Publications of BIU

List of publications where BIU facilities were utilized. Please note that if you have used BIU equipment or other services for your publication, you are expected to acknowledge BIU in your article and inform us about your publication.
2023
  • Ahlstrom, F.H., Viisanen, H., Karhinen, L., Matlik, K., Blomqvist, K.J., Lilius, T.O., Sidorova, Y.A., Palada, V., Rauhala, P.V., Kalso, E.A. The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord. Mol Pain. 2023; 19:17448069231183902.
  • Anisimov, A., Fang, S., Hemanthakumar, K.A., Ord, T., van Avondt, K., Chevre, R., Toropainen, A., Singha, P., Gilani, H., Nguyen, S.D., Karaman, S., Korhonen, E.A., Adams, R.H., Augustin, H.G., Oorni, K., Soehnlein, O., Kaikkonen, M.U., Alitalo, K. The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium. Nat Cardiovasc Res. 2023; 2:307-21.
  • Awashra, M., Elomaa, P., Ojalehto, T., Saavalainen, P., Jokinen, V. Superhydrophilic/Superhydrophobic Droplet Microarrays of Low Surface Tension Biofluids for Nucleic Acid Detection. Advanced Materials Interfaces. 2023; 11:2300596.
  • Basnet, S., Santos, J.M., Quixabeira, D.C.A., Clubb, J.H.A., Gronberg-Vaha-Koskela, S.A.M., Arias, V., Pakola, S., Kudling, T.V., Heinio, C., Havunen, R., Cervera-Carrascon, V., Sorsa, S., Anttila, M., Kanerva, A., Hemminki, A. Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors. Mol Ther Oncolytics. 2023; 28:59-73.
  • Belitskin, D., Munne, P., Pant, S.M., Anttila, J.M., Suleymanova, I., Belitskina, K., Kirchhofer, D., Janetka, J., Kasper, T., Jalil, S., Pouwels, J., Tervonen, T.A., Klefstrom, J. Hepsin promotes breast tumor growth signaling via the TGFbeta-EGFR axis. Mol Oncol. 2023.
  • Chernyaeva, L., Ratti, G., Teirila, L., Fudo, S., Rankka, U., Pelkonen, A., Korhonen, P., Leskinen, K., Keskitalo, S., Salokas, K., Gkolfinopoulou, C., Crompton, K.E., Javanainen, M., Happonen, L., Varjosalo, M., Malm, T., Leinonen, V., Chroni, A., Saavalainen, P., Meri, S., Kajander, T., Wollman, A.J., Nissila, E., Haapasalo, K. Reduced binding of apoE4 to complement factor H promotes amyloid-beta oligomerization and neuroinflammation. EMBO Rep. 2023; 24:e56467.
  • Danti, L., Lundin, K., Sepponen, K., Yohannes, D.A., Kere, J., Tuuri, T., Tapanainen, J.S. CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate. J Ovarian Res. 2023; 16:194.
  • Dumesnil, C., Vanharanta, L., Prasanna, X., Omrane, M., Carpentier, M., Bhapkar, A., Enkavi, G., Salo, V.T., Vattulainen, I., Ikonen, E., Thiam, A.R. Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols. Nat Commun. 2023; 14:915.
  • Eskici, N., Madhusudan, S., Vaaralahti, K., Yellapragada, V., Gomez-Sanchez, C., Karkinen, J., Almusa, H., Brandstack, N., Miettinen, P.J., Wang, Y., Raivio, T. Congenital hypogonadotropic hypogonadism in a patient with a de novo POGZ mutation. Eur J Endocrinol. 2023; 189:271-80.
  • Fei, L., Zhang, K., Poddar, N., Hautaniemi, S., Sahu, B. Single-cell epigenome analysis identifies molecular events controlling direct conversion of human fibroblasts to pancreatic ductal-like cells. Dev Cell. 2023; 58:1701-15 e8.
  • Fred, S.M., Moliner, R., Antila, H., Engelhardt, K.A., Schluter, O.M., Casarotto, P.C., Castren, E. TRKB interaction with PSD95 is associated with latency of fluoxetine and 2R,6R-hydroxynorketamine. Eur J Neurosci. 2023; 57:1215-24.
  • Hasan, M.R., Koskenranta, A., Alakurtti, K., Takatalo, M., Rice, D.P. RAB23 regulates musculoskeletal development and patterning. Front Cell Dev Biol. 2023; 11:1049131.
  • Heilala, M., Lehtonen, A., Arasalo, O., Peura, A., Pokki, J., Ikkala, O., Nonappa, Klefstrom, J., Munne, P.M. Fibrin Stiffness Regulates Phenotypic Plasticity of Metastatic Breast Cancer Cells. Adv Healthc Mater. 2023; 12:e2301137.
  • Ignatenko, O., Malinen, S., Rybas, S., Vihinen, H., Nikkanen, J., Kononov, A., Jokitalo, E.S., Ince-Dunn, G., Suomalainen, A. Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes. J Cell Biol. 2023; 222.
  • Ikonen, L., Pirnes-Karhu, S., Pradhan, S., Jacobs, H.T., Szibor, M., Suomalainen, A. Alternative oxidase causes cell type- and tissue-specific responses in mutator mice. Life Sci Alliance. 2023; 6.
  • Jyske, T., Liimatainen, J., Tienaho, J., Brannstrom, H., Aoki, D., Kuroda, K., Reshamwala, D., Kunnas, S., Halmemies, E., Nakayama, E., Kilpelainen, P., Ora, A., Kaseva, J., Hellstrom, J., Marjomaki, V.S., Karonen, M., Fukushima, K. Inspired by nature: Fiber networks functionalized with tannic acid and condensed tannin-rich extracts of Norway spruce bark show antimicrobial efficacy. Front Bioeng Biotechnol. 2023; 11:1171908.
  • Khanal, P., Boskovic, Z., Lahti, L., Ghimire, A., Minkeviciene, R., Opazo, P., Hotulainen, P. Gas7 Is a Novel Dendritic Spine Initiation Factor. eNeuro. 2023; 10.
  • Koskinen, M.K., Laine, M., Abdollahzadeh, A., Gigliotta, A., Mazzini, G., Journee, S., Alenius, V., Trontti, K., Tohka, J., Hyytia, P., Sierra, A., Hovatta, I. Node of Ranvier remodeling in chronic psychosocial stress and anxiety. Neuropsychopharmacology. 2023; 48:1532-40.
  • Kudling, T.V., Clubb, J.H.A., Pakola, S., Quixabeira, D.C.A., Lahdeniemi, I.A.K., Heinio, C., Arias, V., Havunen, R., Cervera-Carrascon, V., Santos, J.M., Sutinen, E., Rasanen, J., Borenius, K., Mayranpaa, M.I., Aaltonen, E., Sorsa, S., Hemminki, O., Kanerva, A., Verschuren, E.W., Ilonen, I., Hemminki, A. Effective intravenous delivery of adenovirus armed with TNFalpha and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer. Oncoimmunology. 2023; 12:2241710.
  • Kuusanmaki, H., Dufva, O., Vaha-Koskela, M., Leppa, A.M., Huuhtanen, J., Vanttinen, I., Nygren, P., Klievink, J., Bouhlal, J., Polonen, P., Zhang, Q., Adnan-Awad, S., Mancebo-Perez, C., Saad, J., Miettinen, J., Javarappa, K.K., Aakko, S., Ruokoranta, T., Eldfors, S., Heinaniemi, M., Theilgaard-Monch, K., Wartiovaara-Kautto, U., Keranen, M., Porkka, K., Konopleva, M., Wennerberg, K., Kontro, M., Heckman, C.A., Mustjoki, S. Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia. Blood. 2023; 141:1610-25.
  • Lemmetyinen, T.T., Viitala, E.W., Wartiovaara, L., Kaprio, T., Hagstrom, J., Haglund, C., Katajisto, P., Wang, T.C., Domenech-Moreno, E., Ollila, S. Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth. Dis Model Mech. 2023; 16.
  • Li, Z., Antila, S., Nurmi, H., Chilov, D., Korhonen, E.A., Fang, S., Karaman, S., Engelhardt, B., Alitalo, K. Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation. Sci Immunol. 2023; 8:eabq0375.
  • Martinez-Fernandez, C., Jha, S., Aliagas, E., Holmberg, C.I., Nadal, E., Ceron, J. BAP1 Malignant Pleural Mesothelioma Mutations in Caenorhabditis elegans Reveal Synthetic Lethality between ubh-4/BAP1 and the Proteasome Subunit rpn-9/PSMD13. Cells. 2023; 12.
  • Moliner, R., Girych, M., Brunello, C.A., Kovaleva, V., Biojone, C., Enkavi, G., Antenucci, L., Kot, E.F., Goncharuk, S.A., Kaurinkoski, K., Kuutti, M., Fred, S.M., Elsila, L.V., Sakson, S., Cannarozzo, C., Diniz, C., Seiffert, N., Rubiolo, A., Haapaniemi, H., Meshi, E., Nagaeva, E., Ohman, T., Rog, T., Kankuri, E., Vilar, M., Varjosalo, M., Korpi, E.R., Permi, P., Mineev, K.S., Saarma, M., Vattulainen, I., Casarotto, P.C., Castren, E. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nat Neurosci. 2023; 26:1032-41.
  • Monzo, H.J., Kalander, K., Hyytiainen, M.M., Elbasani, E., Wall, J., Moyano-Galceran, L., Tanjore Ramanathan, J., Jukonen, J., Laakkonen, P., Ristimaki, A., Carlson, J.W., Lehti, K., Salehi, S., Puolakkainen, P., Haglund, C., Seppanen, H., Leppa, S., Ojala, P.M. Efficacy and Safety of Glycosphingolipid SSEA-4 Targeting CAR-T Cells in an Ovarian Carcinoma Model. Mol Cancer Ther. 2023; 22:1319-31.
  • Nagaeva, E., Schafer, A., Linden, A.M., Elsila, L.V., Egorova, K., Umemori, J., Ryazantseva, M., Korpi, E.R. Somatostatin-Expressing Neurons in the Ventral Tegmental Area Innervate Specific Forebrain Regions and Are Involved in Stress Response. eNeuro. 2023; 10:ENEURO.0149-23.2023.
  • Nahse, V., Raiborg, C., Tan, K.W., Mork, S., Torgersen, M.L., Wenzel, E.M., Nager, M., Salo, V.T., Johansen, T., Ikonen, E., Schink, K.O., Stenmark, H. ATPase activity of DFCP1 controls selective autophagy. Nat Commun. 2023; 14:4051.
  • Paavonsalo, S., Subashi, Y., Lackman, M.H., Karaman, S. Whole-mount immunofluorescence staining of blood and lymphatic vessels in murine small intestine. STAR Protoc. 2023; 4:102310.
  • Pispa, J., Mikkonen, E., Arpalahti, L., Jin, C., Martinez-Fernandez, C., Ceron, J., Holmberg, C.I. AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans. iScience. 2023; 26:107886.
  • Rantataro, S., Parkkinen, I., Airavaara, M., Laurila, T. Real-time selective detection of dopamine and serotonin at nanomolar concentration from complex in vitro systems. Biosens Bioelectron. 2023; 241:115579.
  • Scharaw, S., Sola-Carvajal, A., Belevich, I., Webb, A.T., Das, S., Andersson, S., Pentinmikko, N., Villablanca, E.J., Goldenring, J.R., Jokitalo, E., Coffey, R.J., Katajisto, P. Golgi organization is a determinant of stem cell function in the small intestine. bioRxiv. 2023.
  • Steffens, S.K., Stenberg, T.H., Wigren, H.M. Alterations in microglial morphology concentrate in the habitual sleeping period of the mouse. Glia. 2023; 71:366-76.
  • Stratoulias, V., Ruiz, R., Kanatani, S., Osman, A.M., Keane, L., Armengol, J.A., Rodriguez-Moreno, A., Murgoci, A.N., Garcia-Dominguez, I., Alonso-Bellido, I., Gonzalez Ibanez, F., Picard, K., Vazquez-Cabrera, G., Posada-Perez, M., Vernoux, N., Tejera, D., Grabert, K., Cheray, M., Gonzalez-Rodriguez, P., Perez-Villegas, E.M., Martinez-Gallego, I., Lastra-Romero, A., Brodin, D., Avila-Carino, J., Cao, Y., Airavaara, M., Uhlen, P., Heneka, M.T., Tremblay, M.E., Blomgren, K., Venero, J.L., Joseph, B. ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain. Nat Neurosci. 2023; 26:1008-20.
  • Talvio, K., Wagner, V.A., Minkeviciene, R., Kirkwood, J.S., Kulinich, A.O., Umemori, J., Bhatia, A., Hur, M., Kakela, R., Ethell, I.M., Castren, M.L. An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis. Commun Biol. 2023; 6:789.
  • Tanjore Ramanathan, J., Zarybnicky, T., Filppu, P., Monzo, H.J., Monni, O., Tervonen, T.A., Klefstrom, J., Kerosuo, L., Kuure, S., Laakkonen, P. Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization. Sci Rep. 2023; 13:17162.
  • Tuohinto, K., DiMaio, T.A., Kiss, E.A., Laakkonen, P., Saharinen, P., Karnezis, T., Lagunoff, M., Ojala, P.M. KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi's sarcoma studies. PLoS Pathog. 2023; 19:e1010753.
  • Ucar, M.C., Hannezo, E., Tiilikainen, E., Liaqat, I., Jakobsson, E., Nurmi, H., Vaahtomeri, K. Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks. Nat Commun. 2023; 14:5878.
  • Vaid, S., Heikinheimo, O., Namba, T. Embryonic mouse medial neocortex as a model system for studying the radial glial scaffold in fetal human neocortex. J Neural Transm (Vienna). 2023; 130:185-94.
  • Valimaki, N., Jokinen, V., Cajuso, T., Kuisma, H., Taira, A., Dagnaud, O., Ilves, S., Kaukomaa, J., Pasanen, A., Palin, K., Heikinheimo, O., Butzow, R., Aaltonen, L.A., Karhu, A. Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas. Am J Hum Genet. 2023; 110:460-74.
  • Wahbi, W., Korelin, K., Sievilainen, M., Karihtala, P., Wilkman, T., Tarkkanen, J., Salo, T., Al-Samadi, A. Evaluation of in vitro and in vivo personalized cancer treatment assays for oral squamous cell carcinoma. Transl Oncol. 2023; 33:101677.
  • Zhu, Y., Kankuri, E., Zhang, X., Wan, Z., Wang, X., Huan, S., Bai, L., Liu, S., Rojas, O.J. Layer-by-Layer Deposition of Low-Solid Nanochitin Emulgels Creates Porous Structures for High Cell Attachment and Proliferation. ACS Appl Mater Interfaces. 2023; 15:27316-26.
2022
  • Al-Akhrass, H., Pietila, M., Lilja, J., Vesilahti, E.M., Anttila, J.M., Haikala, H.M., Munne, P.M., Klefstrom, J., Peuhu, E., Ivaska, J. Sortilin-related receptor is a druggable therapeutic target in breast cancer. Mol Oncol. 2022; 16:116-29.
  • Arora, A., Kivela, A.M., Wang, L., Minkeviciene, R., Taskinen, J.H., Zhang, B., Koponen, A., Sun, J., Shirane, M., Zhou, Y., Hotulainen, P., Raiborg, C., Olkkonen, V.M. Protrudin regulates FAK activation, endothelial cell migration and angiogenesis. Cell Mol Life Sci. 2022; 79:220.
  • Combot, Y., Salo, V.T., Chadeuf, G., Holtta, M., Ven, K., Pulli, I., Ducheix, S., Pecqueur, C., Renoult, O., Lak, B., Li, S., Karhinen, L., Belevich, I., Le May, C., Rieusset, J., Le Lay, S., Croyal, M., Tayeb, K.S., Vihinen, H., Jokitalo, E., Tornquist, K., Vigouroux, C., Cariou, B., Magre, J., Larhlimi, A., Ikonen, E., Prieur, X. Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes. Cell Rep. 2022; 38:110213.
  • Daura, E., Tegelberg, S., Hakala, P., Lehesjoki, A.E., Joensuu, T. Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity. Front Mol Neurosci. 2022; 15:1069122.
  • Dohla, J., Kuuluvainen, E., Gebert, N., Amaral, A., Englund, J.I., Gopalakrishnan, S., Konovalova, S., Nieminen, A.I., Salminen, E.S., Torregrosa Munumer, R., Ahlqvist, K., Yang, Y., Bui, H., Otonkoski, T., Kakela, R., Hietakangas, V., Tyynismaa, H., Ori, A., Katajisto, P. Metabolic determination of cell fate through selective inheritance of mitochondria. Nat Cell Biol. 2022; 24:148-54.
  • Gizaw, N.Y., Kallio, P., Punger, T., Gucciardo, E., Haglund, C., Bohling, T., Lehti, K., Sampo, M., Alitalo, K., Kivela, R. PROX1 transcription factor controls rhabdomyosarcoma growth, stemness, myogenic properties and therapeutic targets. Proc Natl Acad Sci U S A. 2022; 119:e2116220119.
  • Gongalsky, M.B., Muftieva, D.A., Saarinen, J.K.S., Isomaki, A., Pervushin, N.V., Kopeina, G.S., Peltonen, L.J., Strachan, C.J., Zhivotovsky, B., Santos, H.A., Osminkina, L.A. Nonresonant CARS Imaging of Porous and Solid Silicon Nanoparticles in Human Cells. ACS Biomater Sci Eng. 2022; 8:4185-95.
  • Haase, R., Fazeli, E., Legland, D., Doube, M., Culley, S., Belevich, I., Jokitalo, E., Schorb, M., Klemm, A., Tischer, C. A Hitchhiker's guide through the bio-image analysis software universe. FEBS Lett. 2022; 596:2472-85.
  • Karaman, S., Paavonsalo, S., Heinolainen, K., Lackman, M.H., Ranta, A., Hemanthakumar, K.A., Kubota, Y., Alitalo, K. Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance. J Exp Med. 2022; 219:e20210565.
  • Karasev, M.M., Baloban, M., Verkhusha, V.V., Shcherbakova, D.M. Nuclear Localization Signals for Optimization of Genetically Encoded Tools in Neurons. Front Cell Dev Biol. 2022; 10:931237.
  • Karsten, L., Janson, N., Le Joncour, V., Alam, S., Muller, B., Tanjore Ramanathan, J., Laakkonen, P., Sewald, N., Muller, K.M. Bivalent EGFR-Targeting DARPin-MMAE Conjugates. Int J Mol Sci. 2022; 23.
  • Kokate, S.B., Ciuba, K., Tran, V.D., Kumari, R., Tojkander, S., Engel, U., Kogan, K., Kumar, S., Lappalainen, P. Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments. Nat Commun. 2022; 13:6032.
  • Korhonen, E.A., Murtomaki, A., Jha, S.K., Anisimov, A., Pink, A., Zhang, Y., Stritt, S., Liaqat, I., Stanczuk, L., Alderfer, L., Sun, Z., Kapiainen, E., Singh, A., Sultan, I., Lantta, A., Leppanen, V.M., Eklund, L., He, Y., Augustin, H.G., Vaahtomeri, K., Saharinen, P., Makinen, T., Alitalo, K. Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression. J Clin Invest. 2022; 132.
  • Kurtzeborn, K., Kwon, H.N., Iaroshenko, V., Faisal, I., Ambroz, M., Jin, X., Qureshi, T., Kupari, J., Ihermann-Hella, A., Vaananen, J., Tyynismaa, H., Bousova, I., Park, S., Kuure, S. Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK/ERK targets in embryonic kidney. BMC Biol. 2022; 20:112.
  • Kwon, H.N., Kurtzeborn, K., Iaroshenko, V., Jin, X., Loh, A., Escande-Beillard, N., Reversade, B., Park, S., Kuure, S. Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism. Development. 2022; 149.
  • Lackman, M.H., Subashi, Y., Karaman, S. A closer look at adipose tissue lymphatics and their markers. Curr Opin Hematol. 2022; 29:144-50.
  • Long, M., Sanchez-Martinez, A., Longo, M., Suomi, F., Stenlund, H., Johansson, A.I., Ehsan, H., Salo, V.T., Montava-Garriga, L., Naddafi, S., Ikonen, E., Ganley, I.G., Whitworth, A.J., McWilliams, T.G. DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion. EMBO J. 2022; 41:e109390.
  • Micinski, D., Lahti, L., Abouelezz, A. Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy (3D-SIM). J Vis Exp. 2022.
