Mönttinen, H.a.M., Frilander, M.J., and Löytynoja, A. (2023). Generation of de novo miRNAs from template switching during DNA replication. PNAS 120: e2310752120.
Norppa, A.J., Chowdhury, I., Van Rooijen, L.E., Ravantti, J.J., Snel, B., Varjosalo, M., and Frilander, M.J. (2023). Distinct functions for the paralogous RBM41 and U11/U12-65K proteins in the minor spliceosome. bioRxiv 10.1101/2023.10.12.562036, 2023.2010.2012.562036.
Kashkan I, Hrtyan M, Retzer K, Humpolíčková J, Jayasree A, Filepová R, Vondráková Z, Simon S, Rombaut D, Jacobs TB, Frilander MJ, Hejátko J, Friml J, Petrášek J & Růžička K (2022). Mutually opposing activity of PIN7 splicing isoforms is required for auxin-mediated tropic responses in Arabidopsis thaliana. New Phytologist, 233:329-343.
Smolander OP, Blande D, Ahola V, Rastas P, Tanskanen J, Kammonen JI, Oostra V, Pellegrini L, Ikonen S, Dallas T, DiLeo MF, Duplouy A, Duru IC, Halimaa P, Kahilainen A, Kuwar SS, Kärenlampi SO, Lafuente E, Luo S, Makkonen J, Nair A, de la Paz Celorio-Mancera M, Pennanen V, Ruokolainen A, Sundell T, Tervahauta AI, Twort V, van Bergen E, Österman-Udd J, Paulin L, Frilander MJ, Auvinen P & Saastamoinen M (2022). Improved chromosome-level genome assembly of the Glanville fritillary butterfly (Melitaea cinxia) integrating Pacific Biosciences long reads and a high-density linkage map. GigaScience 11, giab097.
de Wolf, B, Oghabian A, Akinyi MV, Hanks S, Tromer EC, van Hooff J, van Voorthuijsen L, van Rooijen LE, Verbeeren J, Uijttewaal ECH, Baltissen MPA, Yost S, Piloquet P, Vermeulen M, Snel B, Isidor B, Rahman N, Frilander MJ & Kops GJPL (2021). Chromosomal instability by mutations in the novel minor spliceosome component CENATAC. The EMBO Journal, 40: e106536.
Norppa AJ & Frilander MJ (2021). The integrity of the U12 snRNA 3′ stem–loop is necessary for its overall stability. Nucleic Acids Research, 49: 2835–2847.
Akinyi MV & Frilander MJ (2021). At the Intersection of Major and Minor Spliceosomes: Crosstalk Mechanisms and Their Impact on Gene Expression. Frontiers in Genetics, 12: 700744.
Frilander M.J. & Barborič M. (2020). The Interlocking Lives of LARP7: Fine-Tuning Transcription, RNA Modification, and Splicing through Multiple Non-coding RNAs. Molecular Cell, 78: 5-8.
Viita, T., Kyheröinen, S., Prajapati, B., Virtanen, J., Frilander, M.J., Varjosalo, M. & Vartiainen, M.K. (2019). Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. Journal of Cell Science, jcs.226852.
Susi, H., Filloux, D., Frilander, M.J., Roumagnac, P. & Laine, A.-L. . (2019). Diverse and variable virus communities in wild plant populations revealed by metagenomic tools. PeerJ, e6140.
Brown, P., RELISH Consortium, Zhou, Y. (2019). Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database, baz085.
Oghabian, A. Greco, D. & Frilander, M.J. (2018). IntEREst: Intron-Exon Retention Estimator. BMC Bioinformatics, 19:130. Software available at Bioconductor and GitHub
Norppa, A.J., Kauppala, T.M., Heikkinen, H.A.,Verma, B., Iwaï, H. & Frilander, M.J. (2018). Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA. RNA, 24: 396-409.
