We offer services on preclinical testing of different nanomaterials.

Services include but are not limited to:

Formulation and synthesis of nanomaterials:

• Synthesis of monodisperse and high-loading drug degree by microfluidics technique (polymeric-based nanoparticles and nanocrystals) in industrial amounts for preclinical testing.
• Testing and development of drug loading methods for nanoparticles.
• Surface biofunctionalization (e.g., peptides and antibodies) of the nanomaterials for targeting applications (cancer, diabetes and cardiovascular diseases).
• Design and synthesis of polymersomes for sustained drug delivery.
• Development of multifunctional nanodelivery systems for targeting, and combination drug therapy and bio-imaging

Characterization of nanocarriers:

• Structural and morphological characterization of nanofomulations (e.g., DLS and zeta-potential).
• Colloidal stability of nanoparticle suspensions.
• Physical stability of loaded drug carriers (DSC and XRD).
• Nanoparticle–drug interaction studies (FTIR and DSC).

Materials and production techniques:

• Nanocrystals and inorganic nanomaterials (nanoporous silica/silicon) drug nanocarriers.
• Microfluidics using glass capillaries.

Biological assessment:

• In vitro (and possibly in vivo) imaging of nanomaterials.
• In vitro USP-based dissolution analysis of nanoformulations.
• HPLC drug loading and release studies.
• Cytotoxicity assays to test all biological responses of drug-based nanoformulations.
• Cellular testing of the nanomaterials–cells interactions, including uptake, proliferation and intracellular drug delivery.
• Permeability drug studies across cell-based monolayers.

Projects are tailored to fit your specific needs, executed by our skilled staff and are charged on a case by case basis. For more information on the services provided, please contact Dr. Santos.