Helsinki Metabolomics center Publications

https://researchportal.helsinki.fi/en/equipments/fimm-metabolomics-ls-ria-metabo-hilife/publications/

 

  1. The metabolome of fecal extracellular vesicles in patients with malignant solid tumors.  Jukkola A, Kalashnikov I, Auvinen P, Kääriäinen OS, Saarnio J, Meriläinen S, Rautio T, Aro R, Häivälä R, Karihtala P, Ruuska-Loewald T, Reunanen J. Sci Rep. 2025 Aug 11;15(1):29402. doi: 10.1038/s41598-025-14250-2. PMID: 40789885.
  2. Complex I Drives Glutamine-Dependent TCA Cycle to Support Viability of MYChigh Breast Cancer Cells. Johanna M. Anttila, Mariel Savelius, Juhi Somani, Daniel Nicorici, Pauliina M. Munne, Linda Id, Aino Peura, Antti O. Hiltunen, July Aung, Ryan Awadhpersad, Bina Prajapati, Martina Peltonen, Hanna Ala-Hongisto, Prson Gautam, Mika J. Välimäki, Topi A. Tervonen, Karina Šapovalovaitė, Raman Devarajan, María Victoria Ruiz Pérez, Minna Mutka, Panu Kovanen, Laura Niinikoski, Tuomo Meretoja, Johanna Mattson, Päivi Heikkilä, Krister Wennerberg, Marie Arsenian-Henriksson, Jukka Westermarck, Tero Aittokallio, Andrei Goga, Christopher B. Jackson, Anni I. Nieminen, Juha Klefström. bioRxiv 2025.05.27.656356; doi:
  3. The effect of extracellular vesicles derived from oral squamous cell carcinoma on the metabolic profile of oral fibroblasts.  Lipka A, Søland TM, Nieminen AI, Sapkota D, Haug TM, Galtung HK . Front Mol Biosci. 2025 Feb 21;12:1492282. doi: 10.3389/fmolb.2025.1492282.
  4. Energy metabolism rewiring following acute UVB irradiation is largely dependent on nuclear DNA damage. Dousset L, Mahfouf W, Younes H, Fatrouni H, Faucheux C, Muzotte E, Khalife F, Rossignol R, Moisan F, Cario M, Claverol S, Favot-Laforge L, Nieminen AI,Vainio S, Ali N, Rezvani HR.Free Radic Biol Med. 2024 Dec 10;227:459-471. doi: 10.1016/j.freeradbiomed.2024.12.030. Online ahead of print. PMID: 39667588
  5. Common lipidomic signatures across distinct acute brain injuries in patient outcome prediction.Hellström S, Sajanti A, Srinath A, Bennett C, Girard R, Jhaveri A, Cao Y, Falter J, Frantzén J, Koskimäki F, Lyne SB, Rantamäki T, Takala R, Posti JP, Roine S,Kolehmainen S, Nazir K, Jänkälä M, Puolitaival J, Rahi M, Rinne J, Nieminen AI, Castrén E, Koskimäki J.Neurobiol Dis. 2024 Dec 9;204:106762. doi: 10.1016/j.nbd.2024.106762. Online ahead of print.PMID: 39662533
  6. Branched-chain amino acid supplementation and voluntary running have distinct effects on the serum metabolome of rats with high or low intrinsic aerobic capacity.Karvinen S, Korhonen TK, Kiviö R, Lensu S, Gajera B, Britton SL, Koch LG, Nieminen AI, Kainulainen H.Front Nutr. 2024 Nov 19;11:1450386. doi: 10.3389/fnut.2024.1450386. eCollection 2024.PMID: 39628463
  7. Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation.Landoni JC, Erkul S, Laalo T, Goffart S, Kivelä R, Skube K, Nieminen AI, Wickström SA, Stewart J, Suomalainen A.Nat Commun. 2024 Sep 14;15(1):8066. doi: 10.1038/s41467-024-52164-1.PMID: 39277581Free PMC article.
  8. Loss of β2-integrin function results in metabolic reprogramming of dendritic cells, leading to increased dendritic cellfunctionality and anti-tumor responses.Harjunpää H, Somermäki R, Saldo Rubio G, Fusciello M, Feola S, Faisal I, Nieminen AI, Wang L, Llort Asens M, Zhao H, Eriksson O, Cerullo V, FagerholmSC.Oncoimmunology. 2024 Jun 21;13(1):2369373. doi: 10.1080/2162402X.2024.2369373. eCollection 2024.PMID: 38915784Free PMC article.
