PhD theses:
Rosendahl Jenni, Vitamin D and extraskeletal effects in children: Studies on infections, allergies and inflammation, 2018,
Hauta-alus Helena, Vitamin D in pregnancy and infancy: Dietary sources and associations with pregnancy outcomes and infant growth, 2019,
Enlund-Cerullo, Vitamin D Metabolism in early childhood : Associations with genetic variants and biomarkers, 2023,
Saara Valkama, Bone strength in early childhood : Associations with vitamin D and motor development, 2025,
Publications (newest first):
Seppälä V, Holmlund-Suila E, Hauta-alus H, Sandboge S, Kajantie E, Rosendahl J, Enlund-Cerullo M, Valkama S, Mäkitie O, Andersson S, Räikkönen K, Heinonen K. High-dose vs standard-dose vitamin D and sleep in early childhood: A randomized clinical trial. Sleep Med. 2026 Jul;143:108913. doi: 10.1016/j.sleep.2026.108913. Epub 2026 Mar 23. PMID: 41887120.
Sandboge S, Seppälä V, Lintula S, Holmlund-Suila E, Hauta-alus H, Kajantie E, Mäkitie O, Andersson S, Räikkönen K, Heinonen K. Vitamin D supplementation in the first 2 years and autism spectrum traits at 6-8 years - a randomized clinical trial. J Child Psychol Psychiatry. 2026 Jan 5. doi: 10.1111/jcpp.70110. Epub ahead of print. PMID: 41486975.
Seppälä V, Sandboge S, Holmlund-Suila E, Hauta-alus H, Lintula S, Kajantie E, Mäkitie O, Andersson S, Räikkönen K, Heinonen K. Early life vitamin D and neurocognitive abilities at age 6-8 years: a randomized clinical trial and observational analysis. Eur Child Adolesc Psychiatry. 2026 Feb;35(2):587-597. doi: 10.1007/s00787-025-02891-7. Epub 2025 Oct 10. PMID: 41071326; PMCID: PMC12957056.
Persia S, Holmlund-Suila E, Valkama S, Enlund-Cerullo M, Rosendahl J, Andersson S, Mäkitie O, Hauta-alus H. Bone turnover markers, and growth and bone parameters in infants participating in a vitamin D intervention study. Endocr Connect. 2024 Dec 20;14(1):e240482. doi: 10.1530/EC-24-0482. PMID: 39555588; PMCID: PMC11728877.
Hauta-alus HH*, Rosendahl J*, Holmlund-Suila EM, Valkama SM, Enlund-Cerullo M, Nurhonen M, Kajantie E, Mäkitie O, Andersson S. Low-grade inflammation from prenatal period to age 6-8 years in a Vitamin D trial. Pediatr Res. 2024 May;95(6):1578-1586. doi: 10.1038/s41390-024-03019-4. Epub 2024 Jan 15. PMID: 38225452; PMCID: PMC11126391.
Enlund-Cerullo M, Holmlund-Suila E, Valkama S, Hauta-alus H, Rosendahl J, Andersson S, Pekkinen M, Mäkitie O. Variation in the fibroblast growth factor 23 (FGF23) gene associates with serum FGF23 and bone strength in infants. Front Genet. 2023 May 22;14:1192368. doi: 10.3389/fgene.2023.1192368. PMID: 37284066; PMCID: PMC10240082.
Sandboge S, Räikkönen K, Lahti-Pulkkinen M, Hauta-alus H, Holmlund-Suila E, Girchenko P, Kajantie E, Mäkitie O, Andersson S, Heinonen K. Effect of Vitamin D3 Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years: A Randomized Clinical Trial. JAMA Netw Open. 2023 May 1;6(5):e2314319. doi: 10.1001/jamanetworkopen.2023.14319. PMID: 37204794; PMCID: PMC10199342.
Pontán F, Hauta-alus H, Valkama S, Rosendahl J, Enlund-Cerullo M, Andersson S, Mäkitie O, Holmlund-Suila E. Alkaline Phosphatase and Hyperphosphatasemia in Vitamin D Trial in Healthy Infants and Toddlers. J Clin Endocrinol Metab. 2023 Sep 18;108(10):e1082-e1091. doi: 10.1210/clinem/dgad208. PMID: 37061810.
