Satta JP, Lan Q, Taketo MM, Mikkola ML. Stabilization of epithelial β-catenin compromises mammary cell fate acquisition and branching morphogenesis. J Invest Dermatol. 28:S0022-202X(23)03201-3. (2023). (Pubmed)
Mäkelä OJM, Mikkola ML. Mesenchyme governs hair follicle formation. Development, 150(22):dev202140 (2023). (Pubmed)
Jacob T, Annusver K, Czarnewski P, Dalessandri T, Kalk C, Levron CL, Sanz NC, Kastriti ME, Mikkola ML, Rendl M, Lichtenberger BM, Donati G, Björklund Å, Kasper M. Molecular and spatial landmarks of early mouse skin development. Dev Cell. 58, 1–23 (2023). (Pubmed)
van Amerongen R, Bentires-Alj M, van Boxtel AL, Clarke RB, Fre S, Suarez EG, Iggo R, Jechlinger M, Jonkers J, Mikkola ML, Koledova ZS, Sørlie T, Vivanco MD. Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research. J Mammary Gland Biol Neoplasia 28(1):17 (2023). (Pubmed)
Myllymäki SM, Kaczyńska B, Lan Q, Mikkola ML. Spatially coordinated cell cycle activity and motility govern bifurcation of mammary branches. J Cell Biol. 222(9):e202209005. (2023). (Pubmed)
Sulic AM, Das Roy R, Papagno V, Lan Q, Saikkonen R, Jernvall J, Thesleff I, Mikkola ML. Transcriptomic landscape of early hair follicle and epidermal development. Cell Rep. 42(6):112643. (2023). (Pubmed)
Jernvall J, Di-Poï N, Mikkola ML, Kratochwil CF. Toward a universal measure of robustness across model organs and systems. Evol Dev. (2023). (Pubmed)
Huang Y, Gui J, Myllymäki SM, Mikkola ML, Shimmi O. Coordination of tissue homeostasis and growth by the Scribble-α-Catenin-Septate junction complex. iScience. 26(4):106490. (2023). (Pubmed)
Huang Y, Gui J, Myllymäki SM, Roy K, Tõnissoo T, Mikkola ML, Shimmi O. Scribble and α-Catenin cooperatively regulate epithelial homeostasis and growth. Front Cell Dev Biol. 10:912001. eCollection (2022). (Pubmed)
Lan Q, Satta J, Myllymäki SM, Trela E, Lindström R, Kaczyńska B, Englund J, Mikkola ML. Protocol for studying embryonic mammary gland branching morphogenesis ex vivo. Methods Mol Biol. 2471:1-18 (2022). (Pubmed)
Trela E, Lan Q, Myllymäki SM, Villeneuve C, Lindström R, Kumar V, Wickström S A, Mikkola ML. Cell influx and contractile actomyosin force drive mammary bud growth and invagination, Journal of Cell Biology (2021). (Pubmed)
Lan Q, Mikkola ML. Protocol: Adeno-Associated Virus-Mediated Gene Transfer in Ex Vivo Cultured Embryonic Mammary Gland. J Mammary Gland Biol Neoplasia (2020). (Pubmed)
Myllymaki SM, Mikkola ML. Inductive signals in branching morphogenesis - lessons from mammary and salivary glands. Dec 2019, Current Opinion in Cell Biology. 61, p. 72-78 7 p. (PubMed)
Biggs LC*, Mäkelä OJM*, Myllymäki SM, Das Roy R, Närhi K, Pispa J, Mustonen T, Mikkola ML. Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation. eLife 7, pii: e36468 (2018). *equal contribution (PubMed)
Elo T*, Lindfors PH*, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Ornitz DM, Poutanen M, Howard BA, Mikkola ML. Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty. Sci Rep 7: 5049 (2017). #) equal contribution (PubMed)
Ahtiainen L, Uski I, Thesleff I, Mikkola ML. Early epithelial signaling center governs tooth budding morphogenesis. J Cell Biol 214: 753-67 (2016). (PubMed)
Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML. Foxi3 deficiency compromises hair follicle stem cell specification and activation. Stem Cells 34:1896-908 (2016). (PubMed)
Voutilainen M, Lindfors PH, Trela E, Lönnblad D, Shirokova V, Elo T, Rysti E, Schmidt-Ullrich R, Schneider P, Mikkola ML. Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway. PLoS Genet 11:e1005676 (2015). (PubMed)
Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J. Replaying evolutionary transitions from the dental fossil record. Nature 512: 44-8 (2014).(PubMed)
Ahtiainen L, Lefebvre S, Lindfors PH, Renvoisé E, Shirokova V, Vartiainen MK, Thesleff I, Mikkola ML. Directional cell migration, but not proliferation, drives hair placode morphogenesis. Dev Cell 28:588-602 (2014). (PubMed)
Huh SH*, Närhi K*, Lindfors PH, Häärä O, Yang L, Ornitz DM, Mikkola ML. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev 27: 450-458 (2013). *equal contribution (PubMed)
Voutilainen M, Lindfors P, Lefebvre S, Ahtiainen L, Fliniaux I, Rysti E, Murtoniemi M, Schneider P, Schmidt-Ullrich R, Mikkola ML. Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-kB. Proc Natl Acad Sci USA109: 5744-5749 (2012). (PubMed)
Närhi K, Tummers M, Ahtiainen L, Itoh N, Thesleff I, Mikkola ML. Sostdc1 defines the size and number of skin appendage placodes. Dev Biol 364: 149-161 (2012). (PubMed)
Harjunmaa E, Kallonen A, Voutilainen M, Hämäläinen K, Mikkola ML, Jernvall J. 2012. On the difficulty of increasing dental complexity. Nature 483: 324-327 (2012). (PubMed)
Lefebvre S, Fliniaux I, Schneider P, Mikkola ML. 2012. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol 132: 1094-1102 (2012). (PubMed)
Häärä O, Fujimori S, Schmidt-Ullrich R, Hartmann C, Thesleff I, Mikkola ML. Ectodysplasin and Wnt pathways are required for salivary branching morphogenesis. Development 138: 2681-2691 (2011). (PubMed)
Pispa J*, Pummila M*, Barker PA, Thesleff I, Mikkola ML. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet 17: 3380-3391 (2008). *equal contribution (PubMed)
Närhi K, Järvinen E, Birchmeier W, Taketo MM, Mikkola ML*, Thesleff I*. Sustained epithelial b-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135:1019-1028 (2008). *equal contribution (PubMed)
Pummila M, Fliniaux I, Jaatinen R, James M, Laurikkala J, Schneider P, Thesleff I, Mikkola ML. Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of BMP activity and induction of Shh expression. Development 134:117-125 (2007) (PubMed)
Laurikkala J*, Mikkola ML*, James M, Tummers M, Mills AA, Thesleff I. 2006. p63 regulates multiple signaling pathways required for ectodermal organogenesis and differentiation. Development 133: 1553-1563 (2006). *equal contribution (PubMed)
Mustonen T*, Ilmonen M*, Pummila M, Kangas AT, Laurikkala J, Jaatinen R, Pispa J, Thesleff I, Mikkola ML. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131: 4907-4919 (2004). *equal contribution (PubMed)
Mustonen T, Pispa J, Mikkola ML, Pummila M, Kangas AT, Pakkasjärvi L, Jaatinen P, Thesleff I. Stimulation of ectodermal organ development by ectodysplasin-A1. Dev Biol 259: 123-136 (2003). (PubMed)
Koppinen P, Pispa J, Laurikkala J, Thesleff I, Mikkola ML. Signalling and the subcellular localization of the TNF receptor Edar. Exp Cell Res 269: 180-192 (2001). (PubMed)
Mikkola ML, Pispa J, Pekkanen M, Paulin L, Nieminen P, Kere J, Thesleff I. Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech Dev. 88: 133-146 (1999). (PubMed)
Srivastava AK, Pispa J, Hartung AJ, Du Y, Ezer S, Jenks T, Shimada T, Pekkanen M, Mikkola ML, Ko MSH, Thesleff I, Kere J, Schlessinger D. The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. Proc Natl Acad Sci USA 94: 13069-13074 (1997). (PubMed)
