Again an article in Journal of Medicinal Chemistary

NeuroCure published again in the Journal of Medicinal Chemistry, this time about new PREP ligand series and novel ligand binding site in PREP.

Year 2024 started nicely, when our manuscript was published at Journal of Medicinal Chemistry. In the article, we presented a novel type of PREP ligands, based on 5-aminothiazole structure, and very importantly, that they bind to a novel binding pocket in PREP. This appears to be more important for protein-protein interactions, such as alpha-synuclein aggregation and autophagy induction. The study was done in collaboration with researchers in University of Antwerp, Belgium, and University of Eastern Finland, Kuopio.