  • Mito, T., Vincent, A.E., Faitg, J., Taylor, R.W., Khan, N.A., McWilliams, T.G., Suomalainen, A. Mosaic dysfunction of mitophagy in mitochondrial muscle disease. Cell Metab. 2022; 34:197-208 e5.
  • Multamaki, E., Garcia de Fuentes, A., Sieryi, O., Bykov, A., Gerken, U., Ranzani, A.T., Kohler, J., Meglinski, I., Moglich, A., Takala, H. Optogenetic Control of Bacterial Expression by Red Light. ACS Synth Biol. 2022; 11:3354-67.
  • Nagaraj, M., Horing, M., Ahonen, M.A., Nguyen, V.D., Zhou, Y., Vihinen, H., Jokitalo, E., Liebisch, G., Nidhina Haridas, P.A., Olkkonen, V.M. GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth. J Lipid Res. 2022; 63:100259.
  • Pfisterer, S.G., Brock, I., Kanerva, K., Hlushchenko, I., Paavolainen, L., Ripatti, P., Islam, M.M., Kyttala, A., Di Taranto, M.D., Scotto di Frega, A., Fortunato, G., Kuusisto, J., Horvath, P., Ripatti, S., Laakso, M., Ikonen, E. Multiparametric platform for profiling lipid trafficking in human leukocytes. Cell Rep Methods. 2022; 2:100166.
  • Pirhonen, J., Szkalisity, A., Hagstrom, J., Kim, Y., Migh, E., Kovacs, M., Holtta, M., Peranen, J., Seppanen, H., Haglund, C., Gil, J., Rezeli, M., Malm, J., Horvath, P., Marko-Varga, G., Puolakkainen, P., Ikonen, E. Lipid Metabolic Reprogramming Extends beyond Histologic Tumor Demarcations in Operable Human Pancreatic Cancer. Cancer Res. 2022; 82:3932-49.
  • Quixabeira, D.C.A., Cervera-Carrascon, V., Santos, J.M., Clubb, J.H.A., Kudling, T.V., Basnet, S., Heinio, C., Gronberg-Vaha-Koskela, S., Anttila, M., Havunen, R., Kanerva, A., Hemminki, A. Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1. Oncoimmunology. 2022; 11:2028960.
  • Rantataro, S., Parkkinen, I., Pande, I., Domanskyi, A., Airavaara, M., Peltola, E., Laurila, T. Nanoscale geometry determines mechanical biocompatibility of vertically aligned nanofibers. Acta Biomater. 2022; 146:235-47.
  • Sepponen, K., Lundin, K., Yohannes, D.A., Vuoristo, S., Balboa, D., Poutanen, M., Ohlsson, C., Hustad, S., Bifulco, E., Paloviita, P., Otonkoski, T., Ritvos, O., Sainio, K., Tapanainen, J.S., Tuuri, T. Steroidogenic factor 1 (NR5A1) induces multiple transcriptional changes during differentiation of human gonadal-like cells. Differentiation. 2022; 128:83-100.
  • Sievilainen, M., Saavalainen, J., Adnan-Awad, S., Salo, T., Al-Samadi, A. IDO1 Inhibition Reduces Immune Cell Exclusion Through Inducing Cell Migration While PD-1 Blockage Increases IL-6 and -8 Secretion From T Cells in Head and Neck Cancer. Front Immunol. 2022; 13:812822.
  • Vaid, S., Heikinheimo, O., Namba, T. Embryonic mouse medial neocortex as a model system for studying the radial glial scaffold in fetal human neocortex. J Neural Transm (Vienna). 2022.
  • Virenque, A., Koivisto, H., Antila, S., Zub, E., Rooney, E.J., Miszczuk, D., Muller, A., Stoka, E., Marchi, N., Alitalo, K., Tanila, H., Noe, F.M. Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury. Brain Behav Immun Health. 2022; 23:100466.
  • Vuoristo, S., Bhagat, S., Hyden-Granskog, C., Yoshihara, M., Gawriyski, L., Jouhilahti, E.M., Ranga, V., Tamirat, M., Huhtala, M., Kirjanov, I., Nykanen, S., Krjutskov, K., Damdimopoulos, A., Weltner, J., Hashimoto, K., Recher, G., Ezer, S., Paluoja, P., Paloviita, P., Takegami, Y., Kanemaru, A., Lundin, K., Airenne, T.T., Otonkoski, T., Tapanainen, J.S., Kawaji, H., Murakawa, Y., Burglin, T.R., Varjosalo, M., Johnson, M.S., Tuuri, T., Katayama, S., Kere, J. DUX4 is a multifunctional factor priming human embryonic genome activation. iScience. 2022; 25:104137.
  • Wang, H., Segersvard, H., Siren, J., Perttunen, S., Immonen, K., Kosonen, R., Chen, Y.C., Tolva, J., Laivuori, M., Mayranpaa, M.I., Kovanen, P.T., Sinisalo, J., Laine, M., Tikkanen, I., Lakkisto, P. Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart Failure. Int J Mol Sci. 2022; 23.
  • Wang, Y., Madhusudan, S., Cotellessa, L., Kvist, J., Eskici, N., Yellapragada, V., Pulli, K., Lund, C., Vaaralahti, K., Tuuri, T., Giacobini, P., Raivio, T. Deciphering the Transcriptional Landscape of Human Pluripotent Stem Cell-Derived GnRH Neurons: The Role of Wnt Signaling in Patterning the Neural Fate. Stem Cells. 2022; 40:1107-21.
  • Yellapragada, V., Eskici, N., Wang, Y., Madhusudan, S., Vaaralahti, K., Tuuri, T., Raivio, T. FGF8-FGFR1 signaling regulates human GnRH neuron differentiation in a time- and dose-dependent manner. Dis Model Mech. 2022; 15.
  • Yoshihara, M., Kirjanov, I., Nykanen, S., Sokka, J., Weltner, J., Lundin, K., Gawriyski, L., Jouhilahti, E.M., Varjosalo, M., Tervaniemi, M.H., Otonkoski, T., Trokovic, R., Katayama, S., Vuoristo, S., Kere, J. Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2. Stem Cell Reports. 2022; 17:1743-56.
  • Zielke, N., Vaharautio, A., Liu, J., Kivioja, T., Taipale, J. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Dev Cell. 2022; 57:1024-36 e5.
2021
  • Almahmoudi, R., Salem, A., Hadler-Olsen, E., Svineng, G., Salo, T., Al-Samadi, A. The effect of interleukin-17F on vasculogenic mimicry in oral tongue squamous cell carcinoma. Cancer Sci. 2021; 112:2223-32.
  • Belitskin, D., Pant, S.M., Munne, P., Suleymanova, I., Belitskina, K., Hongisto, H.A., Englund, J., Raatikainen, T., Klezovitch, O., Vasioukhin, V., Li, S., Wu, Q., Monni, O., Kuure, S., Laakkonen, P., Pouwels, J., Tervonen, T.A., Klefstrom, J. Hepsin regulates TGFbeta signaling via fibronectin proteolysis. EMBO Rep. 2021; 22:e52532.
  • Bertling, E., Blaesse, P., Seja, P., Kremneva, E., Gateva, G., Virtanen, M.A., Summanen, M., Spoljaric, I., Uvarov, P., Blaesse, M., Paavilainen, V.O., Vutskits, L., Kaila, K., Hotulainen, P., Ruusuvuori, E. Carbonic anhydrase seven bundles filamentous actin and regulates dendritic spine morphology and density. EMBO Rep. 2021; 22:e50145.
  • Casarotto, P.C., Girych, M., Fred, S.M., Kovaleva, V., Moliner, R., Enkavi, G., Biojone, C., Cannarozzo, C., Sahu, M.P., Kaurinkoski, K., Brunello, C.A., Steinzeig, A., Winkel, F., Patil, S., Vestring, S., Serchov, T., Diniz, C., Laukkanen, L., Cardon, I., Antila, H., Rog, T., Piepponen, T.P., Bramham, C.R., Normann, C., Lauri, S.E., Saarma, M., Vattulainen, I., Castren, E. Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell. 2021; 184:1299-313 e19.
  • Dichlberger, A., Zhou, K., Back, N., Nyholm, T., Backman, A., Mattjus, P., Ikonen, E., Blom, T. LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles. Biochim Biophys Acta Mol Cell Biol Lipids. 2021; 1866:158855.
  • Duong, T.T., Isomaki, A., Paaver, U., Laidmae, I., Tonisoo, A., Yen, T.T.H., Kogermann, K., Raal, A., Heinamaki, J., Pham, T.M. Nanoformulation and Evaluation of Oral Berberine-Loaded Liposomes. Molecules. 2021; 26.
  • Filippou, A., Pehkonen, H., Karhemo, P.R., Vaananen, J., Nieminen, A.I., Klefstrom, J., Grenman, R., Makitie, A.A., Joensuu, H., Monni, O. ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2021; 13.
  • Filppu, P., Tanjore Ramanathan, J., Granberg, K.J., Gucciardo, E., Haapasalo, H., Lehti, K., Nykter, M., Le Joncour, V., Laakkonen, P. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight. 2021; 6.
  • Gongalsky, M.B., Muftieva, D.A., Saarinen, J.K.S., Isomaki, A., Pervushin, N.V., Kopeina, G.S., Peltonen, L.J., Strachan, C.J., Zhivotovsky, B., Santos, H.A., Osminkina, L.A. Nonresonant CARS Imaging of Porous and Solid Silicon Nanoparticles in Human Cells. ACS Biomater Sci Eng. 2021.
  • Hackman, P., Rusanen, S.M., Johari, M., Vihola, A., Jonson, P.H., Sarparanta, J., Donner, K., Lahermo, P., Koivunen, S., Luque, H., Soininen, M., Mahjneh, I., Auranen, M., Arumilli, M., Savarese, M., Udd, B. Dominant Distal Myopathy 3 (MPD3) Caused by a Deletion in the HNRNPA1 Gene. Neurol Genet. 2021; 7:e632.
  • Hakala, M., Wioland, H., Tolonen, M., Kotila, T., Jegou, A., Romet-Lemonne, G., Lappalainen, P. Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks. Nat Cell Biol. 2021; 23:147-59.
  • Heino, S., Fang, S., Lahde, M., Hogstrom, J., Nassiri, S., Campbell, A., Flanagan, D., Raven, A., Hodder, M., Nasreddin, N., Xue, H.H., Delorenzi, M., Leedham, S., Petrova, T.V., Sansom, O., Alitalo, K. Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas. Sci Adv. 2021; 7:eabj0512.
  • Helle, E., Ampuja, M., Dainis, A., Antola, L., Temmes, E., Tolvanen, E., Mervaala, E., Kivela, R. HiPS-Endothelial Cells Acquire Cardiac Endothelial Phenotype in Co-culture With hiPS-Cardiomyocytes. Front Cell Dev Biol. 2021; 9:715093.
  • Hemanthakumar, K.A., Fang, S., Anisimov, A., Mayranpaa, M.I., Mervaala, E., Kivela, R. Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells. Elife. 2021; 10.
  • Holmi, J.T., Raju, R., Ylönen, J., Subramaniyam, N., Lipsanen, H. Optical amplification by surface-plasmon-resonant Au grating substrates: Monolayer MoS2 with 170-fold second harmonic generation and 3-fold (off-resonance) Raman scattering. Superlattices and Microstructures. 2021; 160:107077.
  • Hujanen, R., Almahmoudi, R., Salo, T., Salem, A. Comparative Analysis of Vascular Mimicry in Head and Neck Squamous Cell Carcinoma: In Vitro and In Vivo Approaches. Cancers (Basel). 2021; 13.
  • Johari, M., Sarparanta, J., Vihola, A., Jonson, P.H., Savarese, M., Jokela, M., Torella, A., Piluso, G., Said, E., Vella, N., Cauchi, M., Magot, A., Magri, F., Mauri, E., Kornblum, C., Reimann, J., Stojkovic, T., Romero, N.B., Luque, H., Huovinen, S., Lahermo, P., Donner, K., Comi, G.P., Nigro, V., Hackman, P., Udd, B. Missense mutations in small muscle protein X-linked (SMPX) cause distal myopathy with protein inclusions. Acta Neuropathol. 2021; 142:375-93.
  • Jukonen, J., Moyano-Galceran, L., Hopfner, K., Pietila, E.A., Lehtinen, L., Huhtinen, K., Gucciardo, E., Hynninen, J., Hietanen, S., Grenman, S., Ojala, P.M., Carpen, O., Lehti, K. Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality. Sci Rep. 2021; 11:8856.
  • Karhu, S.T., Ruskoaho, H., Talman, V. Distinct Regulation of Cardiac Fibroblast Proliferation and Transdifferentiation by Classical and Novel Protein Kinase C Isoforms: Possible Implications for New Antifibrotic Therapies. Mol Pharmacol. 2021; 99:104-13.
  • Koester, J., Miroshnikova, Y.A., Ghatak, S., Chacon-Martinez, C.A., Morgner, J., Li, X., Atanassov, I., Altmuller, J., Birk, D.E., Koch, M., Bloch, W., Bartusel, M., Niessen, C.M., Rada-Iglesias, A., Wickstrom, S.A. Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Nat Cell Biol. 2021; 23:771-81.
  • Lahde, M., Heino, S., Hogstrom, J., Kaijalainen, S., Anisimov, A., Flanagan, D., Kallio, P., Leppanen, V.M., Ristimaki, A., Ritvos, O., Wu, K., Tammela, T., Hodder, M., Sansom, O.J., Alitalo, K. Expression of R-Spondin 1 in Apc(Min/+) Mice Suppresses Growth of Intestinal Adenomas by Altering Wnt and Transforming Growth Factor Beta Signaling. Gastroenterology. 2021; 160:245-59.
  • Lehtimaki, J.I., Rajakyla, E.K., Tojkander, S., Lappalainen, P. Generation of stress fibers through myosin-driven reorganization of the actin cortex. Elife. 2021; 10:e60710.
  • Li, H., Kurtzeborn, K., Kupari, J., Gui, Y., Siefker, E., Lu, B., Matlik, K., Olfat, S., Montano-Rodriguez, A.R., Huh, S.H., Costantini, F., Andressoo, J.O., Kuure, S. Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF. Development. 2021; 148.
  • Maki, K., Nava, M.M., Villeneuve, C., Chang, M., Furukawa, K.S., Ushida, T., Wickstrom, S.A. Hydrostatic pressure prevents chondrocyte differentiation through heterochromatin remodeling. J Cell Sci. 2021; 134.
  • Miroshnikova, Y.A., Manet, S., Li, X., Wickstrom, S.A., Faurobert, E., Albiges-Rizo, C. Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch. Mol Biol Cell. 2021; 32:1724-36.
  • Munne, P.M., Martikainen, L., Raty, I., Bertula, K., Nonappa, Ruuska, J., Ala-Hongisto, H., Peura, A., Hollmann, B., Euro, L., Yavuz, K., Patrikainen, L., Salmela, M., Pokki, J., Kivento, M., Vaananen, J., Suomi, T., Nevalaita, L., Mutka, M., Kovanen, P., Leidenius, M., Meretoja, T., Hukkinen, K., Monni, O., Pouwels, J., Sahu, B., Mattson, J., Joensuu, H., Heikkila, P., Elo, L.L., Metcalfe, C., Junttila, M.R., Ikkala, O., Klefstrom, J. Compressive stress-mediated p38 activation required for ERalpha + phenotype in breast cancer. Nat Commun. 2021; 12:6967.
  • Nguyen, S.D., Korhonen, E.A., Lorey, M.B., Hakanpaa, L., Mayranpaa, M.I., Kovanen, P.T., Saharinen, P., Alitalo, K., Oorni, K. Lysophosphatidylcholine in phospholipase A2-modified LDL triggers secretion of angiopoietin 2. Atherosclerosis. 2021; 327:87-99.
  • Paloviita, P., Hyden-Granskog, C., Yohannes, D.A., Paluoja, P., Kere, J., Tapanainen, J.S., Krjutskov, K., Tuuri, T., Vosa, U., Vuoristo, S. Small RNA expression and miRNA modification dynamics in human oocytes and early embryos. Genome Res. 2021; 31:1474-85.
  • Peteri, U.K., Pitkonen, J., de Toma, I., Nieminen, O., Utami, K.H., Strandin, T.M., Corcoran, P., Roybon, L., Vaheri, A., Ethell, I., Casarotto, P., Pouladi, M.A., Castren, M.L. Urokinase plasminogen activator mediates changes in human astrocytes modeling fragile X syndrome. Glia. 2021; 69:2947-62.
  • Prabhakar, N., Merisaari, J., Le Joncour, V., Peurla, M., Karaman, D.S., Casals, E., Laakkonen, P., Westermarck, J., Rosenholm, J.M. Circumventing Drug Treatment? Intrinsic Lethal Effects of Polyethyleneimine (PEI)-Functionalized Nanoparticles on Glioblastoma Cells Cultured in Stem Cell Conditions. Cancers (Basel). 2021; 13.
  • Prasanna, X., Salo, V.T., Li, S., Ven, K., Vihinen, H., Jokitalo, E., Vattulainen, I., Ikonen, E. Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane. PLoS Biol. 2021; 19:e3000998.
  • Rasanen, M., Sultan, I., Paech, J., Hemanthakumar, K.A., Yu, W., He, L., Tang, J., Sun, Y., Hlushchuk, R., Huan, X., Armstrong, E., Khoma, O.Z., Mervaala, E., Djonov, V., Betsholtz, C., Zhou, B., Kivela, R., Alitalo, K. VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration. Circulation. 2021; 143:65-77.
  • Sahu, B., Pihlajamaa, P., Zhang, K., Palin, K., Ahonen, S., Cervera, A., Ristimaki, A., Aaltonen, L.A., Hautaniemi, S., Taipale, J. Human cell transformation by combined lineage conversion and oncogene expression. Oncogene. 2021; 40:5533-47.
  • Takahashi, K., Kanerva, K., Vanharanta, L., Almeida-Souza, L., Lietha, D., Olkkonen, V.M., Ikonen, E. ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange. EMBO J. 2021; 40:e106871.
  • Tervonen, T.A., Pant, S.M., Belitskin, D., Englund, J.I., Narhi, K., Haglund, C., Kovanen, P.E., Verschuren, E.W., Klefstrom, J. Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin. Cancer Res. 2021; 81:1513-27.
  • Trela, E., Lan, Q., Myllymaki, S.M., Villeneuve, C., Lindstrom, R., Kumar, V., Wickstrom, S.A., Mikkola, M.L. Cell influx and contractile actomyosin force drive mammary bud growth and invagination. J Cell Biol. 2021; 220:e202008062.
  • Vanaveski, T., Molchanova, S., Pham, D.D., Schafer, A., Pajanoja, C., Narvik, J., Srinivasan, V., Urb, M., Koivisto, M., Vasar, E., Timmusk, T., Minkeviciene, R., Eriksson, O., Lalowski, M., Taira, T., Korhonen, L., Voikar, V., Lindholm, D. PGC-1alpha Signaling Increases GABA(A) Receptor Subunit alpha2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in Mice. Front Mol Neurosci. 2021; 14:588230.
  • Wahab, A., Hyytiainen, A., Wahbi, W., Tuomainen, K., Tervo, S., Conesa-Zamora, P., Jauhiainen, L., Makinen, L.K., Paavonen, T., Toppila-Salmi, S., Salem, A., Almangush, A., Salo, T., Al-Samadi, A. The effect of fascin 1 inhibition on head and neck squamous cell carcinoma cells. Eur J Oral Sci. 2021; 129:e12819.
2020
  • Abouelezz, A., Stefen, H., Segerstrale, M., Micinski, D., Minkeviciene, R., Lahti, L., Hardeman, E.C., Gunning, P.W., Hoogenraad, C.C., Taira, T., Fath, T., Hotulainen, P. Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment. iScience. 2020; 23:101053.
  • Amirkavei, M., Pitkanen, M., Kaikkonen, O., Kaarniranta, K., Andre, H., Koskelainen, A. Induction of Heat Shock Protein 70 in Mouse RPE as an In Vivo Model of Transpupillary Thermal Stimulation. Int J Mol Sci. 2020; 21. 
  • Aska, E.M., Dermadi, D., Kauppi, L. Single-Cell Sequencing of Mouse Thymocytes Reveals Mutational Landscape Shaped by Replication Errors, Mismatch Repair, and H3K36me3. iScience. 2020; 23:101452.
  • Barmaki, S., Obermaier, D., Kankuri, E., Vuola, J., Franssila, S., Jokinen, V. A Microfluidic Chip Architecture Enabling a Hypoxic Microenvironment and Nitric Oxide Delivery in Cell Culture. Micromachines (Basel). 2020; 11.
