Division of Neurobiology, Ludwig-Maximilians-Universität MünchenLudwig-Maximilians-Universität München, Germany

Dr. Busse’s research group uses mouse model to investigate neural circuit functions in the visual system. The specific of goal dr. Busse’s lab is to reveal neuronal circuits underlying processing of sensory stimuli, behavioral goals or past experiences as well as to understand how cortico-thalamic feedback modulates activity in the dorsolateral geniculate (dLGN) of the thalamus and in the thalamic reticular nucleus (TRN).  To this end, mouse model is used to measure the activity in local neuronal circuits using silicon probes, and causally interfere with this activity using genetic tools, such as optogenetics.

Recent publications:

Busse L. (2018) Selected publications Working memory freed from the past. Nature. 15;554(7692):306-307.

Saleem AB; Lien AD; Krumin M; Haider B; Roman Roson M; Ayaz A; Reinhold K; Busse L; Carandini M; Harris KD (2017) Subcortical Source and Modulation of the Narrowband Gamma Oscillation in Mouse Visual Cortex Neuron 93: 315-322.

Busse L, Cardin JA, Chiappe ME, Halassa MM, McGinley MJ, Yamashita T, Saleem AB. (2017) Sensation during Active Behaviors. J Neurosci. 8;37(45):10826-10834.

Khastkhodaei, Z., Jurjut, O., Katzner, S., and Busse, L. (2016). Mice can use second-order, contrast-modulated stimuli to guide visual perception. J Neurosci, 36(16):4457–69.

Erisken, S., Vaiceliunaite, A., Jurjut, O., Fiorini, M., Katzner, S., and Busse, L. (2014). Effects of locomotion extend throughout the mouse early visual system. Current Biology, 24(24):2899– 2907.

University Medical Center Hamburg-Eppendorf, Germany

Dr. Donner’s lab investigates how brain states shapes human decision making and how this process is modulated in neuropsychiatric diseases. Specifically Donner lab investigates how specific neuromodulatory systems modulate cortical network dynamics underlying decisions using quantitative analysis of behavior, computational modeling, multimodal neuroimaging (fMRI and MEG), and pharmacological interventions.

Recent publications:

Pfeffer T, Avramiea AE, Nolte G, Engel AK, Linkenkaer-Hansen K, Donner TH. (2018) Catecholamines alter the intrinsic variability of cortical population activity and perception. PLoS Biology;16(2):e2003453.

Braun A, Urai AE, Donner TH. (2018) Adaptive History Biases Result from Confidence-weighted Accumulation of Past Choices. J Neurosci.  Jan 25. pii: 2189-17.

Meindertsma T, Kloosterman NA, Nolte G, Engel AK, Donner TH. (2017)  Multiple Transient Signals in Human Visual Cortex Associated with an Elementary Decision. J Neurosci. 7;37(23):5744-5757.

de Gee JW, Colizoli O, Kloosterman NA, Knapen T, Nieuwenhuis S, Donner TH. (2017)  Dynamic modulation of decision biases by brainstem arousal systems. Elife. 2017 Apr 11;6.

Urai AE, Braun A, Donner TH. (2017) Pupil-linked arousal is driven by decision uncertainty and alters serial choice bias. Nat Communication. 3;8:14637.

 

MRC Brain Network Dynamics Unit, University of Oxford, UK

Dr. Dupret’s The objective is to define how coordination of neuronal activity in the hippocampus and connected subcortical circuits contributes to memory processes during active waking behaviour and sleep. The group performs circuit analyses to: (i) determine how neural representations of the external world are computed, consolidated and recalled in the hippocampus for the purpose of memory;  (ii) establish the mnemonic contribution of oscillatory patterns of network activity (e.g., theta, gamma, sharp wave/ripples); and (iii) define neuronal interactions across brain circuits during the expression of memory-guided behaviours.

Recent publications:

Joshi A, Salib M, Viney TJ, Dupret D, Somogyi P. (2017) Behavior-Dependent Activity and Synaptic Organization of Septo-hippocampal GABAergic Neurons Selectively Targeting the Hippocampal CA3 Area. Neuron. 20;96(6):1342-1357.

McNamara CG, Dupret D. (2017) Two sources of dopamine for the hippocampus. Trends Neurosci. 40(7):383-384.

van de Ven GM, Trouche S, McNamara CG, Allen K, Dupret D (2016) Hippocampal Offline Reactivation Consolidates Recently Formed Cell Assembly Patterns during Sharp Wave-Ripples. Neuron. 7;92(5):968-974.

