Eliisa graduated as medical doctor from University of Helsinki in 2006. In 2011 she defended her PhD on Autoimmune regulator in the maintenance of immunological tolerance. She continued her research as a post-doc at Center for Infectious Medicine, Karolinska Institutet, Stockholm Sweden. There she worked in prof. Hans-Gustaf Ljunggren’s group on tissue-resident natural killer cells. After returning to Finland in 2014, she started her specialization into clinical microbiology at HUSLAB, University Hospital Helsinki. Currently she shares her working hours between managing the research group and as a clinical specialist at HUS Diagnostic Center HUSLAB, division of immunology. In her clinical work, she focuses on the laboratory diagnostics of inborn errors of immunity.
Eliisa’s ideology to research is that it should be fun. Fun means bold experiments in a relaxed working environment. We do hard work when needed, but also maintain a reasonable work-life balance. We work as a team, and every team member is important. Every day we learn something new!
Sini graduated as MD from University of Helsinki in 2009 and had finished also her degree in MSc Tech (Industrial Engineering and Management) in 2007 alongside with medical studies. Sini studied T cell immunology and defended her PhD thesis on Autoimmune polyendocrinopathy – candidiasis – ectodermal dystrophy in 2012 (University of Helsinki, Department of Immunology, group of MD PhD Petteri Arstila). Sini is currently specialising in neurology at the Helsinki University Hospital, and has projects with professor of neuroimmunology Pentti Tienari and adjunct professor Eliisa Kekäläinen underway on multiple sclerosis, myastenia gravis, new-onset refractory status epilepticus and Susac’s syndrome.
Sini and Eliisa are lab mates from the time of PhD studies and share an interest on inspirational out of the box - kind of science. Sini brings the perspective of clinical neurology to the team.
Dawit holds MSc. in Bioinformatics from Aalto University and PhD from University of Helsinki during which he worked extensively on the application and development of Bioinformatic methods for the analysis of high-throughput genomic datasets. He has extensive experience from basic analysis of genomic data to higher level analyses in areas such as variant analysis, gene expression analysis from microarrays to RNAseq (both bulk and single cell data), and immune TCR repertoire analysis.
In his current post-doctoral research, Dawit is involved in the analysis of scRNAseq datasets in projects that study immunological disorders & immunodeficiencies. He utilizes bioinformatics, develops in-house pipelines/methods, and harnesses statistical and machine learning algorithms to help answer critical research questions.
Joona started in the Kekäläinen Lab in 2017 doing "bachelor´s thesis" on anti-cytokine antibodies. Fascinating world of immunology got a grip of him and alongside with medical studies, he started his PhD project in 2019 supervised by PI Kekäläinen and Dr Laakso. In 2021 he graduated as MD from University of Helsinki and currently he is continuing his PhD project.
His main focus is in Germinal Center reaction where he wants to understand how follicular T helper and regulator cells fine tune development of memory B cells and antibodies producing plasma cells. He studies different forms of Germinal Center reaction in autoimmunity (especially neurological diseases multiple sclerosis and myasthenia gravis), immunodeficiency and ovarian cancer with means of flow cytometry, (sc)RNAseq and especially image analysis based on multiplex immunofluorescence stainings.
Suvi is a medical student/PhD student with a research focus on the immunological effects of COVID-19. She started at the lab in 2018 through the MD PhD program researching MAIT cells, but once the COVID pandemic hit, she changed projects.
Kirsten was a student in the translational medicine master's program. She completed her BSc in reproductive biology at the University of Edinburgh and her Msc project studying scRNAseq compatible cell preservation and fixation methods. She is now a PhD student in the Kekäläinen lab.
Xiaobo started her PhD project in Kekäläinen lab from 2021 under the supervision by Eliisa Kekäläinen and Tomas Strandin.
Her main focus is T cell lymphopenia in respiratory viral infections, especially SARS-CoV-2 infection.
Eira holds MSc in Physiology and Neuroscience from the University of Helsinki, where her primary research centered on characterizing APECED patient derived iPSCs for a possible gene and cell therapy approach for APECED. Currently, her main research focuses on the functions of AIRE.
During Alexandra's bachelor’s program, she conducted research at the laboratory of molecular biology at IB Komi SC UB RAS (Russia), focusing on typing specific HLA genes associated with early-onset rheumatoid arthritis. The primary objective of this research was to explore potential molecular-genetic markers for preventive diagnostics. Subsequently, she pursued her MSc studies at the University of Tartu (Estonia), where she investigated the utilisation of epigenetic changes to estimate immune cell levels.
