The ERC Consolidator Grant is a grant scheme targeted at successful researchers for consolidating their research group and establishing an impactful career in Europe.
Consolidator Grants are available to distinguished researchers who have conducted research for 7 to 12 years after their doctoral graduation. In addition, grant recipients are required to have a scientific track record that shows great promise and an excellent research proposal.
Their field of research is not restricted.
In his ERC-funded project, Jaan-Olle Andressoo is looking for a cure for Parkinson's disease from a new perspective: by boosting the physiological processes of the brain itself.
The project is aimed at developing a new, safe and efficacious form of treatment for Parkinson’s disease as well as demonstrating its feasibility.
Andressoo’s research findings will increase the understanding of the physiological role of the glial cell line-derived neurotrophic factor (GDNF) in the functioning of the brain’s dopamine systems. The research conducted by Andressoo’s group is key to the development of novel treatment forms for Parkinson’s disease as well as, among others, substance dependence, ADHD and bipolar disorder.
Andressoo’s group has demonstrated that GDNF is a significant physiological regulator of the function of the brain's dopaminergic neurons.
Gene knock-up via 3’UTR targeting to treat Parkinson’s disease, 2017–2022.
In his ERC-funded project, Mikko Niemi is developing a mathematical model based on systems pharmacology that takes into consideration all individual factors affecting cholesterol medication.
Partly due to adverse effects, as many as a quarter of patients stop taking their cholesterol drugs within a year, even if when the drug is supposed to be taken indefinitely.
The project’s aim is to design a mathematical model that
Once the model developed by Niemi is completed, it can be used to choose the most appropriate cholesterol medication for individual patients. As a result, patients will better tolerate the prescribed drug, while cardiovascular disease mortality may be significantly reduced.
Niemi has already identified mutations which impact the effectiveness of cholesterol medication or increase their adverse effects.
Individualizing statin therapy by using a systems pharmacology decision support algorithm, 2017–2022.
Previously, Niemi conducted research with a Starting Grant awarded by the ERC.
In his ERC-funded project, Timo Laaksonen investigates how to release, in a controlled manner, drugs in the body using blue or UV light.
Compared to more commonly used red light, blue light offers broader opportunities for drug release. For example, the energy of blue or ultraviolet light is enough to detach the drug molecules attached to the surface of a nanocarrier.
Laaksonen’s project aims to understand how to safely target blue or UV light to the site where the drug should be released. Previously, the challenge in using UV light has been its penetration depth in tissue, which even at its best is roughly the breadth of a single hair. In addition, UV light can damage the body.
Blue light could be precisely targeted by upconverting photons to a higher energy level inside the body or by utilising various drug implants activated by light.
Through photodynamic activation, drugs could be released, for example, at a certain time every morning, in addition to which the release rate could be continually adjusted to suit the patient.
PADRE, Photoactivatable Drug Releasing Implants, 2021–2025.
Tuomo Kuusi’s ERC-funded project investigates, both in theory and practice, challenging problems associated with new quantitative theory.
Kuusi’s project focuses on problems that reside in the intersection of probability theory, partial differential equations and the calculus of variations. These areas are united by stochastic homogenisation: the study of large-scale statistical properties of solutions to equations with random coefficients.
The practical applications of Kuusi’s research include mathematical approaches and methods of calculus that support the operations of geothermal power plants. The potential of geothermal energy as a source of district heating is great, as long as the phenomena associated with geophysics are increasingly effectively modelled.
In recent years, Kuusi has actively contributed to major advancements in the development of quantitative theory.
Quantitative stochastic homogenization of variational problems, 2019–2023.
Kirsi S. Mikkonen’s ERC-funded project aims to develop nano-sized particles that have two differently behaving faces, so called Janus particles. Such architecture makes the particles function in a special way at material interfaces, like stabilizing an oil droplet surface in an emulsion. To achieve this, the project will utilize sustainable biopolymers and green technologies.
