Post-doctoral fellow, PhD
My work focuses on establishing novel platforms for three dimensional (3D) in vitro modeling of head and neck squamous cell carcinoma (HNSCC) for drug testing, biomarker validation and molecular studies. The patient derived models developed in this study should provide greater disease relevance than conventional models in drug development. I am also working with the genomic characterization and drug sensitivity screening of HPV-negative, low passage HNSCC cell lines. I am especially interested in the role of EGFR and it’s protein complexes in HNSCC invasion and drug response.
PhD student, MSc
My PhD project focuses on studying 11q13 gene amplification, which is common in different cancers such as in head and neck cancer and breast cancer, and it is related to poor prognosis of the patients. I am studying in more detail the protein function of liprin-α1 and anoctamin 1 (encoded by PPFIA1 and ANO1 at the 11q13) and how they contribute to oncogenic signaling.
PhD student, MSc
Focus of my studies is to investigate the involvement of promising molecular markers for drug response to epidermal growth factor receptor (EGFR) and PI3K/mTOR inhibitors, mainly in head and neck squamous cell carcinoma (HNSCC). Of particular interest is to study further the effect of ANO1 expression on resistance to EGFR-targeted therapy in patient-derived HNSCC cells and three-dimensional models. Additionally, I aim to understand the underlying mechanism of ANO1, as a cellular signalling activator and proliferation promoter. Goal is to provide molecular markers for prediction of drug response, as well as more efficient treatment for HNSCC.
Project coordinator, MSc
My research work includes developing and optimizing three-dimensional patient-derived in vitro models for head and neck cancer aiming to find new perspectives for individualized therapies as well as novel ways for studying invasive head and neck cancer cells. I am also in charge of project management and coordination of company collaborations involving customer projects in genome profiling and cancer models systems.
Lab coordinator / Genome Profiling (FuGU), PhD
I am the lab coordinator for the Biomedicum Functional Genomics Unit (FuGU) which provides both microarray and Illumina-based Next Generation Sequencing for the scientific academic community in Helsinki and beyond. I am responsible for planning, managing and coordinating projects. In addition, I have over 10 years of research experience in fields as diverse as Biochemistry, Cell Biology, Developmental Biology and Microbiology.
Bioinformatics specialist (FuGU), MSc (Tech)
As a bioinformatics specialist, my responsibilities include all tasks related to data-analysis, statistics and visualization of the results such as differential expression and transcriptome analysis of RNAseq and microarray data. I also assist in various technical and measurement procedures and maintain our hardware, most of the software and computational and data storage servers.
Lab manager, NGS and microarrays (FuGU), Lab technician
NGS and microarrays (FuGU), MSc
My work in FuGU contain next-generation sequencing (NGS) related laboratory tasks like quality control measurements and preparation of libraries using NextSeq equipment and various different protocols. I am focused to work with RNA-seq libraries. I have long experience in different kind of molecular laboratory techniques and I am happy to expand the expertise to NGS applications in FuGU.
NGS and microarrays (FuGU), Bioanalyst