Trouche S, Perestenko PV, van de Ven GM, Bratley CT, McNamara CG, Campo-Urriza N, Black SL, Reijmers LG, Dupret D (2016) Recoding a cocaine-place memory engram to a neutral engram in the hippocampus. Nat Neurosci. 19(4):564-7.

McNamara CG, Tejero-Cantero Á, Trouche S, Campo-Urriza N, Dupret D. (2014) Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. Nat Neurosci. 2014 Dec;17(12):1658-60.

Ernst Strüngmann Institute for Neuroscience, Frankfurt, Germany

Dr. Fries’s lab investigates neuronal synchronization’s mechanisms, its consequences and cognitive functions. Networks of neurons typically engage in rhythmic, synchronized activity. Dr. Fries has formulated a Communication-through-Coherence (CTC) hypothesis which describes how communication through brain areas can be facilitated through rhythmic interactions.  Free viewing of natural images induces gamma-band oscillations in early visual cortex. In CTC hypothesis, the gamma rhythm in a lower visual area entrains a gamma rhythm in a higher visual area, which establishes an effective communication protocol: The lower area sends a representation of the visual stimulus rhythmically, and the higher area is most excitable precisely when this representation arrives. At other times, the higher area is inhibited, which excludes competing stimuli. Fries lab has obtained evidence to support this hypothesis using electrophysiology and optogenetic stimulation in primate models.

Recent publications:

Richter CG , Thompson WH, Bosman CA, Fries P Top-down beta enhances bottom-up gamma. Journal of Neuroscience 37 (28).

Ni, J., Wunderle, T., Lewis, C. M., Desimone, R., Diester, I., Fries, P. (2016) Gamma-Rhythmic Gain Modulation. Neuron 92(1), 240-251.

Michalareas, G., Vezoli, J., van Pelt, S., Schoffelen, J.M., Kennedy, H. and Fries, P. (2016) Alpha-beta and Gamma Rhythms Subserve Feedback and Feedforward Influences among Human Visual Cortical Areas. Neuron 89 (2) 384-397.

Fries, P (2015) Rhythms for cognition: communication through coherence Neuron 88 (1), 220-235.

Bastos, A. M., Vezoli, J., Bosman, C. A., Schoffelen, J., Oostenveld, R., Dowdall, J. R., De Weerd, P., Kennedy, H., Fries, P. (2015)  Visual Areas Exert Feedforward and Feedback Influences through Distinct Frequency Channels. Neuron 85(2), 390-401.

AN Landau, HM Schreyer, S van Pelt, P Fries (2015) Distributed attention is implemented through theta-rhythmic gamma modulation Current Biology 25 (17), 2332-2337.

 

LabEx CORTEX, Lyon, France

Dr Kennedy’s lab is interested in the development and connectivity of the cortex. His recent work in the adult brain has established a weighted and directed matrix of inter-areal connectivity. Detailed analysis shows the role of long-range connectivity in establishing the specificity of the cortical network and how connection weights predicts many of the geometrical features of the network. His work in the developing cortex revealed the existence of unique germinal zone in the macaque cortex and with Colette Dehay aims to explore the significance of the heterogeneity of cortical precursors.

Recent publications:

Saraf MP, Balaram P, Pifferi F, Gămănuț R, Kennedy H, Kaas JH. (2018) Architectonic features and relative locations of primary sensory and related areas of neocortex in mouse lemurs. J Comp Neurol. Feb 26.

Gămănuţ R,Kennedy H, Toroczkai Z, Ercsey-Ravasz M, Van Essen DC, Knoblauch K, Burkhalter A.(2018) The Mouse Cortical Connectome, Characterized by an Ultra-Dense Cortical Graph, Maintains Specificity by Distinct Connectivity Profiles. Neuron 97 (3), 698-715.

Borello U, Kennedy H, Dehay C (2018) The logistics of afferent cortical specification in mice and men. Semin Cell Dev Biol. 76:112-119.

Unsupervised lineage-based characterization of primate precursors reveals high proliferative and morphological diversity in the OSVZ. Pfeiffer M, Betizeau M, Waltispurger J, Pfister SS, Douglas RJ, Kennedy H, Dehay C. 2016. J Comp Neurol 524(3):535-63.

