Publications

Most important publications related to the current research field:

Project 1. Tumor microenvironment in oral tongue cancer

  1. Salem A, Almahmoudi R, Listyarifah D, Siponen M, Maaninka K, Al-Samadi A, Salo T, Eklund KK. Histamine H(4) receptor signalling in tongue cancer and its potential role in oral carcinogenesis. Cell Oncol (Dordr). 2017 Dec;40(6):621-630.

  2. Al-Samadi A, Awad SA, Tuomainen T, Zhao Y, Salem A, Parikka P and Salo T. Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models. Oncotarget 2017; doi: 10.18632/oncotarget.17768
  3. Nurmenniemi S, Sinikumpu T, Alahuhta I, Salo S, Sutinen M, Santala M, Risteli J, Nyberg P, Salo T. A novel organotypic model mimics the tumor microenvironment. Am J Pathol 2009; 175:1281-1291.
  4. Vered M, Dayan D, Salo T. Correspondence on: The molecular biology of head and neck cancer. Leemans, C. R et al.   The role of tumor microenvironment in the biology of head and neck cancer: Lessons from mobile tongue cancer. Nat. Rev. Cancer 2011; 11:9-22.
  5. Teppo S, Sundquist E, Vered M, Holappa H, Juha Parkkisenniemi J, Grenman R, Dayan D, Risteli J, Salo T*, Nyber P* (*Equal contribution). The Hypoxic tumor microenvironment regulates invasion of aggressive oral carcinoma cells. Exp Cell Res 2013; 319:376-389.
  6. Pirilä E, Väyrynen O, Sundquist E, Päkkilä K, Nyberg P, Nurmenniemi S, Dayan D, Vered M, Uhlin-Hansen L, Salo T. Macrophages modulate migration and invasion of human tongue squamous cell cancer. Plos One 2015; 10:e012089.
  7. Salo T, Sutinen M, Hoque Apu E, Sundquist E, Cervigne NK, de Oliveira CE, Akram SU, Ohlmeier S, Suomi F, Eklund L, Juusela P, Åström P, Bitu CC, Santala M, Savolainen K, Korvala J, Paes Leme AF, Coletta RD. Sundquist E et al. Neoplastic ecxtracelllar matrix promotes cancer invasion in vitro. BMC Cancer 2015; 16;15:981.

 Project 2. Prognostic markers for oral tongue cancer

  1. Hujanen R, Almahmoudi R, Karinen S, Nwaru BI, Salo T, Salem A. Vasculogenic Mimicry: A Promising Prognosticator in Head and Neck Squamous Cell Carcinoma and Esophageal Cancer? A Systematic Review and Meta-Analysis. Cells. 2020 Feb 24;9(2). pii: E507.

  2. Almahmoudi R, Kasanen M, Sieviläinen M, Salem A, Pirinen M, Salo T, Al-Samadi A. Prognostic value of blood and lymphatic vessel markers in tongue cancer: A systematic review. Cancer Sci. 2019 Nov;110(11):3424-3433.

  3. Sundquist E, Kauppila JH, Veijola J, Mroueh R, Lehenkari P, Laitinen S, Risteli J, Soini Y, Kosma VM, Sawazaki-Calone I, Macedo CC, Bloigu R, Coletta RD, Salo T. Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups. Br J Cancer. 2017 Jan 17. doi: 10.1038/bjc.2016.455. [Epub ahead of print]
  4. Bello I, Vered M, Dayan D, Dobriyan A, Yahalom R, Alanen K, Pentti Nieminen P, Kantola S, Läärä E, Salo E Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer. Oral Oncology 2011; 47:33-38.
  5. Almangush A, Bello IO, Keski-Säntti H, Kauppila J, Pukkila M, Hagström J, Soini Y, Kosma VM, Koivunen P, Grenman R, Leivo I and Salo T. Depth of invasion, tumor budding and worst pattern of invasion classify patients with early stage oral tongue cancer into low- and high-risk categories of mortality. Head and Neck 2014; 36:811-818.
  6. Almangush A, Coletta RD, Bello IO, Bitu C, Keski-Säntti H, Mäkinen LK, Kauppila JH, Pukkila M, Hagström J, Laranne J, Tommola S, Soini Y, Kosma VM, Koivunen P, Kowalski LP, Nieminen P, Grénman R, Leivo I, Salo T. A Simple novel prognostic model for early stage oral tongue cancer. Int J Oral Maxillofac Surg 2015; 44:143-150.
  7. Bagordakis E, Sawazaki-Calone I, Macedo CC, Carnielli CM, de Oliveira CE, Rodrigues PC, Rangel AL, Dos Santos JN, Risteli J, Graner E, Salo T, Paes Leme AF, Coletta RD. Secretome profiling of oral squamous cell carcinoma-associated fibroblasts reveals organization and disassembly of extracellular matrix and collagen metabolic process signatures. Tumour Biol 2016; 37:9045-9057.

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