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“Intriguingly, we also observed that this type of stress fiber generation was most prominent under the nucleus, which stores all genetic information and is the largest organelle in our cells. It could be that cortical stress fibers protect the nucleus or aid the movement of the nucleus along with the rest of the cell body,” adds Dr.
The new findings bring forth an important new feature in the stress fiber toolbox. Cells in the three-dimensional tissue environment rarely display stress fiber precursors typically seen in cells migrating on a cell culture dish. Thus, myosin pulse-mediated assembly process enables assembly of contractile structures in cells migrating in various environments. Because myosin pulses have been witnessed in many different cell- and tissue types, this might serve as a universal mechanism for local force-production in the non-muscle tissues.
Original article:
Lehtimäki JI, Rajakylä K, Tojkander S, Lappalainen P (2021). Generation of stress fibers through myosin-driven re-organization of the actin cortex. eLife Jan 28; 10:e60710
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