Satu Mustjoki, prof. is principal investigator and group leader responsible for the laboratory studies in the Hematology Research unit. She is professor in Translational Hematology (University of Helsinki) and research professor for the Finnish Cancer Institute.

Kimmo Porkka, M.D., Ph.D. is principal investigator and group leader responsible for clinical studies at the Hematology Research Unit. He is a professor of clinical hematology and a specialist in internal medicine and hematology, and works as a chief physician at the Department of Hematology of the Helsinki University Hospital Comprehensive Cancer Center. 

Tiina Kelkka, M.Sc, Ph.D. is a post-doctoral researcher who has specialized in mouse models of inflammation. Her work aims at elucidating the pathogenesis of LGL leukemia associated autoimmunity using mouse models of inflammation. She is also interested in somatic mutations’ capacity to modulate autoimmune inflammation. 

Hanna Rajala (Koskela), M.D., Ph.D. is a post-doctoral researcher who did her PhD thesis related to LGL leukemia, which is a rare hematological malignancy. Hanna's thesis defense was in June 2014 and the title of the thesis was "Molecular pathogenesis of large granular lymphocytic leukemia". Currently Hanna is specializing in internal medicine and doing still research related to LGL leukemia and related autoimmune disorders.

Giljun Park, M.Sc, Ph.D. is a post-doctoral researcher who is specialized in both mouse models of autoimmunity and patients suffering from autoimmune diseases. His work focuses on molecular pathogenesis of LGL leukemia associated autoimmunity. He is also interested in understanding the factors, which induce somatic mutations in lymphoid cells such as STAT3 mutations discovered in LGL leukemia. 

Anna Kreutzman, M.Sc, Ph.D. (HRUH 2008–2012, thesis "Antileukemic immune responses in chronic myeloid leukemia") worked as a postdoctoral researcher in Madrid at the Department of Immunology in Princes University Hospital 2012–2015, where her projects focused on the immunology of complications associated with stem cell transplantation (CMV, GVHD). Currently, her research interest is in cancer immunology and novel immune checkpoint inhibitors. The primary focus of her projects will be on NK-cells and their role in different forms of cancer.

Mikko Keränen, M.D., Ph.D. is a postdoctoral researcher and also specializing in clinical hematology. He is interested in tumor immunology and immunotherapeutics of hematologic malignancies. He is currently investigating the role of clonal lymphocytes in patients with bone marrow failure syndromes. He is also supporting the research of PhD students in the group.

Bhagwan Yadav, M.Sc, Ph.D. is a post-doctoral researcher and computational systems biologist who has specialized in modelling and analysis of high-throughput drug screening data, RNA sequencing data and data integration. He defended his Ph.D. thesis entitled "Quantitative modelling and analysis of drug screening data for personalized cancer medicine" in March 2017. His current research interests include data integration and analysis in projects associated with tumor immunology and autoimmune disorders.

Mika Kontro, M.D., PhD is a specialist in internal medicine and in clinical hematology in HUCH. He a is a co-investigator in clinical AML studies and his research is focused on novel drug screening and sequencing technologies for individualizing therapy in distinct entities of acute leukemia. He defended his Ph.D. thesis entitled "Individualizing therapy for acute leukemia" in September 2017.

Khalid Saeed, Ph.D., defended his thesis in 2018 with the title: ”Functional testing of urological cancer models by RNAi and drug libraries”. Khalid’s thesis was based on precision systems medicine and its goal was to improve therapeutic options in urological cancers. Currently, he is working on a project aiming to identify genetic vulnerabilities of cancer cells towards natural killer cells using genome-wide CRISPR libraries.

Heikki Kuusanmäki, Ph.D., completed his PhD in September 2018 with the title: “Targeting Key Survival Signaling Pathways for the Treatment of Leukemia”. The main discovery of his PhD project was the identification of novel STAT5B mutations in two rare leukemia subtypes, LGL leukemia and T-ALL. During his PhD, Heikki also developed a flow cytometry-based drug-testing platform to assess primary AML sample sensitivities at a single cell resolution. His current interest is to use this platform to predict treatment outcomes in leukemia patients.

Perttu Koskenvesa, M.D., is a specialist in internal medicine and clinical hematology. He is a co-investigator in clinical studies and his research interest is the clinical use of tyrosine kinase inhibitors in hematological malignancies.

Paula Savola, M.D. started in HRUH in 2013, graduated as MD in 2018 and her PhD research project focuses on T-cell clonality and aqcuired mutations in patients with autoimmune disorders.