  9. Elevated fecal calprotectin is associated with gut microbial dysbiosis, altered serum markers and clinical outcomes inolder individuals.Heinzel S, Jureczek J, Kainulainen V, Nieminen AI, Suenkel U, von Thaler AK, Kaleta C, Eschweiler GW, Brockmann K, Aho VTE, Auvinen P, Maetzler W,Berg D, Scheperjans F.Sci Rep. 2024 Jun 12;14(1):13513. doi: 10.1038/s41598-024-63893-0.PMID: 38866914Free PMC article.
  10. Holmberg SM, Feeney RH, Prasoodanan P K V, Puértolas-Balint F, Singh DK, Wongkuna S, Zandbergen L, Hauner H, Brandl B, Nieminen AI, Skurk T, Schroeder BO.Nat Commun. 2024 Apr 25;15(1):3502. doi: 10.1038/s41467-024-47594-w.
  11. , Xing L, Gkini V, Nieminen AI, Zhou HC, Aquilino M, Naumann R, Reppe K, Tanaka K, Carmeliet P, Heikinheimo O, Pääbo S, Huttner WB, Namba T.Nat Commun. 2024 Apr 24;15(1):3468. doi: 10.1038/s41467-024-47437-8.
  12. Shrestha B, Nieminen AI, Matilainen O.Cell Stress Chaperones. 2024 Apr 10;29(3):392-403. doi: 10.1016/j.cstres.2024.04.003. Online ahead of print.PMID: 38608859
  13. Comparative analysis of the effects of different purification methods on the yield and purity of cow milk extracellularvesicles. Kankaanpää S, Nurmi M, Lampimäki M, Leskinen H, Nieminen A, Samoylenko A, Vainio SJ, Mäkinen S, Ahonen L, Kangasluoma J, Petäjä T, Viitala S.J Extracell Biol. 2024 Apr 22;3(4):e149. doi: 10.1002/jex2.149. eCollection 2024 Apr.PMID: 38938848Free PMC article.
  14. Satomaa T, Pynnönen H, Aitio O, Hiltunen JO, Pitkänen V, Lähteenmäki T, Kotiranta T, Heiskanen A, Hänninen AL, Niemelä R, Helin J, Kuusanmaki H, Vänttinen I, Rathod R, Nieminen AI, Yatkin E, Heckman CA, Kontro M, Saarinen J.Mol Cancer Ther. 2024 Apr 2. doi: 10.1158/1535-7163.MCT-23-0720. Online ahead of print.PMID: 38561023
  15. Zetterman T, Nieminen AI, Markkula R, Kalso E, Lötsch J.Clin Transl Sci. 2024 Mar;17(3):e13740. doi: 10.1111/cts.13740.PMID: 38411371
  16. Ali N, Rahat ST, Mäkelä M, Nasserinejad M, Jaako T, Kinnunen M, Schroderus J, Tulppo M, Nieminen AI, Vainio S.Front Physiol. 2023 Dec 7;14:1295852. doi: 10.3389/fphys.2023.1295852. eCollection 2023.PMID: 38143912
  17. Brock P, Sevigny M, Liyanarachchi S, Comiskey DF Jr, Li W, Saarinen S, Yilmaz AS, Nieminen AI, Ringel MD, Peltomäki P, Ollila S, Nieminen TT.Thyroid. 2024 Jan 10. doi: 10.1089/thy.2023.0560. Online ahead of print.PMID: 38062777
  18. Presterud R, Deng WH, Wennerström AB, Burgers T, Gajera B, Mattsson K, Solberg A, Fang EF, Nieminen AI, Stray-Pedersen A, Nilsen H.Mov Disord. 2024 Feb;39(2):360-369. doi: 10.1002/mds.29645. Epub 2023 Oct 29.PMID: 37899683
  19. , Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schönfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK., Science. 2023 Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257. Epub 2023 Jun 9.
    PMID: 37289866
  20. , Ali-Sisto T, Tolmunen T, Kraav SL, Mäntyselkä P, Valkonen-Korhonen M, Honkalampi K, Ruusunen A, Velagapudi V, Lehto SM., J Affect Disord. 2023 Jan 1;320:647-655. doi: 10.1016/j.jad.2022.09.092. Epub 2022 Oct 5.
