The actin cytoskeleton provides force for dynamic cellular processes, such as motility, morphogenesis, cell division, endocytosis, and phagocytosis. The organization and dynamics of actin filament must be precisely controlled during these processes, and consequently defects in regulation of the actin cytoskeleton lead to various diseases including cancer progression, as well as neurological and immunological disorders. Our group uses a wide range of biophysical, biochemical, cell biological, and genetic approaches to uncover the general principles underlying regulation of the actin cytoskeleton, and to reveal how defects in actin dynamics affect the physiological functions of cells.

On social media

@LabLappalainen

We are happy to introduce the new postdoc in the lab, Lina Antenucci. And her lovely dog Pepe who visited as today! https://t.co/9Zjs8JBJAE

Now out in @naturemethods! We report an efficient auxin-inducible degron system with low basal degradation in human… twitter.com/i/web/status/1…

Our paper combining site-directed mutagenesis and molecular simulations of #mitochondrial complex I is now accepted… twitter.com/i/web/status/1…