Research News

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Dr. Santos' research group and collaborators from Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University of Medicine, Chinese Academy of Sciences, Soochow University, and Xi'an Jiaotong University developed electrospun hydrogel fibrous scaffolds based on photocrosslinkable gelatin, which exhibit not only hydrogel properties, but maintain a micro three-dimensional (3D) space structure. The structure surpasses conventional hydrogels in promotion of 3D cell growth on and migration into the scaffolds and vascularization, and is good for repairing random skin flaps.

 

 

 

 

 

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Dr. Santos' research group presents the recent developments in the field of immunotherapy, describing the different systems proposed by categories: polymeric nanoparticles, lipid-based nanosystems, metallic and inorganic nanosystems and, finally, biologically inspired and derived nanovaccines.

 

 

 

 

 

 

 

 

 

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Dr. Santos' research group and collaborators from Harvard University developed a biocompatible double emulsion functionalized with gold nanorods, DNA origami, and porous silicon nanoparticles, as an advanced all-in-one platform for versatile targeted therapeutics and antibody co-delivery. This biocompatible platform can be easily formed with great therapeutics loading capacity and tunable ratio for different cancer treatments, and has great potential in advancing biomedical applications.

 

 

 

 

 

 

 

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Dr. Santos' research group and collaborators from Jiangsu University and Soochow University developed an antibacterial prickly Zn-doped CuO nanoparticle, in which, the multi-dimension nano-piercing process is found to contribute greatly to the enhanced antibacterial activity. Such architecture-enhanced antimicrobial feature gives more insights on the antibacterial mechanism of nanomaterials and also provides a hint on design of novel antibacterial agents.

 

 

 

 

 

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Dr. Santos' research group and collaborators from Harvard University developed a biodegradable, photothermally, and pH responsive calcium carbonate@phospholipid@acetalated dextran hybrid platform for advancing biomedical applications. The versatile, therapeutics co-loaded, photothermally, and pH responsive platform efficiently induces cancer cell death and synergistically reduces multidrug resistance and HER2 expression.

 

 

 

 

 

 

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Dr. Santos' research group and co-workers describe targeted theranostic nanoparticles with dual pH and magnetic responsive properties for intracellular delivery. Using a pH-switch nanoprecipitation method in organic-free solvents, a polymeric-drug conjugate solid nanoparticle containing encapsulated superparamagnetic iron oxide nanoparticles and decorated with a tumor homing peptide, iRGD, are targeted to endothelial and metastatic cancer cells.

 

 

 

 

 

 

 

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Dr. Santos' research group and co-workers describe mucoadhesive and cell-associating porous silicon-based nanoparticles for oral delivery of insulin. Using a highly efficient top-down approach and simple crosslinking chemistry, porous silicon nanoparticles (NPs) are modified with L-cysteine- and cell-penetrating-peptides to enhance permeation of insulin across the intestine wall, through the close proximity to the intestinal epithelia.

 

 

 

 

 

 

 

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Dr. Santos' research group and co-workers describe a novel water soluble desferrioxamine-loaded hydrogel nanofibrous scaffold designed to rapidly recruit angiogenesis relative cells. The scaffold promotes the healing process of diabetic wounds through up-regulating Hif-1a and its downstream genes. Furthermore, the degradation rate of the scaffold is effectively corresponding with the closing rate of the wound, leaving enough space for new epidermis formation.

 

 

 

 

 

 

 

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Dr. Santos' research group and co-workers demonstrated nanoparticles with controlled quality and high throughput that are generated from a microcapillary device using a microfluidic nanoprecipitation approach. The successful preparation of a variety of nanoparticles demonstrates the versatility of this platform. Independently of the formulation parameters, nanoparticles with homogeneous size distribution can always be obtained, showing the great robustness of this platform.

 

 

 

 

 

 

 

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Dr. Santos' research group and co-workers fabricated a multistage drug delivery nanocomposite, comprising porous silicon nanoparticles and micellar pH-responsive polymers, by microfluidic nanoprecipitation. The drug-loaded multistage platform showed high cytocompatibility, pH-dependent cell growth inhibition capacity, and reduced internalization by phagocytic macrophage cells. This nanocomposite is a good candidate for further development as a platform for cancer drug delivery.

