A new pharmacological molecule improves the safety of canine sedation and anaesthesia

A drug discovery made at the will increase the safety of animal sedation and anaesthesia. Vatinoxan, the pharmacological molecule discovered in the study, reduced the adverse effects of other drugs on the cardiovascular system of canine patients.

The research project leading to the discovery was launched more than a decade ago when veterinary researchers were investigating the adverse effects of sedatives and anaesthetics on animal patients. They developed the idea to prevent or at least reduce the disadvantages associated with anaesthetics through the use of drugs, and the new research line generated in the process has led to the submission of two patent applications.

Now, the efficacy and safety of the new drug has been for the first time trialled on canine patients at the of the University of Helsinki.

“As veterinary drug studies take time and money, it is a great achievement that we have succeeded in advancing vatinoxan’s development to the point where it has been possible to trial it on volunteered canine patients,” says , professor of veterinary pharmacology and head of the project.

“It has been rewarding to observe that the new drug really works on the canine patients as expected,” notes , a doctoral student and veterinarian working at the Veterinary Teaching Hospital who served as the project’s principal investigator.

The drug is aimed for a marketing authorisation within a couple of years.

The project was carried out in collaboration with the Universities of Turku, Dublin and Montreal.

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I. J. Kallio-Kujala, H. A. Turunen, M. R. Raekallio, J. M. Honkavaara, K. M. Salla, D. Casoni, H. J. Hautajärvi, O. M. Vainio. The Veterinary Journal, Volume 240, October 2018, Pages 22–26.