What happens when a drug is given to a patient? Our mission is to develop mathematical, statistical and informatics tools to tackle biomedical questions that may potentially lead to breakthroughs in drug discovery. We are focusing on digital twin models for drug response, aiming at a systems-level understanding of how disease signaling pathways can be inhibited by synergistic drug combinations through multi–target perturbations. These methods offer an improved efficiency to identify more effective treatments for personalized medicine.