine E. 2019. The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins. Nat Commun. 10:846.
  8. Guédez G, Pothipongsa A, Sirén S, Liljeblad A, Jantaro S, Incharoensakdi A, Salminen TA. 2019. Crystal structure of dimeric Synechococcus spermidine synthase with bound polyamine substrate and product. Biochem J. 476:1009-1020.
  9. Kiema TR, Thapa CJ, Laitaoja M, Schmitz W, Maksimainen MM, Fukao T, Rouvinen J, Jänis J, Wierenga RK. 2019. The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry. Biochem J. 476:307-332.
  10. Mäntynen S, Sundberg LR, Oksanen HM, Poranen MM. 2019. Half a century of research on membrane-containing bacteriophages: bringing new concepts to modern virology. Viruses 11: e76.
  11. Li DC, Papageorgiou AC. 2019. Cellulases from thermophilic fungi: Recent insights and biotechnological potential. In: Fungi in Extreme Environments: Ecological Role and Biotechnological Significance. Eds: Tiquia-Arahiro SM, Grube M. Springer. pp. X-X. In Press
  12. Lyytinen OL, Starkova D, Poranen MM. 2019. Microbial production of lipid-protein vesicles using enveloped bacteriophage phi6. Microb Cell Fact. 18:29.
  13. Mizuno CM, Prajapati B, Lucas-Staat S, Sime-Ngando T, Forterre P, Bamford DH, Prangishvili D, Krupovic M, Oksanen HM. 2019. Novel haloarchaeal viruses from Lake Retba infecting Haloferax and Halorubrum species. Environ Microbiol. [Epub ahead of print]
  14. Oksanen HM, and Abrescia NGA. 2019. Membrane-containing icosahedral bacteriophage PRD1: the dawn of viral lineages. In: Advances in Experimental Medicine and Biology - 'Physical Virology - Virus Structure and Mechanics’. Ed: Greber, U. Springer. pp. X-X. In Press
  15. Papageorgiou, AC. 2019. X-ray crystallography in structure-function characterization of therapeutic enzymes. Adv. Exper. Med. Biol. In Press.
  16. Santos-Pérez I, Charro D, Gil-Carton D, Azkargorta M, Elortza F, Bamford DH, Oksanen HM, Abrescia NGA. 2019. Structural basis for assembly of vertical single β-barrel viruses. Nat Commun. 10:1184.
  17. Theoharaki C, Chronopoulou E, Vlachakis D, Ataya FS, Giannopoulos P, Maurikou S, Skopelitou K, Papageorgiou AC, Labrou NE. 2019. Delineation of the functional and structural properties of the glutathione transferase family from the plant pathogen Erwinia carotovora. Funct. Integr. Gen. 19:1-12.
  18. Wang L, Ago M, Borghei M, Ishaq A, Papageorgiou AC, Lundahl M, Rojas OM. 2019. Conductive carbon microfibers derived from wet-spun lignin/nanocellulose hydrogels. ACS Sustain. Chem. Eng. In Press
  19. Wolthers KC, Susi P, Jochmans D, Koskinen J, Landt O, Sanchez N, Palm K, Neyts J, Butcher SJ. 2019. Progress in human picornavirus research: New findings from the AIROPico consortium. Antiviral Res. 161:100-107.
  20. Åstrand M, Cuellar J, Hytönen J, Salminen TA. 2019. Predicting the ligand-binding properties of Borrelia burgdorferi s.s. Bmp proteins in light of the conserved features of related Borrelia proteins. J Theor Biol. 462:97-108.

2018

  1. Adriaenssens EM, Wittmann J, Kuhn JH, Turner D, Sullivan MB, Dutilh BE, Jang HB, van Zyl LJ, Klumpp J, Lobocka M, Moreno Switt AI, Rumnieks J, Edwards RA, Uchiyama J, Alfenas-Zerbini P, Petty NK, Kropinski AM, Barylski J, Gillis A, Clokie MRC, Prangishvili D, Lavigne R, Aziz RK, Duffy S, Krupovic M, Poranen MM, Knezevic P, Enault F, Tong Y, Oksanen HM, Rodney Brister J. 2018. Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee. Arch Virol. 163:1125-1129.