 

 

 

 

 

 

 

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Dr. Santos' research group and collaborators developed a multifunctional nanocarrier holding anti-diabetic drugs which slips right through the biological barriers along the gastrointestinal tract and delivers the medicine to the target site. The system can also enhance the nanoparticle's interactions with the intestinal mucus and epithelium, and protect the peptides from enzymatic degradation after the release in the intestine.

 

 

 

 

 

 

 

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Dr. Santos' research group and collaborators from Harvard University developed a nano-in-micro platform composed of porous silicon nanoparticles (PSi NPs) and giant liposomes (PSi NPs@giant liposomes) assembled on a microfluidic chip, which co-loaded and co-delivered hydrophilic and hydrophobic drugs combined with synthesized DNA nanostructures, short gold nanorods, and magnetic nanoparticles. It was demonstrated that the PSi NPs@giant liposomes nano-in-micro platform hold great potential for a cocktail delivery of drugs and DNA nanostructures for effective cancer therapy, controllable drug release with tuneable therapeutics ratio, and both photothermal and magnetic dual responsiveness.

 

 

 

 

 

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Dr. Santos' and collaborators tested a gramicidin embedded biomembrane that interacts with dextran sulfate (DS) and demonstrated that these interactions affect drug transfer across the liquid–liquid interface. Langmuir–Blodgett and voltammetry techniques were used to study the interfacial and physicochemical properties of the system and a detailed characterization of the monolayers was presented, and the drug transfer was discussed as a result of the modified surface charge and compactness of the lipid in the presence of gramicidin, calcium and DS.

 

25 January 2017:  Post-doc, Dr. Vimalkumar Balasubramanian (Ph.D. Chem.), appointed docent (Adjunct Professor) at the Faculty of Pharmacy, University of Helsinki (Finland).

Many congrats. We are very proud of you!

 

 

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17 January 2017: "Superfast Production of Nanocomposites", highlighted in Chemistry Views.

 

 

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16 January 2017: Helsinki Challenge - Proud to be a member of the "Team POCKit": We want to put the power of diagnostics in the hands of the patients.

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January 2017: "Porous Silicon Nanovaccines Combat Cancer", highlighted in Advanced Science News.

 

 

 

 

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Dr. Santos together with Prof. Zhou (Aalto Univerity) received project funding from Academy of Finland for 2 years (2017-2018) to research on:

"Autonomous Microrobotics for Studying Cell-Particle Interactions and Responses"

 

 

 

December 2016: "Cancer Immunotherapy and Nanotechnology: Taking the Best from Two Worlds", highlighted in Advanced Science News.

 

 

 

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24 November 2016: Dr. HÉLDER A. SANTOS RECEIVES THE 2016 ACADEMY OF FINLAND AWARD FOR SOCIAL IMPACT

 

 

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October 2016: "PSi hits the spot - Hélder Santos’ research group is developing medicines of the future through microflows".

(Copyright © Yliopistolehti, University of Helsinki)

 

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October 2016: Chasing a precise pill - Nanotechnology is making drugs more precise. But how?

(Copyright © Yliopistolehti, University of Helsinki)

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September 2016 - Dr. Hongbo Zhang HONORARY MEMBER OF SANTOS' LAB

 

 

 

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June 2016 - Dr. BÁRBARA HERRANZ BLANCO HONORARY MEMBER OF SANTOS' LAB

 

 

 

 

 

 

 

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The doctoral dissertation of PhD candidate Bárbara Herranz Blanco (M.Sc. Pharm.) took place at the Faculty of Pharmacy, University of Helsinki, Finland, on 27.5.2016.

The thesis entitle "Multi-Approach Design and Fabrication of Hybrid Composites for Drug Delivery and Cancer Therapy". I am very proud to have been the main supervisor of Blanco's PhD thesis!

The Opponent of Blanco's PhD thesis was Prof. Leigh Canham from PSiMedica Ltd, Malvern, UK & School of Physics and Astronomy, University of Birmingham, UK, and the Custos was Prof. Jouni Hirvonen, Division of Pharmaceutical Chemistry and Technology, University of Helsinki.

Final grade: Approved/passed

 

 

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APRIL 2016 - Dr. MOHAMMAD-ALI SHAHBAZI (OUR FORMER PhD STUDENT) AWARDED THE BEST THESIS OF UNIV. HELSINKI 2015 . MANY CONGRATS ALI!