  • Elbasani, E., Falasco, F., Gramolelli, S., Nurminen, V., Gunther, T., Weltner, J., Balboa, D., Grundhoff, A., Otonkoski, T., Ojala, P.M. Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter. Viruses. 2020; 12. 
  • Elbasani, E., Gramolelli, S., Gunther, T., Gabaev, I., Grundhoff, A., Ojala, P.M. Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Is Independent of Anaphase-Promoting Complex Activity. J Virol. 2020; 94:e02079-19. 
  • Fang, S., Chen, S., Nurmi, H., Leppanen, V.M., Jeltsch, M., Scadden, D., Silberstein, L., Mikkola, H., Alitalo, K. VEGF-C protects the integrity of the bone marrow perivascular niche in mice. Blood. 2020; 136:1871-83.
  • Gramolelli, S., Elbasani, E., Tuohinto, K., Nurminen, V., Gunther, T., Kallinen, R.E., Kaijalainen, S.P., Diaz, R., Grundhoff, A., Haglund, C., Ziegelbauer, J.M., Pellinen, T., Bower, M., Francois, M., Ojala, P.M. Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production. Cancer Res. 2020; 80:3116-29. 
  • Haaranen, M., Schäfer, A., Järvi, V., & Hyytiä, P. Chemogenetic Stimulation and Silencing of the Insula, Amygdala, Nucleus Accumbens, and Their Connections Differentially Modulate Alcohol Drinking in Rats. Frontiers in behavioral neuroscience, 2020; 14, 580849.
  • Harjuhaahto, S., Rasila, T.S., Molchanova, S.M., Woldegebriel, R., Kvist, J., Konovalova, S., Sainio, M.T., Pennonen, J., Torregrosa-Munumer, R., Ibrahim, H., Otonkoski, T., Taira, T., Ylikallio, E., Tyynismaa, H. ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons. Neurobiol Dis. 2020; 141:104940. 
  • Helle, E., Ampuja, M., Antola, L., Kivela, R. Flow-Induced Transcriptomic Remodeling of Endothelial Cells Derived From Human Induced Pluripotent Stem Cells. Front Physiol. 2020; 11:591450. 
  • Hulmi, J.J., Penna, F., Pollanen, N., Nissinen, T.A., Hentila, J., Euro, L., Lautaoja, J.H., Ballaro, R., Soliymani, R., Baumann, M., Ritvos, O., Pirinen, E., Lalowski, M. Muscle NAD(+) depletion and Serpina3n as molecular determinants of murine cancer cachexia-the effects of blocking myostatin and activins. Mol Metab. 2020; 41:101046. 
  • Ignatenko, O., Nikkanen, J., Kononov, A., Zamboni, N., Ince-Dunn, G., Suomalainen, A. Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effect. Life Sci Alliance. 2020; 3:e202000797. 
  • Jha, S., Holmberg, C.I. Tissue-Specific Impact of Autophagy Genes on the Ubiquitin-Proteasome System in C. elegans. Cells. 2020; 9. 
  • Kallio, P., Jokinen, E., Hogstrom, J., Das, S., Heino, S., Lahde, M., Brodkin, J., Korhonen, E.A., Alitalo, K. Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation. Cancer Res. 2020; 80:2639-50.
  • Karhu, S.T., Kinnunen, S.M., Tolli, M., Valimaki, M.J., Szabo, Z., Talman, V., Ruskoaho, H. GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes. Arch Toxicol. 2020; 94:2113-30. 
  • Koponen, A., Pan, G., Kivela, A.M., Ralko, A., Taskinen, J.H., Arora, A., Kosonen, R., Kari, O.K., Ndika, J., Ikonen, E., Cho, W., Yan, D., Olkkonen, V.M. ORP2, a cholesterol transporter, regulates angiogenic signaling in endothelial cells. FASEB J. 2020; 34:14671-94.
  • Laukkanen, K., Saarinen, M., Mallet, F., Aatonen, M., Hau, A., Ranki, A. Cutaneous T-Cell Lymphoma (CTCL) Cell Line-Derived Extracellular Vesicles Contain HERV-W-Encoded Fusogenic Syncytin-1. J Invest Dermatol. 2020; 140:1466-9 e4.
  • Leppanen, V.M., Brouillard, P., Korhonen, E.A., Sipila, T., Jha, S.K., Revencu, N., Labarque, V., Fastre, E., Schlogel, M., Ravoet, M., Singer, A., Luzzatto, C., Angelone, D., Crichiutti, G., D'Elia, A., Kuurne, J., Elamaa, H., Koh, G.Y., Saharinen, P., Vikkula, M., Alitalo, K. Characterization of ANGPT2 mutations associated with primary lymphedema. Sci Transl Med. 2020; 12.
  • Li, Z., Korhonen, E.A., Merlini, A., Strauss, J., Wihuri, E., Nurmi, H., Antila, S., Paech, J., Deutsch, U., Engelhardt, B., Chintharlapalli, S., Koh, G.Y., Flugel, A., Alitalo, K. Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS. J Clin Invest. 2020; 130:1977-90. 
  • Lund, C., Yellapragada, V., Vuoristo, S., Balboa, D., Trova, S., Allet, C., Eskici, N., Pulli, K., Giacobini, P., Tuuri, T., Raivio, T. Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells. Disease Models & Mechanisms. 2020; 13:dmm040105. 
  • Meneses-Salas, E., Garcia-Melero, A., Kanerva, K., Blanco-Munoz, P., Morales-Paytuvi, F., Bonjoch, J., Casas, J., Egert, A., Beevi, S.S., Jose, J., Llorente-Cortes, V., Rye, K.A., Heeren, J., Lu, A., Pol, A., Tebar, F., Ikonen, E., Grewal, T., Enrich, C., Rentero, C. Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells. Cell Mol Life Sci. 2020; 77:2839-57. 
  • Meriranta, L., Pasanen, A., Alkodsi, A., Haukka, J., Karjalainen-Lindsberg, M.L., Leppa, S. Molecular background delineates outcome of double protein expressor diffuse large B-cell lymphoma. Blood Adv. 2020; 4:3742-53. 
  • Nagaeva, E., Zubarev, I., Bengtsson Gonzales, C., Forss, M., Nikouei, K., de Miguel, E., Elsila, L., Linden, A.M., Hjerling-Leffler, J., Augustine, G.J., Korpi, E.R. Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area. Elife. 2020; 9:e59328.
  • Nava, M.M., Miroshnikova, Y.A., Biggs, L.C., Whitefield, D.B., Metge, F., Boucas, J., Vihinen, H., Jokitalo, E., Li, X., Garcia Arcos, J.M., Hoffmann, B., Merkel, R., Niessen, C.M., Dahl, K.N., Wickstrom, S.A. Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell. 2020; 181:800-17 e22.
  • Paavola, J., Alakoski, T., Ulvila, J., Kilpio, T., Siren, J., Perttunen, S., Narumanchi, S., Wang, H., Lin, R., Porvari, K., Junttila, J., Huikuri, H., Immonen, K., Lakkisto, P., Magga, J., Tikkanen, I., Kerkela, R. Vezf1 regulates cardiac structure and contractile function. EBioMedicine. 2020; 51:102608. 
  • Pispa, J., Matilainen, O., Holmberg, C.I. Tissue-specific effects of temperature on proteasome function. Cell Stress Chaperones. 2020; 25:563-72. 
  • Pohjolainen, L., Easton, J., Solanki, R., Ruskoaho, H., Talman, V. Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Front Pharmacol. 2020; 11:553852.
  • Rajakyla, E.K., Lehtimaki, J.I., Acheva, A., Schaible, N., Lappalainen, P., Krishnan, R., Tojkander, S. Assembly of Peripheral Actomyosin Bundles in Epithelial Cells Is Dependent on the CaMKK2/AMPK Pathway. Cell Rep. 2020; 30:4266-80 e4. 
  • Redchuk, T.A., Karasev, M.M., Verkhusha, P.V., Donnelly, S.K., Hulsemann, M., Virtanen, J., Moore, H.M., Vartiainen, M.K., Hodgson, L., Verkhusha, V.V. Optogenetic regulation of endogenous proteins. Nat Commun. 2020; 11:605. 
  • Salo, V. T., Hölttä-Vuori, M., & Ikonen, E. Seipin-Mediated Contacts as Gatekeepers of Lipid Flux at the Endoplasmic Reticulum–Lipid Droplet Nexus . Contact. 2020.
  • Santinho, A., Salo, V.T., Chorlay, A., Li, S., Zhou, X., Omrane, M., Ikonen, E., Thiam, A.R. Membrane Curvature Catalyzes Lipid Droplet Assembly. Curr Biol. 2020 Jul 6;30(13):2481-2494.e6.
  • Srinivasan, V., Bruelle, C., Scifo, E., Pham, D.D., Soliymani, R., Lalowski, M., Lindholm, D. Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy. iScience. 2020; 23:100790. 
  • Takko, H., Pajanoja, C., Kurtzeborn, K., Hsin, J., Kuure, S., Kerosuo, L. ShapeMetrics: A userfriendly pipeline for 3D cell segmentation and spatial tissue analysis. Dev Biol. 2020; 462:7-19. 
  • Utz, B., Turpin, R., Lampe, J., Pouwels, J., Klefstrom, J. Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis. Sci Rep. 2020; 10:18733. 
  • Vanharanta, L., Peranen, J., Pfisterer, S.G., Enkavi, G., Vattulainen, I., Ikonen, E. High-content imaging and structure-based predictions reveal functional differences between Niemann-Pick C1 variants. Traffic. 2020; 21:386-97. 
  • Verveer, P.J., Sevilla-Sánchez, D., Bloembergen, P.C., Adam, N., Schoonderwoert, V.T.G., van der Voort, H.T.M. Fast Analysis of 2D and 3D Single-Molecule Localization Microscopy Data with Huygens Localizer. Microscopy Today. 2020; 28:20-5. 
  • Woldegebriel, R., Kvist, J., Andersson, N., Ounap, K., Reinson, K., Wojcik, M.H., Bijlsma, E.K., Hoffer, M.J.V., Ryan, M.M., Stark, Z., Walsh, M., Cuppen, I., van den Boogaard, M.H., Bharucha-Goebel, D., Donkervoort, S., Winchester, S., Zori, R., Bonnemann, C.G., Maroofian, R., O'Connor, E., Houlden, H., Zhao, F., Carpen, O., White, M., Sreedharan, J., Stewart, M., Ylikallio, E., Tyynismaa, H. Distinct effects on mRNA export factor GANP underlie neurological disease phenotypes and alter gene expression depending on intron content. Hum Mol Genet. 2020; 29:1426-39. 
  • Zhou, K., Dichlberger, A., Ikonen, E., Blom, T. Lysosome Associated Protein Transmembrane 4B-24 Is the Predominant Protein Isoform in Human Tissues and Undergoes Rapid, Nutrient-Regulated Turnover. Am J Pathol. 2020; 190:2018-28.
2019
  • Abouelezz, A., Micinski, D., Lipponen, A., Hotulainen, P. Sub-membranous actin rings in the axon initial segment are resistant to the action of latrunculin. Biol Chem. 2019; 400:1141-6.
  • Al-Samadi, A., Tuomainen, K., Kivimaki, A., Salem, A., Al-Kubati, S., Hyytiainen, A., Parikka, M., Mesimaki, K., Wilkman, T., Makitie, A., Grenman, R., Salo, T. PCR-based zebrafish model for personalised medicine in head and neck cancer. J Transl Med. 2019; 17:235.
  • Barreiro, K.A., Tulamo, R., Jouppila, A., Alback, A., Lassila, R. Novel Locally Acting Dual Antiplatelet and Anticoagulant (APAC) Targets Multiple Sites of Vascular Injury in an Experimental Porcine Model. Eur J Vasc Endovasc Surg. 2019; 58:903-11.
  • Dapkunas, A., Rantanen, V., Gui, Y., Lalowski, M., Sainio, K., Kuure, S., Sariola, H. Simple 3D culture of dissociated kidney mesenchyme mimics nephron progenitor niche and facilitates nephrogenesis Wnt-independently. Sci Rep. 2019; 9:13433.
  • Diniz, C., Biojone, C., Joca, S.R.L., Rantamaki, T., Castren, E., Guimaraes, F.S., Casarotto, P.C. Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors. PeerJ. 2019; 7:e6493.
  • Faisal, I., Cisneros-Montalvo, S., Hamer, G., Tuominen, M.M., Laurila, P.P., Tumiati, M., Jauhiainen, M., Kotaja, N., Toppari, J., Makela, J.A., Kauppi, L. Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice. Endocrinology. 2019; 160:1119-36.
  • Fred, S.M., Laukkanen, L., Brunello, C.A., Vesa, L., Goos, H., Cardon, I., Moliner, R., Maritzen, T., Varjosalo, M., Casarotto, P.C., Castren, E. Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2. J Biol Chem. 2019; 294:18150-61.
  • Gucciardo, E., Loukovaara, S., Korhonen, A., Lehti, K. An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy. J Vis Exp. 2019.
  • Gungor, B., Vanharanta, L., Holtta-Vuori, M., Pirhonen, J., Petersen, N.H.T., Gramolelli, S., Ojala, P.M., Kirkegaard, T., Ikonen, E. HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo. Mol Metab. 2019; 28:135-43.
  • Haikala, H.M., Anttila, J.M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A.I., Otonkoski, T., Schuler, J., Laajala, T.D., Aittokallio, T., Sihto, H., Mattson, J., Heikkila, P., Leidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J.D., Klefstrom, J. Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nat Commun. 2019; 10:620.
  • Heybrock, S., Kanerva, K., Meng, Y., Ing, C., Liang, A., Xiong, Z.J., Weng, X., Ah Kim, Y., Collins, R., Trimble, W., Pomes, R., Prive, G.G., Annaert, W., Schwake, M., Heeren, J., Lullmann-Rauch, R., Grinstein, S., Ikonen, E., Saftig, P., Neculai, D. Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export. Nat Commun. 2019; 10:3521.
  • Hlushchenko, I., Hotulainen, P. Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines. Biol Chem. 2019; 400:1129-39.
  • Jha, S.K., Rauniyar, K., Chronowska, E., Mattonet, K., Maina, E.W., Koistinen, H., Stenman, U.H., Alitalo, K., Jeltsch, M. KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D. Elife. 2019; 8.
  • Kivela, R., Hemanthakumar, K.A., Vaparanta, K., Robciuc, M., Izumiya, Y., Kidoya, H., Takakura, N., Peng, X., Sawyer, D.B., Elenius, K., Walsh, K., Alitalo, K. Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling. Circulation. 2019; 139:2570-84.
  • Koponen, A., Arora, A., Takahashi, K., Kentala, H., Kivela, A.M., Jaaskelainen, E., Peranen, J., Somerharju, P., Ikonen, E., Viitala, T., Olkkonen, V.M. ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol. Biochimie. 2019; 158:90-101.
  • Laukkanen, K., Saarinen, M., Mallet, F., Aatonen, M., Hau, A., Ranki, A. Cutaneous T-Cell Lymphoma (CTCL) Cell Line-Derived Extracellular Vesicles Contain HERV-W-Encoded Fusogenic Syncytin-1. J Invest Dermatol. 2019.
  • Le Joncour, V., Filppu, P., Hyvonen, M., Holopainen, M., Turunen, S.P., Sihto, H., Burghardt, I., Joensuu, H., Tynninen, O., Jaaskelainen, J., Weller, M., Lehti, K., Kakela, R., Laakkonen, P. Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization. EMBO Mol Med. 2019; 11.
  • Le Joncour, V., Karaman, S., Laakkonen, P.M. Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish. J Vis Exp. 2019:e59384.
  • Leopold, A.V., Chernov, K.G., Shemetov, A.A., Verkhusha, V.V. Neurotrophin receptor tyrosine kinases regulated with near-infrared light. Nat Commun. 2019; 10:1129.
  • Li, S., Prasanna, X., Salo, V.T., Vattulainen, I., Ikonen, E. An efficient auxin-inducible degron system with low basal degradation in human cells. Nat Methods. 2019; 16:866-9.
  • Luukkonen, P.K., Nick, A., Holtta-Vuori, M., Thiele, C., Isokuortti, E., Lallukka-Bruck, S., Zhou, Y., Hakkarainen, A., Lundbom, N., Peltonen, M., Orho-Melander, M., Oresic, M., Hyotylainen, T., Hodson, L., Ikonen, E., Yki-Jarvinen, H. Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. JCI Insight. 2019; 4.
  • Meneses-Salas, E., Garcia-Melero, A., Kanerva, K., Blanco-Munoz, P., Morales-Paytuvi, F., Bonjoch, J., Casas, J., Egert, A., Beevi, S.S., Jose, J., Llorente-Cortes, V., Rye, K.A., Heeren, J., Lu, A., Pol, A., Tebar, F., Ikonen, E., Grewal, T., Enrich, C., Rentero, C. Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells. Cell Mol Life Sci. 2019.
  • Minkeviciene, R., Hlushchenko, I., Virenque, A., Lahti, L., Khanal, P., Rauramaa, T., Koistinen, A., Leinonen, V., Noe, F.M., Hotulainen, P. MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning. Front Mol Neurosci. 2019; 12:276.
  • Naakka, E., Tuomainen, K., Wistrand, H., Palkama, M., Suleymanova, I., Al-Samadi, A., Salo, T. Fully Human Tumor-based Matrix in Three-dimensional Spheroid Invasion Assay. J Vis Exp. 2019.
  • Reichhardt, M.P., Lundin, K., Lokki, A.I., Recher, G., Vuoristo, S., Katayama, S., Tapanainen, J.S., Kere, J., Meri, S., Tuuri, T. Complement in Human Pre-implantation Embryos: Attack and Defense. Front Immunol. 2019; 10:2234.
  • Repo, P., Jarvinen, R.S., Jantti, J.E., Markkinen, S., Tall, M., Raivio, V., Turunen, J.A., Kivela, T.T. Population-based analysis of BAP1 germline variations in patients with uveal melanoma. Hum Mol Genet. 2019; 28:2415-26.
  • Saarinen, J., Gutter, F., Lindman, M., Agopov, M., Fraser-Miller, S.J., Scherliess, R., Jokitalo, E., Santos, H.A., Peltonen, L., Isomaki, A., Strachan, C.J. Cell-Nanoparticle Interactions at (Sub)-Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering. Biotechnol J. 2019; 14:e1800413.
  • Saeed, K., Ojamies, P., Pellinen, T., Eldfors, S., Turkki, R., Lundin, J., Jarvinen, P., Nisen, H., Taari, K., Af Hallstrom, T.M., Rannikko, A., Mirtti, T., Kallioniemi, O., Ostling, P. Clonal heterogeneity influences drug responsiveness in renal cancer assessed by ex vivo drug testing of multiple patient-derived cancer cells. Int J Cancer. 2019; 144:1356-66.
  • Salo, V.T., Ikonen, E. Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets. Curr Opin Cell Biol. 2019; 57:64-70.
  • Salo, V.T., Li, S., Vihinen, H., Holtta-Vuori, M., Szkalisity, A., Horvath, P., Belevich, I., Peranen, J., Thiele, C., Somerharju, P., Zhao, H., Santinho, A., Thiam, A.R., Jokitalo, E., Ikonen, E. Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact. Dev Cell. 2019; 50:478-93 e9.
  • Schmotz, C., Ugurlu, H., Vilen, S., Shrestha, S., Fagerlund, R., Saksela, K. MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recruiting Cellular SH3BP4 via an SH3 Domain-Mediated Interaction. J Virol. 2019; 93:e01613-18.
  • Turunen, S.P., von Nandelstadh, P., Ohman, T., Gucciardo, E., Seashore-Ludlow, B., Martins, B., Rantanen, V., Li, H., Hopfner, K., Ostling, P., Varjosalo, M., Lehti, K. FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death Differ. 2019; 26:2577-93.
  • Yellapragada, V., Liu, X., Lund, C., Kansakoski, J., Pulli, K., Vuoristo, S., Lundin, K., Tuuri, T., Varjosalo, M., Raivio, T. MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence GNRH1 Expression. Front Endocrinol (Lausanne). 2019; 10:48.
2018
  • Achuta, V.S., Moykkynen, T., Peteri, U.K., Turconi, G., Rivera, C., Keinanen, K., Castren, M.L. Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome. Sci Signal. 2018; 11.
  • Ahvenainen, T.V., Makinen, N.M., von Nandelstadh, P., Vahteristo, M.E.A., Pasanen, A.M., Butzow, R.C., Vahteristo, P.M. Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas. Cancer. 2018; 124:4650-6.