Alpha-Beta and Gamma Rhythms Subserve Feedback and Feedforward Influences among Human Visual Cortical Areas. Michalareas G, Vezoli J, van Pelt S, Schoffelen JM, Kennedy H, Fries P. 2016. Neuron 89 (2), 384-397.

Mejias JF, Murray JD, Kennedy H, Wang XJ. Feedforward and feedback frequency-dependent interactions in a large-scale laminar network of the primate cortex. Sci Adv 16;2(11):e1601335.

 

UCL, London, UK

The Mrsic-Flogel’s lab aims to understand the fundamental principles of neural circuit organization and how this organization relates to the computations that support sensory and behavioral function. The approach is to record activity in identified neurons in large ensembles to uncover the computations taking place during sensory processing and sensory-guided behaviors as well as to understand how these computations arise from the neural hardware: from the synaptic interactions between identified cell types that differ in the patterns of input and output connectivity.

Selected publications:

Han Y, Kebschull JM, Campbell RAA, Cowan D, Imhof F, Zador AM, Mrsic-Flogel TD. (2018) The logic of single-cell projections from visual cortex. Nature. Apr 5;556(7699):51-56.

Antolik J, Hofer SB, Bednar JA, Mrsic-Flogel TD (2016) Model Constrained by Visual Hierarchy Improves Prediction of Neural Responses to Natural Scenes. PLoS Comput Biol, 12 (6):e1004927.

Poort J, Khan AG, Pachitariu M, Nemri A, Orsolic I, Krupic J, Bauza M, Sahani M, Keller GB, Mrsic-Flogel TD, Hofer SB (2015) Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex. Neuron 86: 1478-90.

Okun M, Steinmetz NA, Cossell L, Iacaruso MF, Ko H, Barthó P, Moore T, Hofer SB, Mrsic-Flogel TD, Carandini M, Harris KD (2015) Diverse coupling of neurons to populations in sensory cortex. Nature 521: 511-5. 

Cossell L, Iacaruso MF, Muir DR, Houlton R, Sader EN, Ko H, Hofer SB, Mrsic-Flogel TD (2015) Functional organization of excitatory synaptic strength in primary visual cortex. Nature 518: 399-403.

Bernstein Center for Computational Neuroscience, Berlin, Germany

Dr. Ritter’s lab combines advanced multimodal neuroimaging and computational modeling with the aim to identify generative mechanisms of ongoing neuronal dynamics and to elucidate principles of interaction between ongoing dynamics and incoming events or tasks. To this end, the lab uses the virtual brain model for computational modeling of neuroimaging data obtained from ultra-fast EEG-fMRI recordings combined with 3D-spatial and temporal wavelet analysis. 

Recent publications:

Inferring multi-scale neural mechanisms with brain network modelling M Schirner, AR McIntosh, V Jirsa, G Deco, P Ritter. 2018. Elife 7, e28927.

The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core. G Deco, ML Kringelbach, VK Jirsa, P Ritter. 2017. Scientific reports 7 (1), 3095.

Glomb K, Ponce-Alvarez A, Gilson M, Ritter P, Deco G. (2017) Resting state networks in empirical and simulated dynamic functional connectivity. Neuroimage. 1;159:388-40.

How do parcellation size and short-range connectivity affect dynamics in large-scale brain network models? T Proix, A Spiegler, M Schirner, S Rothmeier, P Ritter, VK Jirsa. 2016. NeuroImage 142, 135-149.

Ritter, P., M. Schirner, A.R. McIntosh, V. Jirsa (2013). "The virtual brain integrates computational modeling and multimodal neuroimaging." Brain Connect 3(2):121-145.

Center for Integrative NeuroImaging, University of Tubingen, Germany

The goal of Siegel’s lab is to investigate how cognition and behavior such as perception, decision-making and motor behavior emerge from large-scale interactions across widely distributed neuronal ensembles. And also, to study which neural mechanisms coordinate these interactions, how they are dynamically regulated in a goal-directed fashion, and how these interactions are distributed in neuropsychiatric diseases. The lab combines human (MEG/EEG) and animal electrophysiology aiming to integrate these two lines of research.

Recent publications:

Motor Actions Influence Subsequent Sensorimotor Decisions. Pape A. A., Noury N., Siegel M. (2017) Scientific Reports 7(1): 15913.

