The main focus of our teaching is post-transcriptional regulation of gene expression
mRNA lifecycle from transcription to decay - A highly mechanistic view
529232: mRNA processing in eukaryotes
Time: 18.1. - 29.2. 2016 - Completed.Next time 2019
Place: Biocenter 3, auditorium 2402 (Telkänpönttö)
Lecturer: Doc. Mikko Frilander, Institute of Biotechnology
Required background information: BSc in genetics, biochemisty or a similar field. Basic understanding of eukaryotic gene expression (transcription, translation etc), and cellular and molecular biology is strongly recommended
Contents: In the past recent years the importance of post-transcriptional regulation of gene expression in eukaryotic systems has been widely recognized but due to fast pace of discovery in the field, the standard textbooks are mostly outdated on these subjects. This advanced lecture series aims to fill the gap and will concentrate on the mechanisms and regulation of mRNA processing in eukaryotic cells. The main focus is on the molecular machines involved in mRNA processing (such pre-mRNA splicing, polyadenylation, capping and editing). Further topics are mechanisms and regulation of alternative pre-mRNA splicing, mechanisms and regulations of alternative polyadenylation, mRNA quality control (esp. nonsense mediated decay), translation and translational control, regulation of gene expression by small RNAs and the coupling of mRNA processing with other processes along gene expression pathway.
Symposium, Workshops, journal Club
NGG is genomics training organized by Institute of Biotechnology Genome Biology program. NGG is composed of three independent elements.
Research symposium with top intrenational speakers in the field of genomics.
A journal club focusing on the research papers by the symposim speakers.
Practical workshops giving hands-on training in sequence data analysis.
Learn gene expression from transcription to RNA decay
The course focuses on the mechanisms and regulation of gene expression at different levels. Main topics are Transcriptional regulation, post-transcriptional regulation (RNA processing and translational regulation) and epigenetics.
Prof. Ville Hietakangas
Doc. Mikko Frilander
Prof. Minna Nyström