Sparse Matrix Screens

Helsinki Random I, Helsinki Random II, Helsinki Cryo, Helsinki X-tal Factorial, Helsinki Synergy, JBScreen Wizard 1 - 2 HTS

The classic sparse matrix screen based on Jancaric and Kim (1991) and modified by . Samples salts, polymers, organics and pH (see .

A combined sparse matrix and incomplete factorial screens, samples pH 3.5 to 8.5, low ionic strength, high ionic strength and mixed polymer/salt conditions and halides for potential phasing (see ).

A cryoprotected screen where crystals can be directly frozen from their crystallisation solutions (see).

Incomplete factorial screen adopted and modified from . Includes reagents and conditions different from other random screens we have (see ).

A screen searching for a synergy between mechanistically different precipitants, adapted from . The original screen includes 64 conditions, rest of the block is duplicated as a 67% dilution of selected conditions (see ).

A random sparse matrix screen with a large range of precipitants, buffers and salts. Highly effective for crystallizing proteins, peptides, nucleic acids, or macromolecular complexes (see ).