Oscar Brück, M.D., graduated from the University of Helsinki in 2016 and is currently doing his Ph.D. His research projects focuses on immunophenotyping of hematological and renal cancer as well as immunotherapy using therapeutic cancer vaccines.

Shady Awad, M.D., graduated from Cairo University Medical School in 2007 and then specialized in Clinical Pathology with sub-specialization in hemato-pathology. Since then he has been working in Cytogenetic lab of National Cancer Institute in Egypt where he finished his master thesis about pediatric ALL. He is currently doing his PhD studies at HRUH and his research is focusing on discovering driver mutations in high-risk CML patients.

Helena Hohtari, M.D., graduated from the University of Helsinki in 2013 and is currently specializing in internal medicine. She did her licentiate thesis in HRUH related to Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and is now continuing PhD research on the same subject. The focus of her research lies in discovering safer and more effective ways of treating Ph+ ALL. 

Olli Dufva, B.Med. is an M.D./Ph.D. student whose research focuses on enhancing the treatment of hematologic and solid malignancies via activation of the immune system using novel methods such as targeting immune checkpoints. His projects involve the study of both adaptive and innate immune responses in controlling immunogenic diseases including chronic myeloid leukemia and melanoma.

Sofie Lundgren, B.Med., is a student in the M.D./Ph.D. Programme at the Faculty of Medicine and in Helsinki Doctoral Programme in Clinical Research. She started working on her Ph.D. project in 2015 and the focus of her interest is in the role of T-cell clonality and somatic mutations in patients with bone marrow failure syndromes and autoimmune disorders.

Henna Hakanen, M.Sc. (Biomedicine), from University of eastern Finland / PhD student. She is finishing her masters thesis in characterization of NK cells in melanoma patients treated with immunotherapeutic drugs. After her masters she will start her PhD project that focuses on improving NK cell function in cancer with novel immune checkpoint inhibitors. Henna's main interest in research is cancer immunology and bioinformatics.

Daehong Kim, M.Sc., Ph.D student from Seoul, Korea. Previously, he has studied the therapeutic effects of natural antibiotic peptides in an ulcerative colitis and in Parkinson's disease. Now his research project is focusing on the mechanisms that cause somatic mutations in various types of hematologic malignancies and related autoimmune diseases.

Jani Huuhtanen, B.Med, bioinformatics student (Aalto-University), is an M.D./Ph.D. student interested in next-generation sequencing data, especially bulk RNAseq, single-cell RNAseq and TCRBseq data.  His projects include e.g. T-cell repertoire-analysis, building predicative transcriptomic models and inferring clinical information from genetic data to provide clinical implications for both tumour and autoimmune patients.

 

Moon Hee Lee, M.Sc. received her Master’s degree in Translational Medicine (University of Helsinki) in 2017 and Bachelor's degree in Life Science and Biotechnology at Yonsei University, South Korea, in 2012. Her PhD research project involves tumor-infiltrating lymphocytes (TILs) in renal cell carcinoma.

Mikko TysterM.Sc (Tech) received his Master’s degree from the Lappeenranta University of Technology in 2012 and is currently an M.D. student at the University of Helsinki. His work at HRUH focuses on the characterization of the adaptive immune responses in aplastic anemia and related hematological conditions. His goal is to shed light on the underlying autoimmune mechanisms and develop improved diagnostic tools for clinical use.

Dipabarna BhattacharyaM.Sc, received her Master’s degree (Majoring in genetics) from the university of Helsinki in 2017 and BTech degree in Biotechnology from India in the year 2014. Previously she has worked with GWAS and RNASEQ data analysis.  Her research is focused on understanding the role of the STAT3-pathway and somatic mutations in the regulation of autoimmune inflammation by combining wet lab methods to modern bioinformatics.

Yrjö Koski, BSc. is a MSc. student at Aalto-University majoring in Bioinformatics and digital health. He uses computational tools to analyse genomic data with a special focus in somatic and germline variant calling algorithms. Recently he has been developing tools for creating visualizations from variant data.

Minna Pajuportti has worked as a technician and study nurse in the Hematology Research Unit since 2004. She is responsible for many daily routines both in the lab and office, as well as answering to many questions related to clinical studies. Therefore she calls herself as Jokamies Jantunen.

Hanna Lähteenmäki, M. Sc. joined the Hematology Research Unit in 2011 and works as a senior research assistant. She is responsible for the translational laboratory projects related to clinical studies.

Saara Vaalas is a clinical study coordinator administering activities associated with clinical drug studies. She assists in project planning, takes care of the daily routines and the patient visits. Additionally her job is to oversee accounts, maintain recordkeeping systems and develop procedures. She also is an administrator for the FHRB-registry (www.hematology.fi/fhrb) and acts as the support person for the Finnish Leukemia Group guidelines website (www.hematology.fi).

