Individualized Drug Therapy (INDIVIDRUG)

Recent and ongoing advances in the methods in genomic and pharmacokinetic analyses, as well as the facilitating changes in the legislative environment open up novel possibilities to investigate the individualization of drug therapies.

The Individualized Drug Therapy Research Program brings together groups involved in basic, translational and clinical drug research. The synergistic interdisciplinary combination of experts in in vitro and animal models, pharmacokinetics, pharmacogenetics, systems pharmacology and modeling, as well as clinical research in major therapeutic areas forms a cutting-edge center of individualized drug therapy.
Program director

Mikko Niemi



Biomedicum 2C 307

Haartmaninkatu 8

00014 University of Helsinki

tel. +358 50 428 0998
  • Janne Backman -
  • Michael Jeltsch - 
  •  -
  •  - 
  • Sirpa Loukovaara - 
  • Marjukka Myllärniemi - 
  • Martti Färkkilä
  • Jukka Kanerva
  • Heli Malm
  • Kimmo Porkka
Events
  • Symposium 

"Drug safety during pregnancy and lactation - 30 years of teratology information service in Finland"

April 17th, 2024 // 12:00-16:00 // Biomedicum, lecture hall 2 (Haartmaninkatu 8, Helsinki, Finland)

 
Key Pub­lic­a­tions from IN­DI­VIDRUG
  • Lohela TJ, Poikola S, Backmansson D, Lapatto-Reiniluoto O, Backman JT, Olkkola KT, Lilius TO.  Anesth Analg. 2023 Sep 21.doi: 10.1213/ANE.0000000000006640. Online ahead of print.PMID: 37733945
  • Kujala J, Wester N, Lohela TJ, Kurkela M, Backman JT, Mikladal B, Laurila T, Koskinen J, Lilius TO, Kalso EA.  Br J Clin Pharmacol. 2023 Sep;89(9):2933-2938.doi: 10.1111/bcp.15794. Epub 2023 Jun 7.PMID: 37218304
  • Persson NDÅ, Uusalo P, Nedergaard M, Lohela TJ, Lilius TO. Trends Pharmacol Sci. 2022 Dec;43(12):1030-1040. doi: 10.1016/j.tips.2022.09.007. Epub 2022 Oct 21. PMID: 36280451.
  • Rauniyar, K.; Akhondzadeh, S.; Gąciarz, A.; Künnapuu, J.; Jeltsch, M. . Scientific Reports 2022, 12, 18157, doi:10.1038/s41598-022-22960-0.
  • Lohela, T.J., Lilius, T.O. & Nedergaard, M. . Nat Rev Drug Discov (2022).
  • Kelley, D.H., Bohr, T., Hjorth, P.G., Holst, S.C., Hrabětová, S., Kiviniemi, V., Lilius, T., Lundgaard, I., Mardal, K.-A., Martens, E.A., Mori, Y., Nägerl, U.V., Nicholson, C., Tannenbaum, A., Thomas, J.H., Tithof, J., Benveniste, H., Iliff, J.J., Nedergaard, M., , ISCIENCE (2022)
  • Blomqvist, K. J., Skogster, M. O. B., Kurkela, M. J., Rosenholm, M. P., Ahlström, F. H. G., Airavaara, M. T., Backman, J. T., Rauhala, P. V., Kalso, E. A., & Lilius, T. O. (2022). . Journal of Controlled Release, 344, 214–224
  • Karaman S, Paavonsalo S, Heinolainen K, Lackman MH, Ranta A, Hemanthakumar KA, ... & Alitalo K. Journal of Experimental Medicine. 2022, 219(3), e20210565.
  • Kahma H, Aurinsalo L, Neuvonen M, Katajamäki J, Paludetto MN, Viinamäki J, Launiainen T, Filppula AM, Tornio A, Niemi M, Backman JT. . Eur J Pharm Sci 2021; 19: 05810.
  • Neuvonen M, Hirvensalo P, Tornio A, Rago B, West M, Lazzaro S, Mathialagan S, Varma M, Cerny MA, Costales C, Ramanathan R, Rodrigues AD, Niemi M. . Clinical Pharmacology & Therapeutics. 2020 S. doi: 10.1002/cpt.2053. Epub ahead of print. PMID:32961594.
  • Lehtisalo M, Keskitalo JE, Tornio A, Lapatto-Reiniluoto O, Deng F, Jaatinen T, Viinamäki J, Neuvonen M, Backman JT, Niemi M.  Clinical and Translational Science. 2020, 13(6):1236-1243.<
  • Paavonsalo S, Hariharan S, Lackman MH, Karaman S.  Cells, 2020, 9, 2683.
  • Kaartinen TJK, Tornio A, Tapaninen T, Launiainen T, Isoherranen N, Niemi M & Backman JT. Clinical Pharmacology and Therapeutics. 2020, 108(6):1254-1264.
  • Tapaninen T, Olkkola AM, Tornio A, Neuvonen M, Elonen E, Neuvonen PJ, Niemi M & Backman JT.  Clinical and translational science. 2020, 13(2): 345-351.
  • Blomqvist KJ, Dudek K, Viisanen H, Mätlik, K, Ahlström FHG, Laitila J, Kalso EA, Rauhala PV & Lilius TO. . Journal of Neuroscience Research. 2020.
  • Lohela T, Poikola S, Neuvonen M, Niemi M, Backman J, Olkkola K & Lilius T. Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers. Anesthesia & Analgesia. 2020.
  • Gucciardo E, Loukovaara S, Korhonen A, Lehti K. . Journal of Visualized Experiments. 2019, 25(143).
  • Baryshnikov I, Sund R, Marttunen M, Svirskis T, Partonen T, Pirkola S & Isometsä ET.  Bipolar Disorders. 2020, 22(6): 582-592.
  • Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, Stenman U-H, Alitalo K, Jeltsch M. . eLife. 2019, Vol 8: e44478.
  • Paajanen J, Laaksonen S, Ilonen I, Vehmas T, Mäyränpää MI, Sutinen E, Kettunen E, Salo JA, Räsänen J, Wolff H & Myllärniemi M. . Clinical Lung Cancer. 2020, 21(6):E633-E639.
  • Li X, Frechen S, Moj D, Lehr T, Taubert M, Hsin S, Mikus G, Neuvonen PJ, Olkkola K, Saari T & Fuhr U.  Clinical Pharmacokinetics. 2020, 59(6):781-808.
  • Huttunen P, Taskinen M & Vettenranta K. . Pediatric hematology and oncology. 2020, 37(5):355-364.
  • Ellfolk M, Tornio A, Niemi M, Leinonen MK, Lahesmaa-Korpinen AM, Malm H. . British Journal of Clinical Pharmacology. 2020, 86(5):868-879.