Currently, she is focusing on T-Cell Repertoire implemented as a potential source of personalised treatment options, where we explore APECED patients’ cell receptors and their potential applications in treatment options.
Heather did her master study from the TRANSMED programme. She graduated from the National University of Singapore (NUS) with B.Sc Hons in Life Sciences, and moved on to work on CAR-T cell therapy in the lab of Dario Campana at NUS. Her thesis topic is Long Covid. She enjoys reading and loves spending time with her cat outdoors.
Maria has graduated with the Master of Science degree in Immunology and Microbiology from Moscow State University in Russia. During her Master project she had developed monoclonal antibody against platelet glycocalicin (GC), the extramembranous portion of GPIb alpha glycoprotein. Glycoprotein Ib (GPIb), also known as CD42, is a component of the GPIb-V-IX complex on platelets. Plasma level of Glycocalicin is an important marker for different types of thrombocytopenia in humans. She continued her research career in Finland at the University of Eastern Finland where she was working for many years in the Neurobiology field. Her passion about basic Immunology and human autoimmune diseases finally brought her to Eliisa Kekälainen lab where she has just started her PhD project.
Heidi has started her master thesis in Kekäläinen lab to the Åbo Akademi’s Biomedical Imaging master’s program. She completed her bachelor’s degree in Laboratory Sciences at the Metropolia University of Applied Sciences. Her thesis project is focusing on developing thymic epithelial cell marker panel for CycIF and combining it with RNA scope to visualize the location of different thymic epithelial cell subtypes.
Adam is currently doing his PhD on viral infections and immune reconstitution after pediatric allogenic hematopoietic stem cell transplantation. With the purpose of better being able to predict viral reactivations and infections, he is looking for answers to why and how immune suppression causes viral infections in the post-transplant setting.
As a pediatrician specializing in hematology, his special interests are acute leukemia, virology and immunology. In his spare time, he spends with my family, and every once in a while, on the golf course.
Pauliina is a PhD Student in the Pediatric Research Center and Translational Immunology Research Program and specializing in pediatrics in the New Children’s hospital. Her research focuses on the diagnostics of primary immunodeficiencies and immune reconstitution after allogenic stem cell transplantation in pediatric patients.
Saima is a medical student at the University of Helsinki and is working on her MD thesis and PhD project at Kekäläinen lab. She has a BSc in Computer Science from Aalto University. Her focus at the moment is the application of novel machine learning methods to problems in rare immunological disorders.
Jaakko is a Biomedical Laboratory Scientist student at the Metropolia University of Applied Sciences. He has been working at Lab Kekäläinen as a lab nurse since 2024.
Iivari was a postdoc in Eliisa's lab. His main project aimed for better diagnostics of thymic function after hematopoietic stem cell transplantation. He worked on developing and running single cell mRNA and protein profiling analysis from PBMC samples. Alongside this, he did molecular, cellular and biochemical assays as necessary.
Nelli Heikkilä's principal interest is in the heterogeneity of human T cells, whether it concerns the T cell receptors or T cell phenotypes in healthy body or immunological disorders. She works with various immunological tissues using flow cytometry. She is also interested in T cell receptor repertoire analysis methodology.
Iivo's focus was from immunodeficiency to autoimmunity and back to basic T and B cell biology. His core competency lies in flow cytometry.
Man graduated as PhD in virology from University of Helsinki. Her PhD projects focused on the clinical aspects, pathogenesis and persistence of viruses. She has extensive experience in assay development and optimization of molecular biology methods. She joined Eliisa Kekäläinen’s lab as a Postdoc in 2022. Her project was about the interplay between the immune system and respiratory syncytial virus with a particular focus on mucosal-associated invariant T cells.
Vasco joined the Kekäläinen Lab in 2024. He focused on exploring the impact of immune cells' lipid metabolism on thymus health.
Simo did his master thesis in Kekäläinen lab during 2017 - 2018. The main project was to study IKZF2/HELIOS gene induction in human MAIT cells in response to E.coli bacteria and C.albicans yeast.
Anh finished her master thesis in Kekäläinen lab.
Karen finished her master thesis in Kekäläinen lab. The main project was about anti-interferon autoantibodies and AIRE expression in different diseases.
Vera was a student in the translational medicine program. She joined as a research assistant in 2023, and worker on her master thesis. She completed her bachelor in Biomedical Engineering at the University of Eindhoven, the Netherlands. The main focus of her project in the lab was Recent Thymic Emigrants.