  • Ainola, M., Porola, P., Takakubo, Y., Przybyla, B., Kouri, V.P., Tolvanen, T.A., Hanninen, A., Nordstrom, D.C. Activation of plasmacytoid dendritic cells by apoptotic particles - mechanism for the loss of immunological tolerance in Sjogren's syndrome. Clin Exp Immunol. 2018; 191:301-10.
  • Barmaki, S., Jokinen, V., Obermaier, D., Blokhina, D., Korhonen, M., Ras, R.H.A., Vuola, J., Franssila, S., Kankuri, E. A microfluidic oxygen sink to create a targeted cellular hypoxic microenvironment under ambient atmospheric conditions. Acta Biomater. 2018; 73:167-79.
  • Gebraad, A., Kornilov, R., Kaur, S., Miettinen, S., Haimi, S., Peltoniemi, H., Mannerstrom, B., Seppanen-Kaijansinkko, R. Monocyte-derived extracellular vesicles stimulate cytokine secretion and gene expression of matrix metalloproteinases by mesenchymal stem/stromal cells. FEBS J. 2018; 285:2337-59.
  • Gramolelli, S., Cheng, J., Martinez-Corral, I., Vaha-Koskela, M., Elbasani, E., Kaivanto, E., Rantanen, V., Tuohinto, K., Hautaniemi, S., Bower, M., Haglund, C., Alitalo, K., Makinen, T., Petrova, T.V., Lehti, K., Ojala, P.M. PROX1 is a transcriptional regulator of MMP14. Sci Rep. 2018; 8:9531.
  • Gucciardo, E., Loukovaara, S., Korhonen, A., Repo, P., Martins, B., Vihinen, H., Jokitalo, E., Lehti, K. The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization. J Pathol. 2018; 245:172-85.
  • Gucciardo, E., Loukovaara, S., Salven, P., Lehti, K. Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy. Int J Mol Sci. 2018; 19.
  • Hakanpaa, L., Kiss, E.A., Jacquemet, G., Miinalainen, I., Lerche, M., Guzman, C., Mervaala, E., Eklund, L., Ivaska, J., Saharinen, P. Targeting beta1-integrin inhibits vascular leakage in endotoxemia. Proc Natl Acad Sci U S A. 2018; 115:E6467-E76.
  • Havunen, R., Santos, J.M., Sorsa, S., Rantapero, T., Lumen, D., Siurala, M., Airaksinen, A.J., Cervera-Carrascon, V., Tahtinen, S., Kanerva, A., Hemminki, A. Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus. Mol Ther Oncolytics. 2018; 11:109-21.
  • Heikkinen, T., Ayravainen, A., Hanninen, J., Ahvenainen, T., Butzow, R., Pasanen, A., Vahteristo, P. MED12 mutations and fumarate hydratase inactivation in uterine adenomyomas. Hum Reprod Open. 2018; 2018:hoy020.
  • Hlushchenko, I., Khanal, P., Abouelezz, A., Paavilainen, V.O., Hotulainen, P. ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons. Front Cell Neurosci. 2018; 12:217.
  • Hogstrom, J., Heino, S., Kallio, P., Lahde, M., Leppanen, V.M., Balboa, D., Wiener, Z., Alitalo, K. Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells. Cancer Res. 2018; 78:5820-32.
  • Hulmi, J.J., Nissinen, T.A., Rasanen, M., Degerman, J., Lautaoja, J.H., Hemanthakumar, K.A., Backman, J.T., Ritvos, O., Silvennoinen, M., Kivela, R. Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle. J Cachexia Sarcopenia Muscle. 2018; 9:417-32.
  • Ignatenko, O., Chilov, D., Paetau, I., de Miguel, E., Jackson, C.B., Capin, G., Paetau, A., Terzioglu, M., Euro, L., Suomalainen, A. Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy. Nat Commun. 2018; 9:70.
  • Jiang, Q., Kainulainen, V., Stamatova, I., Korpela, R., Meurman, J.H. Lactobacillus rhamnosus GG in Experimental Oral Biofilms Exposed to Different Carbohydrate Sources. Caries Res. 2018; 52:220-9.
  • Karhu, S.T., Valimaki, M.J., Jumppanen, M., Kinnunen, S.M., Pohjolainen, L., Leigh, R.S., Auno, S., Foldes, G., Boije Af Gennas, G., Yli-Kauhaluoma, J., Ruskoaho, H., Talman, V. Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds. Arch Toxicol. 2018; 92:2897-911.
  • Kovac, B., Makela, T.P., Vallenius, T. Increased alpha-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer. PLoS One. 2018; 13:e0196986.
  • Li, C., Rezov, V., Joensuu, E., Vartiainen, V., Ronty, M., Yin, M., Myllarniemi, M., Koli, K. Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo. Sci Rep. 2018; 8:10070.
  • Marques, E., Peltola, T., Kaski, S., Klefstrom, J. Phenotype-driven identification of epithelial signalling clusters. Sci Rep. 2018; 8:4034.
  • Merezhko, M., Brunello, C.A., Yan, X., Vihinen, H., Jokitalo, E., Uronen, R.L., Huttunen, H.J. Secretion of Tau via an Unconventional Non-vesicular Mechanism. Cell Rep. 2018; 25:2027-35 e4.
  • Novakovic, D., Isomaki, A., Pleunis, B., Fraser-Miller, S.J., Peltonen, L., Laaksonen, T., Strachan, C.J. Understanding Dissolution and Crystallization with Imaging: A Surface Point of View. Mol Pharm. 2018; 15:5361-73.
  • Oja, S., Komulainen, P., Penttila, A., Nystedt, J., Korhonen, M. Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures. Stem Cell Res Ther. 2018; 9:6.
  • Ojarinta, R., Saarinen, J., Strachan, C.J., Korhonen, O., Laitinen, R. Preparation and characterization of multi-component tablets containing co-amorphous salts: Combining multimodal non-linear optical imaging with established analytical methods. Eur J Pharm Biopharm. 2018; 132:112-26.
  • Ollila, S., Domenech-Moreno, E., Laajanen, K., Wong, I.P., Tripathi, S., Pentinmikko, N., Gao, Y., Yan, Y., Niemela, E.H., Wang, T.C., Viollet, B., Leone, G., Katajisto, P., Vaahtomeri, K., Makela, T.P. Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway. J Clin Invest. 2018; 128:402-14.
  • Pant, S.M., Belitskin, D., Ala-Hongisto, H., Klefstrom, J., Tervonen, T.A. Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture. Methods Mol Biol. 2018; 1731:169-78.
  • Pant, S.M., Mukonoweshuro, A., Desai, B., Ramjee, M.K., Selway, C.N., Tarver, G.J., Wright, A.G., Birchall, K., Chapman, T.M., Tervonen, T.A., Klefstrom, J. Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. J Med Chem. 2018; 61:4335-47.
  • Pehkonen, H., Lento, M., von Nandelstadh, P., Filippou, A., Grenman, R., Lehti, K., Monni, O. Liprin-alpha1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton. Cell Commun Signal. 2018; 16:41.
  • Pekkonen, P., Alve, S., Balistreri, G., Gramolelli, S., Tatti-Bugaeva, O., Paatero, I., Niiranen, O., Tuohinto, K., Perala, N., Taiwo, A., Zinovkina, N., Repo, P., Icay, K., Ivaska, J., Saharinen, P., Hautaniemi, S., Lehti, K., Ojala, P.M. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and beta1-integrin activation. Elife. 2018; 7:e32490.
  • Redchuk, T.A., Karasev, M.M., Omelina, E.S., Verkhusha, V.V. Near-Infrared Light-Controlled Gene Expression and Protein Targeting in Neurons and Non-neuronal Cells. Chembiochem. 2018; 19:1334-40.
  • Sandhu, J., Li, S., Fairall, L., Pfisterer, S.G., Gurnett, J.E., Xiao, X., Weston, T.A., Vashi, D., Ferrari, A., Orozco, J.L., Hartman, C.L., Strugatsky, D., Lee, S.D., He, C., Hong, C., Jiang, H., Bentolila, L.A., Gatta, A.T., Levine, T.P., Ferng, A., Lee, R., Ford, D.A., Young, S.G., Ikonen, E., Schwabe, J.W.R., Tontonoz, P. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Cell. 2018; 175:514-29 e20.
  • Strandin, T., Makela, S., Mustonen, J., Vaheri, A. Neutrophil Activation in Acute Hemorrhagic Fever With Renal Syndrome Is Mediated by Hantavirus-Infected Microvascular Endothelial Cells. Front Immunol. 2018; 9:2098.
  • Subramaniyam, N., Shah, A., Dreser, C., Isomaki, A., Fleischer, M., Sopanen, M. Nonlinear plasmonic behavior of nanohole arrays in thin gold films for imaging lipids. Applied Physics Letters. 2018; 112:233109.
  • Talman, V., Teppo, J., Poho, P., Movahedi, P., Vaikkinen, A., Karhu, S.T., Trost, K., Suvitaival, T., Heikkonen, J., Pahikkala, T., Kotiaho, T., Kostiainen, R., Varjosalo, M., Ruskoaho, H. Molecular Atlas of Postnatal Mouse Heart Development. J Am Heart Assoc. 2018; 7:e010378.
  • Tervaniemi, M.H., Katayama, S., Skoog, T., Siitonen, H.A., Vuola, J., Nuutila, K., Tammimies, K., Suomela, S., Kankuri, E., Kere, J., Elomaa, O. Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes. BMC Genomics. 2018; 19:432.
  • Tumiati, M., Hietanen, S., Hynninen, J., Pietila, E., Farkkila, A., Kaipio, K., Roering, P., Huhtinen, K., Alkodsi, A., Li, Y., Lehtonen, R., Erkan, E.P., Tuominen, M.M., Lehti, K., Hautaniemi, S.K., Vaharautio, A., Grenman, S., Carpen, O., Kauppi, L. A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients. Clin Cancer Res. 2018; 24:4482-93.
  • Zhou, K., Dichlberger, A., Martinez-Seara, H., Nyholm, T.K.M., Li, S., Kim, Y.A., Vattulainen, I., Ikonen, E., Blom, T. A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction. ACS Cent Sci. 2018; 4:548-58.
2017
  • Achuta, V.S., Grym, H., Putkonen, N., Louhivuori, V., Karkkainen, V., Koistinaho, J., Roybon, L., Castren, M.L. Metabotropic Glutamate Receptor 5 Responses Dictate Differentiation of Neural Progenitors to NMDA-Responsive Cells in Fragile X Syndrome. Developmental Neurobiology. 2017; 77:438-53.
  • Antila, S., Karaman, S., Nurmi, H., Airavaara, M., Voutilainen, M.H., Mathivet, T., Chilov, D., Li, Z.L., Koppinen, T., Park, J.H., Fang, S., Aspelund, A., Saarma, M., Eichmann, A., Thomas, J.L., Alitalo, K. Development and plasticity of meningeal lymphatic vessels. Journal of Experimental Medicine. 2017; 214:3645-67.
  • Back, N., Kanerva, K., Kurutihallib, V., Yanik, A., Ikonen, E., Mains, R.E., Eipper, B.A. The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together. European Journal of Cell Biology. 2017; 96:407-17.
  • Bjork, S., Ojala, E.A., Nordstrom, T., Ahola, A., Liljestrom, M., Hyttinen, J., Kankuri, E., Mervaala, E. Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes. Frontiers in Physiology. 2017; 8:884.
  • Chernov, K.G., Neuvonen, M., Brock, I., Ikonen, E., Verkhusha, V.V. Introducing inducible fluorescent split cholesterol oxidase to mammalian cells. Journal of Biological Chemistry. 2017; 292:8811-22.
  • Dash, S.N., Narumanchi, S., Paavola, J., Perttunen, S., Wang, H., Lakkisto, P., Tikkanen, I., Lehtonen, S. Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish. American Journal of Physiology-Heart and Circulatory Physiology. 2017; 312:H1085-H95.
  • Dumont, V., Tolvanen, T.A., Kuusela, S., Wang, H., Nyman, T.A., Lindfors, S., Tienari, J., Nisen, H., Suetsugu, S., Plomann, M., Kawachi, H., Lehtonen, S. PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. Faseb Journal. 2017; 31:3978-90.
  • Faisal, I., Kauppi, L. Reduced MAD2 levels dampen the apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidy. Development. 2017; 144:1988-96.
  • Gateva, G., Kremneva, E., Reindl, T., Kotila, T., Kogan, K., Gressin, L., Gunning, P.W., Manstein, D.J., Michelot, A., Lappalainen, P. Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro. Current Biology. 2017; 27:705-13.
  • Havunen, R., Siurala, M., Sorsa, S., Gronberg-Vaha-Koskela, S., Behr, M., Tahtinen, S., Santos, J.M., Karell, P., Rusanen, J., Nettelbeck, D.M., Ehrhardt, A., Kanerva, A., Hemminki, A. Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy. Molecular Therapy-Oncolytics. 2017; 4:77-86.
  • Heikkinen, T., Kampjarvi, K., Keskitalo, S., von Nandelstadh, P., Liu, X., Rantanen, V., Pitkanen, E., Kinnunen, M., Kuusanmaki, H., Kontro, M., Turunen, M., Makinen, N., Taipale, J., Heckman, C., Lehti, K., Mustjoki, S., Varjosalo, M., Vahteristo, P. Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry. Human Mutation. 2017; 38:269-74.
  • Heinolainen, K., Karaman, S., D'Amico, G., Tammela, T., Sormunen, R., Eklund, L., Alitalo, K., Zarkada, G. VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling. Circulation Research. 2017; 120:1414-+.
  • Hulmi, J.J., Nissinen, T.A., Räsänen, M., Degerman, J., Lautaoja, J.H., Hemanthakumar, K.A., Backman, J.T., Ritvos, O., Silvennoinen, M., Kivelä, R. Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle. 2017.
  • Jha, S.K., Rauniyar, K., Karpanen, T., Leppanen, V.M., Brouillard, P., Vikkula, M., Alitalo, K., Jeltsch, M. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. Scientific Reports. 2017; 7:4916.
  • Kara, B., Koroglu, C., Peltonen, K., Steinberg, R.C., Genc, H.M., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V.M., Ikonen, E., Laiho, M., Tolun, A. Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A. European Journal of Human Genetics. 2017; 25:315-23.
  • Lampinen, A.M., Virman, J.P., Bono, P., Luukkaala, T.H., Sunela, K.L., Kujala, P.M., Saharinen, P., Kellokumpu-Lehtinen, P.-L.I. Novel Angiogenesis Markers as Long-Term Prognostic Factors in Patients With Renal Cell Cancer. Clinical Genitourinary Cancer. 2017; 15:e15-e24.
  • Lehtimaki, J.I., Fenix, A.M., Kotila, T.M., Balistreri, G., Paavolainen, L., Varjosalo, M., Burnette, D.T., Lappalainen, P. UNC-45a promotes myosin folding and stress fiber assembly. Journal of Cell Biology. 2017; 216:4053-72.
  • Leppänen, V.-M., Saharinen, P., Alitalo, K. Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proceedings of the National Academy of Sciences. 2017; 114:4376-81.
  • Maliniemi, P., Laukkanen, K., Vakeva, L., Dettmer, K., Lipsanen, T., Jeskanen, L., Bessede, A., Oefner, P.J., Kadin, M.E., Ranki, A. Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas. Oncoimmunology. 2017; 6:e1273310.
  • Markkanen, M., Ludwig, A., Khirug, S., Pryazhnikov, E., Soni, S., Khiroug, L., Delpire, E., Rivera, C., Airaksinen, M.S., Uvarov, P. Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function. Brain Research. 2017; 1675:87-101.
  • Mikkonen, E., Haglund, C., Holmberg, C.I. Immunohistochemical analysis reveals variations in proteasome tissue expression in C. elegans. Plos One. 2017; 12:e0183403.
  • Novakovic, D., Saarinen, J., Rojalin, T., Antikainen, O., Fraser-Miller, S.J., Laaksonen, T., Peltonen, L., Isomaki, A., Strachan, C.J. Multimodal Nonlinear Optical Imaging for Sensitive Detection of Multiple Pharmaceutical Solid-State Forms and Surface Transformations. Analytical Chemistry. 2017; 89:11460-7.
  • Pfisterer, S.G., Gateva, G., Horvath, P., Pirhonen, J., Salo, V.T., Karhinen, L., Varjosalo, M., Ryhanen, S.J., Lappalainen, P., Ikonen, E. Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage. Nature Communications. 2017; 8:14858.
  • Redchuk, T.A., Omelina, E.S., Chernov, K.G., Verkhusha, V.V. Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nature Chemical Biology. 2017; 13:633-+.
  • Saarinen, J., Sozeri, E., Fraser-Miller, S.J., Peltonen, L., Santos, H.A., Isomaki, A., Strachan, C.J. Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopy. International Journal of Pharmaceutics. 2017; 523:270-80.
  • Saeed, K., Rahkama, V., Eldfors, S., Bychkov, D., Mpindi, J.P., Yadav, B., Paavolainen, L., Aittokallio, T., Heckman, C., Wennerberg, K., Peehl, D.M., Horvath, P., Mirtti, T., Rannikko, A., Kallioniemi, O., Ostling, P., af Hallstrom, T.M. Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer. European Urology. 2017; 71:319-27.
  • Saurus, P., Tolvanen, T.A., Lindfors, S., Kuusela, S., Holthofer, H., Lehtonen, E., Lehtonen, S. Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis. Scientific Reports. 2017; 7:10731.
  • Sepponen, K., Lundin, K., Knuus, K., Vayrynen, P., Raivio, T., Tapanainen, J.S., Tuuri, T. The Role of Sequential BMP Signaling in Directing Human Embryonic Stem Cells to Bipotential Gonadal Cells. Journal of Clinical Endocrinology & Metabolism. 2017; 102:4303-14.
  • Steinzeig, A., Molotkov, D., Castren, E. Chronic imaging through "transparent skull" in mice. Plos One. 2017; 12:e0181788.
  • Vaahtomeri, K., Karaman, S., Makinen, T., Alitalo, K. Lymphangiogenesis guidance by paracrine and pericellular factors. Genes & Development. 2017; 31:1615-34.
  • Wasik, A.A., Dumont, V., Tienari, J., Nyman, T.A., Fogarty, C.L., Forsblom, C., Lehto, M., Lehtonen, E., Groop, P.H., Lehtonen, S. Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion. Experimental Cell Research. 2017; 350:336-48.
  • Yin, M., Tissari, M., Tamminen, J., Ylivinkka, I., Ronty, M., von Nandelstadh, P., Lehti, K., Hyytiainen, M., Myllarniemi, M., Koli, K. Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma. Oncotarget. 2017; 8:98280-97.
  • Ylivinkka, I., Sihto, H., Tynninen, O., Hu, Y.Z., Laakso, A., Kivisaari, R., Laakkonen, P., Keski-Oja, J., Hyytiainen, M. Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness. Journal of Experimental & Clinical Cancer Research. 2017; 36:9.
2016
  • Ainola, M., Tomaszewski, W., Ostrowska, B., Wesolowska, E., Wagner, H.D., Swieszkowski, W., Sillat, T., Peltola, E., Konttinen, Y.T. A bioactive hybrid three-dimensional tissue-engineering construct for cartilage repair. Journal of Biomaterials Applications. 2016; 30:873-85.
  • Backlund, M., Paukku, K., Kontula, K.K., Lehtonen, J.Y. Endoplasmic reticulum stress increases AT1R mRNA expression via TIA-1-dependent mechanism. Nucleic Acids Res. 2016; 44:3095-104.
  • Balistreri, G., Viiliainen, J., Turunen, M., Diaz, R., Lyly, L., Pekkonen, P., Rantala, J., Ojala, K., Sarek, G., Teesalu, M., Denisova, O., Peltonen, K., Julkunen, I., Varjosalo, M., Kainov, D., Kallioniemi, O., Laiho, M., Taipale, J., Hautaniemi, S., Ojala, P.M. Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication. PLoS Pathog. 2016; 12:e1005424.
  • Dash, S.N., Hakonen, E., Ustinov, J., Otonkoski, T., Andersson, O., Lehtonen, S. sept7b is required for the differentiation of pancreatic endocrine progenitors. Sci Rep. 2016; 6:24992.
  • Datta, N., Lindfors, S., Miura, N., Saleem, M.A., Lehtonen, S. Data supporting the regulation of FOXC2 in podocyte dysfunction. Data Brief. 2016; 6:514-20.
  • Datta, N., Lindfors, S., Miura, N., Saleem, M.A., Lehtonen, S. Overexpression of transcription factor FOXC2 in cultured human podocytes upregulates injury markers and increases motility. Exp Cell Res. 2016; 340:32-42.
