Taurine deficiency as a driver of aging., Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schönfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK., Science. 2023 Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257. Epub 2023 Jun 9.
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TNIK is a conserved regulator of glucose and lipid metabolism in obesity. Pham TCP, Dollet L, Ali MS, Raun SH, Møller LLV, Jafari A, Ditzel N, Andersen NR, Fritzen AM, Gerhart-Hines Z, Kiens B, Suomalainen A, Simpson SJ, Salling Olsen M, Kieser A, Schjerling P, Nieminen AI, Richter EA, Havula E, Sylow L iScience 2023 Jan 20;26(1):105895. doi: 10.1016/j.isci.2022.105895, PMID: 36590899
Role of the cystathionine β-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome. Panagaki T, Pecze L, Randi EB, Nieminen AI, Szabo C.Redox Biol. 2022 Jul 21;55:102416. PMID:35921774
CRISPR correction of the Finnish ornithine delta-aminotransferase mutation restores metabolic homeostasis in iPSC from patients with gyrate atrophy. Maldonado R, Jalil S, Keskinen T, Nieminen AI, Hyvönen ME, Lapatto R, Wartiovaara K.Mol Genet Metab Rep. 2022 Apr 1;31:100863. PMID:35782600
Machine Learning and Pathway Analysis-Based Discovery of Metabolomic Markers Relating to Chronic Pain Phenotypes. Miettinen T, Nieminen AI, Mäntyselkä P, Kalso E, Lötsch J.Int J Mol Sci. 2022 May 3;23(9):5085. PMID:35563473
Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections. Ianevski A, Yao R, Zusinaite E, Lello LS, Wang S, Jo E, Yang J, Ravlo E, Wang W, Lysvand H, Løseth K, Oksenych V, Tenson T, Windisch MP, Poranen MM, Nieminen AI, Nordbø SA, Fenstad MH, Grødeland G, Aukrust P, Trøseid M, Kantele A, Lastauskienė E, Vitkauskienė A, Legrand N, Merits A, Bjørås M, Kainov DE., 2021,Viruses. 2021 Dec 11;13(12):2489.
Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring, Ghorasaini M, Mohammed Y, Adamski J, Bettcher L, Bowden JA, Cabruja M, Contrepois K, Ellenberger M, Gajera B, Haid M, Hornburg D, Hunter C, Jones CM, Klein T, Mayboroda O, Mirzaian M, Moaddel R, Ferrucci L, Lovett J, Nazir K, Pearson M, Ubhi BK, Raftery D, Riols F, Sayers R, Sijbrands EJG, Snyder MP, Su B, Velagapudi V, Williams KJ, de Rijke YB, Giera M. . Anal Chem. 2021 Dec 14;93(49):16369-16378. Epub 2021 Dec 3. PMID: 34859676
One-carbon and energy metabolism in major depression compared to chronic depression in adolescent outpatients: A metabolomic pilot study. Kurkinen K, Kärkkäinen O, Lehto SM, Luoma I, Kraav S-L, Nieminen AI, Kivimäki P, Therman S, Tolmunen T, 2021, , Journal of Affective Disorders Reports, Dec 6: 100261 https://doi.org/10.1016/j.jadr.2021.100261
Interactive effects of aging and aerobic capacity on energy metabolism-related metabolites of serum, skeletal muscle, and white adipose tissue, Zhuang H, Karvinen S, Törmäkangas T, Zhang X, Ojanen X, Velagapudi V, Alen M, Britton SL, Koch LG, Kainulainen H, Cheng S, Wiklund P. Geroscience. 2021 Dec;43(6):2679-2691. PMID:34089174