  2. Antenucci L, Hytönen VP, Ylänne J. 2018. Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms. J Biol Chem. 293:4591-4602.
  3. Antila CJM, Rraklli V, Blomster HA, Dahlström KM, Salminen TA, Holmberg J, Sistonen L, Cecilia Sahlgren C. 2018. Sumoylation of Notch1 represses its target gene expression during cell stress. Cell Death Differ. 25:600-615.
  4. Atanasova NS, Demina TA, Krishnam Rajan Shanthi SV, Oksanen HM, and Bamford DH. 2018. Extremely halophilic pleomorphic archaeal virus HRPV9 extends the diversity of pleolipoviruses with integrases. Res Microbiol. 169:500-504
  5. Atanasova NS, Heiniö CHE, Demina T, Bamford DH, Oksanen HM. 2018. The unexplored diversity of pleolipoviruses: the surprising case of two viruses with identical major structural modules. Genes 9:131
  6. Azinas S, Bano F, Torca I, Bamford DH, Schwartz GA, Esnaola J, Oksanen HM, Richter RP, Abrescia NG. 2018. Membrane-containing virus particles exhibit the mechanics of a composite material for genome protection. Nanoscale 10:7769-7779.
  7. Biterova E, Esmaeeli M, Alanen HI, Saaranen M, Ruddock LW. 2018. Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease. Sci Rep. 8:6752.
  8. Biterova E, Ignatyev A, Uusimaa J, Hinttala R, Ruddock LW. 2018. Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease. PLoS One 13:e0202391.
  9. Brockmann SJ, Freischmidt A, Oeckl P, Müller K, Ponna SK, Helferich AM, Paone C, Reinders J, Kojer K, Orth M, Jokela M, Auranen M, Udd B, Hermann A, Danzer KM, Lichtner P, Walther P, Ludolph AC, Andersen PM, Otto M, Kursula P, Just S, Weishaupt JH. 2018. CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency. Hum Mol Genet. 27:706-715.
  10. Carvalho LL, Elovaara H, de Ruyck J, Vergoten G, Jalkanen S, Guédez G, Salminen TA.2018. Mapping the interaction site and effect of the Siglec-9 inflammatory biomarker on human primary amine oxidase. Sci Rep. 8:2086.
  11. Chronopoulou EG, Papageorgiou AC, Ataya F, Nianiou-Obeidat I, Madesis P, Labrou NE. 2018. Expanding the plant GSTome through directed evolution: DNA shuffling for the generation of new synthetic enzymes with engineered catalytic and binding properties. Front Plant Sci. 9:1737.
  12. Duyvesteyn HME, Ginn HM, Pietilä MK, Wagner A, Hattne J, Grimes JM, Hirvonen E, Evans G, Parsy M-L, Sauter NK, Brewster AS, Huiskonen JT, Stuart DI, Sutton G, Dennis H. Bamford DH. 2018. Towards in cellulo virus crystallography. Sci. Rep. 8:3771.
  13. Eskelin K, Poranen MM. 2018. Controlled disassembly and purification of functional viral subassemblies using asymmetrical flow field-flow fractionation (AF4). Viruses 10:579
  14. Edqvist J, Blomqvist K, Nieuwland J, Salminen TA. 2018. Plant lipid transfer proteins: are we finally closing in on these enigmatic proteins. J Lipid Res. 59:1374-1382
  15. Gludovacz E, Maresch D, Lopes de Carvalho L, Puxbaum V, Baier LJ, Sützl L, Guédez G, Grünwald-Gruber C, Ulm B, Pils S, Ristl R, Altmann F, Jilma B, Salminen TA, Borth N, Boehm T. 2018. Oligomannosidic glycans at Asn-110 are essential for secretion of human diamine oxidase. J Biol Chem. 293:1070-1087.
  16. Haataja S, Verma P, Fu O, Papageorgiou AC, Pöysti S, Pieters RJ, Nilsson UJ, Finne J. 2018. Rationally designed chemically modified glycodendrimer inhibits Streptococcus suis adhesin SadP at picomolar concentrations. Chemistry 24:1905-1912.