Jutzi, D., Akinyi, M.V., Mechtersheimer, J., Frilander, M.J. & Ruepp M.-D. (2018). The emerging role of minor intron splicing in neurological disorders. Cell Stress, 2:40-54
Verma, B., Norppa, A.J., Akinyi, M.V. & Frilander, M.J. (2018). Minor spliceosome and disease. Seminars in Cell and Developmental Biology, 79:103-112
Martos-Moreno, G.Á., Travieso-Suárez, L., Pozo-Román, J., Muñoz-Calvo, M.T., Chowen, J.A., Frilander, M.J., Pérez-Jurado, L.A., Hawkins, F.G., and Argente, J.(2018). Response to growth hormone in patients with RNPC3 mutations. EMBO Molecular Medicine, e9143.
Orsini L, Brown J.B., Solari O.S., Li D., He S., Podicheti R., Stoiber M.H., Spanier K.I., Gilbert D., Jansen M., Rusch D., Pfrender M.E, Colbourne J.K., Frilander M.J., Kvist J., Decaestecker E., De Schamphelaere K.A.C, De Meester L. (2018). Early transcriptional response pathways in Daphnia magna are coordinated in networks of crustacean specific genes.
Molecular ecology, 27(4):886-897. See a Perspective by Stanford & Rogers.
Verbeeren, J., Verma, B., Niemelä, E.H., Yap, K., Makeyev, E.V., and Frilander, M.J. (2017). Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA. PLoS Genetics, 13(5): e1006824.
Susi, H., Laine, A.-L., Filloux, D., Kraberger, S., Farkas, K., Bernardo, P., Frilander, M.J., Martin, D.P., Varsani, A., and Roumagnac, P. (2017). Genome sequences of a capulavirus infecting Plantago lanceolata in the Åland archipelago of Finland. Archives of Virology 162:2041–2045.
Ahola, V., Wahlberg, N. & Frilander, M. J. (2017): Butterfly genomics: insights from the genome of Melitaea cinxia. Annales Zoologici Fennici 54: 275–291.
Orsini, L., Gilbert, D., Podicheti, R., Jansen, M., Brown, J.B., Solari, O.S., Spanier, K.I., Colbourne, J.K., Rush, D., Decaestecker, E., Asselman, J., De Schamphelaere, K.A.C., Ebert, D., Haag, C.R., Kvist, J., Laforsch, C., Petrusek, A., Beckerman, A.P., Little, T.J., Chaturvedi, A., Pfrender, M.E., De Meester, L., and Frilander, M.J. (2016). Daphnia magna transcriptome by RNA-Seq across 12 environmental stressors. Scientific Data 3:160030.
Känsäkoski J, Jääskeläinen J, Jääskeläinen T, Tommiska J, Saarinen L, Lehtonen R, Hautaniemi S, Frilander MJ, Palvimo JJ, Toppari J, and Raivio T (2016). Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene. Scientific Reports 6:32819
Niemelä E.H., Verbeeren, J., Singha, P., Nurmi V. and Frilander, M.J. (2015). Evolutionarily conserved exon definition interactions with U11 snRNP mediate alternative splicing regulation on U11-48K and U11/U12-65K genes. RNA Biology, 12:1256-1264.
Kvist J., Mattila A.L.K., Somervuo P., Ahola V., Koskinen P., Paulin L., Salmela L., Taipale M., Holm L., Auvinen P., Lehtonen R., Frilander M.J, Hanski I. (2015). Flight-induced changes in gene expression in the Glanville fritillary butterfly. Molecular Ecology, 24:4886–4900.
Ahola V., Koskinen P., Wong S.C., Kvist J., Paulin L, Auvinen P., Saastamoinen M., Frilander M.J., Lehtonen R., Hanski I. (2015). Temperature and sex related effects of serine protease alleles on larval development in the Glanville fritillary butterfly. Journal of Evolutionary Biology, 28:2224-2235
Argente, J., Flores, R., Gutiérrez-Arumí, A., Verma, B., Martos-Moreno, G.A., Cuscó, I., Oghabian, A., Chowen, J.A., Frilander, M.J., and Pérez-Jurado, L.A. (2014). Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. EMBO Molecular Medicine, 6:299–306
Niemelä, E.H., Frilander, M.J. (2014). Regulation of gene expression through inefficient splicing of U12-type introns. RNA Biology 11: 1325-1329.