Palviainen M, Laukkanen K, Tavukcuoglu Z, Velagapudi V, Kärkkäinen O, Hanhineva K, Auriola S, Ranki A, Siljander P. Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles. Cancers (Basel). 2020 Nov 6;12(11):3292. PMID:33172086
Targeted Metabolomics With Ultraperformance Liquid Chromatography-Mass Spectrometry (UPLC-MS) Highlights Metabolic Differences in Healthy and Atopic Staffordshire Bull Terriers Fed Two Different Diets, Moore R, Anturaniemi J, Velagapudi V, Nandania J, Barrouin-Melo SM, Hielm-Björkman A. , A Pilot Study. Front Vet Sci. 2020 Oct 27;7:554296. PMID: 33195525
Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense., Gutiérrez S, Fischer J, Ganesan R, Hos NJ, Cildir G, Wolke M, Pessia A, Frommolt P, Desiderio V, Velagapudi V, Robinson N. Salmonella PLoS Pathog. 2021 Sep 23;17(9):e1009943. PMID: 34555129
Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice, Heikelä H, Ruohonen ST, Adam M, Viitanen R, Liljenbäck H, Eskola O, Gabriel M, Mairinoja L, Pessia A, Velagapudi V, Roivainen A, Zhang FP, Strauss L, Poutanen M. . Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E494-E508. PMID: 32691632
IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder, Kuukasjärvi A, Landoni JC, Kaukonen J, Juhakoski M, Auranen M, Torkkeli T, Velagapudi V, Suomalainen A. Eur J Hum Genet. 2021 Dec;29(12):1833-1837. doi: 10.1038/s41431-021-00939-1. Epub 2021 Jul 26. PMID: 34305140
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy, Pirinen E, Auranen M, Khan NA, Brilhante V, Urho N, Pessia A, Hakkarainen A, Ulla Heinonen JK, Schmidt MS, Haimilahti K, Piirilä P, Lundbom N, Taskinen MR, Brenner C, Velagapudi V, Pietiläinen KH, Suomalainen A. . Cell Metab. 2020 Jul 7;32(1):144. doi: 10.1016/j.cmet.2020.05.020. Erratum for: Cell Metab. 2020 Jun 2;31(6):1078-1090.e5. PMID: 32640244.
Over the Left Prefrontal Cortex Does Not Cause Clinically Significant Changes in Circulating Metabolites, Kortteenniemi A, Ortega-Alonso A, Javadi AH, Tolmunen T, Ali-Sisto T, Kotilainen T, Wikgren J, Karhunen L, Velagapudi V, Lehto SM. Anodal tDCS . Front Psychiatry. 2020 May 7;11:403. doi: 10.3389/fpsyt.2020.00403. PMID: 32458831
Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography–Tandem Mass Spectrometry; Quantitation and Comparison of TCA Cycle Intermediates in Human Serum, Plasma, Kasumi-1 Cell and Murine Liver Tissue.Rathod, R.; Gajera, B.; Nazir, K.; Wallenius, J.; Velagapudi, V. Metabolites 2020, 10, 103. https://doi.org/10.3390/metabo10030103.
Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders. Sci Rep 9, 16054 (2019). Haruna T, Takayuki M, Vidya V, Kaori I, Moe U, Kazuto N, Anu S & Jun-Ichi H. https://doi.org/10.1038/s41598-019-52372-6.