  • Fang, S., Nurmi, H., Heinolainen, K., Chen, S., Salminen, E., Saharinen, P., Mikkola, H.K., Alitalo, K. Critical requirement of VEGF-C in transition to fetal erythropoiesis. Blood. 2016; 128:710-20.
  • Haikala, H.M., Klefstrom, J., Eilers, M., Wiese, K.E. MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell Cycle. 2016; 15:316-23.
  • Holtta-Vuori, M., Sezgin, E., Eggeling, C., Ikonen, E. Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation. Traffic. 2016; 17:1054-7.
  • Jiang, Q., Stamatova, I., Kainulainen, V., Korpela, R., Meurman, J.H. Interactions between Lactobacillus rhamnosus GG and oral micro-organisms in an in vitro biofilm model. BMC Microbiology. 2016; 16:149.
  • Jokinen, R., Marttinen, P., Stewart, J.B., Neil Dear, T., Battersby, B.J. Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division. Hum Mol Genet. 2016; 25:706-14.
  • Kampjarvi, K., Kim, N.H., Keskitalo, S., Clark, A.D., von Nandelstadh, P., Turunen, M., Heikkinen, T., Park, M.J., Makinen, N., Kivinummi, K., Lintula, S., Hotakainen, K., Nevanlinna, H., Hokland, P., Bohling, T., Butzow, R., Bohm, J., Mecklin, J.P., Jarvinen, H., Kontro, M., Visakorpi, T., Taipale, J., Varjosalo, M., Boyer, T.G., Vahteristo, P. Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms. Prostate. 2016; 76:22-31.
  • Kivela, R., Salmela, I., Nguyen, Y.H., Petrova, T.V., Koistinen, H.A., Wiener, Z., Alitalo, K. The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation. Nat Commun. 2016; 7:13124.
  • Korhonen, E.A., Lampinen, A., Giri, H., Anisimov, A., Kim, M., Allen, B., Fang, S., D'Amico, G., Sipila, T.J., Lohela, M., Strandin, T., Vaheri, A., Yla-Herttuala, S., Koh, G.Y., McDonald, D.M., Alitalo, K., Saharinen, P. Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest. 2016; 126:3495-510.
  • Kuusela, S., Wang, H., Wasik, A.A., Suleiman, H., Lehtonen, S. Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. Cell Death Dis. 2016; 7:e2302.
  • Lampinen, A.M., Virman, J.P., Bono, P., Luukkaala, T.H., Sunela, K.L., Kujala, P.M., Saharinen, P., Kellokumpu-Lehtinen, P.I. Novel Angiogenesis Markers as Long-Term Prognostic Factors in Patients With Renal Cell Cancer. Clin Genitourin Cancer. 2016.
  • Lund, C., Pulli, K., Yellapragada, V., Giacobini, P., Lundin, K., Vuoristo, S., Tuuri, T., Noisa, P., Raivio, T. Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells. Stem Cell Reports. 2016; 7:149-57.
  • Mah, P.T., Novakovic, D., Saarinen, J., Van Landeghem, S., Peltonen, L., Laaksonen, T., Isomäki, A., Strachan, C.J. Elucidation of Compression-Induced Surface Crystallization in Amorphous Tablets Using Sum Frequency Generation (SFG) Microscopy. Pharmaceutical Research. 2016:1-14.
  • Makinen, N., Aavikko, M., Heikkinen, T., Taipale, M., Taipale, J., Koivisto-Korander, R., Butzow, R., Vahteristo, P. Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12. PLoS Genet. 2016; 12:e1005850.
  • Matilainen, O., Jha, S., Holmberg, C.I. 2016. Fluorescent Tools for In Vivo Studies on the Ubiquitin-Proteasome System. In Proteostasis: Methods and Protocols. R. Matthiesen, editor. Springer New York, New York, NY. 215-22.
  • Motazacker, M.M., Pirhonen, J., van Capelleveen, J.C., Weber-Boyvat, M., Kuivenhoven, J.A., Shah, S., Hovingh, G.K., Metso, J., Li, S., Ikonen, E., Jauhiainen, M., Dallinga-Thie, G.M., Olkkonen, V.M. A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity. Atherosclerosis. 2016; 249:140-7.
  • Muhonen, V., Salonius, E., Haaparanta, A.M., Jarvinen, E., Paatela, T., Meller, A., Hannula, M., Bjorkman, M., Pyhalto, T., Ella, V., Vasara, A., Toyras, J., Kellomaki, M., Kiviranta, I. Articular cartilage repair with recombinant human type II collagen/polylactide scaffold in a preliminary porcine study. J Orthop Res. 2016; 34:745-53.
  • Mäkela, J., Mudo, G., Pham, D.D., Di Liberto, V., Eriksson, O., Louhivuori, L., Bruelle, C., Soliymani, R., Baumann, M., Korhonen, L., Lalowski, M., Belluardo, N., Lindholm, D. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X-linked inhibitor of apoptosis protein. Eur J Neurosci. 2016; 43:626-39.
  • Okuneva, O., Li, Z., Korber, I., Tegelberg, S., Joensuu, T., Tian, L., Lehesjoki, A.E. Brain inflammation is accompanied by peripheral inflammation in Cstb -/- mice, a model for progressive myoclonus epilepsy. J Neuroinflammation. 2016; 13:298.
  • Pehkonen, H., von Nandelstadh, P., Karhemo, P.R., Lepikhova, T., Grenman, R., Lehti, K., Monni, O. Liprin-alpha1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery. Sci Rep. 2016; 6:24486.
  • Pirhonen, J., Arola, J., Sädevirta, S., Luukkonen, P., Karppinen, S.-M., Pihlajaniemi, T., Isomäki, A., Hukkanen, M., Yki-Järvinen, H., Ikonen, E. Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study. PLOS ONE. 2016; 11:e0147804.
  • Pfisterer, S.G., Peranen, J., Ikonen, E. LDL-cholesterol transport to the endoplasmic reticulum: current concepts. Curr Opin Lipidol. 2016; 27:282-7.
  • Rautiola, J., Lampinen, A., Mirtti, T., Ristimaki, A., Joensuu, H., Bono, P., Saharinen, P. Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma. PLoS One. 2016; 11:e0153745.
  • Rasanen, M., Degerman, J., Nissinen, T.A., Miinalainen, I., Kerkela, R., Siltanen, A., Backman, J.T., Mervaala, E., Hulmi, J.J., Kivela, R., Alitalo, K. VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A. 2016; 113:13144-9.
  • Robciuc, M.R., Kivela, R., Williams, I.M., de Boer, J.F., van Dijk, T.H., Elamaa, H., Tigistu-Sahle, F., Molotkov, D., Leppanen, V.M., Kakela, R., Eklund, L., Wasserman, D.H., Groen, A.K., Alitalo, K. VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications. Cell Metab. 2016; 23:712-24.
  • Rämö, O., Kumar, D., Gucciardo, E., Joensuu, M., Saarekas, M., Vihinen, H., Belevich, I., Smolander, O.-P., Qian, K., Auvinen, P., Jokitalo, E. NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology. Scientific Reports. 2016; 6:35969.
  • Salo, V.T., Belevich, I., Li, S., Karhinen, L., Vihinen, H., Vigouroux, C., Magre, J., Thiele, C., Holtta-Vuori, M., Jokitalo, E., Ikonen, E. Seipin regulates ER-lipid droplet contacts and cargo delivery. EMBO J. 2016; 35:2699-716.
  • Saurus, P., Kuusela, S., Dumont, V., Lehtonen, E., Fogarty, C.L., Lassenius, M.I., Forsblom, C., Lehto, M., Saleem, M.A., Groop, P.H., Lehtonen, S. Cyclin-dependent kinase 2 protects podocytes from apoptosis. Sci Rep. 2016; 6:21664.
  • Tervaniemi, M.H., Katayama, S., Skoog, T., Siitonen, H.A., Vuola, J., Nuutila, K., Sormunen, R., Johnsson, A., Linnarsson, S., Suomela, S., Kankuri, E., Kere, J., Elomaa, O. NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis. Sci Rep. 2016; 6:22745.
  • Vishwanatha, K.S., Back, N., Lam, T.T., Mains, R.E., Eipper, B.A. O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking. J Biol Chem. 2016; 291:9835-50.
  • Ylosmaki, L., Fagerlund, R., Kuisma, I., Julkunen, I., Saksela, K. Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein. Viruses. 2016; 8:101.
  • Zou, J., Isomäki, A., Hirvonen, T., Aarnisalo, A., Jero, J., Pyykkö, I. Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy. Journal of Otology. 2016; 11:127-33.
2015
  • Aspelund, A., Antila, S., Proulx, S.T., Karlsen, T.V., Karaman, S., Detmar, M., Wiig, H., Alitalo, K. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 2015; 212:991-9.
  • Blom, T., Li, S., Dichlberger, A., Back, N., Kim, Y.A., Loizides-Mangold, U., Riezman, H., Bittman, R., Ikonen, E. LAPTM4B facilitates late endosomal ceramide export to control cell death pathways. Nat Chem Biol. 2015; 11:799-806.
  • Bonnemaison, M.L., Back, N., Duffy, M.E., Ralle, M., Mains, R.E., Eipper, B.A. Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine alpha-Amidating Monooxygenase, a Luminal Cuproenzyme. J Biol Chem. 2015; 290:21264-79.
  • Castren, E., Sillat, T., Oja, S., Noro, A., Laitinen, A., Konttinen, Y.T., Lehenkari, P., Hukkanen, M., Korhonen, M. Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum. Stem Cell Res Ther. 2015; 6:167.
  • Christophersen, P.C., Birch, D., Saarinen, J., Isomaki, A., Nielsen, H.M., Yang, M., Strachan, C.J., Mu, H. Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy. J Control Release. 2015; 197:111-20.
  • Darville, N., Saarinen, J., Isomaki, A., Khriachtchev, L., Cleeren, D., Sterkens, P., van Heerden, M., Annaert, P., Peltonen, L., Santos, H.A., Strachan, C.J., Van den Mooter, G. Multimodal non-linear optical imaging for the investigation of drug nano-/microcrystal-cell interactions. Eur J Pharm Biopharm. 2015; 96:338-48.
  • den Hollander, B., Dudek, M., Ojanpera, I., Kankuri, E., Hyytia, P., Korpi, E.R. Manganese-enhanced magnetic resonance imaging reveals differential long-term neuroadaptation after methamphetamine and the substituted cathinone 4-methylmethcathinone (mephedrone). Int J Neuropsychopharmacol. 2015; 18.
  • Faisal, I., Kauppi, L. Sex chromosome recombination failure, apoptosis, and fertility in male mice. Chromosoma. 2015.
  • Hakanpaa, L., Sipila, T., Leppanen, V.M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K., Saharinen, P. Endothelial destabilization by angiopoietin-2 via integrin beta1 activation. Nat Commun. 2015; 6:5962.
  • Holopainen, T., Rasanen, M., Anisimov, A., Tuomainen, T., Zheng, W., Tvorogov, D., Hulmi, J.J., Andersson, L.C., Cenni, B., Tavi, P., Mervaala, E., Kivela, R., Alitalo, K. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Proc Natl Acad Sci U S A. 2015; 112:13063-8.
  • Hyvonen, M.E., Dumont, V., Tienari, J., Lehtonen, E., Ustinov, J., Havana, M., Jalanko, H., Otonkoski, T., Miettinen, P.J., Lehtonen, S. Early-onset diabetic E1-DN mice develop albuminuria and glomerular injury typical of diabetic nephropathy. Biomed Res Int. 2015; 2015:102969.
  • Jarvinen, E., Ismail, K., Muniandy, M., Bogl, L.H., Heinonen, S., Tummers, M., Miettinen, S., Kaprio, J., Rissanen, A., Ollikainen, M., Pietilainen, K.H. Biotin-dependent functions in adiposity: a study of monozygotic twin pairs. Int J Obes (Lond). 2015.
  • Jokinen, R., Lahtinen, T., Marttinen, P., Myohanen, M., Ruotsalainen, P., Yeung, N., Shvetsova, A., Kastaniotis, A.J., Hiltunen, J.K., Ohman, T., Nyman, T.A., Weiler, H., Battersby, B.J. Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice. Genetics. 2015; 200:221-35.
  • Lahtela, J., Pradhan, B., Narhi, K., Hemmes, A., Sarkioja, M., Kovanen, P.E., Brown, A., Verschuren, E.W. The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis. Dis Model Mech. 2015; 8:393-401.
  • Loukovaara, S., Gucciardo, E., Repo, P., Lohi, J., Salven, P., Lehti, K. A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion. Case Rep Ophthalmol. 2015; 6:228-38.
  • Marques, E., Englund, J.I., Tervonen, T.A., Virkunen, E., Laakso, M., Myllynen, M., Makela, A., Ahvenainen, M., Lepikhova, T., Monni, O., Hautaniemi, S., Klefstrom, J. Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers. Oncogene. 2015.
  • Mattila, O.S., Rantanen, V., Saksi, J., Strbian, D., Pikkarainen, T., Hautaniemi, S., Lindsberg, P.J. Workflow for automated quantification of cerebromicrovascular gelatinase activity. Microvasc Res. 2015; 97:19-24.
  • Nurmi, H., Saharinen, P., Zarkada, G., Zheng, W., Robciuc, M.R., Alitalo, K. VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption. EMBO Mol Med. 2015; 7:1418-25.
  • Nuutila, K., Peura, M., Suomela, S., Hukkanen, M., Siltanen, A., Harjula, A., Vuola, J., Kankuri, E. Recombinant human collagen III gel for transplantation of autologous skin cells in porcine full-thickness wounds. J Tissue Eng Regen Med. 2015; 9:1386-93.
  • Polinati, P.P., Ilmarinen, T., Trokovic, R., Hyotylainen, T., Otonkoski, T., Suomalainen, A., Skottman, H., Tyni, T. Patient-Specific Induced Pluripotent Stem Cell-Derived RPE Cells: Understanding the Pathogenesis of Retinopathy in Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency. Invest Ophthalmol Vis Sci. 2015; 56:3371-82.
  • Polinati, P.P., Valanne, L., Tyni, T. Malonyl-CoA decarboxylase deficiency: long-term follow-up of a patient new clinical features and novel mutations. Brain Dev. 2015; 37:107-13.
  • Richter, U., Lahtinen, T., Marttinen, P., Suomi, F., Battersby, B.J. Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness. J Cell Biol. 2015; 211:373-89.
  • Riihijarvi, S., Fiskvik, I., Taskinen, M., Vajavaara, H., Tikkala, M., Yri, O., Karjalainen-Lindsberg, M.L., Delabie, J., Smeland, E., Holte, H., Leppa, S. Prognostic influence of macrophages in patients with diffuse large B-cell lymphoma: a correlative study from a Nordic phase II trial. Haematologica. 2015; 100:238-45.
  • Scifo, E., Szwajda, A., Soliymani, R., Pezzini, F., Bianchi, M., Dapkunas, A., Debski, J., Uusi-Rauva, K., Dadlez, M., Gingras, A.C., Tyynela, J., Simonati, A., Jalanko, A., Baumann, M.H., Lalowski, M. Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells. J Proteomics. 2015; 123:42-53.
  • Scifo, E., Szwajda, A., Soliymani, R., Pezzini, F., Bianchi, M., Dapkunas, A., Debski, J., Uusi-Rauva, K., Dadlez, M., Gingras, A.C., Tyynela, J., Simonati, A., Jalanko, A., Baumann, M.H., Lalowski, M. Quantitative analysis of PPT1 interactome in human neuroblastoma cells. Data Brief. 2015; 4:207-16.
  • Tamminen, J.A., Yin, M., Ronty, M., Sutinen, E., Pasternack, A., Ritvos, O., Myllarniemi, M., Koli, K. Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res. 2015; 332:102-15.
  • Tamminen, K., Balboa, D., Toivonen, S., Pakarinen, M.P., Wiener, Z., Alitalo, K., Otonkoski, T. Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1. PLoS One. 2015; 10:e0134551.
  • Tatti, O., Gucciardo, E., Pekkonen, P., Holopainen, T., Louhimo, R., Repo, P., Maliniemi, P., Lohi, J., Rantanen, V., Hautaniemi, S., Alitalo, K., Ranki, A., Ojala, P.M., Keski-Oja, J., Lehti, K. MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma. Cancer Res. 2015; 75:2083-94.
  • Tervonen, T.A., Belitskin, D., Pant, S.M., Englund, J.I., Marques, E., Ala-Hongisto, H., Nevalaita, L., Sihto, H., Heikkila, P., Leidenius, M., Hewitson, K., Ramachandra, M., Moilanen, A., Joensuu, H., Kovanen, P.E., Poso, A., Klefstrom, J. Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene. 2015.
  • Tolvanen, T.A., Dash, S.N., Polianskyte-Prause, Z., Dumont, V., Lehtonen, S. Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes. J Cell Sci. 2015; 128:4588-600.
  • Valimaki, N., Demir, H., Pitkanen, E., Kaasinen, E., Karppinen, A., Kivipelto, L., Schalin-Jantti, C., Aaltonen, L.A., Karhu, A. Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas. J Clin Endocrinol Metab. 2015; 100:3918-27.
  • Vassilev, B., Sihto, H., Li, S., Holtta-Vuori, M., Ilola, J., Lundin, J., Isola, J., Kellokumpu-Lehtinen, P.L., Joensuu, H., Ikonen, E. Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers. Am J Pathol. 2015; 185:987-1000.
  • Weber-Boyvat, M., Kentala, H., Lilja, J., Vihervaara, T., Hanninen, R., Zhou, Y., Peranen, J., Nyman, T.A., Ivaska, J., Olkkonen, V.M. OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. Exp Cell Res. 2015; 331:278-91.
  • Werner, S., Brors, B., Eick, J., Marques, E., Pogenberg, V., Parret, A., Kemming, D., Wood, A.W., Edgren, H., Neubauer, H., Streichert, T., Riethdorf, S., Bedi, U., Baccelli, I., Jucker, M., Eils, R., Fehm, T., Trumpp, A., Johnsen, S.A., Klefstrom, J., Wilmanns, M., Muller, V., Pantel, K., Wikman, H. Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2. Cancer Discov. 2015; 5:506-19.
  • Wiese, K.E., Haikala, H.M., von Eyss, B., Wolf, E., Esnault, C., Rosenwald, A., Treisman, R., Klefstrom, J., Eilers, M. Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. EMBO J. 2015; 34:1554-71.
  • Zarkada, G., Heinolainen, K., Makinen, T., Kubota, Y., Alitalo, K. VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci U S A. 2015; 112:761-6.
2014
  • Af Hallstrom, T.M., Zhao, H., Tian, J., Rantanen, V., Reese, S.W., Nolley, R., Laiho, M., Peehl, D.M. A tissue graft model of DNA damage response in the normal and malignant human prostate. J Urol. 2014; 191:842-9.
  • Aspelund, A., Tammela, T., Antila, S., Nurmi, H., Leppanen, V.M., Zarkada, G., Stanczuk, L., Francois, M., Makinen, T., Saharinen, P., Immonen, I., Alitalo, K. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. J Clin Invest. 2014; 124:3975-86.
  • Bautista, G., Pfisterer, S.G., Huttunen, M.J., Ranjan, S., Kanerva, K., Ikonen, E., Kauranen, M. Polarized THG microscopy identifies compositionally different lipid droplets in mammalian cells. Biophys J. 2014; 107:2230-6.
  • Colis, L., Peltonen, K., Sirajuddin, P., Liu, H., Sanders, S., Ernst, G., Barrow, J.C., Laiho, M. DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. Oncotarget. 2014; 5:4361-9.
  • D'Amico, G., Korhonen, E.A., Anisimov, A., Zarkada, G., Holopainen, T., Hagerling, R., Kiefer, F., Eklund, L., Sormunen, R., Elamaa, H., Brekken, R.A., Adams, R.H., Koh, G.Y., Saharinen, P., Alitalo, K. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest. 2014; 124:824-34.
  • Dash, S.N., Lehtonen, E., Wasik, A.A., Schepis, A., Paavola, J., Panula, P., Nelson, W.J., Lehtonen, S. Sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesis. J Cell Sci. 2014; 127:1476-86.
  • Dudek, M., Abo-Ramadan, U., Hermann, D., Brown, M., Canals, S., Sommer, W.H., Hyytia, P. Brain activation induced by voluntary alcohol and saccharin drinking in rats assessed with manganese-enhanced magnetic resonance imaging. Addict Biol. 2014.