 

 

 

 

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The doctoral dissertation of PhD candidate Neha Shrestha (M.Sc. Pharm.) took place at the Faculty of Pharmacy, University of Helsinki, Finland, on 1.4.2016.

The thesis entitle "Mesoporous Silicon Systems for Oral Protein/Peptide-Based Diabetes Mellitus Therapy". I am very proud to have been the main supervisor of Shrestha's PhD thesis!

The Opponent of Shrestha's PhD thesis was Prof. Alejandro Sosnik from Technion – Israel Institute of Technology (Israel), and the Custos was Prof. Jouni Hirvonen, Division of Pharmaceutical Chemistry and Technology, University of Helsinki.

Final grade: Approved/passed with honors/distinction

 

 

 

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March 2016 - Dr. MOHAMMAD-ALI SHAHBAZI NOMITAED THE 1ST HONORARY MEMBER OF SANTOS' LAB

 

 

 

 

22.4.2015

Dr. Dongfei Liu, post-doc in our research group, was awarded with the outstanding best doctoral thesis of the University of Helsinki in 2014, for its highest and outstanding research quality.

The monetary award was given in hand by the vice-rector of the University of Helsinki by occasion of at The Annual Celebration of The University of Helsinki Funds.

This is one the rare times such awarded is given to a doctoral thesis at the Faculty of Pharmacy. This is again an excellent achievement by our research group, and a prize for the high quality work!

It was a fantastic pleasure to have been Liu's main supervisor of his thesis together with Prof. Dean Jouni Hirvonen.

We are all extremely proud of Dongfei and his academic accomplishments. Outstanding job and the greatest congratulations to you.

Terrific work and enjoy this great moment!

 

 

 

 

 

 

 

 

 

 

 

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The doctoral dissertation of PhD candidate Chang-Fang Wang (M.Sc. Chem.) took place at the Faculty of Pharmacy, University of Helsinki, Finland, on 2.3.2015.

The thesis entitle "Chemical Surface Modification of Porous Silicon Nanoparticles for Cancer Therapy". I am very proud to have been the main supervisor of Wang's PhD thesis!

The Opponent of Wang's PhD thesis was Dr. Luca de Stefano from the Institute for Microelectronics and Microsystems Unit of Naples-National Research Council (Italy), and the Custos was Prof. Jouni Hirvonen, Division of Pharmaceutical Chemistry and Technology, University of Helsinki.

Final grade: Approved/passed

 

 

 

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The doctoral dissertation of PhD candidate Mohammad-Ali Shahbazi (M.Sc. Pharmacy) took place at the Faculty of Pharmacy, University of Helsinki, Finland, on 13.2.2015.

The thesis entitle "Effect of Surface Chemistry on the Immune Responses and Cellular Interactions of Porous Silicon Nanoparticles" is now the fastest doctoral thesis at the Faculty of Pharmay, finalized in less than 3 years (2 years and 7 months). I am extremely proud to have been the main supervisor of Shahbazi's PhD thesis!

The Opponent of Shahbazi's PhD thesis was Prof. Ijeoma Uchegbu from the University College London (UK), and the Custos was Prof. Jouni Hirvonen, Division of Pharmaceutical Chemistry and Technology, University of Helsinki.

Final grade: Approved/passed with honors/distinction

 

 

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Our group is very proud to be part of this fantastic project and awesome collaborative consortium - The 3iRegeneration project!

Check what we awesome research will do in within this project in here!

 

 

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I am extremely proud and happy to endorse our many congratulations to our student Mohammad-Ali Shahbazi for receiving on 14th of January 2015 The Best Young Researcher of Pharmaceutical Sciences worth of 3000 EUR in The 20th Razi Medical Sciences Research Festival, in Tehran, Iran.

This event celebrates the country's leading scholars and researchers inside and outside the region and ISESCO Member States to introduce the premier medical research, with emphasis on aspects of innovation.

This award is a result of Ali's great research work in our lab.

We are all very proud and happy for your fantastic achievement!

On behalf of all members of Santos' Lab, very many congrats!

December - Dr. Santos was nominated for the World Portuguese Network as Adviser for the area of Science. Over the past years Dr. Santos has contributed tremendously for the promotion and increase of the Portuguese Scientific community working at and visiting the University of Helsinki, Finland.

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The doctoral dissertation of PhD candidate Dongfei Liu (M.Med Pharmacy) took place at the Faculty of Pharmacy, University of Helsinki, Finland, on 29.8.2014.

