International Scientific Advisory Board selects the research programs of RPU through a competitive application procedure every six years. Research programs provide the critical mass to combine biomedical, translational and clinical research with dynamic use of space, equipment and resources. Thus, they form a synergistic platform for top-class scientific and translational discoveries. Nine research programs, selected for the years 2019-2025, comprise of 90 research groups in total. RPU is located in Meilahti campus in Helsinki.
Director of Research Programs Unit
Henna Tyynismaa
henna.tyynismaa@helsinki.fi
tel. +358 2941 25654 (office)
Vice Director
Päivi Ojala
paivi.ojala@helsinki.fi
Vice Director
Outi Monni
outi.monni@helsinki.fi
Merja Tynjälä
merja.tynjala@helsinki.fi
tel. +358 2941 25321
Suvi Rokolampi
suvi.rokolampi@helsinki.fi
tel. +358 2941 26656
HR Specialist Päivi Sinisalo
hr-ltdk@helsinki.fi
Maaria Puupponen
maaria.puupponen@helsinki.fi
tel. +358 50 448 9981
Applied Tumor Genomics (ATG)
Petri Mäkelä
petri.makela@helsinki.fi
tel. +358 50 441 8437
Clinical and Molecular Metabolism (CAMM)
Maaria Puupponen
maaria.puupponen@helsinki.fi
tel. +358 50 448 9981
Human Microbiome Research (HUMI)
Evgenia Dikareva
evgenia.dikareva@helsinki.fi
tel. +358 50 448 9371
Individualized Drug Therapy (INDIVIDRUG)
Petri Mäkelä
petri.makela@helsinki.fi
tel. +358 50 441 8437
Translational Immunology Program (TRIMM)
Francesca De Lorenzo
francesca.delorenzo@helsinki.fi
tel +358 50 452 4919
Sleep and stress in health and in transition from acute to chronic diseases (SLEEPWELL)
Tiina Härkönen
tiina.harkonen@helsinki.fi
tel +358 50 311 6173
Systems Oncology (ONCOSYS)
Karen Ahlnäs
karen.ahlnas@helsinki.fi
tel +358 50 472 8052
Translational Cancer Medicine Program (CAN-PRO)
Saija Piiroinen
saija.piiroinen@helsinki.fi
tel +358 50 476 3490
Stem Cells and Metabolism Research Program (STEMM)
Kaisa Sarkkinen
kaisa.a.sarkkinen@helsinki.fi
Program
9:30 Registration, Morning Coffee & Poster set-up
10:00 Opening of Science Day
10:15 Scientific Session I: CAMM - Chair: Timo Otonkoski
Markus Perola: FinRegistry and Finngen: nation-wide studies for common disease prediction and aetiology
Kirsi Pietiläinen: Adipose tissue mitochondrial metabolism in obesity and weight loss
Sanna Lehtonen: Towards a better understanding of and new treatments for diabetic kidney disease
11:15 Poster teaser talks I
Alexandra Lahtinen: Exploring tumor evolution in high-grade serous ovarian cancer prior to treatment
Joona Sarkkinen: Ectopic germinal centers in the thymus accurately predict prognosis of myasthenia gravis after thymectomy
Kristiina Kanerva & Xin Zhou: Inducible removal and reconstitution of membrane compartments in living cells
Marie-Noëlle Paludetto: Hydroxychloroquine is metabolized by CYP2D6, CYP3A4 and CYP2C8, and inhibits CYP2D6 in vitro
Norman Carcaño: Pharmacological tankyrase inhibition improves mitochondrial oxidative capacity in the kidney proximal tubules and protects against fibrosis in diabetic kidney disease
Prima Sanjaya: Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping
Risto Halonen: Slow oscillation-spindle coupling in overnight memory and the role of BDNF Val66Met
Joseph Ndika: Epigenetic differences in long non-coding RNA expression in Finnish and Russian Karelia teenagers with contrasting risk of allergy and asthma
Pauliina Kallio: PROX1 expression protects intestinal adenomas and colorectal cancer cells from radiation-induced DNA damage
12:00 Lunch
13:00 Scientific Session II: STEMM - Chair: Kirsi Pietiläinen
Timo Otonkoski: Generation of fully functional human pancreatic islets from stem cells: Implications for diabetes therapy
Thomas McWilliams: Targeting autophagy in health and disease
Juha Kere: Reprogramming to study human embryonic genome activation
14:00 Poster teaser talks II
Dipabarna Bhattacharya: Synergistic Role of Leukemic and Non-Leukemic Immune Repertoires in CD8 T-Cell Large Granular Lymphocytic Leukemia as Identified by Single-Cell Transcriptomics
Jun Dai & Shuyu Zheng: ReSisTrace: Tracing Back Primed Resistance in Cancer
Rita Turpin: Contextual Assessment of Treatment Effect on Tumor Immune Microenvironment using Patient-Derived Explant Cultures (PDECs)
Juan Cruz Landoni: Overactive mitochondrial DNA replisome causes neonatal heart failure via ferroptosis
Noora Pöllänen: NAD+ depletion: a novel disease mechanism and therapy target for cancer cachexia
Joonas Naamanka: Genome-wide Analysis Identifies SORCS3 as a Novel Susceptibility Locus for Panic Disorder in the FinnGen Study
Honey Bokharaie: A hyperbright tag for the real-time in-vivo tracing of low-abundance secreted proteins
Outi Lyytinen: Phage therapy initiative in Helsinki
Norman Zielke: Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation
14:45 Afternoon Coffee
15:15 Scientific Session III - Chair: Henna Tyynismaa
Katri Korpela: Microbial ecosystems biology in the human gut
Anni Virtanen: Predicting the natural history of uterine cervical precancerous lesions
Micaela Hernberg: Developing drug therapy for advanced melanoma
16:15 Poster teaser talks III
Siiri Reinikka: Genomic landscape of endometrial polyps
Rebecka Ventin-Holmberg: The Effect of Antibiotics on the Infant Gut Fungal Microbiota
Anssi Mykkänen: Genome-wide association study of simvastatin pharmacokinetics
Jukka Vanhanen (Hanna Harno): S2-targeted rTMS influences sleep, as measured by the OURA-ring, in CRPS patients
Tomáš Zárybnický: RNA shuttling regulation in physiology and disease - lessons from in vivo studies
Elina Pietilä: Precision immuno-oncology in ovarian cancer
Roosa Jokela: Identification of novel interactions between infant gut microbiota composition and environmental exposures and health outcomes
Sini Heinonen: Roux-en-Y (RYGB) versus One-anastomosis (OAGB/SAGB) gastric bypass (RYSA study): weight loss and metabolic improvements at 1 year after surgery - A randomized study
Toni Lemmetyinen: Fetal/regenerative reprogramming of intestinal epithelium by fibroblast derived Neuregulin-1
17:00 Poster Session
18:30 Dinner & Best Poster Awards & RPU Summer Party