    PMID: 36208690
  21. Pham TCP, Dollet L, Ali MS, Raun SH, Møller LLV, Jafari A, Ditzel N, Andersen NR, Fritzen AM, Gerhart-Hines Z, Kiens B, Suomalainen A, Simpson SJ, Salling Olsen M, Kieser A, Schjerling P, Nieminen AI, Richter EA, Havula E, Sylow L  iScience 2023 Jan 20;26(1):105895. doi: 10.1016/j.isci.2022.105895, PMID: 36590899
  22. Rahat ST, Mäkelä M, Nasserinejad M, Ikäheimo TM, Hyrkäs-Palmu H, Valtonen RIP, Röning J, Sebert S, Nieminen AI, Ali N, Vainio S., Int J Mol Sci. 2023 Apr 19;24(8):7507. doi: 10.3390/ijms24087507.
  23. Pinto SM, Subbannayya Y, Kim H, Hagen L, Górna MW, Nieminen AI, Bjørås M, Espevik T, Kainov D, Kandasamy RK. iScience. 2022 Dec 28:105895. doi: 10.1016/j.isci.2022.105895. Online ahead of print. PMID: 36590899*
  24. Mahdi A, Wodaje T, Kövamees O, Tengbom J, Zhao A, Jiao T, Henricsson M, Yang J, Zhou Z, Nieminen AI, Levin M, Collado A, Brinck J, Pernow J. J Intern Med. 2023 Feb;293(2):228-245. doi: 10.1111/joim.13580. PMID: 36324273
  25. Neupane N, Rajendran J, Kvist J, Harjuhaahto S, Hu B, Kinnunen V, Yang Y, Nieminen AI, Tyynismaa H. Commun Biol. 2022 Oct 5;5(1):1060. doi: 10.1038/s42003-022-04034-z. PMID: 36198903
  26. Role of the cystathionine β-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome. Panagaki T, Pecze L, Randi EB, Nieminen AI, Szabo C.Redox Biol. 2022 Jul 21;55:102416. 
  27. CRISPR correction of the Finnish ornithine delta-aminotransferase mutation restores metabolic homeostasis in iPSC from patients with gyrate atrophy. Maldonado R, Jalil S, Keskinen T, Nieminen AI, Hyvönen ME, Lapatto R, Wartiovaara K.Mol Genet Metab Rep. 2022 Apr 1;31:100863. 
  28. Machine Learning and Pathway Analysis-Based Discovery of Metabolomic Markers Relating to Chronic Pain Phenotypes. Miettinen T, Nieminen AI, Mäntyselkä P, Kalso E, Lötsch J.Int J Mol Sci. 2022 May 3;23(9):5085.
  29. Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections. Ianevski A, Yao R, Zusinaite E, Lello LS, Wang S, Jo E, Yang J, Ravlo E, Wang W, Lysvand H, Løseth K, Oksenych V, Tenson T, Windisch MP, Poranen MM, Nieminen AI, Nordbø SA, Fenstad MH, Grødeland G, Aukrust P, Trøseid M, Kantele A, Lastauskienė E, Vitkauskienė A, Legrand N, Merits A, Bjørås M, Kainov DE., 2021,Viruses. 2021 Dec 11;13(12):2489.
  30. Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring, Ghorasaini M, Mohammed Y, Adamski J, Bettcher L, Bowden JA, Cabruja M, Contrepois K, Ellenberger M, Gajera B, Haid M, Hornburg D, Hunter C, Jones CM, Klein T, Mayboroda O, Mirzaian M, Moaddel R, Ferrucci L, Lovett J, Nazir K, Pearson M, Ubhi BK, Raftery D, Riols F, Sayers R, Sijbrands EJG, Snyder MP, Su B, Velagapudi V, Williams KJ, de Rijke YB, Giera M. . Anal Chem. 2021 Dec 14;93(49):16369-16378. Epub 2021 Dec 3.
  31. One-carbon and energy metabolism in major depression compared to chronic depression in adolescent outpatients: A metabolomic pilot study. Kurkinen K, Kärkkäinen O, Lehto SM, Luoma I, Kraav S-L, Nieminen AI, Kivimäki P, Therman S, Tolmunen T, 2021, , Journal of Affective Disorders Reports, Dec 6: 100261
  32. Interactive effects of aging and aerobic capacity on energy metabolism-related metabolites of serum, skeletal muscle, and white adipose tissue, Zhuang H, Karvinen S, Törmäkangas T, Zhang X, Ojanen X, Velagapudi V, Alen M, Britton SL, Koch LG, Kainulainen H, Cheng S, Wiklund P. Geroscience. 2021 Dec;43(6):2679-2691.