The thesis entitle "Porous Silicon-Based Multicomposites for Controlled Drug Delivery" is now the fastest doctoral thesis at the faculty of Pharmay, finalized in less than 3 years (2 years and 10 months). I am extremely proud to have been the main supervisor of Liu's PhD thesis!

The Opponent of Liu's PhD thesis was Prof. Bruno Sarmento from the Institute of Biomedical Engineering (INEB), University of Porto (Portugal), and the Custos was Prof. Jouni Hirvonen, Division of Pharmaceutical Chemistry and Technology, University of Helsinki.

Final grade: Approved/passed with honors/distinction

 

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REWARD BY THE FACULTY OF PHARMACY (UNIVERSITY OF HELSINKI) FOR THE EXCEPTIONALLY PRODUCTIVE RESEARCH WORK OF Dr. SANTOS AND HIS RESEARCH GROUP

November - The Dean of the Faculty of Pharmacy, University of Helsinki, has decided to reward Dr. Santos for his exceptionally productive research work in 2014. "Dr. Santos' publications (> 29) have significant impacted the outcome of the Faculty of Pharmacy in 2014", the Dean wrote!

Many congratulations to all in Santos' lab!

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GRANT AWARD - Dr. HONGBO ZHANG

October - The Jane and Aatos Erkko Foundation has awarded a € 283.000 grant for Dr. Hongbo Zhang's research project about "Porous silicon-based multifunctional nanoshuttle for targeted intracellular drug delivery". The grant is for three years. Many congratulations to Dr. Zhang for this fantastic grant!

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OUTSTANDING ORAL DRUG DELIVERY PAPER AWARD

July - Dr. Hongbo Zhang (post-doc in our research group), will receive the "Outstanding Oral Drug Delivery Paper Award" at the 41st Annual Meeting & Exposition of the Controlled Release Society to be held in Chicago, USA (July 13-16).

Many congratulations to Zhang et al. for this fantastic award!

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Participation in interview in written and web media (in English)

May - Investigating nanomedicines and bioanalysis (in English; Copyright © Insight Publishers Ltd 2014), in Finland: Flying the flag for the research excellence, Finland.

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Participation in interview in written and web media (in English)

May - Nano-Medicine (in English; Copyright © Technology Academy Finland 2014), in Better Life - Millennium Technology Prize 10th Jubilee publication, TAF, Finland.

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10.4 - Dongfei Liu (PhD student in my group) received a Chinese Government Award for Outstanding Self-Financed Students Abroad.

The scholarship is sponsored by the Chinese Ministry of Education, and the award recognizes the academic excellence of self-financed Chinese students studying overseas and is granted across all fields of study.

Many Congrats to Dongfei!

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9.4 - Michela Mori and Michela Cola (former Erasmus exchange students in our research group), have received the degree of Dr. and M.Sc., respectively, at the University of Pavia (Italy).

Dr. Hélder A. Santos was the supervisor of both Master's thesis at the University of Helsinki.

Many congrats to both Michelas!

We are very happy and proud of your achievements and wish you all the best for your future endeavors.

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1.4 (PBP2014, Lisbon) - APV Award to Luis M. Bimbo (former PhD student in my research group) for one of the Most Outstanding Doctoral Thesis in the Pharmaceutical Sciences attributed by the International Association for Pharmaceutical Technology (APV), which was supervised by Adj. Prof. Hélder A. Santos and co-supervised by Prof. Jouni Hirvonen.

Once again porous silicon research was awarded internationally. In addition, this also demonstrates that the supervision in our research group is at the very high level in Europe and in the world and keeps getting prizes internationally!

I am very proud of all our research group!

Congrats to all and let's continue in this direction in the future! 

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17.3 - Congratulations to Mónica Ferreira and Dongfei Liu, Both PhD students in my group, awarded with a travel grant from the Chancellor’s travel grant, University of Helsinki. Congrats and Well done!  

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4.2 - Congratulations to Patrick V. Almeida, PhD student in my group, awarded with a personal research Grant from the Finnish ultural Foundation. Well done!  

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TEKES CONSORTIUM PROJECT (2014-2016)

3i - Innovative Induction Initiative: Induction of new cells by innovative pharmaceuticals for vitality of people (news in Finnish)

A strategic research consortium coordinated by Professor Heikki Ruskoaho receives a € 4.8 million grant for three years (2014-2016) to find out new means to cure heart and brain diseases. The vision is to enhance the functions of the patient's own heart or brain stem cells to help to repair the damages.