The main aims of the project are to:
Mikkonen’s project will create new understanding of emulsions, which are key materials in food, pharmaceuticals, cosmetics, and various chemicals. The project will develop a green route to new materials, which allows using our natural resources more sustainably. In the future, this research will help companies produce daily used commodities with less burden for the environment.
Kirsi S. Mikkonen explores the combination of wood-based raw materials in food matrices. Her earlier research showed that hemicelluloses efficiently stabilize food structures. Hemicelluloces can be recovered from side streams of wood and grain production. Mikkonen also develops fungal biomass for value-added materials, and studies active packaging to prevent food waste. Active packaging interacts with its contents to e.g. increase shelf life.
Green route to wood-derived Janus particles for stabilized interfaces (PARTIFACE) 2020–2025.
Peter H. Johansson’s ERC funded project studies what happens, when supermassive black holes merge.
Johansson’s project aims to model, at unprecedented accuracy, the small-scale dynamics of merging supermassive black holes in global galactic-scale simulations of massive galaxies. The project uses a new Helsinki-developed simulation code KETJU and Finnish national supercomputers to run simulations.
The main aims of the project are to
Johansson’s project will create a more complete understanding of how merging supermassive black holes affect the evolution of massive galaxies. The project will provide simulated predictions of the expected electromagnetic and gravitational wave signals from merging supermassive black holes. These predictions provide a comparison point for observations by current and future space-missions.
Johansson’s research has showed that mergers of supermassive black holes are responsible for producing diffuse low-stellar density cores in massive galaxies by ejecting stars in complex three-body interactions. Johansson works broadly on many topics in theoretical astrophysics, including the formation and evolution of supermassive black holes, massive early-type galaxies and massive stellar clusters.
Post-Newtonian modelling of the dynamics of supermassive black holes in galactic-scale hydrodynamical simulations (KETJU) 2019–2024.
Kristiina Mannermaa’s ERC funded project investigates social links between humans and animals in hunter-gatherer burial sites in north-eastern Europe, ca 9,000–7,500 years ago. The project combines various bioarchaeological research methods to study the life histories of humans, animals and animal-derived artefacts in prehistoric burial sites.
The main aims of the project are to:
Mannermaa’s project provides new understanding of how northern hunter-gatherers created their cultures and identities together with animals which they were dependent on. The project investigates how this prehistoric identity developed and how it has transmitted to modern cultures in northern areas. Knowledge about past human-animal relations from thousands of years ago can also help understand and evaluate our own attitudes towards animals.
Mannermaa has previously studied the roles of birds in prehistoric societies, and carried out pioneering work in the early faunal history of mammals and birds in Fennoscandia, the Baltic region and Russia. Mannermaa is internationally known, for example for her extensive research and skills in analysing burnt and fragmented osseous materials. Her research group has developed a method to find and identify hairs and feathers in thousands of years old soil samples.
The Animals Make Identities: The Social Bioarchaeology of Late Mesolithic and Early Neolithic Cemeteries in North-East Europe (AMI) 2020–2025.
Anna-Liisa Laine’s ERC-funded project investigates the functioning and evolution of resistance under the simultaneous attack of different pathogens.
Laine’s research is focused on the virus communities of wild plants. Nature is host to an enormously broad spectrum of viral diversity, which science has only in recent years been able to effectively describe. Many unanswered questions are still associated with the interaction between hosts and their virus communities.
The project aims to provide answers to the following three key questions:
The project produces new information on the formation of virus communities in nature, and how their diversity impacts the functioning and evolution of their host plants’ resistance. The research helps to understand the mechanisms that regulate pathogens in the wild. In the long run, Laine’s research may also be helpful in preventing plant diseases and reducing the use of biocides.
Laine’s research group has demonstrated that the structure of the virus communities of wild plants varies considerably between both individual hosts and populations, while the genetic variation of the host species explains most of the variation among virus communities.