Repeated Transcranial Magnetic Stimulation-Induced Motor Evoked Potentials Correlate With the Subject-Specific Serum Metabolic Profile of Creatine. J Clin Neurophysiol. 2019.Kallioniemi E, Kärkkäinen O, Määttä S, Könönen M, Kivimäki P, Kaarre O, Velagapudi V, Kekkonen V, Lehto SM, Laukkanen E, Tolmunen T. PMID:30720554
Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci. Clin Epigenetics. 2019 Jan 5;11(1):1.Gupta R, van Dongen J, Fu Y, Abdellaoui A, Tyndale RF, Velagapudi V, Boomsma DI, Korhonen T, Kaprio J, Loukola A, Ollikainen M. PMID:30611298
Changes in the serum metabolite profile correlate with decreased brain grey matter volume in heavy-drinking young adults. Alcohol. 2019; 75:89-97. Heikkinen, N., Kärkkäinen, O., Laukkanen, E., Kekkonen, V., Kaarre, O., Kivimäki, P., Könönen, M., Velagapudi, V., Nandania, J., Lehto, S., Niskanen, E., Vanninen, R., Tolmunen, T. PMID:30513444
Metabolomes of mitochondrial diseases and inclusion body myositis: treatment targets and biomarkers. EMBO Molecular Medicine. 2018 Dec;10(12).Buzkova, J., Nikkanen, J., Ahola, S., Hakonen, A., Sevastianova, K., Hovinen, T., Yki-Järvinen, H., Pietiläinen, K., Lönnqvist, T., Velagapudi, V., Carroll, C., Suomalainen, A. PMID:30373890
A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents. Viruses. 2018 Aug 12;10(8).Zusinaite E, Ianevski A, Niukkanen D, Poranen MM, Bjørås M, Afset JE, Tenson T, Velagapudi V, Merits A, Kainov DE. PMID:30103549
Simultaneous measurement of folate cycle metabolites using liquid chromatography-tandem mass spectrometry from different biological matrices. Journal of Chromatography B. 2018; 15:1092: 168-178.Nandania, J., Kokkonen, M., Euro, L, Velagapudi, V. PMID:29906678
Adipose tissue mitochondrial gene expression profile associates with long-term weight loss success. International Journal of Obesity. 2018; 42;817–825. Jokinen, R., Rinnankoski-Tuikka, R., Kaye, S., Saarinen, L., Heinonen, S., Myöhänen, M., Rappou, E., Jukarainen, S., Kaprio, J., Rissanen, A., Pessia, A., Velagapudi, V., Virtanen, K., Pirinen, E and Pietiläinen, K. PMID:29203860
Validation and automation of high-throughput multi-targeted method for semi-quantification of endogenous metabolites from different biological matrices using tandem mass spectrometry. Metabolites. 2018; 5:8:3. Nandania, J., Peddinti, G., Pessia, A., Kokkonen, M., Velagapudi, V. PMID:30081599
Pre-analytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for “Precision Medicine and Pharmacometabolomics Task Group” – The Metabolomics Society Initiative). Clinical Chemistry. 2018; 64:8:1158-1182. Kirwan, J., Brennan, L., Broadhurst, D., Fiehn, O., Cascante, M., Dunn, W., Schmidt, M., Velagapudi, V. PMID:29921725
Plasma metabolites reveal distinct profiles associating with different metabolic risk factors in monozygotic twin pairs. International Journal of Obesity. 2018;Muniandy, M., Velagapudi, V., Hakkarainen, A., Lundbom, J., Lundbom, N., Rissanen, A., Kaprio, J., Pietiläinen, K., Ollikainen, M. PMID:29907843
Understanding the metabolic burden of recombinant antibody production in Saccharomyces cerevisiae using a quantitative metabolomics approach. Yeast. 2018; 35(4):331-341. De Ruijter, J., Koskela, E., Nandania, J., Frey, A., Velagapudi, V. PMID: 29159981