  17. Hackenberg C, Hakanpää J, Cai F, Antonyuk S, Eigner C, Meissner S, Laitaoja M, Jänis J, Kerfeld CA, Dittmann E, Lamzin VS. 2018. Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria. Proc Natl Acad Sci U S A. 115:7141-7146.
  18. Haikarainen T, Maksimainen M. Obaji E, Lehtiö L. 2018. Development of a screening assay for mono-ADP-ribosyl hydrolyzing macrodomains using AlphaScreen technology. SLAS Disc. 23:255-263.
  19. Haining AWM, Rahikainen R, Cortes E, Lachowski D, Rice A, von Essen M, Hytönen VP, Del Río Hernández A. 2018. Mechanotransduction in talin through the interaction of the R8 domain with DLC1. PLoS Biol. 16:e2005599.
  20. Harrus D, Khoder-Agha F, Peltoniemi M, Hassinen A, Ruddock L, Kellokumpu S, Glumoff T. 2018. The dimeric structure of wild-type human glycosyltransferase B4GalT1. PLoS One. 3:e0205571.
  21. Hepojoki J, Hepojoki S, Smura T, Szirovicza L, Dervas E, Prähauser B, Nufer L, Schraner EM, Vapalahti O, Kipar A, Hetzel U. 2018. Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses-The representatives of genus hartmanivirus, family Arenaviridae. PLoS Pathog. 14:e1007415.
  22. iNEXT Consortium. 2018. iNEXT: a European facility network to stimulate translational structural biology. FEBS Lett. 592:1909-1917.
  23. Karki S, Paudel P, Sele C, Skhumatov AV, Kajander T. 2018. The structure of SALM5 suggests a dimeric assembly for the presynaptic RPTP ligand recognition. Protein Eng Des Sel. 31:147-157.
  24. Kaur I, Ruskamo S, Koivunen J, Heljasvaara R, Lackman JJ, Izzi V, Petäjä-Repo UE, Kursula P, Pihlajaniemi T. 2018. The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated. Biochem J. 475:3577-3593.
  25. King AWT, Mäkelä V, Kedzior SA, Laaksonen T, Partl GJ, Heikkinen S, Koskela H, Heikkinen HA, Holding AJ, Cranston ED, Kilpeläinen I. 2018. Liquid-state NMR analysis of nanocelluloses. Biomacromolecules. 19:2708-2720.
  26. Koskela MM, Dahlström KM, Goñi G, Lehtimäki N, Nurmi M, Velazquez-Campoy A, Hanke G, Bölter B, Salminen TA, Medina M, Mulo P. 2018. Arabidopsis FNRL protein is an NADPH-dependent chloroplast oxidoreductase resembling bacterial ferredoxin-NADP+ reductases. Physiol Plant. 162(2):177-190.
  27. Kotila T, Kogan K, Enkavi G, Guo S, Vattulainen I, Goode BL, Lappalainen P. 2018. Structural basis of actin monomer re-charging by cyclase-associated protein. Nat Commun. 9:1892.
  28. Laitinen OH, Svedin E, Kapell S, Hankaniemi MM, Larsson PG, Domsgen E, Stone VM, Määttä JAE, Hyöty H, Hytönen VP, Flodström-Tullberg M. 2018. New coxsackievirus 2Aproand 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms. J Virol Methods. 255:29-37.
  29. Lampi M, Oksanen HM, Meier F, Moldenhauer E, Poranen MM, Bamford DH, and Eskelin K. 2018. Asymmetrical flow field-flow fractionation in purification of an enveloped bacteriophage ɸ6. J Chrom B. 1095: 251-257.
  30. Laulumaa S, Nieminen T, Raasakka A, Krokengen OC, Safaryan A, Hallin EI, Brysbaert G, Lensink MF, Ruskamo S, Vattulainen I, Kursula P. 2018. Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins. BMC Struct Biol. 18:8.
  31. Leigh B, Breitbart M, Oksanen HM, Bamford DH, Dishaw L. 2018. Genome sequence of PM2-like phage Cr39582 induced from Pseudoalteromonas sp. isolated from the gut of Ciona robusta. Genome Announc. 6:e00368-18.