Interaction between pathogens also affects the incidence of diseases in the wild. The earlier in the growing season a plant is infected, the more pathogenic strains it is infected with when the summer ends.
Resistance evolution in response to spatially variable pathogen communities, 2017–2022.
Previously, Laine conducted research with a Starting Grant awarded by the ERC.
Kaius Tuori’s ERC-funded project investigates the tension between the private and the public.
Separating the office and its holder as well as binding the administration of the office to law, legally stipulated procedures and places is one of the most important premises of republican administration. In other words, the work of public offices should be carried out publicly in a public space. From the ancient Roman Republic, this has been associated with a contradiction: how can the ideal of equality be realised if there are no public spaces?
Tuori’s project investigates the conflict between the ideal of republican administration and the reality, observing not only republican theory and practice throughout European history, but also the structure of urban areas and their public spaces.
The project focuses on the built environment, allowing the researchers to analyse changes in social relationships and structures as well as ideologies and justice in a new way. The project investigates how the tension between the private and the public evolves and shapes the republican tradition starting from ancient Rome.
The republican ideals from the rule of law to equality are central also to the successes and problems of Finnish society. By shedding light on the significance of public space and the transparency of administration in the republican tradition, the project highlights the changes in self-understanding faced also by Finnish administration.
Law, Governance and Space: Questioning the Foundations of the Republican Tradition (SpaceLaw), 2018–2023.
Previously, Tuori received a Starting Grant from the ERC for the FoundLaw project, which focused on the development of the idea of European judicial tradition after the Second World War.
Tuori also heads the Academy of Finland’s Centre of Excellence in Law, Identity and the European Narratives.
Emilia Kilpua’s ERC-funded project investigates the magnetic fields of the Sun’s coronal mass ejections, which are enormous magnetic clouds of plasma.
So far, the magnetic field of flux ropes associated with the ejections cannot be predicted, and the structure of the turbulent area in front of the ejections, known as the sheath region, remains unknown. Kilpua’s project is developing novel techniques for predicting magnetic fields and is investigating in detail sheath regions in the solar wind.
The project has three primary goals:
The Sun’s coronal mass ejections are the underlying cause of almost all major storms in Earth’s inner space. The magnetic field of the ejections cannot be reliably predicted, as measuring and modelling it in the corona is very challenging. The results of Kilpua’s project will help to considerably improve space weather forecasts.
Kilpua’s group has developed a model that predicts the structure of the ejection’s flux rope down in the corona, utilising magnetic field observations on the Sun’s surface. The group has concluded a comprehensive analysis of plasma waves and turbulence in the sheath regions of solar ejections.
The Structure and Evolution of Solar Magnetic Flux Ropes and Their Magnetosheaths (SolMAG), 2017–2022.
Minna Palmroth’s ERC-funded project focuses on space weather and how to model and forecast it better.
Space weather denotes the conditions in Earth’s inner space, which may cause harm to technical devices or human health. Space weather phenomena are caused by particle streams originating in the Sun, or solar wind, and the Earth’s magnetic field. In Palmroth’s project, these phenomena are investigated by combining top-level expertise in space physics with high-performance computing.
The project’s primary goals are
Palmroth’s project produces new knowledge pertaining to space weather, providing results that will help to measure and predict space weather with increasing accuracy. Among other things, improved space weather forecasts assist in avoiding damage caused by space weather to satellites and electrical grids.
Palmroth’s group has developed an entirely new kind of method for modelling space weather known as Vlasiator, currently the world’s most accurate large-scale depiction of Earth’s inner space.
Plasma Reconnection, Shocks and Turbulence in Solar System Interactions: Modelling and Observations, 2016–2022.
