As diabetes is on the rise, we are seeking for therapeutic approaches that would revitalize and regenerate the remaining beta cells in diabetes patients. We are studying beta cell protective- and regenerative growth factors and small molecule compounds targeting ER stress and the UPR in vitro in primary beta cells and cell lines and in vivo in diabetes mouse models. We have discovered that ER stress regulating growth factor MANF and its derivatives can protect and restore beta cells by novel mechanism. We have developed MANF knockout and inducible transgenic mice, and combining genomic, cellular and molecular biology approaches aim to reveal the exact roles of those factors and compounds in ER stress-induced beta cell dysfunction and diabetes pathogenesis.
Our main directions are:
Maria Lindahl, PhD, Docent
Institute of Biotechnology, HiLIFE
Biocenter 2, room 6029c
P.O. Box 56 (Viikinkaari 5D)
00014 University of Helsinki
Maria is a Principal Investigator/Associate Group Leader at BI.