Pape A. A., Siegel M. (2017) Motor Cortex Activity Predicts Response Alternation during Sensorimotor Decisions. Nature Communications 7: 13098.

Siegel M., Buschmann T. J., Miller E. K. (2015)  Cortical Information Flow During Flexible Sensorimotor Decisions Science 348(6241): 1352-55.

Hipp J. F., Siegel M. (2015) BOLD fMRI Correlation Reflects Frequency-Specific Neuronal Correlation. Current Biology 25, 1368-1374.

Siegel M., Donner T. H., Engel A. K. (2012) Spectral fingerprints of large-scale neuronal interactions.  Nature Reviews Neuroscience 13:121-134.

Department of Neuroscience and Biomedical Engineering, Aalto University, Helsinki, Finland

The goal of Salmelin’s lab is to reveal neural organization of language (function and dysfunction) and functional relevance of cortical activation and connectivity using neuroimaging as well as methodological development for imaging and analysis. The goal is to reveal a scientific description of language processing in a healthy human brain, and to provide essential groundwork for an informed and efficient description and treatment of developmental and acquired language disorders.

Selected publications:

Information properties of morphologically complex words modulate brain activity during word reading. Hakala T, Hultén A, Lehtonen M, Lagus K, Salmelin R. (2018) Human Brain Mapping. in press

Exploring the Organization of Semantic Memory through Unsupervised Analysis of Event-related Potentials. van Vliet M, Van Hulle MM, Salmelin R. (2018). Journal of cognitive neuroscience 30 (3), 381-392.

The right hemisphere is highlighted in connected natural speech production and perception. Alexandrou AM, Saarinen T, Mäkelä S, Kujala J, Salmelin R (2017) NeuroImage 152, 628-638.

Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland

The main research interest is to develop novel brain imaging methods; using them to reveal some secrets of the brain and to develop methods to diagnose and treat the brain. Dr. Ilmoniemi is currently developing hybrid of MEG and MRI (MEG-MRI), new methods for TMS and novel solutions to the biomagnetic inverse problem.

Selected publications:

Koponen LM, Nieminen JO, Ilmoniemi RJ. (2018) Multi-locus transcranial magnetic stimulation-theory and implementation. Brain Stimul. 23. pii: S1935-861X(18)30097-4.

Koponen LM, Nieminen JO, Mutanen TP, Ilmoniemi RJ. (2018) Noninvasive extraction of microsecond-scale dynamics from human motor cortex. Hum Brain Mapp. in press

Automatic and robust noise suppression in EEG and MEG The SOUND algorithm. Mutanen, Tuomas P.; Metsomaa, Johanna; Liljander, Sara; Ilmoniemi, Risto J. Neuroimage. 2018 Feb 1;166:135-151.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland

Dr. Alho’s group main research interest lies in identifying brain areas and the functional networks involved in auditory cognition. Dr. Alho’s goals are also to a  investigate how multitasking and gaming affects cognition and brain activity. The group uses behavioral methods, fMRI, EEG, MEG and eye-tracking.

Selected publications

Salmela, V., Salo, E., Salmi, J. & Alho, K. (2018). Spatiotemporal dynamics of attention networks revealed by representational similarity analysis of EEG and fMRI. Cerebral Cortex. 28, 2, p. 549–560.

Moisala M, Salmela V, Hietajärvi L, Carlson S, Vuontela V, Lonka K, Hakkarainen K, Salmela-Aro K, Alho K. (2016) Gaming is related to enhanced working memory performance and task-related cortical activity. Brain Res. 2017. Jan 15;1655:204-215.

Moisala M, Salmela V, Hietajärvi L, Salo E, Carlson S, Salonen O, Lonka K, Hakkarainen K, Salmela-Aro K, Alho K. Media multitasking is associated with distractibility and increased prefrontal activity in adolescents and young adults. Neuroimage. 1;134:113-12.

Oja L, Huotilainen M, Nikkanen E, Oksanen-Hennah H, Laasonen M, Voutilainen A, von Wendt L, Alho K (2016) Behavioral and electrophysiological indicators of auditory distractibility in children with ADHD and comorbid ODD. (2016) Brain Res. 1;1632:42-50.