Aleksi Vuorinen’s ERC funded project investigates how ordinary matter behaves at the most extreme densities found in our present-day Universe: inside the cores of neutron stars. Under the immensely strong gravitational fields there, even atomic nuclei – let alone single atoms – break apart. This likely creates an entirely new phase of matter, which consists of liberated quarks and gluons.
The central questions of Vuorinen’s project are:
A definite confirmation of the existence of quark matter inside neutron stars would be a milestone result in particle physics and astrophysics. It will likely occur through an intense collaboration between many different research groups. Vuorinen’s group has already taken some very promising steps in this direction. In 2020, they were able to present the first-ever model-independent evidence for the presence of quark matter cores.
Vuorinen has worked extensively on determining the properties of dense quark matter. His group is responsible for state-of-the-art results for many different physical quantities. He has also frequently applied these results to the study of neutron stars, and has significantly decreased our current uncertainties in the thermodynamic properties of neutron star matter.
High-density QCD matter from first principles (DenseMatter), 2017–2022.
Pipsa Saharinen’s ERC-funded project investigates the permeability of blood vessel walls and how to improve the functioning of the vascular system in the case of severe inflammation.
The function of the cardiovascular system is dependent on the condition of the vascular system. In the case of septicaemia, its most severe form, septic shock, and many other diseases, the walls of the body’s smallest capillaries leak, with an unusual amount of fluid oozing into the tissue. At its worst, this can result in the disruption of vital functions.
Saharinen’s project seeks mechanisms that regulate the integrity and permeability of blood vessels, as well as the opportunity to utilise these regulatory mechanisms in the development of vascular therapies.
The project’s primary goals are to
Leaking blood vessels constitute a substantial problem, and they are a factor also in severe types of Covid-19. Increased permeability in blood vessel walls reduces the passage of blood and the supply of oxygen to tissues, maintaining swelling and inflammation. Mechanisms that could be targeted with drugs that would reduce the permeability of blood vessels are not known.
Earlier, Saharinen’s group has identified mechanisms used by a vascular growth factor known as angiopoietin 2 to weaken the cell junctions in blood vessels. Their findings serve as a starting point for the ERC-funded project.
ANTILEAK, Development of antagonists against vascular leakage, 2018–2023.
Sara A. Wickström’s ERC funded project investigates how adult stem cells that are present in most of our tissues, are regulated to maintain tissue function and regenerate them after injury.
Wickström’s project focuses on skin epidermis and hair follicle stem cells. As the skin constantly self-renews and regenerates through activity of epidermal and hair follicle stem cells, these cells provide a powerful, clinically relevant model system.
The main aims of the project are to:
The results of Wickström’s project will likely lay foundations for developing pharmacological treatments that boost the tissues own regenerative potential, which might be more effective and safer than stem cell transplantation.
Research in Wickström’s group focuses on understanding how complex tissues such as the skin are formed, maintained and regenerated, and how cancer escapes these structural and cell state barriers to uncontrolled growth.
Recent key discoveries include how mechanical force can alter nuclear and chromatin architecture to regulate stem cell state and protect stem cell DNA from damage. The group has further uncovered a critical role for the metabolic state of the stem cell in regulating its state and long term maintenance of the stem cell pool.
Mechanisms of stem cell population dynamics and reprogramming (STEMpop) 2018–2023.
Jörg Tiedemann’s ERC funded project examines how translations of documents can help teach a machine to understand the meanings of text.
Humans use language in versatile ways. That makes it difficult for a machine to map text back to the ideas we try to communicate. This project uses translations into a large variety of languages to teach a machine to pick up the intended meaning of a text.
The project’s main aims are to develop:
Natural language processing has more impact on society than most people realise. Tiedemann’s research can, among other things, help avoid misguided decisions based on incorrect machine interpretations and reduce linguistic barriers that prevent people in certain groups from participating in an information-based society.
Tiedemann has been involved in research and development that has influenced language technology worldwide. Resources that he has been involved in developing include e.g. OPUS, the biggest collection of public translation data to date, and open translation tools such as the Finnish-Swedish translation engine fiksmö.
