Varjosalo Lab's longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling potential and how the signaling is changed in diseases in the immuno-oncology axis. For this purpose, we have developed experimental and computational methods to identify the protein-interactions formed by these signaling molecules. Additionally, we employ quantitative mass spectrometry -based proteomics on assessing the protein abundance changes, as well as phosphorylation status of the tissues/cells. Furthermore, combining the data from the different sets of ‘omics’ data (proteomics, HTS and HiSeq), allows us to generate global and systems level understanding on how disease-causing mutations mediate their effects, enabling also the development of therapeutic or diagnostic approaches.
Markku Varjosalo, PhD
Institute of Biotechnology, HiLIFE
Biocenter 3, room 3318
P.O. Box 65 (Viikinkaari 1)
00014 University of Helsinki
Phone: +358 2941 59413
fax: +358 2941 59416
Lab manager Sini Miettinen´s phone: +358 294159414
Markku is a Principal Investigator/Research Director at BI and the Director of the Viikki Proteomics Unit.