  • Hakonen, E., Ustinov, J., Eizirik, D.L., Sariola, H., Miettinen, P.J., Otonkoski, T. In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes. Diabetologia. 2014; 57:970-9.
  • Hakonen, E., Ustinov, J., Palgi, J., Miettinen, P.J., Otonkoski, T. EGFR signaling promotes beta-cell proliferation and survivin expression during pregnancy. PLoS One. 2014; 9:e93651.
  • Hyrskyluoto, A., Bruelle, C., Lundh, S.H., Do, H.T., Kivinen, J., Rappou, E., Reijonen, S., Waltimo, T., Petersen, A., Lindholm, D., Korhonen, L. Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1alpha. Hum Mol Genet. 2014; 23:5928-39.
  • Hyvonen, M., Enback, J., Huhtala, T., Lammi, J., Sihto, H., Weisell, J., Joensuu, H., Rosenthal-Aizman, K., El-Andaloussi, S., Langel, U., Narvanen, A., Bergers, G., Laakkonen, P. Novel target for peptide-based imaging and treatment of brain tumors. Mol Cancer Ther. 2014; 13:996-1007.
  • Isomaki, A., Sillat, T., Ainola, M., Liljestrom, M., Konttinen, Y.T., Hukkanen, M. Label-free imaging of adipogenesis by coherent anti-stokes Raman scattering microscopy. Methods Mol Biol. 2014; 1142:189-201.
  • Jarvinen, E., Muhonen, V., Haaparanta, A.M., Kellomaki, M., Kiviranta, I. Optical projection tomography can be used to investigate spatial distribution of chondrocytes in three-dimensional biomaterial scaffolds for cartilage tissue engineering. Biomed Mater Eng. 2014; 24:1549-53.
  • Jeltsch, M., Jha, S.K., Tvorogov, D., Anisimov, A., Leppanen, V.M., Holopainen, T., Kivela, R., Ortega, S., Karpanen, T., Alitalo, K. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. Circulation. 2014; 129:1962-71.
  • Joensuu, T., Tegelberg, S., Reinmaa, E., Segerstrale, M., Hakala, P., Pehkonen, H., Korpi, E.R., Tyynela, J., Taira, T., Hovatta, I., Kopra, O., Lehesjoki, A.E. Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation. PLoS One. 2014; 9:e89321.
  • Kivela, R., Bry, M., Robciuc, M.R., Rasanen, M., Taavitsainen, M., Silvola, J.M., Saraste, A., Hulmi, J.J., Anisimov, A., Mayranpaa, M.I., Lindeman, J.H., Eklund, L., Hellberg, S., Hlushchuk, R., Zhuang, Z.W., Simons, M., Djonov, V., Knuuti, J., Mervaala, E., Alitalo, K. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Mol Med. 2014; 6:307-21.
  • Kupari, J., Airaksinen, M.S. Different requirements for GFRalpha2-signaling in three populations of cutaneous sensory neurons. PLoS One. 2014; 9:e104764.
  • Marbacher, S., Marjamaa, J., Bradacova, K., von Gunten, M., Honkanen, P., Abo-Ramadan, U., Hernesniemi, J., Niemela, M., Frosen, J. Loss of mural cells leads to wall degeneration, aneurysm growth, and eventual rupture in a rat aneurysm model. Stroke. 2014; 45:248-54.
  • Marinkovic, I., Mattila, O.S., Strbian, D., Meretoja, A., Shekhar, S., Saksi, J., Abo-Ramadan, U., Rantanen, V., Lindsberg, P.J., Tatlisumak, T. Evolution of intracerebral hemorrhage after intravenous tPA: reversal of harmful effects with mast cell stabilization. J Cereb Blood Flow Metab. 2014; 34:176-81.
  • Neuvonen, M., Manna, M., Mokkila, S., Javanainen, M., Rog, T., Liu, Z., Bittman, R., Vattulainen, I., Ikonen, E. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. PLoS One. 2014; 9:e103743.
  • Nousiainen, H.O., Quintero, I.B., Myohanen, T.T., Voikar, V., Mijatovic, J., Segerstrale, M., Herrala, A.M., Kulesskaya, N., Pulkka, A.E., Kivinummi, T., Abo-Ramadan, U., Taira, T., Piepponen, T.P., Rauvala, H., Vihko, P. Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations. PLoS One. 2014; 9:e97851.
  • Parviainen, S., Ahonen, M., Diaconu, I., Hirvinen, M., Karttunen, A., Vaha-Koskela, M., Hemminki, A., Cerullo, V. CD40 ligand and tdTomato-armed vaccinia virus for induction of antitumor immune response and tumor imaging. Gene Ther. 2014; 21:195-204.
  • Peltonen, K., Colis, L., Liu, H., Jaamaa, S., Zhang, Z., Af Hallstrom, T., Moore, H.M., Sirajuddin, P., Laiho, M. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014; 13:2537-46.
  • Peltonen, K., Colis, L., Liu, H., Trivedi, R., Moubarek, M.S., Moore, H.M., Bai, B., Rudek, M.A., Bieberich, C.J., Laiho, M. A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell. 2014; 25:77-90.
  • Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R., Olkkonen, V.M. PNPLA3 mediates hepatocyte triacylglycerol remodeling. J Lipid Res. 2014; 55:739-46.
  • Tamminen, J.A., Yin, M., Ronty, M., Sutinen, E., Pasternack, A., Ritvos, O., Myllarniemi, M., Koli, K. Overexpression of activin-A and -B in malignant mesothelioma - Attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res. 2014.
  • Taskinen, M., Louhimo, R., Koivula, S., Chen, P., Rantanen, V., Holte, H., Delabie, J., Karjalainen-Lindsberg, M.L., Bjorkholm, M., Fluge, O., Pedersen, L.M., Fjorden, K., Jerkeman, M., Eriksson, M., Hautaniemi, S., Leppa, S. Deregulation of COMMD1 is associated with poor prognosis in diffuse large B-cell lymphoma. PLoS One. 2014; 9:e91031.
  • Wasik, A.A., Koskelainen, S., Hyvonen, M.E., Musante, L., Lehtonen, E., Koskenniemi, K., Tienari, J., Vaheri, A., Kerjaschki, D., Szalay, C., Revesz, C., Varmanen, P., Nyman, T.A., Hamar, P., Holthofer, H., Lehtonen, S. Ezrin is down-regulated in diabetic kidney glomeruli and regulates actin reorganization and glucose uptake via GLUT1 in cultured podocytes. Am J Pathol. 2014; 184:1727-39.
  • Wiener, Z., Band, A.M., Kallio, P., Hogstrom, J., Hyvonen, V., Kaijalainen, S., Ritvos, O., Haglund, C., Kruuna, O., Robine, S., Louvard, D., Ben-Neriah, Y., Alitalo, K. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-beta. Proc Natl Acad Sci U S A. 2014; 111:E2229-36.
  • Wiener, Z., Hogstrom, J., Hyvonen, V., Band, A.M., Kallio, P., Holopainen, T., Dufva, O., Haglund, C., Kruuna, O., Oliver, G., Ben-Neriah, Y., Alitalo, K. Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance. Cell Rep. 2014; 8:1943-56.
  • von Nandelstadh, P., Gucciardo, E., Lohi, J., Li, R., Sugiyama, N., Carpen, O., Lehti, K. Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton. Mol Biol Cell. 2014; 25:2556-70.
  • Zheng, W., Nurmi, H., Appak, S., Sabine, A., Bovay, E., Korhonen, E.A., Orsenigo, F., Lohela, M., D'Amico, G., Holopainen, T., Leow, C.C., Dejana, E., Petrova, T.V., Augustin, H.G., Alitalo, K. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions. Genes Dev. 2014; 28:1592-603.
  • Zhong, W., Zhou, Y., Li, J., Mysore, R., Luo, W., Li, S., Chang, M.S., Olkkonen, V.M., Yan, D. OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. Exp Cell Res. 2014; 322:227-35.
2013
  • Anisimov, A., Leppanen, V.M., Tvorogov, D., Zarkada, G., Jeltsch, M., Holopainen, T., Kaijalainen, S., Alitalo, K. The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands. Sci Signal. 2013; 6:ra52.
  • Anisimov, A., Tvorogov, D., Alitalo, A., Leppanen, V.M., An, Y., Han, E.C., Orsenigo, F., Gaal, E.I., Holopainen, T., Koh, Y.J., Tammela, T., Korpisalo, P., Keskitalo, S., Jeltsch, M., Yla-Herttuala, S., Dejana, E., Koh, G.Y., Choi, C., Saharinen, P., Alitalo, K. Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation. 2013; 127:424-34.
  • Gaal, E.I., Tammela, T., Anisimov, A., Marbacher, S., Honkanen, P., Zarkada, G., Leppanen, V.M., Tatlisumak, T., Hernesniemi, J., Niemela, M., Alitalo, K. Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization. Blood. 2013; 122:658-65.
  • Hackman, P., Sarparanta, J., Lehtinen, S., Vihola, A., Evila, A., Jonson, P.H., Luque, H., Kere, J., Screen, M., Chinnery, P.F., Ahlberg, G., Edstrom, L., Udd, B. Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1. Ann Neurol. 2013.
  • Holtta-Vuori, M., Salo, V.T., Ohsaki, Y., Suster, M.L., Ikonen, E. Alleviation of seipinopathy-related ER stress by triglyceride storage. Hum Mol Genet. 2013; 22:1157-66.
  • Hyrskyluoto, A., Pulli, I., Tornqvist, K., Ho, T.H., Korhonen, L., Lindholm, D. Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-kappaB pathway. Cell Death Dis. 2013; 4:e646.
  • Kaivosoja, E., Suvanto, P., Barreto, G., Aura, S., Soininen, A., Franssila, S., Konttinen, Y.T. Cell adhesion and osteogenic differentiation on three-dimensional pillar surfaces. J Biomed Mater Res A. 2013; 101:842-52.
  • Kanerva, K., Uronen, R.L., Blom, T., Li, S., Bittman, R., Lappalainen, P., Peranen, J., Raposo, G., Ikonen, E. LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route. Dev Cell. 2013; 27:249-62.
  • Keranen, M.A., Tuuminen, R., Syrjala, S., Krebs, R., Walkinshaw, G., Flippin, L.A., Arend, M., Koskinen, P.K., Nykanen, A.I., Lemstrom, K.B. Differential effects of pharmacological HIF preconditioning of donors versus recipients in rat cardiac allografts. Am J Transplant. 2013; 13:600-10.
  • Koch, S., Scifo, E., Rokka, A., Trippner, P., Lindfors, M., Korhonen, R., Corthals, G.L., Virtanen, I., Lalowski, M., Tyynela, J. Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain. Neurobiol Dis. 2013; 50:107-19.
  • Koivuniemi, R., Makela, J., Hokkanen, M.E., Bruelle, C., Ho, T.H., Ola, R., Korhonen, L., Schroder, J., Kataoka, H., Lindholm, D. Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells. PLoS One. 2013; 8:e56117.
  • Li, L., Hu, Y., Ylivinkka, I., Li, H., Chen, P., Keski-Oja, J., Hyytiainen, M. NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence. PLoS One. 2013; 8:e80363.
  • Makarov, A., Ylivinkka, I., Nyman, T.A., Hyytiainen, M., Keski-Oja, J. Ephrin-As, Eph receptors and integrin alpha3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells. Cell Biol Int. 2013; 37:1080-8.
  • Markkanen, M., Karhunen, T., Llano, O., Ludwig, A., Rivera, C., Uvarov, P., Airaksinen, M.S. Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS. J Comp Neurol. 2013.
  • Matilainen, O., Arpalahti, L., Rantanen, V., Hautaniemi, S., Holmberg, C.I. Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Cell Rep. 2013; 3:1980-95.
  • Mikkonen, L., Hirvonen, J., Janne, O.A. SUMO-1 regulates body weight and adipogenesis via PPARgamma in male and female mice. Endocrinology. 2013; 154:698-708.
  • Moore, H.M., Bai, B., Matilainen, O., Colis, L., Peltonen, K., Laiho, M. Proteasome activity influences UV-mediated subnuclear localization changes of NPM. PLoS One. 2013; 8:e59096.
  • Nieminen, A.I., Eskelinen, V.M., Haikala, H.M., Tervonen, T.A., Yan, Y., Partanen, J.I., Klefstrom, J. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc Natl Acad Sci U S A. 2013; 110:E1839-48.
  • Pajarinen, J., Kouri, V.P., Jamsen, E., Li, T.F., Mandelin, J., Konttinen, Y.T. The response of macrophages to titanium particles is determined by macrophage polarization. Acta Biomater. 2013; 9:9229-40.
  • Pietiainen, V., Vassilev, B., Blom, T., Wang, W., Nelson, J., Bittman, R., Back, N., Zelcer, N., Ikonen, E. NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation. J Cell Sci. 2013; 126:3961-71.
  • Quintero, I.B., Herrala, A.M., Araujo, C.L., Pulkka, A.E., Hautaniemi, S., Ovaska, K., Pryazhnikov, E., Kulesskiy, E., Ruuth, M.K., Soini, Y., Sormunen, R.T., Khirug, L., Vihko, P.T. Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma. PLoS One. 2013; 8:e73072.
  • Raissadati, A., Jokinen, J.J., Syrjala, S.O., Keranen, M.A., Krebs, R., Tuuminen, R., Arnaudova, R., Rouvinen, E., Anisimov, A., Soronen, J., Pajusola, K., Alitalo, K., Nykanen, A.I., Lemstrom, K. Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants. Transpl Int. 2013; 26:1126-37.
  • Sarek, G., Ma, L., Enback, J., Jarviluoma, A., Moreau, P., Haas, J., Gessain, A., Koskinen, P.J., Laakkonen, P., Ojala, P.M. Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. Oncogene. 2013; 32:1091-8.
  • Scifo, E., Szwajda, A., Debski, J., Uusi-Rauva, K., Kesti, T., Dadlez, M., Gingras, A.C., Tyynela, J., Baumann, M.H., Jalanko, A., Lalowski, M. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. J Proteome Res. 2013; 12:2101-15.
  • Sokolenko, A.P., Bulanova, D.R., Iyevleva, A.G., Aleksakhina, S.N., Preobrazhenskaya, E.V., Ivantsov, A.O., Kuligina, E.S., Mitiushkina, N.V., Suspitsin, E.N., Yanus, G.A., Zaitseva, O.A., Yatsuk, O.S., Togo, A.V., Kota, P., Dixon, J.M., Larionov, A.A., Kuznetsov, S.G., Imyanitov, E.N. High prevalence of GPRC5A germline mutations in BRCA1-mutant breast cancer patients. Int J Cancer. 2013; 134:2352-8.
  • Sugiyama, N., Gucciardo, E., Tatti, O., Varjosalo, M., Hyytiainen, M., Gstaiger, M., Lehti, K. EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion. J Cell Biol. 2013; 201:467-84.
  • Tamminen, J.A., Parviainen, V., Ronty, M., Wohl, A.P., Murray, L., Joenvaara, S., Varjosalo, M., Lepparanta, O., Ritvos, O., Sengle, G., Renkonen, R., Myllarniemi, M., Koli, K. Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug. Oncogenesis. 2013; 2:e66.
  • Ylivinkka, I., Hu, Y., Chen, P., Rantanen, V., Hautaniemi, S., Nyman, T.A., Keski-Oja, J., Hyytiainen, M. Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion. J Cell Sci. 2013; 126:2459-69.
2012
  • Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A. Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice. Cell Metab. 2012; 15:100-109.
  • Band AM, Laiho M. SnoN oncoprotein enhances estrogen receptor-a transcriptional activity. Cell Signal. 2012; 24:922-930.
  • Blom T, Li Z, Bittman R, Somerharju P, Ikonen E. Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case. Traffic. 2012; 13:1234-1243.
  • Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z, Andersson LC, Pihlajaniemi T, Min W, Alitalo K. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res. 2012; 72:3512-3521.
  • Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, Alitalo K. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst. 2012; 104:461-475.
  • Hölttä-Vuori M, Vainio S, Kauppi M, Van Eck M, Jokitalo E, Ikonen E. Endosomal Actin Remodeling by Coronin-1A Controls Lipoprotein Uptake and Degradation in Macrophages. Circ Res. 2012; 110:450-455.
  • Hongisto H, Vuoristo S, Mikhailova A, Suuronen R, Virtanen I, Otonkoski T, Skottman H. Laminin-511 expression is associated with the functionality of feeder cells in human embryonic stem cell culture. Stem Cell Res. 2012; 8:97-108.
  • Hu Y, Ylivinkka I, Chen P, Li L, Hautaniemi S, Nyman TA, Keski-Oja J, Hyytiäinen M. Netrin-4 promotes glioblastoma cell proliferation through integrin ß4 signaling. Neoplasia. 2012; 14:219-227.
  • Hyrskyluoto A, Reijonen S, Kivinen J, Lindholm D, Korhonen L. GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway. Exp Cell Res. 2012; 318:33-42.
  • Jansson LC, Louhivuori L, Wigren HK, Nordström T, Louhivuori V, Castrén ML, Åkerman KE. Brain-derived neurotrophic factor increases the motility of a particular N-methyl-D-aspartate /GABA-responsive subset of neural progenitor cells. Neuroscience. 2012; 224:223-234.
  • Järvinen PM, Myllärniemi M, Liu H, Moore HM, Leppäranta O, Salmenkivi K, Koli K, Latonen L, Band A, Laiho M. Cysteine-rich protein 1 is Regulated by Transforming Growth Factor-ß1 and Expressed in Lung Fibrosis. J Cell Physiol. 2012; 227:2605-2612.
  • Jäämaa S, Sankila A, Rantanen V, Peltonen K, Järvinen PM, Af Hällström TM, Ruutu M, Taari K, Andersson LC, Laiho M. Contrasting DNA Damage Checkpoint Responses in Epithelium of the Human Seminal Vesicle and Prostate. Prostate. 2012; 72:1060-1070.
  • Karhemo PR, Ravela S, Laakso M, Ritamo I, Tatti O, Mäkinen S, Goodison S, Stenman UH, Hölttä E, Hautaniemi S, Valmu L, Lehti K, Laakkonen P. An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis. J Proteomics. 2012; 77:87-100.
  • Kinnari TJ, Lampikoski H, Hyyrynen T, Aarnisalo AA. Bacterial biofilm associated with chronic laryngitis. Arch Otolaryngol Head Neck Surg. 2012; 138:467-70.
  • Koivisto A, Hukkanen M, Saarnilehto M, Chapman H, Kuokkanen K, Wei H, Viisanen H, Åkerman KE, Lindstedt K, Pertovaara A. Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: Sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Pharmacol Res. 2012; 65:149-158.
  • Kovac B, Teo JL, Mäkelä TP, Vallenius T. Assembly of non-contractile dorsal stress fibers requires a-actinin-1 and Rac1 in migrating and spreading cells. J Cell Sci. 2012; 126:263-73
  • Kuronen M, Hermansson M, Manninen O, Zech I, Talvitie M, Laitinen T, Gröhn O, Somerharju P, Eckhardt M, Cooper JD, Lehesjoki AE, Lahtinen U, Kopra O. Galactolipid deficiency in the early pathogenesis of neuronal ceroid lipofuscinosis model Cln8mnd: implications to delayed myelination and oligodendrocyte maturation. Neuropathol Appl Neurobiol. 2012; 38:471-486.
  • Lampikoski H, Aarnisalo AA, Jero J, Kinnari TJ. Mastoid biofilm in chronic otitis media. Otol Neurotol. 2012; 33:785-8.
  • Lavilla-Alonso S, Bauer MM, Abo-Ramadan U, Ristimäki A, Halavaara J, Desmond RA, Wang D, Escutenaire S, Ahtiainen L, Saksela K, Tatlisumak T, Hemminki A, Pesonen S. Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development. Cancer Gene Ther. 2012; 19:126-134.
  • Nissilä E, Ohsaki Y, Weber-Boyvat M, Perttilä J, Ikonen E, Olkkonen VM. ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion. Biochim Biophys Acta. 2012; 1821:1472-1484.
  • Nokisalmi P, Rajecki M, Pesonen S, Escutenaire S, Soliymani R, Tenhunen M, Ahtiainen L, Hemminki A. Radiation-Induced Upregulation of Gene Expression from Adenoviral Vectors Mediated by DNA Damage Repair and Regulation. Int J Radiat Oncol Biol Phys. 2012; 83:376-384.
  • Ola R, Lefebvre S, Braunewell KH, Sainio K, Sariola H. The expression of Visinin-like 1 during mouse embryonic development. Gene Expr Patterns. 2012; 12:53-62.