Department of Health, National Institute for Health, Helsinki, Finland

The research group of Dr. Paunio has focused on understanding the individual variation in susceptibility to disturbed sleep, emotions, and mental health, with the basic idea that only by understanding the basic mechanisms and inter-individual variation behind the reactivity of these mechanisms one can develop targeted, individualized tools to ameliorate sleep- and stress-related disturbances. The group has also identified genetic risk variants for major psychiatric diseases including schizophrenia and bipolar disorder in the Finnish population and as part of large international collaborative networks.

Selected publications:

Mäkelä, T. E., Peltola, M. J., Nieminen, P., Paavonen, E. J., Saarenpää-Heikkilä, O., Paunio, T., Kylliäinen, A. (2018) Night awakening in infancy: Developmental stability and longitudinal associations with psychomotor development.: Developmental Psychology. in press

Liuhanen, J., Suvisaari, J., Kajantie, E., Miettunen, J., Sarin, A-P., Järvelin, M-R., Lönnqvist, J., Veijola, J., Paunio, T (2018) Interaction between compound genetic risk for schizophrenia and high birth weight contributes to social anhedonia and schizophrenia in women. Psychiatry Research. 259: 48-153.

Leminen MM, Virkkala J, Saure E, Paajanen T, Zee PC, Santostasi G, Hublin C, Müller K, Porkka-Heiskanen T, Huotilainen M, Paunio T. (2017) Enhanced Memory Consolidation Via Automatic Sound Stimulation During Non-REM Sleep. Sleep. 1;40(3).

Neuroscience Center, University of Helsinki, Helsinki, Finland

Dr. Khirug’s group examines the synapse as a tripartite structure composed of a /pre/synaptic neuron (terminal), a /post/synaptic neuron (dendritic spine), and a /peri/synaptic astrocytic process (PAP) that intimately enwraps the other two synaptic components and actively participates in synaptic function and plasticity. Experiments are carried out either in the intact brain of living animals, but they also use acute brain slices and cultured cells. In addition to investigating fundamental physiological mechanisms, the group is studying several pathological models such as stroke, neurodegeneration and brain trauma.

Selected publications:

Gureviciene, I., Gurevicius, K., Mugantseva, E., Kislin, M., Khiroug, L., & Tanila, H. (2017). Amyloid Plaques Show Binding Capacity of Exogenous Injected Amyloid-beta. Journal of Alzheimer's Disease, 55(1), 147-157.

Cui, L., Nitzsche, F., Pryazhnikov, E., Tibeykina, M., Tolppanen, L., Rytkonen, J., Huhtala, T., Mu, J-W., Khiroug, L., Boltze J., Jolkkonen, J. (2017). Integrin alpha 4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection. Stroke, 48(10), 2895-+.

Markkanen, M., Ludwig, A., Khirug, S., Pryazhnikov, E., Soni, S., Khirug, L., Delpire, E., Rivera, C., Airaksinen, M. S., Uvarov, P. (2017). Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function. Brain Research , 1675, 87-101.

Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., Yalcin, I., Lindholm, J., Vesa L., Sato, V., Cordeira, J., Autio, H., Kislin, M., Rios, M., Joca, S., Casarotto, P., Khiroug, L., Lauri, S., Taira, T., Castrén, E., Rantamäki, T. (2017). Isoflurane produces antidepressant effects and induces TrkB signaling in rodents. Scientific Reports, 7, [7811].

Neuroscience Center, University of Helsinki, Helsinki, Finland

The research group of Dr. Kaila has focused on studying the role of ion-regulatory proteins in the control of neuronal excitability at the molecular, single-cell, network and in vivo levels.

Selected publications:

Summanen, M., Back, S., Voipio, J., & Kaila, K. (2018). Surge of Peripheral Arginine Vasopressin in a Rat Model of Birth Asphyxia. Frontiers in Cellular Neuroscience, 12, [2].

de Groot, C., Floriou-Servou, A., Tsai, Y-C., Fruh, S., Kohler, M., Parkin, G., Schwerdel, C., Bosshard, Kaila, K., G., Fritschy, J-M., Tyagarajan, S. K. (2017). RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of alpha 2 GABA(A) receptors. PLoS Genetics, 13(10), [1007073].

Spoljaric, A., Seja, P., Spoljaric, I., Virtanen, M. A., Lindfors, J., Uvarov, P., Summanen, M., Crow, A. K., Hsueh, B., Puskarjov, M., Ruusuvuori, E., Voipio, J., Deisseroth, K., Kaila, K. (2017). Vasopressin excites interneurons to suppress hippocampal network activity across a broad span of brain maturity at birth. Proceedings of the National Academy of Sciences of the United States of America, 114(50), E10819-E10828.

