For clinically early stage (cT1-2N0) oral tongue squamous cell carcinoma (OTSCC), the prognosis is unpredictable with a potential of aggressive invasion, regional metastases and cancer mortality. Currently, there are no reliable markers available in clinical practice to select those patients with early OTSCC who might benefit from multi-modality treatment. We aim to Identify novel markers that could predict the outcome of patients with early OTSCC in order to apply effective individualized treatment.
We are developing a reliable ex vivo method to analyze oral squamous cell carcinoma patients´ tissue samples to be able to recognize those patients who most likely benefit from radio-chemotherapy. This model aims to detect the cancer invasion potential, enabling the treatment plan towards “personalized medicine “approach.
The microbial environment is changing when cancer occurs. What effects do microbes have on the cancer? We isolated extracellular vesicles (EVs) from oral cancer related microbes for analyzing the effects of these EVs on cancer cell proliferation, migration and invasion. Various research groups are working on effects of curcumin on different types of cancer, so we spiked the EVs, isolated from Candida strains, with curcumin to visualize if the effects on the oral cancer cells increased.