An international consortium co-led by the University of Helsinki has been awarded a grant of total 2 million euros for developing personalized medicine for improved understanding of related pathogenesis to improve management of SIRS (the systemic inflammatory response syndrome) in critically ill paediatric patients. The amount of
At the University of Helsinki, the consortium is led by Academy Research Fellow
Diagnostic tools to guide targeted treatment
The systemic inflammatory response syndrome (SIRS) mimics or is caused by infectious sepsis. Severe SIRS is characterized by sudden dysfunction of multiple organ systems (e.g. disorientation, excessive coagulation, acute kidney failure). Even with prompt recognition of an underlying disease, mortality rates of 7-25% are seen.
Presently, we lack targeted therapy for SIRS. Its triggers may vary or remain unknown. Frequently, emergency treatment decisions are made blindly, without knowledge on the underlying pathology or trigger. Despite reports of widespread changes in gene transcription (transcriptomics), as well as quantitative and qualitative changes in proteins (proteomics), systematic omics studies are still lacking in SIRS.
RNA expression and proteomic profiles into development of treatments
As partners in TIPS and in the absence of readily available diagnostic tools to guide targeted treatment for paediatric SIRS patients, the researchers at the University of Helsinki and HUS have set the goal of defining omics-generated personalised immune profiles to guide diagnostics and to aid development of patient-tailored therapies and in the long-term improved outcome.
“Investigation of root causes, tailored treatments and prognosis of severe paediatric SIRS may improve if collective characterization and quantification omics are utilized,” Markku Varjosalo says.