Sato, S. S., Artoni, P., Landi, S., Cozzolino, O., Parra, R., Pracucci, E., Trovato, F., Szczurkowska, J., Luin, S., Arosio, D., Beltram, F., Cancedda, L., Kaila, K., Ratto, G. M. (2017). Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo. Proceedings of the National Academy of Sciences of the United States of America, 114(41), E8770-E8779.

Kelen, D., Andorka, C., Szabo, M., Alafuzoff, A., Kaila, K., & Summanen, M. (2017). Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome. PLoS One, 12(9), [0184593].

Neuroscience Center, University of Helsinki, Helsinki, Finland

The group of Dr. Lauri focuses on studying the molecular mechanisms guiding activity-dependent development of glutamatergic circuitry in the limbic system and in particular, the roles of ionotropic glutamate receptors in this process. So far, the group has identified several novel features related to functions and regulation of AMPA and kainate-type glutamate receptors at the developing synapses. Their current research aims to understand in detal how these mechanisms contribute to development and fine-tuning of the neural circuits underlying behavior under physiological and aberrant conditions, such as early life stress.

Selected publications:

Atanasova, T., Kharybina, Z., Kaarela, T. A. M., Huupponen, J. T., Luchkina, N., Taira, T. P., & Lauri, S. E. (2017). GluA4 Dependent Plasticity Mechanisms Contribute to Developmental Synchronization of the CA3-CA1 Circuitry in the Hippocampus. Neurochemical Research.

Orav, E., Atanasova, T., Shintyapina, A., Kesaf, S., Kokko, M., Partanen, J. M., Taira, T. P., Lauri, S. E. (2017). NETO1 Guides Development of Glutamatergic Connectivity in the Hippocampus by Regulating Axonal Kainate Receptors. eNeuro, 4(3), [e0048-17].

Kourdougli, N., Pellegrino, C., Renko, J-M., Khirug, S., Chazal, G., Kukko-Lukjanov, T-K., Lauri, S. E., Gaiarsa, J-L., Zhou, L., Peret, A., Castrén E., Tuominen, R. K., Crepel, V., Rivera Baeza, C. (2017). Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy. Annals of Neurology, 81(2), 251-265.

Luchkina, N. V., Coleman, S. K., Huupponen, J., Cai, C., Kivistö, A., Taira, T., Keinänen, K., Lauri, S. E. (2017). Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses. Neuropharmacology, 112, 46-56.

Neuroscience Center, University of Helsinki, Helsinki, Finland

Dr. Rivera's group is interested in the developmental like events triggered under pathophysiological conditions to integrate surviving as well as newly adult born neurons into the post traumatic network. They have recently found that the interplay between intracellular chloride homeostasis, GABAergic transmission and neurotrophic factors signaling is a cornerstone in the structural and synaptic plasticity found in clinically important paradigms for epilepsy and CNS injury. The group's current focus is on the role of these mechanisms for the crosstalk between interneurons and granular cell progenitors in the dentate gyrus and the consequent impact on cognitive decline associated with temporal lobe epilepsy and traumatic brain injury.

Selected publications:

Kourdougli N, Pellegrino C, Khirug S, Renko JM, Vaha M, Chazal G, Gaiarsa JL, Tuominen R, Crépel V, Rivera C. (2017) Glutamatergic network rewiring is triggered by depolarising GABA in epilepsy. Annal of Neurology Ann Neurol. 81:251-265.

Ludwig A, Rivera C, Uvarov P. (2017) A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells. BMC Neurosci. 18:23.

Markkanen M, Ludwig A, Khirug S, Pryazhnikov E, Soni S, Khiroug L, Delpire E,  Rivera C, Airaksinen MS, Uvarov P. (2017) Implications of the N-terminal heterogeneity for the neuronal K-Cl cotransporter KCC2 function. Brain Res. 1675:87-101.

Friedel P, Ludwig A, Pellegrino C, Agez M, Jawhari A, Rivera C, Medina I.( 2017) A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2. eNeuro. 4(4).

Achuta VS, Möykkynen T, Peteri UK, Turconi G, Rivera C, Keinänen K, Castrén ML. (2018) Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome. Sci Signal. 11 (513).