Niemelä, E.H., Oghabian, A., Staals, R.H.J., Pruijn, G. and Frilander, M.J. (2014). Global analysis of the nuclear processing of unspliced U12-type introns by the exosome. Nucleic Acids Research, 42:7358-7369.
Mikkilä, J., Eskelinen, A.-P., Niemelä, E.H., Linko, V., Frilander, M.J., Törmä, P., and Kostiainen, M.A. (2014). Virus-Encapsulated DNA Origami Nanostructures for Cellular Delivery. Nano Letters, 14:2196–2200.
Turunen, J.J., Pavlova, L.V., Hengesbach, M., Helm, M., Müller, S., Hartmann, R.K. and Frilander, M.J. (2014) RNA ligation. In Hartmann, R. K., Bindereif, A., Schön, A. and Westhof, E. (eds.), Handbook of RNA biochemistry. 2nd ed. Wiley-VCH GmbH & Co. KGA, Weinheim, Vol. 1, pp. 45-88.
Somervuo P., Kvist J., Ikonen S., Ahonla V., Auvinen P., Paulin L., Koskinen P., Holm L., Taipale M., Ruokolainen A., Saarnio S., Taipale J., Sirén J., Corander J., Frilander M.J., Lehtonen R. & Hanski I. (2014) Transcriptome Analysis Reveals Signature of Adaptation to Landscape Fragmentation. PLoS ONE, 9(7):e104668.
Ahola V., Lehtonen R., Somervuo P., Salmela L., Koskinen P., Rastas P., Välimäki N., Paulin L., Kvist J., Wahlberg N., Tanskanen J., Hornett E.A., Ferguson L.C., Luo S., Cao Z., de Jong M.A., Duplouy A., Smolander O-P., Vogel H., McCoy R.C., Qian K., Chong W.S., Zhang Q., Ahmad F., Haukka J.K., Josh A., Salojärvi J., Wheat C.W., Grosse-Wilde E., Hughes D., Katainen R., Pitkänen E., Ylinen J., Waterhouse R.M., Turunen M., Vähärautio A., Schulman A.H., Taipale M., Lawson D., Ukkonen E., Mäkinen V., Goldsmith M.R., Holm L., Auvinen P., Frilander M.J. & Hanski I. (2014). The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera. Nature Communications, 5:4737.
Turunen, J.J., Verma, B., Nyman, T.A., and Frilander, M.J. (2013). HnRNPH1/H2, U1 snRNP and U11 snRNP co-operate to regulate the stability of the U11-48K pre-mRNA. RNA, 19:380-389
Turunen, J.J., Niemelä, E., Verma, B., and Frilander, M.J. (2013). The significant other: Splicing by the Minor Spliceosome. Wiley Interdisciplinary Reviews - RNA, 4:61-76.
Among the Top10 WIRES-RNA articles!
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Qian, K., Pietilä, T., Rönty, M., Michon, F., Frilander, M.J., Ritari, J., Tarkkanen, J., Paulín, L., Auvinen, P., and Auvinen, E. (2013). Identification and Validation of Human Papillomavirus Encoded microRNAs. PLoS ONE , 8(7):e70202.
Kvist J., Wheat C.W., Kallioniemi E., Saastamoinen M., Hanski I. & Frilander M.J. (2013). Temperature treatments during larval development reveal extensive heritable and plastic variation in gene expression and life history traits. Molecular Ecology, 22:602–619
Tollenaere, C., Susi, H., Nokso-Koivisto, J., Koskinen, P. Tack, A. J. M., Auvinen, P. Paulin, L., Frilander, M. J., Lehtonen, R. & Laine, A.-L. (2012). SNP Design from 454 Sequencing of Podosphaera plantaginis Transcriptome Reveals a Genetically Diverse Pathogen Metapopulation with High Levels of Mixed-Genotype Infection. PLoS ONE, 7(12): e52492.
