Publications

Take a look at our research findings and publications!

2019

Defining the molecular state of human cancer. Sahu B, Pihlajamaa P, Zhang K, Palin K, Ahonen S, Cervera A, Ristimaki A, Aaltonen LA, Hautaniemi S, Taipale J. bioRxiv 2019

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy. Göös H*, Fogarty CL*, Sahu B*, Plagnol V, Rajamäki K, Nurmi K, Liu X, Einarsdottir E, Jouppila A, Pettersson T, Vihinen H, Krjutskov K, Saavalainen P, Järvinen A, Muurinen M, Greco D, Scala G, Curtis J, Nordström D, Flaumenhaft R, Vaarala O, Kovanen PE, Keskitalo S, Ranki A, Kere J, Lehto M, Notarangelo LD, Nejentsev S, Eklund KK, Varjosalo M, Taipale J, Seppänen MRJ. The Journal of Allergy and Clinical Immunology 2019

2018

The interaction landscape between transcription factors and the nucleosome. Zhu F, Farnung L, Kaasinen E, Sahu B, Yin Y, Wei B, Dodonova SO, Nitta KR, Morgunova E, Taipale M, Cramer P, Taipale J. Nature 2018

Contribution of allelic imbalance to colorectal cancer. Palin K*, Pitkänen E*, Turunen M*, Sahu B*, Pihlajamaa P*, Kivioja T*, Kaasinen E, Välimäki N, Hänninen UA, Cajuso T, Aavikko M, Tuupanen S, Kilpivaara O, van den Berg L, Kondelin J, Tanskanen T, Katainen R, Grau M, Rauanheimo H, Plaketti RM, Taira A, Sulo P, Hartonen T, Dave K, Schmierer B, Botla S, Sokolova M, Vähärautio A, Gladysz K, Ongen H, Dermitzakis E, Bramsen JB, Ørntoft TF, Andersen CL, Ristimäki A, Lepistö A, Renkonen-Sinisalo L, Mecklin JP, Taipale J, Aaltonen LA. Nature Communications 2018

A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility. Wei B, Jolma A, Sahu B, Orre LM, Zhong F, Zhu F, Kivioja T, Sur I, Lehtiö J, Taipale M, Taipale J. Nature Biotechnology 2018

2017

Characterization of an androgen-responsive, ornithine decarboxylase-related protein in mouse kidney. Silander KM, Pihlajamaa P, Sahu B, Jänne OA, Andersson LC. Bioscience Reports 2017

Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Science 2017

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes. Kaustio M, Haapaniemi E, Göös H, Hautala T, Park G, Syrjänen J, Einarsdottir E, Sahu B, Kilpinen S, Rounioja S, Fogarty CL, Glumoff V, Kulmala P, Katayama S, Tamene F, Trotta L, Morgunova E, Krjutškov K, Nurmi K, Eklund K, Lagerstedt A, Helminen M, Martelius T, Mustjoki S, Taipale J, Saarela J, Kere J, Varjosalo M, Seppänen M. The Journal of Allergy and Clinical Immunology 2017

2016

PeakXus: comprehensive transcription factor binding site discovery from ChIP-Nexus and ChIP-Exo experiments. Hartonen T, Sahu B, Dave K, Kivioja T, Taipale J. Bioinformatics 2016

2015

Androgen receptor- and PIAS1-regulated gene programs in molecular apocrine breast cancer cells. Malinen M, Toropainen S, Jääskeläinen T, Sahu B, Jänne OA, Palvimo JJ. Molecular and Cellular Endocrinology 2015

Determinants of Receptor- and Tissue-Specific Actions in Androgen Signaling. Pihlajamaa P, Sahu B, Jänne OA. Endocrine Reviews 2015

Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer. Heinonen H, Lepikhova T, Sahu B, Pehkonen H, Pihlajamaa P, Louhimo R, Gao P, Wei GH, Hautaniemi S, Jänne OA, Monni O. International Journal of Cancer 2015

SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Toropainen S, Malinen M, Kaikkonen S, Rytinki M, Jääskeläinen T, Sahu B, Jänne OA, Palvimo JJ. Nucleic Acids Research 2015

2014

Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo. Sahu B*, Pihlajamaa P*, Dubois V, Kerkhofs S, Claessens F, Jänne OA. Nucleic Acids Research 2014

Tissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs. Pihlajamaa P*, Sahu B*, Lyly L, Aittomäki V, Hautaniemi S, Jänne OA. The EMBO Journal 2014

2013

Genomic region operation kit for flexible processing of deep sequencing data. Ovaska K, Lyly L, Sahu B, Jänne OA, Hautaniemi S. IEEE/ACM Transactions on Computational Biology and Bioinformatics 2013

FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells. Sahu B, Laakso M, Pihlajamaa P, Ovaska K, Sinielnikov I, Hautaniemi S, Jänne OA. Cancer Research 2013

2012

Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer. Jalava SE, Urbanucci A, Latonen L, Waltering KK, Sahu B, Jänne OA, Seppälä J, Lähdesmäki H, Tammela TL, Visakorpi T. Oncogene 2012

Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer. Urbanucci A, Sahu B, Seppälä J, Larjo A, Latonen LM, Waltering KK, Tammela TL, Vessella RL, Lähdesmäki H, Jänne OA, Visakorpi T. Oncogene 2012

2011

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. Sahu B, Laakso M, Ovaska K, Mirtti T, Lundin J, Rannikko A, Sankila A, Turunen JP, Lundin M, Konsti J, Vesterinen T, Nordling S, Kallioniemi O, Hautaniemi S, Jänne OA. The EMBO Journal 2011

Cytoplasmic accumulation of incompletely glycosylated SHBG enhances androgen action in proximal tubule epithelial cells. Hong EJ, Sahu B, Jänne OA, Hammond GL. Molecular Endocrinology 2011

2010

Androgen receptor and androgen-dependent gene expression in lung. Mikkonen L, Pihlajamaa P, Sahu B, Zhang FP, Jänne OA. Molecular and Cellular Endocrinology 2010

2009

Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens. Waltering KK, Helenius MA, Sahu B, Manni V, Linja MJ, Jänne OA, Visakorpi T. Cancer Research 2009