Many congrats to Ariella Machness, PhD student from UCLA, and looking forward to welcome you to my lab.
Multiple drug resistance (MDR), the mechanism by which cancers develop resistance to chemotherapeutic drugs, is a major limitation for effective cancer treatment. One approach to overcome MDR is to co-deliver small interfering RNA (siRNA) and a chemotherapeutic in porous silicon nanoparticles. This project aims to formulate magnetically responsive porous silicon nanoparticles delivering siRNA/chemotherapeutics to shed light on how siRNA delivery can be remotely-controlled. This work will use both magnetic manipulation and heating to improve siRNA localization and controlled release at a tumor site.
More info about the project can be found in here
More info can be found from the Academy of Finland website in here