  33. Palviainen M, Laukkanen K, Tavukcuoglu Z, Velagapudi V, Kärkkäinen O, Hanhineva K, Auriola S, Ranki A, Siljander P. Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles. Cancers (Basel). 2020 Nov 6;12(11):3292.  
  34. Targeted Metabolomics With Ultraperformance Liquid Chromatography-Mass Spectrometry (UPLC-MS) Highlights Metabolic Differences in Healthy and Atopic Staffordshire Bull Terriers Fed Two Different Diets, Moore R, Anturaniemi J, Velagapudi V, Nandania J, Barrouin-Melo SM, Hielm-Björkman A. , A Pilot Study. Front Vet Sci. 2020 Oct 27;7:554296.
  35. Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense., Gutiérrez S, Fischer J, Ganesan R, Hos NJ, Cildir G, Wolke M, Pessia A, Frommolt P, Desiderio V, Velagapudi V, Robinson N. Salmonella PLoS Pathog. 2021 Sep 23;17(9):e1009943.
  36. Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice, Heikelä H, Ruohonen ST, Adam M, Viitanen R, Liljenbäck H, Eskola O, Gabriel M, Mairinoja L, Pessia A, Velagapudi V, Roivainen A, Zhang FP, Strauss L, Poutanen M. . Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E494-E508.
  37. IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder, Kuukasjärvi A, Landoni JC, Kaukonen J, Juhakoski M, Auranen M, Torkkeli T, Velagapudi V, Suomalainen A. Eur J Hum Genet. 2021 Dec;29(12):1833-1837. doi: 10.1038/s41431-021-00939-1. Epub 2021 Jul 26.
  38. Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy, Pirinen E, Auranen M, Khan NA, Brilhante V, Urho N, Pessia A, Hakkarainen A, Ulla Heinonen JK, Schmidt MS, Haimilahti K, Piirilä P, Lundbom N, Taskinen MR, Brenner C, Velagapudi V, Pietiläinen KH, Suomalainen A. . Cell Metab. 2020 Jul 7;32(1):144. doi: 10.1016/j.cmet.2020.05.020. Erratum for: Cell Metab. 2020 Jun 2;31(6):1078-1090.e5.
  39. Over the Left Prefrontal Cortex Does Not Cause Clinically Significant Changes in Circulating Metabolites, Kortteenniemi A, Ortega-Alonso A, Javadi AH, Tolmunen T, Ali-Sisto T, Kotilainen T, Wikgren J, Karhunen L, Velagapudi V, Lehto SM. Anodal tDCS . Front Psychiatry. 2020 May 7;11:403. doi: 10.3389/fpsyt.2020.00403.
  40. Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography–Tandem Mass Spectrometry; Quantitation and Comparison of TCA Cycle Intermediates in Human Serum, Plasma, Kasumi-1 Cell and Murine Liver Tissue. Rathod, R.; Gajera, B.; Nazir, K.; Wallenius, J.; Velagapudi, V.  Metabolites 2020, 10, 103. .
  41. Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders. Sci Rep 9, 16054 (2019). Haruna T, Takayuki M, Vidya V, Kaori I, Moe U, Kazuto N, Anu S & Jun-Ichi H. .
  42. Repeated Transcranial Magnetic Stimulation-Induced Motor Evoked Potentials Correlate With the Subject-Specific Serum Metabolic Profile of Creatine. J Clin Neurophysiol. 2019.Kallioniemi E, Kärkkäinen O, Määttä S, Könönen M, Kivimäki P, Kaarre O, Velagapudi V, Kekkonen V, Lehto SM, Laukkanen E, Tolmunen T. 
  43. Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci. Clin Epigenetics. 2019 Jan 5;11(1):1.Gupta R, van Dongen J, Fu Y, Abdellaoui A, Tyndale RF, Velagapudi V, Boomsma DI, Korhonen T, Kaprio J, Loukola A, Ollikainen M. 
  44. Changes in the serum metabolite profile correlate with decreased brain grey matter volume in heavy-drinking young adults. Alcohol. 2019; 75:89-97. Heikkinen, N., Kärkkäinen, O., Laukkanen, E., Kekkonen, V., Kaarre, O., Kivimäki, P., Könönen, M., Velagapudi, V., Nandania, J., Lehto, S., Niskanen, E., Vanninen, R., Tolmunen, T. 
