People

Principal Investigator, Docent in Molecular Genetics

I am a Docent (Adjunct Professor) in Molecular Genetics from the Faculty of Medicine at the University of Helsinki.

I am a molecular biologist by training with specialization in cancer research, mainly in transcription factor function and gene regulation in cancer. My area of expertise is in transcription factor biology using several genome-wide functional genomics methods (ChIP-seq/nexus, bulk/single-cell RNA-seq), chromatin conformation (ATAC-seq, DHS-seq), chromatin architecture methods (in situ HiC, ChIA-PET), cell fate conversion using transcription factors (transdifferention) and high-throughput enhancer assays (MPRAs such as STARR-seq).

I am a Principal Investigator within the Applied Tumor Genomics program of the Research Programs Unit at the Faculty of Medicine, University of Helsinki. As a principal investigator, I am leading the Enhancer Biology lab to understand the role of lineage-specific transcription factors and their collaboration with cancer-specific oncogenes in driving tumorigenesis.

Biswajyoti's research profile on ORCiD

Biswajyoti's research profile in the University of Helsinki's research portal (TUHAT)

Biswajyoti on LinkedIn

 

 

Post-doctoral fellow

I received my Ph.D. in Pathology and Physiopathology at China Medical University in June, 2019 and then started my postdoc in Biswajyoti Sahu’s lab. Currently, my project focuses on the lineage-specific oncogenic reprogramming and the changes of 3D-genome architecture during the reprogramming process. In particular, I use defined transcription factors for converting one cell type to another by a method known as transdifferentiation. The goal is to understand the role of these defined factors in modulating chromatin structure and gene expression during this dynamic process of transdifferentiation.

TRANSMED stu­dent

I am a final year TRANSMED student and doing my Masters' thesis in the lab of Biswajyoti Sahu. I am interested in understanding the role of non-coding genome in gene regulation. In particular, I am looking at the transposable elements and their role in oncogenic repogramming of enhancers. I am involved in the computational analysis of RNA-seq data for gene expression, transcription factor binding, chromatin accessibility and functional enhnacer activity data.

Post-doctoral fellow

I completed my Ph.D. from Chinese Academy of Sciences in China in July 2013 and then joined Professor Marikki Laiho's group as a post-doctoral fellow at the University of Helsinki till Dec. 2019 working on therapeutic modulation of RNA polymerase I using small molecule inhibitors. From Januray 2020, I have joined Biswajyoti Sahu's lab and my role is to understand the role of lineage-specific transcription factors in tumorigenesis.

Post-doctoral fellow

I received my Ph.D. in Biochemistry and Molecular Medicine from University of Oulu, Finland in 2019 under the supervision of Professor Gonghong Wei and then started my postdoc in Biswajyoti Sahu’s lab. Currently, my project focuses on understanding the epigenome repogramming during prostate cancer disease progression and role of lineage-specific transcription factors in modulating the 3D-genome architecture.

PhD student

I received my M.Sc. in Molecular Biology and Genetics at Middle East Technical University, Turkey in Sep, 2020. I also did an internship in University of Bergen-Norway during my masters program. I have recently started my PhD studies in Biswajyoti Sahu’s lab. 

Marco Bardus,

M.Eng. University of Turin, Italy