Arponen H, Waltimo-Sirén J, Hauta-alus HH, Tuhkiainen M, Sorsa T, Tervahartiala T, Andersson S, Mäkitie O, Holmlund-Suila E. Effects of a 2-Year Early Childhood Vitamin D3 Intervention on Tooth Enamel and Oral Health at Age 6-7 Years. Horm Res Paediatr. 2023;96(4):385-394. doi: 10.1159/000528536. Epub 2022 Dec 6. PMID: 36473453.
Hauta-alus HH, Holmlund-Suila EM, Valkama SM, Enlund-Cerullo M, Rosendahl J, Coghlan RF, Andersson S, Mäkitie O. Collagen X Biomarker (CXM), Linear Growth, and Bone Development in a Vitamin D Intervention Study in Infants. J Bone Miner Res. 2022 Sep;37(9):1653-1664. doi: 10.1002/jbmr.4650. Epub 2022 Aug 4. PMID: 35838180; PMCID: PMC9544705.
Holmlund-Suila EM*, Hauta-alus HH*, Enlund-Cerullo M, Rosendahl J, Valkama SM, Andersson S, Mäkitie O. Iron status in early childhood is modified by diet, sex and growth: Secondary analysis of a randomized controlled vitamin D trial. Clin Nutr. 2022 Feb;41(2):279-287. doi: 10.1016/j.clnu.2021.12.013. Epub 2021 Dec 13. PMID: 34999321.
Jolliffe DA, Camargo CA Jr, Sluyter JD, Aglipay M, Aloia JF, Ganmaa D, Bergman P, Bischoff-Ferrari HA, Borzutzky A, Damsgaard CT, Dubnov-Raz G, Esposito S, Gilham C, Ginde AA, Golan-Tripto I, Goodall EC, Grant CC, Griffiths CJ, Hibbs AM, Janssens W, Khadilkar AV, Laaksi I, Lee MT, Loeb M, Maguire JL, Majak P, Mauger DT, Manaseki-Holland S, Murdoch DR, Nakashima A, Neale RE, Pham H, Rake C, Rees JR, Rosendahl J, Scragg R, Shah D, Shimizu Y, Simpson-Yap S, Trilok-Kumar G, Urashima M, Martineau AR. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol. 2021 May;9(5):276-292. doi: 10.1016/S2213-8587(21)00051-6. Epub 2021 Mar 30. PMID: 33798465.
Hauta-alus HH, Holmlund-Suila EM, Kajantie E, Rosendahl J, Valkama SM, Enlund-Cerullo M, Andersson S, Mäkitie O. The Effects of Vitamin D Supplementation During Infancy on Growth During the First 2 Years of Life. J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1140-e1155. doi: 10.1210/clinem/dgaa943. PMID: 33347567.
Valkama S, Holmlund-Suila E, Ireland A, Hauta-alus H, Enlund-Cerullo M, Rosendahl J, Andersson S, Mäkitie O. Peripheral quantitative computed tomography (pQCT) in 12- and 24-month-old children - Practical aspects and descriptive data. Bone. 2020 Dec;141:115670. doi: 10.1016/j.bone.2020.115670. Epub 2020 Sep 30. PMID: 33007527.
Holmlund-Suila E, Hauta-alus HH, Andersson S. Maternal Vitamin D and Offspring Bone Mineral Parameters and Growth. JAMA Pediatr. 2020 May 1;174(5):409-410. doi: 10.1001/jamapediatrics.2019.6102. PMID: 32091553.
Kämpe A, Enlund-Cerullo M, Valkama S, Holmlund-Suila E, Rosendahl J, Hauta-alus H, Pekkinen M, Andersson S, Mäkitie O. Genetic variation in GC and DYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: a genome-wide association study in 24-month-old Finnish children. PLoS Genet 2019.
Enlund-Cerullo M, Hauta-alus H, Valkama S, Rosendahl J, Andersson S, Mäkitie O, Holmlund-Suila E. Fibroblast growth factor 23 concentrations and modifying factors in children from age 12 to 24 months. Bone. 2020 Dec;141:115629. doi: 10.1016/j.bone.2020.115629. Epub 2020 Sep 10. PMID: 32919110.
Enlund-Cerullo M, Koljonen L, Holmlund-Suila E, Hauta-alus H, Rosendahl J, Valkama S, Helve O, Hytinantti T, Viljakainen H, Andersson S, Mäkitie O, Pekkinen M. Genetic Variation of the Vitamin D Binding Protein Affects Vitamin D Status and Response to Supplementation in Infants. The Journal of Clinical Endocrinology & Metabolism (JCEM). 2019 Nov 1;104(11):5483-5498. doi: 10.1210/jc.2019-00630. PMID: 31365099.
