We study the molecular mechanism of proteins involved in biological energy conversion and mitochondrial function/dysfunction (respiratory complexes I-V). We apply multi-scale computational approaches such as atomistic and coarse-grained MD simulations, DFT calculations and hybrid QM/MM simulations to understand enzyme mechanism in great depth.
For this purpose, we rely on high performance supercomputing infrastructure (CSC, Finland and PRACE) and on extensive collaborations with experimental groups in Finland and abroad. Our research bridges the two campuses of the University of Helsinki, Viikki and Kumpula, fostering close collaboration, networking and teaching. For more details on our research, see our group website below.
Vivek Sharma, PhD, Docent
Visiting Scholar
Institute of Biotechnology, HiLIFE
Vivek is a Principal Investigator/Visiting Scholar at BI and Associate Professor at the Faculty of Science (Department of Physics), University of Helsinki. His research is supported by the Academy of Finland, University of Helsinki, Sigrid Jusélius Foundation, Jane and Aatos Erkko Foundation and Magnus Ehrnrooth Foundation.