The SISu data resource was first made accessible for the research community in March 2014 when the first version of the SISu project's website was launched. SISu research team is committed to continue providing Finnish genetic information online and developing the website by adding new interactive features. The user interface of the new SISu v4. web service has been redesigned based on interviews and usability tests to make the website more informative and user friendly.
The most important new feature implemented is the new visualization tool which combines geospatial information with genome variant data. With this tool, the user can get information about the county-specific frequencies of alleles that are present in the FINRISK data set. Depending on the rarity of the allele, the tool shows either the county of residence of each individual carrier or a color-coded visualization of the allele frequencies in Finland.
The current data release (4.1) is based on 10490 exome-sequenced samples from twelve different Finnish cohorts and includes over 1.3 million variants, including 130 000 insertion/deletion variants.
The key research groups of the SISu project are from the Universities of Helsinki, Eastern Finland and Oulu, the Institute for Health and Welfare, Finland, Lund University, the Wellcome Trust Sanger Institute, University of Oxford, the Broad Institute of MIT and Harvard, University of Michigan, Washington University in St. Louis, and University of California, Los Angeles (UCLA). Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki coordinates the project.
Hannele Laivuori, Research coordinator
Institute for Molecular Medicine Finland (FIMM), University of Helsinki