Metabolomics /Infrastructures /

FIMM Metabolomics/Lipidomics/Fluxomics Unit (FIMM Meta)

Principal Investigator & Contact Person:

A/Prof. Vidya Velagapudi (vidya.velagapudi@helsinki.fi)

Chair of the Metabo-HiLIFE Platform

+358 (0)50 3175087

Location:

Biomedicum 2U, E204

Tukholmankatu 8, Meilahti campus,

HiLIFE, University of Helsinki.

 

Services
Instruments

Services

  • High-throughput tar­geted and quant­it­at­ive metabolomics

Analysis of hundreds of polar metabolites in a single method using MRM strategy.

  • High-throughput tar­geted and quant­it­at­ive lipidomics

Analysis of thousand lipid molecular species in a single method using the Lipidyzer platform.

  • High-throughput untar­geted and qual­it­at­ive metabolomics

Analysis of hundreds of known metabolites (identified and confirmed using in-house library, and public  databases), and thousands of metabolite features in a single method. 

  • Metabolic flux analysis 

Isotope enrichment analysis and metabolic flux analsis of central carbon metabolism and other pathways using tracer studies.

  • Customised analytical methods 

Targeted methods for folate cycle intermediates, NAD metabolism related intermediates, TCA cycle  intermediates etc. We are also open to develop new analytical methods based on the user demand.

  • Data analysis 

We offer complete metabolomics/lipidomics data analysis using advanced biostatistical and chemometric methods including integrated omics data analysis and metabolic pathway analysis, reporting, data quality checks, documentation, figures, table etc.

Instruments

Available Technologies

  • Automated sample preparation with Hamilton Robotics MICROLAB® STAR Line
  • ACQUITY ultra pressure liquid chromatography (UPLC)® coupled to WATERS Xevo-TQ-S triple quadrupole mass spectrometer.
  • UPLC coupled to AB/SCIEX 5500 QTRAP mass spectrometer with the Lipidyzer platform.
  • UPLC coupled to AGILENT 6550 iFunnel QToF mass spectrometer.
  • UPLC coupled to AB/SCIEX 6500+ QTRAP mass spectrometer.
  • UPLC coupled to ThermoFisher Qexactive Classic ORBITRAP mass spectrometer.