Principal Investigator, PhD
PhD and Docent (Cancer Genetics), University of Helsinki
Principal Investigator,
Research coordinator, PhD
My reseach focuses on the iCAN-RARE project, where our aim is to integrate different types of molecular profiling data for the identification and reporting clinically important molecular findings in rare tumors. We are also carrying out ex vivo drug screening, multiplex fluorescence imaging and high-content screening to identify experimental or approved drugs, or drug combinations for patients with rare tumors. While tumor microenvironment has significant impact in drug responses, we are investigating the heterogeneity of tumors and their tumor microenvironment using immunofluorescently stained tissue microarrays. In addition to research, I am in charge of coordinating the iCANDOC doctoral program for Digital Precision Cancer Medicine.
Project scientist, PhD
My research projects are focused on pre-clinical studies of boron neutron capture therapy (BNCT) in head and neck squamous cell carcinoma. BNCT is biologically directed radiotherapy, which is targeted to the tumors by boron carriers. Boron atoms capture neutrons and split into energetic charged particles destroying cancerous tissue. In our research, we are particularly interested in exploring whether BNCT sensitizes tumors to immunotherapy in a molecular level. We are also establishing experimental workflows together with BNCT facility, Helsinki University Hospital, for measuring relative biological effectiveness of BNCT in different tumor models.
PhD student, MSc
Focus of my research is to investigate potent biomarkers, mainly for the drug response of head and neck squamous cell carcinoma (HNSCC). My aim is to better understand the underlying molecular mechanisms of drug resistance to targeted therapies and the signaling pathways involved, such as the RAF-MEK-ERK pathway. To achieve this, I employ a variety of methods, such as transcriptomics using next generation sequencing (NGS) technologies, high-throughput drug screening, as well as established cell & molecular biology methods, including immunofluorescence confocal microscopy, Western blotting and assays measuring cellular or metabolic changes associated with viable or nonviable cells. University of Helsinki Research portal:
PhD student
I am a PhD student at the iCANDOC doctoral program for Digital Precision Cancer Medicine. My research project focuses on the pre-clinical investigation of therapeutic effectiveness of boron neutron capture therapy (BNCT) in head and neck squamous cell carcinoma. Pre-clinical study of BNCT as an efficient cancer therapy is carried out together with our BNCT research and clinical collaborators.
RI (research infrastructure) Specialist (FIMM Genomics), MSc
I am responsible in planning, managing and coordinating projects in FIMM Genomics which provides Illumina and AVITI-based next-generation sequencing and other genomics analysis tools for the scientific academic community in Helsinki and beyond. In addition, I have long experience in biochemistry, cell biology, developmental biology and cancer biology.
RI Specialist, Bioinformatician (FIMM Genomics), MSc
Working as a computational biologist I'm tasked with managing and analyzing the genomics data produced at FIMM Genomics. A part of that I advice our users in experiment design of the projects. I'm also responsible in maintaining some of FIMM Genomics hardware and required software and I take part on the bioinformatics teaching on the campus.
RI coordinator (FIMM Genomics), Senior lab technician
My work in FIMM Genomics contain next-generation sequencing related laboratory tasks like quality control measurements and preparation of libraries for Illumina NovaSeq X Plus and AVITI24 equipment using a number of different sequencing library preparation protocols. I am also carrying out projects with Olink and NanoString technologies. I have long experience in NGS and I am always keen on expanding my expertise to novel applications related to NGS and other genomics technologies.
RI technician (FIMM Genomics), MSc
My work focuses on next-generation sequencing related laboratory tasks like quality control measurements and preparation of libraries for Illumina NovaSeq X Plus and AVITI24 sequencers using a number of different sequencing library preparation protocols. I am also carrying out projects with Olink and NanoString technologies.