Kujala P, Rikkonen M, Ahola T, Kelve M, Saarma M, Kääriäinen, L. Monoclonal antibodies specific for Semliki Forest virus replicase protein nsP2. J Gen Virol 78: 343-351 (1997). (Pubmed)
Peränen J, Rikkonen M, Hyvönen M, Kääriäinen L. T7 vectors with a modified T7lac promoter for expression of proteins in Escherichia coli. Anal Biochem 236: 371-373 (1996). (Pubmed)
Rikkonen M. Functional significance of the nuclear targeting and NTP-binding motifs of Semliki Forest virus nonstructural protein nsP2. Virology 218: 352-361 (1996). (Pubmed)
Rikkonen M, Peränen J, Kääriäinen L. ATPase and GTPase activities associated with Semliki Forest virus nonstructural protein nsP2. J Virol 68: 5804-5810 (1994). (Pubmed)
Peränen J, Rikkonen M, Kääriäinen L. A method for exposing hidden antigenic sites in paraformaldehyde fixed cultured cells - applied to initially unreactive antibodies. J Histochem Cytochem 41: 447-454 (1993). (Pubmed)
Rikkonen M, Peränen J, Kääriäinen L. Nuclear and nucleolar targeting signals of Semliki Forest virus nonstructural protein nsP2. Virology 189: 462-473 (1992). (Pubmed)
Peränen J, Rikkonen M, Liljeström P, Kääriäinen L. Nuclear localization of Semliki Forest virus nonstructural protein nsP2. J Virol 64: 1888-1896 (1990). (Pubmed)
Myllymaki SM, Mikkola ML. Inductive signals in branching morphogenesis - lessons from mammary and salivary glands. Dec 2019, Current Opinion in Cell Biology. 61, p. 72-78 7 p. (PubMed)
Mikkola ML. In Utero Protein Therapy for an Inherited Developmental Disorder. N Engl J Med 378: 1637-8 (2018). (PubMed)
Thesleff I, Mikkola ML. Development of ectodermal organs. Semin Cell Dev Biol 25-26:1-2 (2014). (PubMed)
Biggs LC, Mikkola ML. Early inductive events in ectodermal appendage morphogenesis. Semin Cell Dev Biol 25-26C:11-21 (2014). (PubMed)
Lindfors PH, Voutilainen M, Mikkola ML.Ectodysplasin/NF-κB signaling in embryonic mammary gland development. J Mammary Gland Biol Neoplasia 18:165-9 (2013) (PubMed)
Mikkola ML. The Edar subfamily in hair and exocrine gland development. In Wallach D et al. (eds.), Advances in TNF Family Research, Adv Exp Med Biol 691: 23-33 (2011). (Pubmed)
Mikkola ML, Costanzo A, Thesleff I, Roop DR, Koster MI. Treasure or artifact: A decade of p63 research speaks for itself. Cell Death Differ 17: 180-183 (2010). (Pubmed)
Wright T, Morris C, Clements S, D’Souza R, Gaide O, Mikkola M, Zonana J. Classifying Ectodermal Dysplasias: Incorporating the Molecular Basis and Pathways (Workshop II). Am J Med Genet Part A, 149A: 2062-2067 (2009). (Pubmed)
Mikkola ML. Controlling the number of tooth rows. Sci Signal 2, pe53 (2009). (Pubmed)
Mikkola ML. Molecular aspects of hypohidrotic ectodermal dysplasia. Am J Med Genet Part A, 149A: 2031-6 (2009). (Pubmed)
Mikkola ML. TNF superfamily in skin appendage development. Cytokine Growth Factor Rev 19: 219-230 (2008). (Pubmed)
Mikkola ML. p63 in skin appendage development. Cell Cycle 6: 285-290 (2007). (Pubmed)
Mikkola ML. Genetic basis of skin appendage development. Semin Cell Dev Biol 18: 225-236 (2007). (Pubmed)
Mikkola ML, Millar SE. The mammary bud as a skin appendage: unique and shared aspects of development. J Mammary Gland Biol Neoplasia 11:187-203 (2006). (Pubmed)
Mikkola ML, Thesleff I. Ectodysplasin signaling in development. Cytokine Growth Factor Rev 14: 211-24 (2003). (Pubmed)
Thesleff I, Mikkola ML. Growth factors in tooth development. Int Rev Cytol 271: 93-135 (2002). (Pubmed)
Thesleff I, Mikkola ML. Death domain signaling giving life to ectodermal organs. Science’s STKE. (2002). (Pubmed)