Pessa, H.K.J. & Frilander, M.J. (2011). Minor Splicing, Disrupted. Science, 332:184-185. (Perspective). Download pdf reprint.
Helenius K, Yang Y, Tselykh TV, Pessa HK, Frilander MJ, Mäkelä TP. (2011). Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover. Nucleic Acids Research, 39:5025-5035.
Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvönen ME, Perälä N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, de Angelis MH, Frilander MJ, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M, Lappalainen P. (2011). Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. Journal of Cell Science, 124:1245-1255.
Wheat CW, Fescemyer HW, Kvist J, Tas E, Vera JC, Frilander MJ, Hanski I, Marden JH. (2011). Functional genomics of life history variation in a butterfly metapopulation. Molecular Ecology, 20:1813-1828. See a Perspective by Klepsatel & Flatt.
Verbeeren J., Niemelä E.H., Turunen J.J., Will C.L., Ravantti J.J., Lührmann R. & Frilander M.J. (2010). An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Molecular Cell, 37:821-833.
Pessa, H.K.J., Greco D., Kvist J., Wahlström G., Heino T.I., Auvinen P. & Frilander M.J. (2010). Gene Expression Profiling of U12-Type Spliceosome Mutant Drosophila Reveals Widespread Changes in Metabolic Pathways. PLoS ONE, 5(10): e13215.
Michon F., Kyyrönen M., Tummers M., Frilander M.J. & Thesleff I. (2010). Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs. Developmental Biology, 340:355-368.
Wheat C.W., Haag C., Marden J., Hanski I. & Frilander M.J. (2010). Molecular evidence for balancing selection at a candidate gene (Pgi) influencing ecological dynamics in a butterfly metapopulation. Molecular Biology and Evolution, 27:267-281.
Sundström J.F., Vaculova A., Smertenko A.P., Savenkov E.I., Golovko A., Minina E., Tiwari B.S., Rodriguez-Nieto S., Zamyatnin A.A. Jr., Välineva T., Saarikettu J., Frilander M.J., Suarez M.F., Zavialov A., Ståhl U., Hussey P.J., Silvennoinen O., Sundberg E., Zhivotovsky B. & Bozhkov P.V. (2009). Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome. Nature Cell Biology, 11:1347-1354.
Orsini L., Wheat C.W., Haag C.R., Kvist J., Frilander M.J. & Hanski, I. (2009). Fitness differences associated with Pgi SNP genotypes in the Glanville fritillary butterfly (Melitaea cinxia). Journal of Evolutionary Biology, 22:367-375.
Pessa, H.K.J., Will, C.L., Meng, X., Schneider, C., Watkins, N.J., Perälä, N., Nymark, M., Turunen, J.J., Lührmann, R. & Frilander, M.J. (2008). Minor spliceosome components are predominantly localized in the nucleus. PNAS, 105: 8655-8660. See a Commentary by Joan Steitz et al.
Turunen J.J., Will C.L., Grote M., Lührmann R. & Frilander M.J. (2008). The U11-48K protein contacts the 5' splice site of U12-type introns and the U11-59K protein. Molecular and Cellular Biology, 28:3548-3560.
Paatero A.O., Turakainen H., Happonen L.J., Olsson C., Palomäki T., Pajunen M.I., Meng X., Otonkoski T., Tuuri T., Berry C., Malani N., Frilander M.J., Bushman F.D. & Savilahti H. (2008). Bacteriophage Mu integration in yeast and mammalian genomes. Nucleic Acids Research, 36:e148.
Marden J.H., Fescemyer H.W., Saastamoinen M., MacFarland S.P., Vera J.C., Frilander M.J., & Hanski I. (2008). Weight and nutrition affect pre-mRNA splicing associated with energetics and life history. Journal of Experimental Biology, 211:3653-3660.
Vera J.C., Wheat C.W., Fescemyer H.W., Frilander M.J.,Crawford D.L., Hanski I. & Marden J.H. (2008). Rapid transcriptome characterization for a non-model organism using massively parallel 454 pyrosequencing. Molecular Ecology, 17:1636-1647. See a Perspective by Hans Ellegren.