Our research team is very proud to be part of this exciting project!

ERC STARTING GRANT (2013-2017)

Dr. HÉLDER A. SANTOS RECEIVES ERC STARTING GRANT FOR 2013-2017 (news in Finnish)

University of Helsinki News (11.9.2012), in English

Academy of Finland News (20.9.2012), in Finnish

University of Helsinki News (11.9.2012), in Finnish

ERC Starting Grant press release (10.9.2012)

(Copyright 2012 European Research Council)

LIFE SCIENCE - List of Selected Principal Investigators (10.9.2012)

(Copyright 2012 European Research Council)

Other related news:

Farmasian tutkimukselle merkittävät apurahat (9.11.2012), in Finnish

Tekniikka Talous (10.9.2012), in Finnish

TV Ciência (11.9.2012), in portuguese

Ministério da Educção e Ciência (12.9.2012), in portuguese

Expresso newspaper (15.9.2012), in portuguese

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YOUNG RESEARCHER'S AWARD 2013 - 11.9.2013

Young Researcher's Award 2013 by the Faculty of Pharmacy, University of Helsinki, for the outstanding research achievements between 2008-2012

 

Award given by Dean of the faculty

 

 

 

 

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The dissertation for Master Degree in Pharmacy of Giulia Anselmi (Pharmacy) took place at the Faculty of Pharmacy, University of Pavia, Italy, on 25.7.2013.

Master thesis: "Surface modification of porous silicon materials for wound healing applications". I am extremely proud to have been the supervisor of this thesis during Giulia's Erasmus exchange visit to our Division from 1.9.2012 - 31.1.2013! The supervisor at Univeristy of Pavia was Prof. Carla Caramella.

Final grade: Accepted with Excellent

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The dissertation for Master Degree in Pharmacy of Heleen Vande Capelle (Pharmacy) took place at the Faculty of Pharmaceutical Sciences, Ghent University, Belgium, on 27.6.2013.

Master thesis: "Characterisation of drug loaded porous silica using different analytical techniques". I am extremely proud to have been the co-supervisor/promoter of this thesis during Heleen's Erasmus exchange visit to our Division from 11.2 - 24.5.2013! The supervisor/promoter at Ghent Univeristy was Prof. Chris Vervaet.

Final grade: Accepted

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The dissertation for Doctoral Degree in Chemistry of José Ribeiro (M.Sc. Chem.) took place at the Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Portugal, on 12.4.2013.

Doctoral thesis: Characterization and Optimization of Electrochemical Sensors for Biogenic Amines" (in portuguese). The supervisors of the thesis were Prof. Eng. António Fernando Silva and Prof. Carlos M. Melo.

I was very delighted to have been one of the opponents of this thesis at the Faculty of Sciences, University of Porto, Portugal.

Final grade: Accepted with honors

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The dissertation for Doctoral Degree in Radiochemistry of Mirkka Sarparanta (M.Sc. Chem.) took place at the Department of Chemistry, Faculty of Sciences, University of Helsinki, Finland, on 11.1.2013.

Doctoral thesis: 18F-Radiolabeled Porous Silicon Particles for Drug Delivery: Tracer Development and Evaluation in Rats". The supervisor of the thesis was Adj. Prof. (Doc.) Anu Airaksinen.

I was very delighted to have been a collaborator to Mirkka's work.

The Opponent of Mirkka's thesis was Prof. Philip Blower from King's College London (UK).

Final grade: Accepted with honors

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10.9.2013 - Seminar by Professor CARLA CARAMELLA, Department of Drug Sciences, University of Pavia, Italy.