  32. Levanova A, Poranen MM. 2018. Application of steric exclusion chromatography on monoliths for separation and purification of RNA molecules. J Chrom A. 1574:50-59.
  33. Li DC, Papageorgiou AC. 2018. Cellulases from thermophilic fungus: Structural and functional insights. In 'Fungi in extreme environments: Ecological and biotechnological significance', Springer Publishers, ed. S. Tiquia-Arashiro
  34. Luhtanen AM, Eronen-Rasimus E, Oksanen HM, Tison J-L, Delille B, Dieckmann G, Rintala J-M, Bamford DH. 2018. The first known virus isolates from Antarctic sea ice have complex infection patterns. FEMS Microbiol Ecol. 94:fiy028.
  35. Medarametla P, Gatta V, Kajander T, Laitinen T, Tammela P, Poso A. 2018. Structure-based virtual screening of LsrK kinase inhibitors to target quorum sensing. ChemMedChem. 2018 13:2400-2407.
  36. Millerioux Y, Mazet M, Bouyssou G, Allmann S, Kiema TR, Bertiaux E, Fouillen, L, Thapa C, Biran M, Plazolles N, Dittrich-Domergue F, Crouzols A, Wierenga RK, Rotureau B, Moreau P, Bringaud F. 2018. De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: carbon source preferences and metabolic flux redistributions. PLoS Pathog. 14:e1007116.
  37. Mikula KM, Krumwiede L, Plückthun A, Iwaï H. 2018. Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation.  J Biomol NMR. 71:225-235.
  38. Murthy AV, Sulu R, Koski MK, Tu H, Anantharajan J, Sah-Teli SK, Myllyharju J, Wierenga RK. 2018. Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif. Protein Sci. 27:1692-1703.
  39. Murthy S, Desantis J, Verheugd P, Maksimainen MM, Venkannagari H, Massari S, Ashok Y, Obaji E, Nkizinkinko Y, Lüscher B, Tabarrini O, Lehtiö L. 2018. 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. Eur J Med Chem. 156:93-102.
  40. Myllykoski M, Eichel MA, Jung RB, Kelm S, Werner HB, Kursula P. 2018. High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1. J Neurochem. 147:764-783.
  41. Nguyen VD, Biterova E, Salin M, Wierenga RK, Ruddock LW. 2018. Crystal structure of human anterior gradient protein 3. Acta Crystallogr F Struct Biol Commun. 74(Pt 7):425-430.
  42. Niehl A, Soininen M, Poranen MM, Heinlein M. 2018. Synthetic biology approach for plant protection using dsRNA. Plant Biotechnol J. 16(9): 1679-1687.
  43. Nkizinkiko Y, Desantis J, Koivunen J, Haikarainen T, Murthy S, Sancineto L, Massari S, Ianni F, Obaji E, Loza MI, Pihlajaniemi T, Brea J, Tabarrini O, Lehtiö L. 2018. 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci. Rep. 8:1680.
  44. Norppa AJ, Kauppala TM, Heikkinen HA, Verma B, Iwai H, Frilander MJ. 2018. Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA. RNA. 24:396-409.
  45. Obaji E, Haikarainen T, Lehtiö L. 2018. Structural basis for DNA break recognition by ARTD2/PARP2. Nucleic Acids Res. 46:12154-12165.
  46. Oeemig JS, Ollila OHS, Iwaï H. 2018. NMR structure of the C-terminal domain of TonB protein from Pseudomonas aeruginosa. PeerJ 6:e5412.
  47. Ojanen MJT, Uusi-Mäkelä MIE, Harjula SE, Saralahti AK, Oksanen KE, Kähkönen N, Määttä JAE, Hytönen VP, Pesu M, Rämet M. 2018. Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio). Sci Rep. 9:995
  48. Ollila OHS, Heikkinen HA, Iwai H. 2018. Rotational dynamics of proteins from spin relaxation times and molecular dynamics simulations. J. Phys. Chem. 122: 6559-6569.
