Translational neuropsychiatric genetics

William Hennah research group

Neuropsychiatric disorders are debilitating disorders that damage functions in the entire range of human mental activity. Studies to understand the biological origins of neuropsychiatric disorders have been carried out for decades. However, no biological markers or genetic risk factors can yet be considered as an aid to diagnosis, demonstrating that we still have far to go to understand mental illness.

The main aim of the group is to further our understanding of psychiatric disorders, through the analysis of the genetic and biological mechanisms that undoubtedly underlie them. Focusing on the space between genes and diagnosis to initiate the translation of genetic discoveries.

Our group uses multiple levels of traits and biological measures to translate our understanding of psychiatric illness. Initially by using next generation sequencing to identify functional variations. We then aim to use alternative phenotypes of psychological, pharmacological, and biological origin to gain insight into the mechanisms and implications of genetic risk.