Lecture: "NANOCARRIERS FOR DRUG DELIVERY TO OVERCOME BIOLOGICAL BARRIERS"

9.00 am, room 2063, Viikin Biocenter 2, Viikinkaari 5

Host: Dr. Hélder A. Santos

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6.9.2013 - Seminar by Distinguished Professor ERKKI RUOSLAHTI, Sanford-Burnham Medical Research Institute in La Jolla, CA, USA

Lecture: "VASCULAR ZIP CODES IN NOVEL TUMOR THERAPIES"

9.30 am, INFO SALI 1 (AUD), Viikin infokeskus Korona, Viikinkaari 11

Host: Dr. Hélder A. Santos

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5.9.2013 - BEST POSTER AWARD - INTERNATIONAL AUTUMN SCHOOL, Turku, 2013

Ali_Poster_Winner

The BEST POSTER at the INTERNATIONAL AUTUMN SCHOOL "Nanostructured Materials in Biomedical Applications" (2nd to 6th of September, Turku, Finland) was the poster of our group entitled:

"THE MECHANISMS OF SURFACE CHEMISTRY EFFECTS OF MESOPOROUS SILICON NANOPARTICLES ON IMMUNOTOXICITY AND BIOCOMPATIBILITY"

by Mohammad-Ali Shahbazi, Mehrdad Hamidi, Ermei Mäkilä, Hongbo Zhang, Patrick Almeida, Martti Kaasalainen, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos

Many congratulations to Ali et al. for this fantastic award!

 

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13.6 - Today we had the great honor and pleasure to had the official visit of the Portuguese Ambassador in Finland, Your Excellency Dr. Fátima Prestrello; Prof. Dr. José Pereira Miguel and Prof. José Calheiros, respectively, President and Vice-preseident of the National Health Institute Doutor Ricardo Jorge (National Health Institute Doutor Ricardo Jorge, IP; and Dr. Eva Falcão, Directorate-General of Health. During this meeting it was present besides myself, also Prof. Dean Jouni Hirvonen, and the Portuguese community working/studying at the Faculty of Pharmacy, University of Helsinki.

Visit_Portuguese_Ambassador

 

 

 

 

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14.5 - Congratulations to Chang-Fang Wang, PhD student in my group, awarded with a travel grant from the Faculty of Pharmacy, University of Helsinki, to the ULLA Summer School in London. Well done!  

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Participation in interview for written and web media (in Portuguese)

13.4 - Os emigrantes de talento (in Portuguese; Copyright © Expresso 2013), in Expresso newspaper, Portugal. 

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4.4 - Congratulations to Mohammed-Ali Shahbazi, PhD student in my group, awarded with a travel grant from the Chancellor’s travel grant, University of Helsinki. Well done!  

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7.3 - Congratulations to Dongfei Liu, PhD student in my group, awarded with a travel grant from the Finnish Pharmaceutical Society. Well done!  

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27.2 - Congratulations to Patrick Almeida, PhD student in my group, awarded with a research grant from the Finnish Cultural Foundation. Well done!  

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27.11 - Congratulations to Dr. Hongbo Zhang, post-doc in my group, awarded with a personal post-doc Pooli research grant from the Suomen Kulttuurirahasto. Well done!  

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19.11 - Congratulations to Mónica Ferreira, PhD student in my group, awarded with a personal research Grant from the Drug Research Doctoral Program, Faculty of Pharmacy, University of Helsinki. Well done!

The dissertation for Master Degree in Molecular Therapies of Ana Francisca Araújo (Pharmacy) took place at the Instituto Superior de Ciências de Saúde - Norte, Gandra, Portugal, on 17.12.2012.

Master thesis: "Understanding the mechanism of protein intestinal permeation by using enterocyte-based in vitro co-culture cells". The supervisor of the thesis was Prof. Bruno Sarmento from Univerity of Porto/INEB/Instituto Superior de Ciências de Saúde - Norte, Portugal.

I was very delighted to have been the opponent of this thesis at the Instituto Superior de Ciências de Saúde - Norte, Gandra, Portugal.

Final grade: Accepted with 19 points out of 20!

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The dissertation for Master Degree in Pharmacy of Francesca Villanova (Pharmacy) took place at the Faculty of Pharmacy, University of Pavia, Italy, on 26.10.2012.

Master thesis: "Characterization and In Vitro Evaluation of Dual Drug Loaded Porous Si Particles". I am extremely proud to have been the supervisor of this thesis during Francesca's Erasmus exchange visit to our Division from 1.9.2012 - 31.1.2013! The supervisor at Univeristy of Pavia was Prof. Carla Caramella.

I was very delighted to have been the opponent of the thesis and to be part of the evaluation thesis commission at the University of Pavia.

Final grade: Accepted with Excellent!

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The doctoral dissertation of PhD candidate Luis M. Bimbo (M.Sc. Pharmacy) took place at the Faculty of Pharmacy, University of Helsinki, Finland, on 4.2.2012.