Found in Translation – Natural Language Understanding with Cross-Lingual Grounding, 2018–2023.
Ari Pekka Mähönen’s ERC funded project studies how trees grow thicker.
Mähönen’s project uses the thale cress, or Arabidopsis thaliana, root as a model to investigate the development of cork and vascular cambium. All the growth originates from stem cells. While stem cells of vascular cambium produce xylem (wood) and phloem, stem cells of cork cambium produce a protective layer at the surface called phellem (cork).
The main aims of this project are to:
Mähönen’s group aims to provide detailed understanding of the regulatory mechanisms driving wood and cork formation first in the Arabidopsis thaliana, and then in trees. This will lay the foundation for further studies on radial thickening and provide the basis for manipulation of radial growth in crop plants and trees.
By combining lineage tracing with molecular genetics, Mähönen’s research group showed for the first time a molecular mechanism positioning and specifying the stem cells of vascular cambium in the Arabidopsis thaliana root. The techniques learned during this key study are used in the current study to identify the stem cells of cork cambium.
Thickening of plant organs by nested stem cells (CORKtheCAMBIA), 2019-2024.
Miia Lindström’s ERC-funded project investigates why and in what conditions the Clostridium botulinum bacterium produces the lethal botulinum toxin, also known as botox.
Even though the C. botulinum bacterium has been known for roughly two centuries, it remains interesting for its neurotoxin production. Already at a quantity of one millionth of a gram, botulin causes botulism, which manifests as quadriplegia in humans and animals.
The project’s aim is to expand the knowledge previously gained by Lindström’s group on the functioning of a single repressor to a comprehensive understanding of how and in what kind of conditions C. botulinum produces the neurotoxin.
Lindström’s research will uncover the cellular connection between the production of the botulinum toxin and spore formation, which will open new avenues for controlling the food safety and public health risks caused by the C. botulinum bacterium.
Project name and duration
Why does Clostridium botulinum kill? – In search for botulinum neurotoxin regulators, 2017–2021.
The aim of Tuomas Tahko’s ERC-funded project is to develop a new theory on the unity of knowledge.
In the project, Tahko utilises cases from biology, chemistry and physics, observing what it means when a certain scientific phenomenon can be explained through another phenomenon, and examining what conditions we can set for the unity of science.
Unity criteria that can be applied to multiple disciplines would be very useful tools for determining the expertise needed for understanding specific phenomena.
Tahko has transferred to the University of Bristol.
The Metaphysical Unity of Science, 2018–2023.
Vincenzo Cerullo’s ERC funded project uses viruses as trojan horses to push the human body to fight cancer. The human immune system is programmed to fight viruses but not to fight cancer, because cancer originate from our own tissues.
Cerullo’s approach is to attach pieces of tumor called tumor-antigens onto the surface of common cold viruses. Once these viruses are in the body, the body tries to eliminate the virus. Because the virus is covered with tumor antigens, the body also starts to attack the tumor as if the tumor were a virus. Cerullo calls this technology PeptiCRAd, “a virus in tumor’s clothing”.
The main aims of this project are to
Cerullo’s project seeks to create a personalized cancer vaccine. Among the project’s many results are several different patents and invention disclosures, a spin-off company and applications of the PeptiCRAd technology to potential and existing COVID-19 vaccines.
Cerullo is among the first to demonstrate that oncolytic viruses exert their efficacy through their interaction with the immune system. Cerullo’s group has also demonstrated that the PeptiCRAd technology is an efficient way to control the quality and the amolitude of the anti-tumor immune response after oncolytic virus treatments.
Cerullo’s team has also developed a microfluidic-based chip to rapidly scan patients’ tumors and design personalized cancer vaccine.
Project name and duration
Personalized oncolytic vaccines for cancer immunotherapy: PeptiCrad, 2016–2021.