Global arginine bioavailability ratio is decreased in patients with major depressive disorder. Journal of Affective Disorders. 2018; 15;229:145. Ali-Sisto, T., Tolmunen, T., Toffol, E., Viinamäki, H., Mäntyselkä, P., Valkonen-Korhonen, M., Honkalampi, K., Ruusunen, A., Velagapudi, V., Lehto, S.M. PMID:29310063
Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C.elegans. Cell. Scott TA, Quintaneiro LM, Norvaisas P, Lui PP, Wilson MP, Leung KY, Herrera-Dominguez L, Sudiwala S, Pessia A, Clayton PT, Bryson K, Velagapudi V, Mills PB, Typas A, Greene NDE, Cabreiro F. (2017). PMID:2843124
Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins. Viruses. 2017; 9, 271. Bulanova, D., Ianevski, A., Bugai, A., Akimov, Y., Kuivanen, S., Paavilainen, H., Kakkola, L., Nandania, J., Turunen, L., Ohman, T., Ala-Hongisto, H., Pesonen, H.M., Kuisma, M.S., Honkimaa, A., Walton, E.L., Oksenych, V., Lorey, M.B., Guschin, D., Shim, J., Kim, J., Than, T.T., Chang, S.Y., Hukkanen, V., Kulesskiy, E., Marjomaki, V.S., Julkunen, I., Nyman, T.A., Matikainen, S., Saarela, J.S., Sane, F., Hober, D., Gabriel, G., De Brabander, J.K., Martikainen, M., Windisch, M.P., Min, J.Y., Bruzzone, R., Aittokallio, T., Vähä-Koskela, M., Vapalahti, O., Pulk, A., Velagapudi, V., Kainov, D.E. PMID:28946654
mTORC1 Regulates Mitochondrial Folate Cycle and the Integrated Stress Response in Mitochondrial Disease. Cell Metabolism. 2017; 26(2):419-428. Khan, N.A., Nikkanen, J., Yatsuga, S., Wang, L., Jackson, C., Pessia, A., Riikka Kivelä, Velagapudi, V., Anu Suomalainen. PMID:28768179
Metabolomic profiling of extracellular vesicles and alternative normalisation methodsreveal enriched metabolites and strategies to study prostate cancer related changes. Puhka, M., Takatalo, M., Nordberg, M.E., Valkonen, S., Nandania, J., Aatonen, M., Yliperttula, M., Laitinen, S., Velgapudi, V., Mirtti, T., Kallioniemi, O., Rannikko, A., Siljander, P.R.M., af Hallstrom, T.M. Theranostics. 2017; 7(16): 3824-3841.
Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation. Scientific Reports. Purhonen, J., Rajendran, J., Mörgelin, M., Uusi-Rauva, K., Katayama, S., Krjutskov, K., Einarsdottir, E., Velagapudi, V., Kere, J., Jauhiainen, M., Fellman, V., Kallijärvi, J. (2017). PMID:28424480
Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics. The FASEB Journal. Vorrink, S..U., Ullah, S., Schmidt, S., Nandania, J., Velagapudi, V., Beck, O., Ingelman-Sundberg, M., Lauschke, V.M. (2017). PMID:28264975
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. Journal of Cell Biology. Schatton, D., Pla-Martin, D., Marx, M.C., Hansen, H., Mourier, A., Nemazanyy, I., Pessia, A., Zentis, P., Corona, T. Kondylis, V., Barth, E., Schauss, A.C., Velagapudi, V., Rugarli, E. (2017).PMID:28188211
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology. Disease Models and Mechanisms. Szibor, M., Dhandapani, PK., Dufour, E., Holmström, KM., Zhuang, Y., Salwig, I., Wittig, I., Heidler, J., Gizatullina, Z., Gainutdinov, T., Consortium, GM., Fuchs, H., Gailus-Durner, V., de Angelis, MH., Nandania, J., Velagapudi, V., Wietelmann, A., Rustin, P., Gellerich, FN., Jacobs, HT., Braun, T. (2017). PMID:28067626
Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism. Antiviral Research. Kuivanen, S., Bespalov, MM., Nandania, J., Ianevski, A., Velagapudi, V., De Brabander, JK., Kainov, DE., Vapalahti, O. (2017). PMID:28049006.