The thesis entitle "Biocompatibility and Biofunctionalization of Mesoporous Silicon Particles" is the first thesis on biomedical applications of Porous Silicon in Finland. I am extremely proud to have been the main supervisor of Luis' thesis!

The Opponent of Luis' thesis was Prof. Mauro Ferrari from The Methodist Hospital Research Institute (USA), and the Custos was Prof. Jouni Hirvonen, Division of Pharmaceutical Technology, University of Helsinki.

Final grade: Accepted with honors

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In collaboration with Harvard University we have introduced in our lab a microfludic-based technique for the development of advanced drug delivery systems.

Microfluidic-1

 

 

 

 

 

 

Microfluidic-2

 

 

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Participation in interview for written and web media (in Finnish)

December 2012 - Täsmälääkintää nanoteknologialla (in Finnish), in Apteekin Hyllyltä magazine, Finland.

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Participation in interview for written and web media (in Portuguese)

 26.11.2012 - Um investigador português na área da nanotecnologia médica (in Portuguese), in Mundo Português newspaper, Portugal.

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My research visit (4-11.11.2012) to the Experimental Soft Condensed Matter Group, School of Engineering and Applied Sciences/Department of Physics, Harvard University, USA

HOSTS: Professor David A. Weitz and Dr. Sabiruddin Mirza

 

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1. Albert Wuokko Award (Finland's most prestigious Pharmaceutical Award bestowed by the Finnish Pharmaceutical Society worth of 4000 EUR) and the Best Doctoral Thesis by the Viikki Research Group Organization was to Dr. Luis M. Bimbo, Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland, was given to a member of our research group as a result of his high-level PhD thesis, which was supervised by Adj. Prof. Hélder A. Santos and Prof. Jouni Hirvonen. 

Congratulations to Luis!

 

2. Special Seminar in Pharmaceutical Technology, Prof. BRUNO SARMENTO, CICS, Department of Pharmaceutical Sciences, Instituto Superior de Ciências da Saúde – Gandra, Portugal; & INEB- Institute of Biomedical Engineering, University of Porto, Portugal - Lecture: "IN VITRO INTESTINAL CO-CULTURE CELL MODEL TO EVALUATE AND CORRELATE IN VIVO INTESTINAL ABSORPTION OF CHITOSAN-BASED MUCOADHESIVE NANOPARTICLES AND INSULIN AS MODEL THERAPEUTIC PROTEIN".

Host: Dr. Hélder A. Santos

 

3. Special Seminar in Pharmaceutical Technology, Prof. ANTÓNIO J. RIBEIRO, Center for Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, Portugal - Lecture: "M CELL EFFECT ON INTESTINAL UPTAKE OF INSULIN NANOPARTICLES".

Host: Dr. Hélder A. Santos

 

4. Special Seminar in Pharmaceutical Technology, Prof. CLIVE PRESTIDGE, Wark Research Institute, University of South Australia, Australia - Lecture: "NANOSTRUCTURE FACILITATING ENHANCED DRUG DELIVERY".

Host: Dr. Hélder A. Santos

 

3. Hélder A. Santos*, Porous Silicon- Revolutionising Drug Targeting and Delivery, NANO - the magazine for small science 2012, Issue 24, 19–22.

 

5. The 1st Viikki Campus Post Doc Day took place last 26.4.2012 and as a member of the organizing committee I am very proud to say that the event was a great success! I look forward for the next event.

 

6. 9.2.2011 - Visit of H.E. Mr. Anibal Cavaco Silva, the President of the Portuguese Republic to Aalto University, Finland. Dr. Hélder A. Santos had the honor to be present in such event, met H.E. Mr. President, and gave a short overview on his research in Pharmaceeutical Nanotechnology.

2011

The doctoral dissertation of PhD Tarja Limnell (M.Sc. Health Biosciences) took place at the Faculty of Pharmacy, University of Helsinki, Finland, on 15.10.2011.

The thesis entitle "Mesoporous Silica- and Silicon-Based Materials as Carriers for Poorly Water Soluble Drugs" is the first thesis in Finland on this subject. I am proud to have been co-supervisor of Tarja's thesis!

The Opponent of Tarja's thesis was Prof. Carla Caramella from University of Pavia (Italy), and the Custos was Prof. Jouni Hirvonen, Division of Pharmaceutical Technology, University of Helsinki.