Tiina Kasanen Bachelor of Laboratory Services, graduated from Metropolia, University of Applied Sciences, in 2008. She started working in Hematology Research Unit at the end of the 2012 as a laboratory technician, taking care of clinical samples and participating in clinical studies.

Jay Klievink, M.Sc (Nutrition and Health), graduated from Wageningen UR, the Netherlands in 2011. Jay joined the HRU as a laboratory technician in 2016 and assists in research projects and general laboratory practices.

Eeva Lind-Ekholm is a part-time scientific secretary who works full-time as a secretary at the HUCH hematology division. She has more than 10 years of experience in clinical study administration and legislation. Eeva has been indispensable in getting the vast amount of paperwork done and submitted in good order and just before dead-line.

Jukka Vakkila, M.D., Ph.D. is a pediatric hematologist and a senior consultant in cancer immunology. He is participating in clinical trials dealing with immune system related drugs and supporting the research of PhD students in the group. His main interest is monitoring the tumor specific immunity and immune suppression in patients. 

Can Hekim, M.Sc., Ph.D. is a postdoctoral researcher who is specialized in biochemistry and molecular biology with main focus on tumor biology. His primary scientific interest is immunobiological mechanims in cancer progression. Currently, he investigates the off-target effect mechanisms of tyrosine kinase inhibitor therapy. 

Sari Hernesniemi, M.Sc. (biochemistry), graduated at the University of Turku in 2008. The aim of her PhD research project is to characterize CML stem cells and to study the immunological effects of tyrosine kinase inhibitors on leukemic and normal cells. In November 2012 Sari had her thesis defense and title of her thesis was "Aberrant kinase activation as a therapy target: Chronic myeloid leukemia as a model disease". 

Peter Rohon, M.D. is a clinical hematologist from Olomouc University Hospital (Czech Republic). His research is related to immunological effects of CML therapy and recently he has been especially interested in the mechanisms of long-term remissions induced by interferon-α monotherapy. Peter defended his thesis in the University of Olomouc in 2010 and is continuing collaborating with our research group. 

Kati Penttinen, B.M. is a M.D. student in the University of Helsinki. Her research project was related to the molecular basis of LGL leukemia and it was part of her undergraduate studies.   

Sari Haavisto is a study nurse, who works mostly in the hematological out patient clinic in Meilahti hospital. She is also doing part time work in our unit related to company-sponsored clinical studies and helping with the CRFs. 

Sari Nikkola is a study nurse, who works mostly in the hematological ward in Meilahti hospital. She is also participating in the clinical studies and in the hematological registry project.   

Emmi Vakkila is a medical student and a part-time assistant in laboratory. Prior to medical school, she studied food chemistry and nutrition. Her licentiate thesis in medicine focuses on anti-leukemia immunity in CML. 

Jaakko Eskelinen, B.M. is a M.D. student in the University of Helsinki. His research project is related to somatic genetic changes in chronic phase CML patients and it is part of his undergraduate medical studies. 

Paavo Pietarinen, M.Sc. (Pharmacy), graduated from the University of Helsinki in 2012. Before starting his PhD project in HRU he worked on cancer drug database. His interests are pharmacogenomics and personalized drug treatment. He is currently focusing on drug responses in chronic and advanced phase chronic myeloid leukemia. 

Vanessa Rebecca Gasparini, B.Sc., Master's student coming from the University of Padova (Italy). Erasmus student that is doing her Master thesis focused on the functional characterization of STAT3 and STAT5b mutations discovered in large granular lymphocyte (LGL) leukemia. She is also validating novel somatic mutations discovered in STAT-mutation negative patients. 

Emma Andersson, M.Sc. graduated from the University of Helsinki in 2012 with human genetics as a major subject. Her research projects focus on discovering the pathogenetic events of rare hematological malignancies such as LGL-leukemia as well as finding new drug targets for patients suffering from T-cell prolymphocytic leukemia. 

Mohamed El Missiry, MB BCh, MSc. A Physician specialized in Hematology. His PhD work is involved in studying the role of immune cells in diagnosis, follow up and treatment of chronic myeloid leukemia.

Mette Ilander, Ph.D. received her doctoral degree from University of Helsinki 2016. Currently she is coordinating the biomarker studies which are run in conjunction with the clinical trials and has a special interest in tumor immunology.

Antti Lankinen is a biomedical engineering student at Imperial College London. His research was focused on developing computational methods for biomarker discovery and detection in acute myeloid leukemia from flow cytometry data.