Yang, J., Välineva, T., Hong, J., Bu, T., Yao, Z. Jensen, O.N., Frilander, M.J. & Silvennoinen, O. (2007). Transcriptional coactivator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome. Nucleic Acids Research, 35:4485-4494.
Pessa, H.K.J, Ruokolainen, A., & Frilander M.J. (2006). The abundance of the spliceosomal snRNPs is not limiting the splicing of U12-type introns. RNA, 12:1883-1892.
Frilander, M.J. & Meng, X. (2005). Proximity of the U12 snRNA with both the 5' splice site and the branch point during early stages of spliceosome assembly. Molecular and Cellular Biology, 25:4813-4825.
Frilander, M.J. & Turunen J.J. (2005). RNA ligation by T4 DNA ligase. In Handbook of RNA biochemistry (Bindereif, A, Hartmann, R, Schön, A, & Westhof, E. Eds.), pp. 36-52. ISBN 3-527-30826-1. Wiley_VCH, Weinheim, Germany.
Schneider, C., Will, C.L., Watkins, N.J., Brosius, J, Frilander, M.J. & Lührmann, R. (2004). Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila. PNAS, 101: 9584-9589.
Pirttimaa, M.J., Paatero, A.O., Frilander, M.J., & Bamford, D.H. (2002). Nonspecific NTPase P4 of dsRNA bacteriophage phi6 is required for ssRNA packaging and transcription. Journal of Virology, 76: 10122-10127.
McConnell, T.S., Cho, S.J., Frilander, M.J. & Steitz, J.A. (2002). Branch point selection in the splicing of U12-dependent introns in vitro. RNA, 8:579-586.
Frilander, M.J. & Steitz, J.A. (2001). Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosome. Molecular Cell, 7:217-226.
Frilander, M.J. & Steitz, J.A. (1999). Initial recognition of U12-dependent introns requires both U11/5' splice site and U12/branchpoint interactions. Genes & Development, 13:851-863.
Full list of publication with citation data:
Heli Pessa (2010)
U12-type Spliceosome: Localization and Effects of Splicing Efficiency on Gene Expression
Janne Turunen (2012)
The function and regulation of the U11-48K protein in U12-dependent splicing
Elina Niemelä (2014)
The regulation of U12-dependent splicing and its significance to mRNA stability
Jouni Kvist (2014)
Functional genomics of the Glanville fritillary butterfly
Jens Verbeeren (2016)
Regulation of the minor spliceosome through alternative splicing and nuclear retention of the U11/U12-65K mRNA
Ali Oghabian (2018)
Bioinformatics analysis of intron retention events associated with the minor spliceosome
Frilander, M.J. Ribosomi osoittautui RNA-entsyymiksi. (2001). Duodecim, 117, 7-8 (Editorial in Finnish).
Frilander M.J. RNA - elämän alkuperän kemia (2002). Duodecim, 118:2419-2422. (Review in Finnish).
Mikko Frilander & Reetta Kettunen. Vieraskynä: Hiiren perimä kertoo yhtä lailla ihmisestä. Helsingin sanomat 27.12. 2002 (Editorial in a national newspaper)
Sariola H., Frilander M., Heino T., Jernvall J., Partanen J., Sainio K., Salminen M. & Thesleff I. (2003). Kehitysbiologia: Solusta yksilöksi. Kustannus Oy Duodecim, Helsinki. 311 pages. ISBN 951-656-099-7. (Developmental biology textbook in Finnish).
Frilander M. J. (2006). DNA ja geenisäätelyn periaatteet. In Perinnöllisyyslääketiede (P. Aula, H. Kääriäinen and A. Palotie ed.). Vol 3, pp. 1-30. Kustannus Oy Duodecim, Helsinki, Finland. (A chapter in a medical genetic textbook).
Frilander M.J. (2008). Täpläverkkoperhonen liiti genomiaikaan. Duodecim, 124, 2242-2243.
Frilander M.J. (2009). Kemian Nobel-palkinto ribosomien rakenteen selvittäjille. Duodecim, 125, 2476-2477.