  45. Metabolomes of mitochondrial diseases and inclusion body myositis: treatment targets and biomarkers. EMBO Molecular Medicine. 2018  Dec;10(12).Buzkova, J., Nikkanen, J., Ahola, S., Hakonen, A., Sevastianova, K., Hovinen, T., Yki-Järvinen, H., Pietiläinen, K., Lönnqvist, T., Velagapudi, V., Carroll, C., Suomalainen, A.  
  46. A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents. Viruses. 2018 Aug 12;10(8).Zusinaite E, Ianevski A, Niukkanen D, Poranen MM, Bjørås M, Afset JE, Tenson T, Velagapudi V, Merits A, Kainov DE. 
  47. Simultaneous measurement of folate cycle metabolites using liquid chromatography-tandem mass spectrometry from different biological matrices. Journal of Chromatography B. 2018; 15:1092: 168-178.Nandania, J., Kokkonen, M., Euro, L, Velagapudi, V. 
  48. Adipose tissue mitochondrial gene expression profile associates with long-term weight loss success. International Journal of Obesity. 2018; 42;817–825. Jokinen, R., Rinnankoski-Tuikka, R., Kaye, S., Saarinen, L., Heinonen, S., Myöhänen, M., Rappou, E., Jukarainen, S., Kaprio, J., Rissanen, A., Pessia, A., Velagapudi, V., Virtanen, K., Pirinen, E and Pietiläinen, K. 
  49. Validation and automation of high-throughput multi-targeted method for semi-quantification of endogenous metabolites from different biological matrices using tandem mass spectrometry. Metabolites. 2018; 5:8:3. Nandania, J., Peddinti, G., Pessia, A., Kokkonen, M., Velagapudi, V. 
  50. Pre-analytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for “Precision Medicine and Pharmacometabolomics Task Group” – The Metabolomics Society Initiative). Clinical Chemistry. 2018; 64:8:1158-1182. Kirwan, J., Brennan, L., Broadhurst, D., Fiehn, O., Cascante, M., Dunn, W., Schmidt, M., Velagapudi, V. 
  51. Plasma metabolites reveal distinct profiles associating with different metabolic risk factors in monozygotic twin pairs. International Journal of Obesity. 2018;Muniandy, M., Velagapudi, V., Hakkarainen, A., Lundbom, J., Lundbom, N., Rissanen, A., Kaprio, J., Pietiläinen, K., Ollikainen, M. 
  52. Understanding the metabolic burden of recombinant antibody production in Saccharomyces cerevisiae using a quantitative metabolomics approach. Yeast. 2018; 35(4):331-341. De Ruijter, J., Koskela, E., Nandania, J., Frey, A., Velagapudi, V. 
  53. Global arginine bioavailability ratio is decreased in patients with major depressive disorder. Journal of Affective Disorders. 2018; 15;229:145. Ali-Sisto, T., Tolmunen, T., Toffol, E., Viinamäki, H., Mäntyselkä, P., Valkonen-Korhonen, M., Honkalampi, K., Ruusunen, A., Velagapudi, V., Lehto, S.M. 
  54. Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C.elegans. Cell. Scott TA, Quintaneiro LM, Norvaisas P, Lui PP, Wilson MP, Leung KY, Herrera-Dominguez L, Sudiwala S, Pessia A, Clayton PT, Bryson K, Velagapudi V, Mills PB, Typas A, Greene NDE, Cabreiro F. (2017).
  55. Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.  Viruses. 2017; 9, 271. Bulanova, D., Ianevski, A., Bugai, A., Akimov, Y., Kuivanen, S., Paavilainen, H., Kakkola, L., Nandania, J., Turunen, L., Ohman, T., Ala-Hongisto, H., Pesonen, H.M., Kuisma, M.S., Honkimaa, A., Walton, E.L., Oksenych, V., Lorey, M.B., Guschin, D., Shim, J., Kim, J., Than, T.T., Chang, S.Y., Hukkanen, V., Kulesskiy, E., Marjomaki, V.S., Julkunen, I., Nyman, T.A., Matikainen, S., Saarela, J.S., Sane, F., Hober, D., Gabriel, G., De Brabander, J.K., Martikainen, M., Windisch, M.P., Min, J.Y., Bruzzone, R., Aittokallio, T., Vähä-Koskela, M., Vapalahti, O., Pulk, A., Velagapudi, V., Kainov, D.E. 
