Radiopharmaceutical Chemistry
Location
Department of Chemistry, Chemicum, A.I. Virtasen aukio 1, 00560 Helsinki
Services
- Custom synthesis of PET radiotracers labelled with fluorine-18, gallium-68 and zirconium-89 based on reported procedures or developed based on customer leads
- Radiolabelling of SPECT radiotracers with commercially available radionuclides such as technetium-99m and indium-111
- Procurement of tritiated and carbon-14-labeled radiotracers for autoradiography studies
- Preparation and analysis of radioactive biological samples
Instruments/facilities
- IBA cyclone 10/5 cyclotron for the production of PET radionuclides such as fluorine-18 and carbon-11
- A-type laboratory equipped with hot cells and remote-controlled synthesis units for working with high radioactivity and positron/gamma emitters
- Variety of (radio)analytical equipment including gamma counter, liquid scintillation counter, gamma spectrometers and radio-HPLCs for detection and measurement of radioactivity, quality control of the radiotracers and biodistribution studies
- Well-equipped B-type animal laboratory for biodistribution studies and tracer biological evaluation
- Digital autoradiography systems (Fujifilm FLA-5100 scanner with Aida Image analysis software, ai4r BeaQuant real-time autoradiography system with BeaMage analysis software)
- Cryostat microtome (Leica CM1950) for the preparation of sections for histology and autoradiography
User fees
The UH internal prices (excl. VAT) valid for 2024–2025 are listed below. Please ask a quotation for your project if you need multiple services. External users, please contact Associate Prof. Mirkka Sarparanta for pricing and access to service.
| Service | €/h |
| Project planning and assistance | 45 |
| Radiochemistry (labor) | 60 |
| Use of (radio)synthesis and analytical equipment | 35 |
| Image analysis / Assisted use of the imaging systems | 45 |
| Leica CM1950 cryosectioning | 20 |
| FLA-5100 digital autoradiography | 20 |
| BeaQuant real-time autoradiography | 20 |
| Use of image analysis software (workstation) | 5 |
| Radiotracers | €/batch* |
| 2-[18F]fluoro-2-deoxyglucose, [18F]FDG, <2 GBq | 370 |
| Al[18F]F-RESCA-rat serum albumin, <2 GBq | 310 |
| 99mTc-human serum albumin nanocolloid (Rotop NanoHSA®), 1–6 GBq | 259** |
| 99mTc-DTPA (Technescan®), 1–6 GBq | 288** |
*Radiotracer prices include radionuclide production, radiochemistry work, use of radioanalytical instrumentation, radiolabeling precursor and quality control. The price of the transportation to Biomedicum 1 or Biocenter 3 will be added.
**For 99mTc-radiolabeling, a 4.3-GBq 99Mo/99mTc UltraTechneKow® generator (890 €) is ordered. The generator is good for approximately 5–7 radiolabelings within one week.
