Selected Publications
Satta JP*, Lindström R*, Myllymäki SM, Lan Q, Trela E, Prunskaite-Hyyryläinen R, Kaczyńska B, Voutilainen M, Kuure S, Vainio SJ, Mikkola ML. Exploring the principles of embryonic mammary gland branching morphogenesis. Development. 151(15):dev202179 (2024). (Pubmed)
Lan Q, Trela E, Lindström R, Satta JP, Kaczyńska B, Christensen MM, Holzenberger M, Jernvall J, Mikkola ML. Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland. Elife. 13.e93326. (2024). (Pubmed)
Satta JP, Lan Q, Taketo MM, Mikkola ML. Stabilization of epithelial β-catenin compromises mammary cell fate acquisition and branching morphogenesis. J Invest Dermatol. 28:S0022-202X(23)03201-3. (2023). (Pubmed)
Mäkelä OJM, Mikkola ML. Mesenchyme governs hair follicle formation. Development, 150(22):dev202140 (2023). (Pubmed)
Myllymäki SM, Kaczyńska B, Lan Q, Mikkola ML. Spatially coordinated cell cycle activity and motility govern bifurcation of mammary branches. J Cell Biol. 222(9):e202209005. (2023). (Pubmed)
Sulic AM, Das Roy R, Papagno V, Lan Q, Saikkonen R, Jernvall J, Thesleff I, Mikkola ML. Transcriptomic landscape of early hair follicle and epidermal development. Cell Rep. 42(6):112643. (2023). (Pubmed)
Jernvall J, Di-Poï N, Mikkola ML, Kratochwil CF. Toward a universal measure of robustness across model organs and systems. Evol Dev. (2023). (Pubmed)
Lan Q, Satta J, Myllymäki SM, Trela E, Lindström R, Kaczyńska B, Englund J, Mikkola ML. Protocol for studying embryonic mammary gland branching morphogenesis ex vivo. Methods Mol Biol. 2471:1-18 (2022). (Pubmed)
Trela E, Lan Q, Myllymäki SM, Villeneuve C, Lindström R, Kumar V, Wickström SA, Mikkola, ML. Cell influx and contractile actomyosin force drive mammary bud growth and invagination, Journal of Cell Biology (2021). (Pubmed)
Biggs LC*, Mäkelä OJ*, Myllymäki SM, Das Roy R, Närhi K, Pispa J, Mustonen T, Mikkola ML. Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation. eLife 7, pii: e36468 (2018). *equal contribution (PubMed)
Elo T*, Lindfors PH*, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Ornitz DM, Poutanen M, Howard BA, Mikkola ML. Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty. Sci Rep 7: 5049 (2017). *equal contribution (PubMed)
Ahtiainen L, Uski I, Thesleff I, Mikkola ML. Early epithelial signaling center governs tooth budding morphogenesis. J Cell Biol 214: 753-67 (2016). (PubMed)
Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML. Foxi3 deficiency compromises hair follicle stem cell specification and activation. Stem Cells 34:1896-908 (2016). (PubMed)
Voutilainen M, Lindfors PH, Trela E, Lönnblad D, Shirokova V, Elo T, Rysti E, Schmidt-Ullrich R, Schneider P, Mikkola ML. Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway. PLoS Genet 11:e1005676 (2015). (PubMed)
Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J. Replaying evolutionary transitions from the dental fossil record. Nature 512: 44-8 (2014).(PubMed)
Ahtiainen L, Lefebvre S, Lindfors PH, Renvoisé E, Shirokova V, Vartiainen MK, Thesleff I, Mikkola ML. Directional cell migration, but not proliferation, drives hair placode morphogenesis. Dev Cell 28:588-602 (2014). (PubMed)
Huh SH*, Närhi K*, Lindfors PH, Häärä O, Yang L, Ornitz DM, Mikkola ML. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev 27: 450-458 (2013). *equal contribution (PubMed)
Voutilainen M, Lindfors PH, Lefebvre S, Ahtiainen L, Fliniaux I, Rysti E, Murtoniemi M, Schneider P, Schmidt-Ullrich R, Mikkola ML. Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-kB. Proc Natl Acad Sci USA109: 5744-5749 (2012). (PubMed)
Närhi K, Tummers M, Ahtiainen L, Itoh N, Thesleff I, Mikkola ML. Sostdc1 defines the size and number of skin appendage placodes. Dev Biol 364: 149-161 (2012). (PubMed)
Harjunmaa E, Kallonen A, Voutilainen M, Hämäläinen K, Mikkola ML, Jernvall J. On the difficulty of increasing dental complexity. Nature 483: 324-327 (2012). (PubMed)
Lefebvre S, Fliniaux I, Schneider P, Mikkola ML. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol 132: 1094-1102 (2012). (PubMed)
Häärä O, Fujimori S, Schmidt-Ullrich R, Hartmann C, Thesleff I, Mikkola ML. Ectodysplasin and Wnt pathways are required for salivary branching morphogenesis. Development 138: 2681-2691 (2011). (PubMed)
Pispa J*, Pummila M*, Barker PA, Thesleff I, Mikkola ML.Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet 17: 3380-3391 (2008). *equal contribution (PubMed)
Närhi K, Järvinen E, Birchmeier W, Taketo MM, Mikkola ML*, Thesleff I*. Sustained epithelial b-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135:1019-1028 (2008).*equal contribution (PubMed)
Pummila M, Fliniaux I, Jaatinen R, James MJ, Laurikkala J, Schneider P, Thesleff I, Mikkola ML. Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of BMP activity and induction of Shh expression. Development 134:117-125 (2007) (PubMed)
Laurikkala J*, Mikkola ML*, James M, Tummers M, Mills AA, Thesleff I. p63 regulates multiple signaling pathways required for ectodermal organogenesis and differentiation. Development 133: 1553-1563 (2006). *equal contribution (PubMed)
Mustonen T*, Ilmonen M*, Pummila M, Kangas AT, Laurikkala J, Jaatinen R, Pispa J, Gaide O, Schneider P, Thesleff I, Mikkola ML. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131: 4907-4919 (2004). *equal contribution (PubMed)
Mustonen T, Pispa J, Mikkola ML, Pummila M, Kangas AT, Pakkasjärvi L, Jaatinen R, Thesleff I. Stimulation of ectodermal organ development by ectodysplasin-A1. Dev Biol 259: 123-136 (2003). (PubMed)
Koppinen P, Pispa J, Laurikkala J, Thesleff I, Mikkola ML. Signalling and the subcellular localization of the TNF receptor Edar. Exp Cell Res 269: 180-192 (2001). (PubMed)
Mikkola ML, Pispa J, Pekkanen M, Paulin L, Nieminen P, Kere J, Thesleff I. Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech Dev. 88: 133-146 (1999). (PubMed)
Srivastava AK, Pispa J, Hartung AJ, Du Y, Ezer S, Jenks T, Shimada T, Pekkanen M, Mikkola ML, Ko MSH, Thesleff I, Kere J, Schlessinger D. The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. Proc Natl Acad Sci USA 94: 13069-13074 (1997). (PubMed)