  • Partanen JI, Tervonen TA, Myllynen M, Lind E, Imai M, Katajisto P, Dijkgraaf GJ, Kovanen PE, Mäkelä TP, Werb Z, Klefström J. Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci USA. 2012; 109:E388-97.
  • Peura M, Kaartinen I, Suomela S, Hukkanen M, Bizik J, Harjula A, Kankuri E, Vuola J. Improved skin wound epithelialization by topical delivery of soluble factors from fibroblast aggregates. Burns 2012; 38:541-550.
  • Pitkonen M, Abo-Ramadan U, Marinkovic I, Pedrono E, Hasan KM, Strbian D, Durukan A, Tatlisumak T. Long-term evolution of diffusion tensor indices after temporary experimental ischemic stroke in rats. Brain Res. 2012; 1445:103-110.
  • Robciuc MR, Skrobuk P, Anisimov A, Olkkonen VM, Alitalo K, Eckel RH, Koistinen HA, Jauhiainen M, Ehnholm C. Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. PLoS One. 2012; 7:e46212.
  • Sarek G, Ma L, Enbäck J, Järviluoma A, Moreau P, Haas J, Gessain A, Koskinen PJ, Laakkonen P, Ojala PM. Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas. Oncogene. 2012; Epub ahead of print.
  • Sarparanta J, Jonson PH, Golzio C, Sandell S, Luque H, Screen M, McDonald K, Stajich JM, Mahjneh I, Vihola A, Raheem O, Penttilä S, Lehtinen S, Huovinen S, Palmio J, Tasca G, Ricci E, Hackman P, Hauser M, Katsanis N, Udd B. Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy. Nat Genet. 2012; 44:450–455.
  • Sillat T, Saat R, Pöllänen R, Hukkanen M, Takagi M, Konttinen YT. Basement membrane collagen type IV expression by human mesenchymal stem cells during adipogenic differentiation. J Cell Mol Med. 2012; 16:1485-95.
  • Tamminen JA, Myllärniemi M, Hyytiäinen M, Keski-Oja J, Koli K. Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling. J Cell Biochem. 2012; 113:2234-2247
  • Tervaniemi MH, Siitonen HA, Söderhäll C, Minhas G, Vuola J, Tiala I, Sormunen R, Samuelsson L, Suomela S, Kere J, Elomaa O. Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization. PLoS One. 2012; 7:e49920.
  • Thiel A, Narko K, Heinonen M, Hemmes A, Tomasetto C, Rio MC, Haglund C, Mäkelä TP, Ristimäki A. Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. Int J Cancer 2012; 131:1032-41.
  • Uusi-Rauva K, Kyttälä A, van der Kant R, Vesa J, Tanhuanpää K, Neefjes J, Olkkonen VM, Jalanko A. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. Cell Mol Life Sci. 2012; 69:2075-2089.
  • Zou J, Poe D, Ramadan UA, Pyykkö I. Oval window transports Gd-DOTA from the rat middle ear to the vestibulum and scala vestibuli shown by in vivo MRI. Ann Oto Rhinol Laryn. 2012; 121:119-128.
  • Zou J, Sood R, Ranjan S, Poe D, Ramadan UA, Pyykkö I, Kinnunen PK. Size-dependent passage of liposome nanocarriers with preserved posttransport integrity across the middle-inner ear barriers in rats. Otol Neurotol. 2012; 33:666-673.
2011
  • Tammela T, Saaristo A, Holopainen T, Ylä-Herttuala S, Andersson LC, Virolainen S, Immonen I,Alitalo K. Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis. Sci Transl Med. 2011 Feb 9;3(69)
  • Leppänen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Ylä-Herttuala S, Ballmer-Hofer K, Alitalo K. Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood. 2011 Feb 3;117(5):1507-15. Epub 2010 Dec 8.
  • Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK. Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet. 2011 Jun;7(6):e1002119. Epub 2011 Jun 9.
  • Karhemo, P-R., Rivinoja, A., Lundin, J., Hyvönen, M., Chernenko, A., Lammi, J., Sihto, H., Lundin, M., Heikkilä, P., Joensuu, H., Bono, P. and Laakkonen, P. An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer. Am. J. Pathol. 2011;179(2):1004-14.
  • Mattila OS, Strbian D, Saksi J, Pikkarainen TO, Rantanen V, Tatlisumak T, Lindsberg PJ. Cerebral mast cells mediate blood-brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation. Stroke 2011 Dec;42(12):3600-5. Epub 2011 Oct 6.
  • Moore HM, Bai B, Boisvert FM, Latonen L, Rantanen V, Simpson JC, Pepperkok R, Lamond AI, Laiho M. Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation. Mol Cell Proteomics. 2011 Oct;10(10):M111.009241. Epub 2011 Jul 21.
  • Latonen L, Moore HM, Bai B, Jäämaa S, Laiho M. Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability. Oncogene. 2011 Feb 17;30(7):790-805. Epub 2010 Oct 18.
  • Tuuminen, R., Syrjälä, S., Krebs, R., Keränen, M.A.I., Koli, K., Abo-Ramadan, U., Nykänen, A.I. and Lemström K.B.: Donor simvastatin treatment abolishes rat cardiac allograft ischemia-reperfusion injury and chronic rejection through microvascular protection. Circulation , 2011;124:1138-1150
  • Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol. 2011 Sep 11;13(10):1202-13.
  • Hernández M, Gamonal J, Salo T, Tervahartiala T, Hukkanen M, Tjäderhane L, Sorsa T. Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice. J Periodontal Res 2011;46:58-66.
  • Tatti O, Arjama M, Ranki A, Weiss SJ, Keski-Oja J, Kaisa Lehti. (2011) Membrane-Type-3 Matrix Metalloproteinase (MT3-MMP) Functions as a Matrix Composition-Dependent Effector of Melanoma Cell Invasion. PLoS ONE 6(12): e28325. doi:10.1371/journal.pone.0028325
  • Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T, Lehti K, Ylä-Herttuala S, Alitalo K. Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor. Blood. 2011 Jul 28;118(4):1154-62. Epub 2011 May 12.
  • Thiel A, Narko K, Heinonen M, Hemmes A, Tomasetto C, Rio MC, Haglund C, Mäkelä TP, Ristimäki A. Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. Int J Cancer. 2011 Oct 27. doi: 10.1002/ijc.27331. [Epub ahead of print]
  • Lavilla-Alonso S, Abo-Ramadan U, Halavaara J, Escutenaire S, Tatlisumak T, Saksela K, Kanerva A, Hemminki A, Pesonen S. Optimized mouse model for the imaging of tumor metastasis upon experimental therapy. PLOS ONE 2011; 6(11), e26810.
  • Marjamaa J, Antell H, Abo-Ramadan U, Hernesniemi JA, Niemelä MR, Kangasniemi M. High-resolution TOF MR angiography at 4.7 Tesla for volumetric and morphologic evaluation of coiled aneurysm neck remnants in a rat model. Acta Radiol 2011;52:340-8.
  • Planagumà P, Liljeström M, Alameda F, Bützow R, Virtanen I, Reventós J, Hukkanen M. Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma. Hum Pathol 2011;42:57-67.
  • Vihervaara T, Uronen RL, Wohlfahrt G, Björkhem I, Ikonen E, Olkkonen VM. Sterol binding by OSBP-related protein 1L regulates late endosome motility and function. Cell Mol Life Sci 2011;68:537-51.
  • Zou J, Yoshida T, Ramadan UA, Pyykkö I. Dynamic enhancement of the rat inner ear after ultra-small-volume administration of Gd-DOTA to the medial wall of the middle ear cavity. ORL J Otorhinolaryngol Relat Spec 2011;73:275-81.
  • Alan E. Renton, Elisa Majounie, Adrian Waite, Javier Simón-Sánchez, Sara Rollinson, J. Raphael Gibbs, Jennifer C. Schymick, Hannu Laaksovirta, John C. van Swieten, Liisa Myllykangas, Hannu Kalimo, Anders Paetau, Yevgeniya Abramzon, Anne M. Remes, Alice Kaganovich, Sonja W. Scholz, Jamie Duckworth, Jinhui Ding, Daniel W. Harmer, Dena G. Hernandez, Janel O. Johnson, Kin Mok, Mina Ryten, Danyah Trabzuni, Rita J. Guerreiro, Richard W. Orrell, James Neal, Alex Murray, Justin Pearson, Iris E. Jansen, David Sondervan, Harro Seelaar, Derek Blake, Kate Young, Nicola Halliwell, Janis Bennion Callister, Greg Toulson, Anna Richardson, Alex Gerhard, Julie Snowden, David Mann, David Neary, Michael A. Nalls, Terhi Peuralinna, Lilja Jansson, Veli-Matti Isoviita, Anna-Lotta Kaivorinne, Maarit Hölttä-Vuori, Elina Ikonen, Raimo Sulkava, Michael Benatar, Joanne Wuu, Adriano Chió, Gabriella Restagno, Giuseppe Borghero, Mario Sabatelli, The ITALSGEN Consortium, David Heckerman, Ekaterina Rogaeva, Lorne Zinman, Jeffrey D. Rothstein, Michael Sendtner, Carsten Drepper, Evan E. Eichler, Can Alkan, Ziedulla Abdullaev, Svetlana D. Pack, Amalia Dutra, Evgenia Pak, John Hardy, Andrew Singleton, Nigel M. Williams, Peter Heutink, Stuart Pickering-Brown, Huw R. Morris, Pentti J. Tienari, and Bryan J. Traynor. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD. Neuron 2011;72:257-268
  • Anna Meuronen. The role of inflammation and matrix proteins in airway remodelling. Helsinki University Biomedical Dissertations 2011
  • Camilla Norrmén, Tuomas Tammela, Tatiana V. Petrova and Kari Alitalo. Biological Basis of Therapeutic Lymphangiogenesis. Circulation 2011;123:1335-1351
  • Chiara Procaccini, Teemu Aitta-aho, Külli Jaako-Movits, Alexander Zharkovsky, Anne Panhelainen, Rolf Sprengel, Anni-Maija Linden and Esa R. Korpi. Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice. European Journal of Neuroscience 2011;33:161-174
  • Fang Cheng, Pirita Pekkonen, Simonas Laurinavicius, Nami Sugiyama, Stephen Henderson, Thomas Günther, Ville Rantanen, Elisa Kaivanto, Mervi Aavikko, Grzegorz Sarek, Sampsa Hautaniemi, Peter Biberfeld, Lauri Aaltonen, Adam Grundhoff, Chris Boshoff, Kari Alitalo, Kaisa Lehti, and Päivi M. Ojala. KSHV-Initiated Notch Activation Leads to Membrane-Type-1MatrixMetalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition . Cell Host & Microbe 2011;10:577-590
  • Ilkka Liikanen, Vladia Monsurrò, Laura Ahtiainen, Mari Raki, Tanja Hakkarainen, Iulia Diaconu, Sophie Escutenaire, Otto Hemminki, João D Dias, Vincenzo Cerullo, Anna Kanerva, Sari Pesonen, Daniela Marzioni, Marco Colombatti and Akseli Hemminki. Induction of Interferon Pathways Mediates In Vivo Resistance to Oncolytic Adenovirus. Molecular Therapy 2011;19:10:1858-1866
  • Karoliina Vuoriluoto, Gunilla Högnäs, Pipsa Meller, Kaisa Lehti, Johanna Ivaska. Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP. Matrix Biology 2011;30:207-217
  • Maria Sundvik, Hisaaki Kudo, Pauliina Toivonen, Stanislav Rozov, Yu-Chia Chen, and Pertti Panula. The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1 in zebrafish. FASEB Journal 2011;25:4338-4347
  • Maurice Jansen . Using fluorescent and non-fluorescent sterols to study rafts and intracellular cholesterol transport in mammalian cells. Helsinki University Biomedical Dissertations 2011
  • Maurice Jansen, Yuki Ohsaki, Laura Rita Rega, Robert Bittman, Vesa M. Olkkonen and Elina Ikonen. Role of ORPs in Sterol Transport from Plasma Membrane to ER and Lipid Droplets in Mammalian Cells. Traffic 2011;12:218-231
  • Noora Putkonen, Jyrki P. Kukkonen, Guiseppa Mudo, Jaana Putula, Natale Belluardo, Dan Lindholm and Laura Korhonen. Involvement of cyclin-dependent kinase-5 in the kainic acid-mediated degeneration of glutamatergic synapses in the rat hippocampus. European Journal of Neuroscience 2011;34:1212-1221
  • Pauliina Porola. Sex steroids in Sjögren's syndrome. Helsinki University Biomedical Dissertations 2011
  • Pernilla von Nandelstadh, Rabah Soliymani, Marc Baumann and Olli Carpen. Analysis of myotilin turnover provides mechanistic insight into the role of myotilinopathy-causing mutations. Biochemical Journal 2011;436:113-121
  • Roxana Ola, Madis Jakobson, Jouni Kvist, Nina Perälä, Satu Kuure, Karl-Heinz Braunewell, Darren Bridgewater, Norman D. Rosenblum, Dmitri Chilov, Tiina Immonen, Kirsi Sainio, and Hannu Sariola. The GDNF Target Vsnl1 Marks the Ureteric Tip. Journal of the American society of nephrology 2011;22:274-284
  • Sari Jäämaa. DNA damage recognition in the normal epithelium of human prostate and seminal vesicles. Helsinki University Biomedical Dissertations 2011
  • Satu Massinen, Marie-Estelle Hokkanen, Hans Matsson, Kristiina Tammimies, Isabel Tapia-Páez, Vanina Dahlström-Heuser, Juha Kuja-Panula, Jan Burghoorn, Kristian E. Jeppsson, Peter Swoboda, Myriam Peyrard-Janvid, Rune Toftgård, Eero Castrén, Juha Kere. Increased Expression of the Dyslexia Candidate Gene DCDC2 Affects Length and Signaling of Primary Cilia in Neurons. PLoS One 2011;6:6:e20580
  • Wenbin Zhong, You Zhou, Shiqian Li, Tianhong Zhou, Hongling Ma, Kunde Wei, Hongye Li, Vesa M. Olkkonen, Daoguang Yana. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Experimental Cell Research 2011;317:2353-2363
2010
  • Ahonen MT, Diaconu I, Pesonen S, Kanerva A, Baumann M, Parviainen ST, Spiller B, Cerullo V, Hemminki A. Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5. PLoS One 2010;5(9).
  • Antell H, Numminen J, Abo-Ramadan U, Niemelä MR, Hernesniemi JA, Kangasniemi M. Optimization of high-resolution USPIO magnetic resonance imaging at 4.7 T using novel phantom with minimal structural interference. J Magn Reson Imaging 2010;32:1184-96.
  • Blom T, Bäck N, Mutka AL, Bittman R, Li Z, de Lera A, Kovanen PT, Diczfalusy U, Ikonen E. FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. Circ Res 2010;106:720-9.
  • Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, Carmeliet P, Lemström KB, Shibuya M, Ylä-Herttuala S, Alhonen L, Mervaala E, Andersson LC, Knuuti J, Alitalo K. VEGF-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak or inflammation. Circulation 2010;122:1725-33.
  • Bäck N, Rajagopal C, Mains RE, Eipper BA. Secretory granule membrane protein recycles through multivesicular bodies. Traffic 2010;11:972-86.
  • Enzerink A, Rantanen V, Vaheri A. Fibroblast nemosis induces angiogenic responses of endothelial cells. Exp Cell Res 2010;316:826-35.
  • Guse K, Sloniecka M, Diaconu I, Ottolino-Perry K, Tang N, Ng C, Le Boeuf F, Bell JC, McCart JA, Ristimäki A, Pesonen S, Cerullo V, Hemminki A. Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models. J Virol 2010;84:856-66.
  • Hamer G, Matilainen O, Holmberg CI. A photoconvertible reporter of the ubiquitin-proteasome system in vivo. Nature Methods 2010;7:473-8.
  • Hölttä-Vuori M, Salo TV, Nyberg L, Brackmann C, Enejder A, Panula P, and Ikonen E (2010) Zebrafish: gaining popularity in lipid research. Biochem J 2010: 429: 235-242.
  • Jäämaa S, Af Hällström TM, Sankila A, Rantanen V, Koistinen H, Stenman UH, Zhang Z, Yang Z, De Marzo AM, Taari K, Ruutu M, Andersson LC, Laiho M. DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue. Cancer Res 2010;70:8630-41.
  • Kaivosoja E, Myllymaa S, Kouri VP, Myllymaa K, Lappalainen R, Konttinen YT. Enhancement of silicon using micro-patterned surfaces of thin films. Eur Cell Mater 2010;19:147-57.
  • Lavilla-Alonso S, Bauerschmitz G, Abo-Ramadan U, Halavaara J, Escutenaire S, Diaconu I, Tatlisumak T, Kanerva A, Hemminki A, Pesonen S. Adenoviruses with an avß integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases. J Transl Med 2010;8:80.
  • Leppäranta O, Pulkkinen V, Koli K, Vähätalo R, Salmenkivi K, Kinnula VL, Heikinheimo M, Myllärniemi M. Transcription factor GATA-6 is expressed in quiescent myofibroblasts in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 2010;42:626-32.
  • Myllymaa S, Kaivosoja E, Myllymaa K, Sillat T. Korhonen H, Lappalainen R, Konttinen YT. Adhesion, spreading and osteogenic differentiation of mesenchymal stem cells cultured on micropatterned diamond, titanium, tantalum and chromium coating. J Mater Sci Mater Med 2010;21:329-41.
  • Norrmén C, Vandevelde W, Ny A, Saharinen P, Gentile M, Haraldsen G, Puolakkainen P, Lukanidin E, Dewerchin M, Alitalo K, Petrova TV. Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity. Blood 2010;115:906-9.
  • Pedrono E, Durukan A, Strbian D, Marinkovic I, Shekhar S, Pitkonen M, Abo-Ramadan U, Tatlisumak T. An optimized mouse model for transient ischemic attack. J Neuropathol Exp Neurol 2010;69:188-95.
  • Poduval P, Sillat T, Virtanen I, Dabagh-Meshin M, Konttinen YT. Immigration check for neutrophils in RA lining: laminin α5 low expression regions act as exit point. Scand J Rheumatol 2010;39:132-40.
  • Rajamäki K, Lappalainen J, Oörni K, Välimäki E, Matikainen S, Kovanen PT, Eklund KK. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One 2010;5:e11765.
  • Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K. Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development. Gene Dev 2010; 24: 875-80.
  • Sarek G, Järviluoma A, Moore HM, Tojkander S, Vartia S, Biberfeld P, Laiho M, Ojala PM. Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PLoS Pathog 2010;6:e1000818.
  • Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K. FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Proc Natl Acad Sci USA 2010;107:15786-91.
  • Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Ingvarsen S, Engelholm LH, Kallioniemi O, Alitalo K, Taipale J, Keski-Oja J, Lehti K. FGF receptor-4 regulates tumor invasion by coupling FGF-signaling to extracellular matrix degradation. Cancer Res, 2010;70:7851-61.
  • Takkunen M, Hukkanen M, Liljeström M, Grenman R, Virtanen I. Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia. J Cell Mol Med 2010;14:1569-93.
  • Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell 2010;18:630-40.
  • Uronen RL, Lundmark P, Orho-Melander M, Jauhiainen M, Larsson K, Siegbahn A, Wallentin L, Zethelius B, Melander O, Syvänen AC, Ikonen E. Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels. Arterioscler Thromb Vasc Biol 2010;30:1614-20.
  • Zhou Y, Li S, Mäyränpää MI, Zhong W, Bäck N, Yan D, Olkkonen VM. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. Exp Cell Res 2010;316:3304-16.
  • Zou J, Zhang W, Poe D, Zhang Y, Ramadan UA, Pyykkö I. Differential passage of gadolinium through the mouse inner ear barriers evaluated with 4.7 T MRI. Hear Res 2010;259:36-43.
  • Zou J, Ramadan UA, Pyykkö I. Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through the round window membrane. Otol Neurotol 2010;31:637-41.
  • Zou J, Sood R, Ranjan S, Poe D, Ramadan UA, Kinnunen PK, Pyykkö I. Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium. J Nanobiotechnology 2010;18:8:32.
  • Zou J, Zhang W, Poe D, Qin J, Fornara A, Zhang Y, Ramadan UA, Muhammed M, Pyykkö I. MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear. Nanomedicine (Lond) 2010;5:739-54.
2009
  • Abo-Ramadan U, Durukan A, Pitkonen M, Marinkovic I, Tatlisumak E, Pedrono E, Soinne L, Strbian D, Tatlisumak T. Post-ischemic leakiness of the blood-brain barrier: A quantitative and systematic assessment by Patlak plots. Exp Neurol 2009;219:328-33.
