To destroy or not to destroy?

Our immune system protects us efficiently from infections by destroying the invaders. But sometimes the system is overactive leading to damage of also our own cells and tissues (in autoimmune diseases) or does not protect us well enough leading to serious infections. Our research has three themes. The first theme is in understanding the mechanisms behind uncontrolled complement activation in inflammatory disorders. The second theme is in understanding the role of microbial infections in altering complement mediated inflammation. The third theme is in understanding why overactive complement system leads to hemolytic uremic syndrome (HUS).