Post-doctoral fellow, PhD
My work focuses on establishing novel platforms for three dimensional (3D) in vitro modeling of head and neck squamous cell carcinoma (HNSCC) for drug testing, biomarker validation and molecular studies. The patient derived models developed in this study should provide greater disease relevance than conventional models in drug development. I am also working with the genomic characterization and drug sensitivity screening of HPV-negative, low passage HNSCC cell lines. I am especially interested in the role of EGFR and it’s protein complexes in HNSCC invasion and drug response.
Post-doctoral fellow, PhD
I am studying PPFIA1 and ANO1 genes, encoding for liprin-α1 and anoctamin-1 proteins. These genes are located at the 11q13 region of the genome, which is commonly amplified in different cancers such as in head and neck cancer and breast cancer and is related to poor prognosis of the patients. I am exploring how liprin-α1 and anoctamin-1 proteins contribute to cancer progression and oncogenic signalling.
PhD student, MSc
Focus of my studies is to investigate the involvement of promising molecular markers for drug response to epidermal growth factor receptor (EGFR) and PI3K/mTOR inhibitors, mainly in head and neck squamous cell carcinoma (HNSCC). Of particular interest is to study further the effect of ANO1 expression on resistance to EGFR-targeted therapy in patient-derived HNSCC cells and three-dimensional models. Additionally, I aim to understand the underlying mechanism of ANO1, as a cellular signalling activator and proliferation promoter. Goal is to provide molecular markers for prediction of drug response, as well as more efficient treatment for HNSCC.
PhD student, MSc
My research work includes developing and optimizing three-dimensional patient-derived in vitro models for head and neck cancer aiming to find new perspectives for individualized therapies as well as novel ways for studying invasive head and neck cancer cells. I am also in charge of project management and coordination of company collaborations involving customer projects in genome profiling and cancer models systems.
Undergraduate student (genetics)
My project focuses on characterization of knockout mice created using CRISPR/Cas-9 technology for our gene of interest. My main task currently is to genotype the animals. I am interested in exploring the cellular responses of the knockout in relevant cells and later on I will participate in the phenotypic analysis of the edited mice.
Lab coordinator / Genome Profiling (FuGU), PhD
I am the lab coordinator for the Biomedicum Functional Genomics Unit (FuGU) which provides both microarray and Illumina-based Next Generation Sequencing for the scientific academic community in Helsinki and beyond. I am responsible for planning, managing and coordinating projects. In addition, I have over 10 years of research experience in fields as diverse as Biochemistry, Cell Biology, Developmental Biology and Microbiology.
Working as a computational biologist I'm tasked with managing and analyzing the genomics data produced at Biomedicum Functional Genomics Unit (FuGU). A part of that I advice our users in experiment design of the projects. I'm also responsible in maintaining FuGU's hardware and required software and I take part on the bioinformatics teaching on the campus.
Lab manager, NGS and microarrays (FuGU), Lab technician
My work in FuGU contain next-generation sequencing and microarray related laboratory tasks like quality control measurements and preparation of libraries using Illumina NextSeq and MiSeq equipment and a number of different sequencing library preparation protocols. I have long experience in NGS and I am always keen on expanding my expertise to novel applications related to NGS and other genomics technologies.
Laboratory engineer, NGS and microarrays (FuGU)
I work in FuGU as a laboratory engineer. I have long experience in multiple next-generation sequencing (NGS) applications and microarray technologies. In addition to laboratory tasks, my responsibilities include maintaining and updating our instrumentation and LIMS database.