The tumour microenvironment (TME) provides a supportive niche for cancer to evade therapies and progress towards metastatic disease. In our group we are investigating the components of the TME that are important for this supportive role, with the aim of disrupting this niche and re-sensitising the tumour to therapeutic interventions. We are particularly interested in the components of the extracellular matrix (ECM) that are important for therapy resistance and how these change during aging. We are also working to understand the link between cancer invasion and metastatic dissemination, developing probes to mark sites of intravasation to help us to better understand the temporal dynamics of cancer dissemination.