Our research group focuses on developing and applying a systems pharmacology approach for rational combinatorial therapy in cancer treatment. A wide range of both dry-lab and wet-lab experiments are conducted in order to address issues like how to prioritize drug combinations based on single drug response data, how to develop the strategy of combinatorial therapy based on synergy, efficacy, and toxicity, and how to explain the molecular basis for drug combinations using target deconvolution and functional omics methods.