  56. mTORC1 Regulates Mitochondrial Folate Cycle and the Integrated Stress Response in Mitochondrial Disease. Cell Metabolism. 2017; 26(2):419-428. Khan, N.A., Nikkanen, J., Yatsuga, S., Wang, L., Jackson, C., Pessia, A., Riikka Kivelä, Velagapudi, V., Anu Suomalainen. 
  57. Metabolomic profiling of extracellular vesicles and alternative normalisation methodsreveal enriched metabolites and strategies to study prostate cancer related changes. Puhka, M., Takatalo, M., Nordberg, M.E., Valkonen, S., Nandania, J., Aatonen, M., Yliperttula, M., Laitinen, S., Velgapudi, V., Mirtti, T., Kallioniemi, O., Rannikko, A., Siljander, P.R.M., af Hallstrom, T.M. Theranostics. 2017; 7(16): 3824-3841.
  58. Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation. Scientific Reports. Purhonen, J., Rajendran, J., Mörgelin, M., Uusi-Rauva, K., Katayama, S., Krjutskov, K., Einarsdottir, E., Velagapudi, V., Kere, J., Jauhiainen, M., Fellman, V., Kallijärvi, J. (2017). 
  59. Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics. The FASEB Journal. Vorrink, S..U., Ullah, S., Schmidt, S., Nandania, J., Velagapudi, V., Beck, O., Ingelman-Sundberg, M., Lauschke, V.M. (2017).
  60. CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.  Journal of Cell Biology. Schatton, D., Pla-Martin, D., Marx, M.C., Hansen, H., Mourier, A., Nemazanyy, I., Pessia, A., Zentis, P., Corona, T. Kondylis, V., Barth, E., Schauss, A.C., Velagapudi, V., Rugarli, E. (2017).
  61. Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology. Disease Models and Mechanisms. Szibor, M., Dhandapani, PK., Dufour, E., Holmström, KM., Zhuang, Y., Salwig, I., Wittig, I., Heidler, J., Gizatullina, Z., Gainutdinov, T., Consortium, GM., Fuchs, H., Gailus-Durner, V., de Angelis, MH., Nandania, J., Velagapudi, V., Wietelmann, A., Rustin, P., Gellerich, FN., Jacobs, HT., Braun, T. (2017). 
  62. Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism. Antiviral Research. Kuivanen, S., Bespalov, MM., Nandania, J., Ianevski, A., Velagapudi, V., De Brabander, JK., Kainov, DE., Vapalahti, O. (2017).
  63. Regulation of Kynurenine Biosynthesis during Influenza Virus Infection. The FEBS Journal. Gaelings, L., Söderholm, S., Bugai, A., Fu, Y., Nandania, J., Schepens, B., Lorey, M.B., Tynell, J., Ginste, L.S., Goffic, R.L., Miller, M.S., Kuisma, M., Marjomäki, V., Brabander, J.D., Matikainen, S., Nyman, T.A., Bamford, D., Saelens, X., Julkunen, I., Paavilainen, H., Hukkanen, V., Velagapudi, V., Kainov, D.E. (2017).
  64. The association between musculoskeletal pain and circulating ornithine – A population-based study. Pain Medicine. Mäntyselkä, P., Ali-Sisto, T., Kautiainen, H., Savolainen, J., Niskanen, L., Viinamäki, H., Velagapudi, V., Lehto, S.M. (2016).
  65. Combined immunodeficiency with hypoglycemia caused by mutations in hypoxia up-regulated 1. The Journal of Allergy and Clinical Immunology. Haapaniemi, E., Fogarty, C., Katayama, S., Vihinen, H., Keskitalo, S., Ilander, M., Krjutškov, K., Mustjoki, S., Lehto, M., Hautala, T., Jokitalo, E., Velagapudi, V., Varjosalo, M., Seppänen, M., Kere, J. (2016). 
  66. Effect of high-carbohydrate diet on plasma metabolomics in mice with mitochondrial respiratory chain complex III deficiency due to a Bcs1l mutation. International Journal of Molecular Sciences. Rajendran, J., Tomašić, N., Kotarsky, H., Hansson, E., Velagapudi, V., Kallijärvi, J., Fellman, V. (2016). 
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