1. Marquardt, N. et al. Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69-CD56dim cells. J. Allergy Clin. Immunol. 139, 1321–1330.e4 (2017).
  2. Forkel, M. et al. Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers. Eur. J. Immunol. 47, 1280–1294 (2017).
  3. Heikkilä, N. et al. Expanded CD4(+) Effector/Memory T Cell Subset in APECED Produces Predominantly Interferon Gamma. J. Clin. Immunol. 36, 555–63 (2016).
  4. Marquardt, N. et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J. Immunol. 194, 2467–71 (2015).
  5. Kekäläinen, E. et al. Lymphopenia-induced proliferation in the absence of functional Autoimmune regulator (Aire) induces colitis in mice. Immunol. Lett. 167, 17–22 (2015).
  6. Laakso, S. M. et al. In vivo analysis of helper T cell responses in patients with autoimmune polyendocrinopathy – candidiasis – ectodermal dystrophy provides evidence in support of an IL-22 defect. Autoimmunity 47, 556–562 (2014).
  7. Pekkarinen, P. T. et al. Impaired intestinal tolerance in the absence of a functional complement system. J. Allergy Clin. Immunol. 131, 1167–1175 (2013).
  8. Björkström, N. K., Kekäläinen, E. & Mjösberg, J. Tissue-specific effector functions of innate lymphoid cells. Immunology 139, 416–427 (2013).
  9. Ivarsson, M. A. et al. Differentiation and functional regulation of human fetal NK cells. J. Clin. Invest. 123, 3889–3901 (2013).
  10. Laakso, S. M. et al. IL-7 dysregulation and loss of CD8+ T cell homeostasis in the monogenic human disease autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Immunol. 187, 2023–30 (2011).
  11. Laakso, S. M. et al. Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population. J. Autoimmun. 35, 351–7 (2010).
  12. Kekäläinen, E., Hänninen, A., Maksimow, M. & Arstila, T. P. T cells expressing two different T cell receptors form a heterogeneous population containing autoreactive clones. Mol. Immunol. 48, 211–8 (2010).
  13. Tuovinen, H. et al. gammadelta T cells develop independently of Aire. Cell. Immunol. 257, 5–12 (2009).
  14. Tuovinen, H., Kekäläinen, E., Rossi, L. H., Puntila, J. & Arstila, T. P. Cutting edge: human CD4-CD8- thymocytes express FOXP3 in the absence of a TCR. J. Immunol. 180, 3651–4 (2008).
  15. Kekäläinen, E. et al. A defect of regulatory T cells in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J. Immunol. 178, 1208–15 (2007).
  16. Tuuminen, T. et al. Human CD8+ T cell memory generation in Puumala hantavirus infection occurs after the acute phase and is associated with boosting of EBV-specific CD8+ memory T cells. J. Immunol. 179, 1988–95 (2007).
  17. Kekäläinen, E., Miettinen, A. & Arstila, T. P. Does the deficiency of Aire in mice really resemble human APECED? Nat. Rev. Immunol. 7, 1 (2007).

See in the Pubmed