  • Ainola M, Li TF, Mandelin J, Hukkanen M, Choi SJ, Salo J, Konttinen YT. Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction. Ann Rheum Dis 2009;68:427-34.
  • Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen VM, Jeltsch M, Ylä-Herttuala S, Alitalo K. Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res 2009;104:1302-12.
  • Cheng F, Weidner-Glunde M, Varjosalo M, Rainio EM, Lehtonen A, Schulz TF, Koskinen PJ, Taipale J, Ojala PM. KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA. PLoS Pathog 2009;5:e1000324.
  • Durukan A, Marinkovic I, Strbian D, Pitkonen M, Pedrono E, Soinne L, Abo-Ramadan U, Tatlisumak T. Post-ischemic blood-brain barrier leakage in rats: one-week follow-up by MRI. Brain Res 2009;1280:158-65.
  • Koski A, Rajecki M, Guse K, Kanerva A, Ristimäki A, Pesonen S, Escutenaire S, Hemminki A. Systemic adenoviral gene delivery to orthotopic murine breast tumors with ablation of coagulation factors, thrombocytes and Kupffer cells. J Gene Med 2009;11:966-77.
  • Lehti K, Rose N, Valavaara S, Weiss SJ, Keski-Oja J. MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing. J Cell Science 2009;122:126-35.
  • Linden AM, Johnson BG, Trokovic N, Korpi ER, Schoepp DD. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology 2009;57:172-82.
  • Linder MD, Mäyränpää MI, Peränen J, Pietilä TE, Pietiäinen VM, Uronen RL, Olkkonen VM, Kovanen PT, Ikonen E. Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages. Arterioscler Thromb Vasc Biol 2009;29:883-8.
  • Marincovic I, Strbian D, Pedrono E, Vekovischeva O, Shekhar S, Durukan A, Korpi E, Abo-Ramadan U, Tatlisumak T. Decompressive craniectomy for intracerebral hemorrhage: the earlier the better. Neurosurgery 2009;65:780-6.
  • Marjamaa J, Tulamo R, Frösen J, Abo-Ramadan U, Hernesniemi J, Niemelä M, Kangasniemi M. Occlusion of neck remnant in experimental rat aneurysms after treatment with platinum or PGLA-coated coils. Surg Neurol 2009;71:458-65.
  • Norrmén C, Ivanov K, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin H, Ylä-Herttuala S, Alitalo K, Petrova T. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biology 2009;185:439-57.
  • Perttilä J, Merikanto K, Naukkarinen J, Surakka I, Martin NW, Tanhuanpää K, Grimard V, Taskinen MR, Thiele C, Salomaa V, Jula A, Perola M, Virtanen I, Peltonen L, Olkkonen VM. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. J Mol Med 2009; 87:825-35.
  • Poduval P, Sillat T, Virtanen I, Porola P, KonttinenYT. Abnormal basement membrane type IV collagen alpha chain composition in labial salivary glands in Sjögren’s syndrome. Arthritis Rheum 2009;60:938-45, 2009.
  • Poe D, Zou J, Zhang W, Qin J, Ramadan UA, Fornara A, Muhmmed M, Pyykkö I. MRI of the cochlea with superparamagnetic iron oxide nanoparticlescompared to Gadolinium chelate contrast agents in a rat model. Eur J Nanomedicine 2009;2:29-36.
  • Rajecki M, af Hällström T.M, Hakkarainen T, Nokisalmi P, Hautaniemi S, Nieminen A.I, Tenhunen M, Desmond R.M, Chen D.T, Guse K, Stenman U-H, Gargini R, Kapanen M, Klefström J, Kanerva A, Pesonen S, Hemminki A. Mre11 Inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation. Int J Cancer 2009;125:2441-9.
  • Sallinen V, Torkko V, Sundvik M, Reenilä I, Khrustalyov D, Kaslin J, Panula P. MPTP and MPP+ target specific aminergic cell populations in larval zebrafish. J Neurochem 2009;108:719-31.
  • Sillat T, Pöllänen R, Lopes JRC, Porola P, Ma G, Korhonen M, Konttinen YT. Intracrine androgenic apparatus in human bone marrow stromal cells. J Cell Mol Med 2009;13:3296-3302.
  • Sobota JA, Bäck N, Eipper BA, Mains RE. Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. J Cell Sci 2009;122:3542-53.
  • Spaan M, Porola P, Laine M, Rozman B, Azuma M, Konttinen YT. Healthy human salivary glands contain a DHEA-sulphate processing intracrine machinery, which is deranged in primary Sjögren’s syndrome. J Cell Mol Med 2009;13:1261-70.
  • Vuoristo S, Virtanen I, Takkunen M, Palgi J, Kikkawa Y, Rousselle P, Sekiguchi K, Tuuri T, Otonkoski T. Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support. J Cell Mol Med 2009;13:2622-33.
2008
  • Ahola S, Myllytie P, Österberg M, Teerinen T, Laine J. Effect of polymer adsorption on cellulose nanofibril water binding capacity and aggregation. Bio Res 2008;3:1315-28.
  • Ainola M, Valleala H, Nykänen P, Risteli J, Hanemaaijer R, Konttinen YT. Erosive arthritis in a patient with pycnodysostosis: an experiment of nature. Arthritis Rheum 2008;58:3394-401.
  • Beklen A, Hukkanen M, Richardson R, Konttinen YT. Immunohistochemical localization of toll-like receptors 1-10 in periodontitis. Oral Microbiol Immunol 2008;23:425-31.
  • Gorfu G, Virtanen I, Hukkanen M, Lehto VP, Rousselle P, Kenne E, Lindbom L, Kramer R, Tryggvason K, Patarroyo M. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol 2008;84:701-12.
  • Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, Baldwin ME, Stacker SA, Achen MG, Alitalo K. Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol 2008;28:4843-50.
  • Hölttä-Vuori M, Uronen RL, Repakova J, Salonen E, Vattulainen I, Panula P, Li Z, Bittman R, Ikonen E. BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms. Traffic 2008;9:1839-49.
  • Jacobs S, Ruusuvuori E, Sipilä ST, Haapanen A, Damkier HH, Kurth I, Hentschke M, Schweizer M, Rudhard Y, Laatikainen LM, Tyynelä J, Praetorius J, Voipio J, Hübner CA. Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Proc Natl Acad Sci USA 2008;8;105:311-6.
  • Jansen M, Pietiäinen VM, Pölönen H, Rasilainen L, Koivusalo M, Ruotsalainen U, Jokitalo E, Ikonen E. Cholesterol substitution increases the structural heterogeneity of caveolae. J Biol Chem 2008;283:14610-8.
  • Kantola A, Keski-Oja J, Koli K. Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesion. Exp Cell Res 2008;314:2488-500.
  • Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, Kivelä R, Helkamaa T, Merentie M, Jeltsch M, Paavonen K, Andersson LC, Mervaala E, Hassinen IE, Ylä-Herttuala S, Oresic M, Alitalo K. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res 2008;103:1018-26.
  • Koli K, Ryynänen M, Keski-Oja J. Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells. Bone 2008;43:679-88.
  • Laine M, Virtanen I, Porola P, Rotar Z, Rozman B, Poduval P, Konttinen YT. Acinar epithelial cell laminin-receptors in labial salivary glands in Sjögren’s syndrome. Clin Exp Rheumatol 2008;26:807-13.
  • Latonen L, Järvinen PM, Laiho M. Cytoskeleton-interacting LIM-domain protein CRP1 suppresses cell proliferation and protects from stress-induced cell death. Exp Cell Res 2008;314:738-47.
  • Laulajainen M, Muranen T, Carpén O, Grönholm M. Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton. Oncogene 2008;27:3233-43.
  • Lyly A, Marjavaara SK, Kyttälä A, Uusi-Rauva K, Luiro K, Kopra O, Martinez LO, Tanhuanpää K, Kalkkinen N, Suomalainen A, Jauhiainen M, Jalanko A. Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism. Hum Mol Genet 2008;17:1406-17.
  • Mattila J, Kallijärvi J, Puig O. RNAi screening for kinases and phosphatases identifies FoxO regulators. Proc Natl Acad Sci USA 2008;105:14873-8.
  • Otonkoski T, Banerjee M, Korsgren O, Thornell LE, Virtanen I. Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation. Diabetes Obes Metab 2008;10 Suppl 4:119-27.
  • Partanen S, Haapanen A, Kielar C, Pontikis C, Alexander N, Inkinen T, Saftig P, Gillingwater TH, Cooper JD, Tyynelä J. Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis. J Neuropathol Exp Neurol 2008;67:16-29.
  • Reijonen S, Putkonen N, Nørremølle A, Lindholm D, Korhonen L. Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins. Exp Cell Res 2008;314:950-60.
  • Strbian D, Durukan A, Pitkonen M, Marinkovic I, Tatlisumak E, Pedrono E, Abo-Ramadan U, Tatlisumak T. The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia. Neuroscience 2008;153:175-81.
  • Takkunen M, Ainola M, Vainionpää N, Grenman R, Patarroyo M, García de Herreros A, Konttinen YT, Virtanen I. Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells. Histochem Cell Biol 2008;130:509-25.
  • Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 2008;454:656-60.
  • Varjosalo M, Björklund M, Cheng F, Syvänen H, Kivioja T, Kilpinen S, Sun Z, Kallioniemi O, Stunnenberg HG, He WW, Ojala P, Taipale J. Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell 2008;133:537-48.
  • Vilen ST, Nyberg P, Hukkanen M, Sutinen M, Ylipalosaari M, Bjartell A, Paju A, Haaparanta V, Stenman UH, Sorsa T, Salo T. Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. Exp Cell Res 2008;314:914-26.
  • Virtanen I, Banerjee M, Palgi J, Korsgren O, Lukinius A, Thornell LE, Kikkawa Y, Sekiguchi K, Hukkanen M, Konttinen YT, Otonkoski T. Blood vessels of human islets of Langerhans are surrounded by a double basement membrane. Diabetologia 2008;51:1181-91.
  • Väänänen AJ, Salmenperä P, Hukkanen M, Miranda KM, Harjula A, Rauhala P, Kankuri E. Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide. Free Radic Biol Med 2008;45:749-55.
2007
  • Beklen A, Ainola M, Hukkanen M, Gürgan C, Sorsa T. Konttinen YT. MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis. J Dent Res 2007;86:347-51.
  • Haapanen A, Ramadan UA, Autti T, Partanen S, Joensuu R, Saftig P, Tyynelä J. In vivo MRI reveals severe atrophy and signal intensity changes in the brains of the cathepsin D knock-out mice. Magn Reson Imaging 2007;25:1024-31.
  • Kiviharju-af Hällström TM, Jäämaa S, Mönkkönen M, Peltonen K, Andersson LC, Medema RH, Peehl DM, Laiho M. Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement. Proc Natl Acad Sci USA 2007;104:7211-16.
  • Koivusalo M, Jansen M, Somerharju P, Ikonen E. Endocytic trafficking of sphingomyelin depends on its acyl chain length. Mol Biol Cell 2007;18:5113-23.
  • Koopal S, Furuhjelm JH, Järviluoma A, Jäämaa S, Pyakurel P, Pussinen C, Wirzenius M, Biberfeld P, Alitalo K, Laiho M, Ojala PM. Viral oncogene-induced DNA damage response is activated in Kaposi’s sarcoma tumorigenesis. PLoS Pathogens 2007;3:1348-60.
  • Laine H, Doetzlhofer A, Mantela J, Ylikoski J, Laiho M, Roussel M, Segil N, Pirvola U. p19Ink4d and p21Cip1 collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. J Neuroscience 2007;27:1434-44.
  • Linder MD, Uronen RL, Hölttä-Vuori M, van der Sluijs P, Peränen J, Ikonen E. Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells. Mol Biol Cell 2007;18:47-56.
  • Muranen T, Grönholm M, Lampin A, Lallemand D, Zhao F, Giovannini M, Carpén O. The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton. Hum Mol Genet 2007;16:1742-51.
  • Nieminen AI, Partanen JI, Hau A, Klefstrom J. c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. EMBO J 2007;26:1055-67.
  • Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA 2007;104:14694-9.
  • Poduval P, Sillat T, Beklen A, Kouri VP, Virtanen I, Konttinen YT. Type IV collagen a-chain composition in normal and arthritic synovial lining. Arthritis Rheum 56:3959-67.
  • Sarek G, Kurki S, Enbäck J, Iotzova G, Haas J, Laakkonen P, Laiho M, Ojala PM. Therapeutic potential of small-molecule inhibitor of the p53-Mdm2 interaction in primary erffusion lymphomas. J Clin Invest 2007;117:1019-28.
  • Strbian D, Tatlisumak T, Ramadan UA, Lindsberg PJ. Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab 2007;27:795-802.
  • Tammela T, Saaristo A, Holopainen T, Lyytikkä J, Kotronen A, Pitkonen M, Abo-Ramadan U, Ylä-Herttuala S, Petrova TV, Alitalo K. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation. Nat Med 2007;13:1458–66.
  • Taskinen M, Karjalainen-Lindsberg M-L, Nyman H, Eerola L-M, Leppä S. A high tumor-associated macrophage content predicts favourable outcome in follicular lymphoma patients treated with rituximab and CHOP. Clin Cancer Res 2007;13:5784-89.
  • Vainionpää N, Bützow R, Hukkanen M, Jackson DG, Pihlajaniemi T, Sakai LY, Virtanen I. Basement membrane protein distribution in LYVE-1-immunoreactive lymphatic vessels of normal tissues and ovarian carcinomas. Cell Tissue Res 2007;328:317-28.
  • Vainionpää N, Lehto VP, Tryggvason K, Virtanen I. Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function. Lab Invest 2007;87:780-91.
  • Willberg J, Hormia M, Takkunen M, Kikkawa Y, Sekiguchi K, Virtanen I. Lutheran blood group antigen as a receptor for alpha5 laminins in gingival epithelia. J Periodontol 2007;78:1810-8.
2006
  • Francí C, Takkunen M, Dave N, Alameda F, Gómez S, Rodríguez R, Escrivà M, Montserrat-Sentís B, Baró T, Garrido M, Bonilla F, Virtanen I, García de Herreros A. Expression of Snail protein in tumor-stroma interface. Oncogene 2006; 25:5134-44.
  • Frösen J, Marjamaa J, Myllärniemi M, Abo-Ramadan U, Tulamo R, Niemelä M, Hernesniem J, Jääskeläinen J. Contribution of mural and bone marrow-derived neointimal cells to thrombus organization and wall remodeling in a microsurgical murine saccular aneurysm model. Neurosurgery 2006;58:936-44.
  • Grönholm M, Muranen T, Toby GG, Utermark T, Hanemann CO, Golemis EA, Carpén O. A functional association between merlin and HEI10, a cell cycle regulator. Oncogene 2006;25:4389-98.
  • Gürpinar ÖA, Beklen A, Hukkanen M, Cehreli ZC, Onur MA, Konttinen YT. Effects of two multi-step self-etch primer/adhesives on apoptosis in human gingival fibroblasts in vitro. J Biomed Mat Res Part B - Appl Biomat 2006;79:435-40.
  • Karvonen U, Jänne OA, Palvimo JJ. Androgen receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion. Exp Cell Res 2006;312:3165-83.
  • Katz S, Hukkanen M, Lounatmaa K, Rousselle P, Tervo T, Virtanen I. Cooperation of isoforms of laminin-332 and tenascin-CL during early adhesion and spreading of immortalized human corneal epithelial cells. Exp Eye Res 2006;83:1412-22.
  • Ma GF, Liljeström M, Ainola M, Chen T, Tiainen VM, Lappalainen R, Konttinen YT, Salo J: Expression of ADAM9 (meltrin-?) around aseptically loosened total hip replacement implants. Rheumatology 2006;45:808-14.
  • Marjamaa J, Tulamo R, Abo-Ramadan U, Hakovirta H, Frösen J, Rahkonen O, Niemelä M, Bornstein P, Penttinen R, Kangasniemi M. Mice with a deletion in the first intron of the Col1a1 gene develop dissection and rupture of aorta in the absence of aneurysms: high-resolution magnetic resonance imaging, at 4.7 T, of the aorta and cerebral arteries. Magn Reson Med 2006;55:592-7.
  • Ruuttila P, Niiranen H, Kellomäki M, Törmälä P, Konttinen YT, Hukkanen M. Characterization of human primary osteoblast response on bioactive glass (BaG13-93)- coated poly-L,DL-lactide (SR-PLA70) surface in vitro. J Biomed Mater Res B Appl Biomater 2006;78:97-104.
  • Saaristo A, Tammela T, Färkkilä A, Kärkkäinen M, Suominen E, Ylä-Herttuala S, Alitalo A. Vascular endothelial growth factor-C accelerates diabetic wound healing. Am J Pathol 2006;169:1080-87.
  • Takkunen M, Grenman R, Hukkanen M, Korhonen M, García de Herreros A, Virtanen I. Snail-dependent and -independent epithelial-mesenchymal transition in oral squamous carcinoma cells. J Histochem Cytochem 2006;54:1263-75.
  • Vainio S, Jansen M, Koivusalo M, Róg T, Karttunen M, Vattulainen I, Ikonen E. Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts. J Biol Chem 2006;281:348-55.
  • Vainionpää N, Kikkawa Y, Lounatmaa K, Miner JH, Rousselle P, Virtanen I. Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am J Physiol Cell Physiol 2006;290:C764-75.
  • Väänänen AJ, Salmenperä P, Hukkanen M, Rauhala P, Kankuri E. Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages. Free Radic Biol Med 2006;41:120-31.
2005
  • Hasenson S, Määttä M, Rousselle P, Kikkawa Y, Miner JH, Tervo T, Virtanen I. The immortalized human corneal epithelial cells adhere to laminin-10 by using Lutheran glycoproteins and integrin alpha3beta1. Exp Eye Res 2005; 81:415-21.
  • Hölttä-Vuori M, Alpy F, Tanhuanpää K, Jokitalo E, Mutka AL, Ikonen E. MLN64 is involved in actin-mediated dynamics of late endocytic organelles. Mol Biol Cell 2005;16:3873-86.
  • Konttinen YT, Ma J, Ruuttila P, Hukkanen M, Santavirta S. Chondrocyte-mediated collagenolysis correlates with cartilage destruction grades in osteoarthritis. Clin Exp Rheumatol 2005;23:19-26.
  • Konttinen YT, Tensing EK, Laine M, Porola P, Törnwall J, Hukkanen M. Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjögren's syndrome. J Rheumatol 2005;32:1071-5.
  • Ma GF, Ainola M, Liljeström M, Santavirta S, Poduval P, Zhao D, Chen T, Konttinen YT. Increased expression and processing of ADAM 12 (meltrin-a) in osteolysis associated with aseptic loosening of total hip replacement implants. J Rheumatol 32:1943-50, 2005.
  • Mandelin J, Liljeström M, Li TF, Ainola M, Hukkanen M, Salo J, Santavirta S, Konttinen YT. Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation. J Biomed Mater Res B Appl Biomater 2005;74:582-8.
  • Muranen T, Grönholm M, Renkema GH, Carpén O. Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin. Oncogene 2005;24:1150-8.
  • Peltonen K, Kiviharju T, Järvinen P, Ra R, Laiho M. Histone deacetylase inhibitor provokes p53 independent cell cycle arrest and apoptosis in melanoma cell lines. Pigment Cell Res 2005;18:196-202.
  • Rigamonti E, Helin L, Lestavel S, Mutka A-L, Lepore M, Fontaine C, Bouhlel MA, Bultel S, Fruchart JC, Ikonen E, Clavey V, Staels B, and Chinetti-Gbaguidi G. Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ Res 2005;97: 682-689.
2004
  • Bäck N, Litonius E, Mains RE, Eipper BA. Fluoride causes reversible dispersal of Golgi cisternae and matrix in neuroendocrine cells. Eur J Cell Biol 2004;83:389-402.
  • Kurki S, Peltonen K, Latonen L, Kiviharju T, Ojala PM, Meek D. Laiho M. Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell 2004;5:465-75.
  • Laine M, Virtanen I, Salo T, Konttinen YT. Segment-specific but pathologic laminin isoform profiles in human labial salivary glands of patients with Sjogren's syndrome. Arthritis Rheum 2004;50:3968-73.
  • Tatlisumak T, Strbian D, Abo-Ramadan U, Li F. The role of diffusion- and perfusion-weighted magnetic resonance imaging in drug development for ischemic stroke: from laboratory to clinics. Curr Vasc Pharmacol 2004;2:343-55.