Regulation of Kynurenine Biosynthesis during Influenza Virus Infection. The FEBS Journal. Gaelings, L., Söderholm, S., Bugai, A., Fu, Y., Nandania, J., Schepens, B., Lorey, M.B., Tynell, J., Ginste, L.S., Goffic, R.L., Miller, M.S., Kuisma, M., Marjomäki, V., Brabander, J.D., Matikainen, S., Nyman, T.A., Bamford, D., Saelens, X., Julkunen, I., Paavilainen, H., Hukkanen, V., Velagapudi, V., Kainov, D.E. (2017).PMID:27860276
The association between musculoskeletal pain and circulating ornithine – A population-based study. Pain Medicine. Mäntyselkä, P., Ali-Sisto, T., Kautiainen, H., Savolainen, J., Niskanen, L., Viinamäki, H., Velagapudi, V., Lehto, S.M. (2016).PMID:28034972
Combined immunodeficiency with hypoglycemia caused by mutations in hypoxia up-regulated 1. The Journal of Allergy and Clinical Immunology. Haapaniemi, E., Fogarty, C., Katayama, S., Vihinen, H., Keskitalo, S., Ilander, M., Krjutškov, K., Mustjoki, S., Lehto, M., Hautala, T., Jokitalo, E., Velagapudi, V., Varjosalo, M., Seppänen, M., Kere, J. (2016). PMID:27913302
Effect of high-carbohydrate diet on plasma metabolomics in mice with mitochondrial respiratory chain complex III deficiency due to a Bcs1l mutation. International Journal of Molecular Sciences. Rajendran, J., Tomašić, N., Kotarsky, H., Hansson, E., Velagapudi, V., Kallijärvi, J., Fellman, V. (2016). PMID:27809283
Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study. International Archives of Allergy and Immunology. Zinkevičienė A, Kainov D, Girkontaitė I, Lastauskienė E, Kvedarienė V, Fu Y, Anders S, Velagapudi V. (2016). PMID: 27771694
Fecal and serum metabolomics in pediatric inflammatory bowel disease. Journal of Crohn’s and Colitis. Kolho, K-L., Pessia, A., Jaakkola, T., de Vos, W., Velagapudi, V. (2016). PMID: 27609529
Modified Atkins diet induces subacute selective ragged red fiber lysis in mitochondrial myopathy patients. EMBO Molecular Medicine. Ahola, S., Auranen, M., Isohanni, P., Niemisalo, S., Buzkova, J., Velagapudi, V., Lundbom, N., Hakkarainen, A., Piirilä, P., Pietiläinen, K., Suomalainen, A. (2016). PMID: 27647878Press release
JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Research. Fu Y, Gaelings L, Söderholm S, Belanov S, Nandania J, Nyman TA, Matikainen S, Anders S, Velagapudi V, Kainov DE. (2016). PMID: 27451344
GATA4 regulates blood-testis barrier function and lactate metabolism in mouse Sertoli cells. Endocriniology. Schrade, A., Kyrönlahti, A., Akinrinade, O., Pihlajoki, M., Fischer, S., Martinez Rodriguez, V., Velagapudi V, Toppari, J., Wilson, DB., Heikinheimo, M. (2016). PMID: 26974005
Purine metabolism is dysregulated in patients with major depressive disorder. Psychoneuroendocrinology. Ali-Sisto, T., Tolmunen, T., Toffol, E., Viinamäki, H., Mäntyselkä, P., Valkonen-Korhonen, M., Honkalampi, K., Ruusunen, A., Velagapudi V, Lehto, S.M. (2016). MID: 27153521
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools And Remodel One-Carbon Metabolism. Cell Metabolism. Nikkanen J, Forsström S, Euro L, Paetau I, Kohnz R.A, Wang L, Chilov D, Viinamäki J, Roivainen A, Marjamäki P, Liljenbäck H, Ahola S, Buzkova J, Terzioglu M, Khan N.A, Pirnes-Karhu S, Paetau A, Lönnqvist T, Sajantila A, Isohanni P, Tyynismaa H, Nomura D.K, Battersby B, Velagapudi V, Carroll C.J, Suomalainen A. (2016). PMID: 26924217
GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells. Endocrinology. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Häkkinen M, Fischer S, Alastalo T.P, Velagapudi V, Toppari J, Wilson D.B, Heikinheimo M (2015). PMID: 25668067
Vitamin B12–dependent taurine synthesis regulates growth and bone mass. Journal of Clinical Investigation. Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Wilkinson D, Santhanam B, Sarper N, Clare S, Vassiliou GS, Velagapudi V, Dougan G, Yadav V.K. (2014).PMID: 24911144
Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3. EMBO Molecular Medicine. Khan N.A, Auranen M, Paetau I, Pirinen E, Euro L, Forsström S, Pasila L, Velagapudi V, Carroll C.J, Auwerx J, Suomalainen A. (2014). PMID: 24711540