  49. Penttinen L, Rutanen C, Jänis J, Rouvinen J, Hakulinen N. 2018. Unraveling substrate specificity and catalytic promiscuity of Aspergillus oryzae catechol oxidase. Chembiochem. 19:2348-2352.
  50. Penttinen L, Rutanen C, Saloheimo M, Kruus K, Rouvinen J, Hakulinen N. 2018. A new crystal form of Aspergillus oryzae catechol oxidase and evaluation of copper site structures in coupled binuclear copper enzymes. PLoS One. 13:e0196691.
  51. Pietilä MK, van Hemert MJ, Ahola T. 2018. Purification of highly active alphavirus replication complexes demonstrates altered fractionation of multiple cellular membranes. J Virol. 92:e01852-17.
  52. Ponna SK, Myllykoski M, Kursula P. 2018. Crystallographic home-source X-ray data for the atomic-resolution experimental phasing of the Shank3 SH3 domain structure from pseudomerohedrally twinned crystals. Data Brief. 20:1912-1916.
  53. Ponna SK, Ruskamo S, Myllykoski M, Keller C, Boeckers TM, Kursula P. 2018. Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3. J Neurochem. 145:449-463.
  54. Rahman MM, Andberg M, Koivula A, Rouvinen J, Hakulinen N. 2018. The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family. Sci Rep. 8:865
  55. Saarinen NVV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomäki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A, Honkimaa A, Hankaniemi MM, Flodström-Tullberg M, Hyöty H, Hytönen VP, Laitinen OH. 2018. A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses. Sci Rep. 8:33.
  56. Salminen TA, Eklund DM, Joly V, Blomqvist K, Matton DP, Edqvist J. 2018. Deciphering the evolution and development of the cuticle by studying lipid transfer proteins in mosses and liverworts. Plants 7:6.
  57. Shakeel, S., Evans, J.D., Hazelbaker, M., Kao, C. C., Vaughan, R.C., Butcher, S.J. 2018. Intrinsically-disordered N-termini in human parechovirus 1 capsid proteins bind encapsidated RNA. Sci Rep. 8:5820.
  58. Shao D, Tapio K, Auer S, Toppari JJ, Hytönen VP, Ahlskog M. 2018. Surface characteristics control the attachment and functionality of (chimeric) avidin. Langmuir. 34:15335-15342.
  59. Shiraishi Y, Natsume M, Kofuku Y, Imai S, Nakata K, Mizukoshi T, Ueda T, Iwaï H, Shimada I. 2018. Phosphorylation-induced conformation of ß2-adrenoceptor related to arrestin recruitment revealed by NMR. Nat Commun. 9:194.
  60. Sipilä KH, Drushinin K, Rappu P, Jokinen J, Salminen TA, Salo AM, Käpylä J, Myllyharju J, Heino J. 2018. Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms. J Biol Chem. 293:7645-7658.
  61. Stone VM, Hankaniemi MM, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, Laitinen OH, Hytönen VP, Flodström-Tullberg M. 2018. A coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes. Diabetologia. 61:476-481.
  62. Sun X, Ilca SL, Huiskonen JT, Poranen MM. 2018. Dual role of a viral polymerase in viral genome replication and particle self-assembly. mBio. 9: e01242-18.
  63. Tapio K, Shao D, Auer S, Tuppurainen J, Ahlskog M, Hytönen VP, Toppari JJ. 2018. A DNA-nanoparticle actuator enabling optical monitoring of nanoscale movements induced by an electric field. Nanoscale. 10:19297-19309.
  64. Yang D, Viitasuo M, Pooch F, Tenhua H, Hietala S. 2018. Poly(N-acryloylglycinamide) microgels as nanocatalyst platform. Polym. Chem. 9: 517-524.
  65. Zhang Y, Jumppanen M, Maksimainen MM, Auno S, Awol Z, Ghemtio L, Venkannagari H, Lehtiö L, Yli-Kauhaluoma J, Xhaard H, Boije Af Gennäs G. 2018. Adenosine analogs bearing phosphate isosteres as human MDO1 ligands. Bioorg Med Chem. 26:1588-1597.

All Instruct-FI publications since 2013 (May 2, 2019)