Final grade: Accepted!

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1) 1.10.2011 - The 4BBBB Young Researcher Award poster was attributted to my PhD Student Luis M. Bimbo. Poster: L.M. Bimbo*, M. Sarparanta, E. Mäkilä, T. Laaksonen, L. Peltonen, V.-P. Lehto, A.J. Airaksinen, J. Salonen, J. Hirvonen, H. A. Santos, "Mesoporous silicon particles as biocompatible drug delivery agents", 4th BBBB – Bled International Conference on Pharmaceutical Sciences, 29th September–1st October 2011, Bled, Slovenia. *Presenter.

2) 13.9.2011 - Appointed Adjunct Professor (Docent) in Pharmaceutical Nanotechnology, Faculty of Pharmacy, University of Helsinki.

3) 17.8.2011 - Funding granted for Additional Research Costs (1.9.2011-31.12.2014), Research Council for Health, Academy of Finland.

4) 8.7.2011 - Research Conducted at University of Helsinki Has Provided New Information about Drug Discovery, Design and Development, Therapeutics Daily News, USA.

5) 8.6.2011 - Project granted for Academy Research Fellow position (1.9.2011-31.8.2016), Research Council for Health, Academy of Finland.

6) 21.1.2011 - An interview with Dr. Hélder A. Santos, Semanário Grande Porto (Regional Newspaper), (in Portuguese).

7) January 2011 - Top Reviewer in Pharmaceutical Sciences 2010: Elsevier

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2010

 1) 28.9.2010 - Portugal awards a citizen who is creating a science career in Finland (in English) / Portugali palkitsi Suomessa tutkijanuraa luovan kansalaisensa (in Finnish), University of Helsinki News.

2) 29.7.2010 - Câmara Munincipal de Tarouca paid formal tribute to Hélder A. Santos for his Award in the "Prémio Talento 2009" (Talent Prize 2009) in Science, 29th of July 2010, Tarouca, Portugal.

Others related:

a) Rádio Clube de Lamego; b) Secretário de Estado da Administração Local ; c) MINISTÉRIO DOS NEGÓCIOS ESTRANGEIROS - Gabinete do Secretário de Estado das Comunidades Portuguesas ; d) Blog - Parliament member - Acácio Pinto

(in portuguese)

Local newspapers:

a) Douro Hoje; b) Journal do Douro-1; c) Journal do Douro-2; d) Jornal Sempre Jovem

(in portuguese)

3) 23.7.2010 - Hélder A. Santos was Nominated and Winner of the "Prémio Talento 2009" (Talent Prize 2009) in Science, Attributed by the Portuguese Government, Ministry of Foreigner Affairs, State Secretary of the Portuguese Communities, 23rd of July 2010, Lisbon, Portugal:

RTP1 video clip1 (National Public TV)

RTP1 video clip2 (National Public TV) - 11 MB (4 min)

RTP1 video clip2 (National Public TV) - 85 MB (4.5 min)

(C) Copyright 2010 - Rádio e Televisão de Portugal (RTP)

(in Portuguese)

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4) September 2010 - Guest Editor in Current Drug Metabolism. Special Issue: "In Vitro Models Used in Drug Discovery: Drug Absorption and Metabolism".

5) May 2010 - September 2011 - Guest Editor in Current Drug Discovery Technologies. Special Issue: "Innovative Technology for Drug Delivery Applications: From Nanocapsules and Biopolymers to Inorganic Materials".

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2007-2009

 

1) 16.12.2009 - Nanohituset vievät lääkeaineet entistä paremmin kohteeseensa, Aamulehti Newspaper, p. B22 (Section: Science Today) (in Finnish).

2) 2.12.2009 - Nanotechnology may also facilitate weight loss, Academy of Finland (in English).

3) 25.11.2009 - Nanoteknologiasta apua myös laihdutukseen, Academy of Finland (in Finnish).

4) 12.12.2008 - Project granted for 3-years research (1.1.2009-31.12.2011), University of Helsinki Research Funds .

5) 18.9.2008 - Project granted for Postdoctoral Research Fellow position (1.1.2009-31.12.2011), Research Council for Health, Academy of Finland.

6) 9.8.2007 - CRS/Eurand Grand Prize Award on Innovations in Oral Drug Delivery Technologies in 2007.