Rosendahl J, Pelkonen AS, Helve O, Hauta-alus H, Holmlund-Suila E, Valkama S, Enlund-Cerullo M, Viljakainen H, Hytinantti T, Mäkitie O, Andersson S, Mäkelä MJ. High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants. J Pediatr. 2019 Jun;209:139-145.e1. doi: 10.1016/j.jpeds.2019.02.021
Hauta-alus HH, Kajantie E, Holmlund-Suila EM, Rosendahl J, Valkama SM, Enlund-Cerullo M, Helve OM, Hytinantti TK, Viljakainen HT, Andersson S, Mäkitie OM. High Pregnancy, Cord Blood, and Infant Vitamin D Concentrations May Predict Slower Infant Growth. The Journal of Clinical Endocrinology & Metabolism (JCEM) 2019, 104: 397-407. doi: 10.1210/jc.2018-00602
Hauta-alus H, Holmlund-Suila E, Andersson S, Mäkitie O, Viljakainen H. Reply to Letter to the Editor to Maternal vitamin D status during pregnancy in Europe: the two sides of the story. Eur J Nutr 2017. doi: 10.1007/s00394-017-1452-9.
Hauta-alus H, Holmlund-Suila E, Rita H, Enlund-Cerullo M, Rosendahl J, Valkama S, Helve O, Surcel H-M, Mäkitie O, Andersson S, Viljakainen H. Season, dietary factors and physical activity modify 25-hydroxy vitamin D during pregnancy. European Journal of Nutrition 2018, Jun;57(4):1369-1379. doi: 10.1007/s00394-017-1417-z.
Hauta-alus H, Korkalo L, Holmlund-Suila E, Rosendahl J, Valkama S, Enlund-Cerullo M, Helve O, Hytinantti T, Mäkitie O, Andersson S, Viljakainen H. Food and Nutrient Intake and Nutrient Sources in 1-Year-Old Infants in Finland: A Cross-Sectional Analysis. Nutrients 2017 Dec 1;9(12). doi: 10.3390/nu9121309.
Hauta-alus H, Viljakainen H, Holmlund-Suila E, Enlund-Cerullo M, Rosendahl J, Valkama S, Helve O, Hytinantti T, Mäkitie O, Andersson S. Maternal Vitamin D Status, Gestational Diabetes and Infant Birth Size. BMC Pregnancy and Childbirth 2017, Dec 15;17(1):420. doi: 10.1186/s12884-017-1600-5.
Holmlund-Suila E, Enlund-Cerullo M, Valkama S, Hauta-alus H, Rosendahl J, Helve O, Hytinantti T, Viljakainen H, Andersson S, Mäkitie O. Sex and Iron Modify Fibroblast Growth Factor 23 (FGF23) Concentration in 1-Year-Old Children. J Clin Endocrinol Metab. 2017 Dec 1;102(12):4526-4533. doi: 10.1210/jc.2017-01211.
Valkama S, Holmlund-Suila E, Enlund-Cerullo M, Rosendahl J, Hauta-alus H, Helve O, Hytinantti T, Viljakainen H, Andersson S, Mäkitie O. No severe hypercalcemia with daily vitamin D3 supplementation of up to 30 µg during the first year of life. Horm Res Paediatr. 2017 Jun 23. doi: 10.1159/000477298.
Helve O, Viljakainen H, Holmlund-Suila E, Rosendahl J, Hauta-alus H, Enlund-Cerullo M, Valkama S, Heinonen K, Raikkonen K, Hytinantti T, Makitie O, Andersson S: Towards evidence-based vitamin D supplementation in infants: vitamin D intervention in infants (VIDI) - study design and methods of a randomised controlled double-blinded intervention study. BMC Pediatr 2017, 17(1):91-017-0845-5.
Rosendahl J, Holmlund-Suila E, Helve O, Viljakainen H, Hauta-alus H, Valkama S, Enlund-Cerullo M, Hytinantti T, Tervahartiala T, Sorsa T, Mäkitie O, Andersson S. 25-hydroxyvitamin D correlates with matrix metalloproteinase 8 and high sensitivity CRP in cord blood of healthy newborns. Pediatr Res 2017; doi: 10.1038/pr.2017.9.
*Authors contributed equally