The failure to regenerate tissue with age is a major health issue. A contributor to this decline is the loss of stem cell function. Despite the essential role of stem cells, it is still unclear how they fail to maintain their functions during ageing and disease.
We discovered a new aspect of stem cell ageing in vivo: cellular enlargement. With age and damage, stem cells increase in size causing their functional decline. However, we are only beginning to understand how size impacts stem cell fitness and the physiological importance of this process remains unsolved.
My team addresses these fascinating questions:
Institute of Biotechnology, HiLIFE
P.O.Box 56 (Viikinkaari 5 D)
00014 University of Helsinki
Jette is Principal Investigator/Group Leader at BI. She holds a position of Academy Research Fellow a term of 1 September 2021 - 31 August 2026. She also holds a position in Karolinska Institutet, Sweden, starting in 2022.