Program

8:00 AM Registration desk opens

9:00 AM Opening words & welcome

Day 1 - Theme: Human islet development and its defects

9:03   Session 1: Islet development and stem cell islets

Maike Sander: Understanding and treating diabetes with stem cell islets
Rachel Jennings: A single cell atlas of human pancreas development
Malgorzata Borowiak: Shaping It Up: Mechanosignaling in the Differentiation and Expansion of Human Pancreatic Beta Cells
Christian Honoré: Detailed in vitro and in vivo characterization of off-target cell populations developing during differentiation of human pluripotent stem cells (hPSC) to pancreatic islet-like clusters

Chair: Diego Balboa

11:15   Session 2: Genetics of human islet development

Tom Barsby: Metabolic maturation of stem cell-derived islets
Elisa De Franco: Using genome sequencing to gain novel insights into beta cell biology
Valerie Schreiber: Unveiling TOX as a novel regulator of pancreatic beta cell development and function
Alina Walth-Hummel: The transcription co-factors TBL1 and TBLR1 are novel regulators of β-cell identity
Annelore Van Mulders: A critical role for iron import through the transferrin receptor in developing ß-cells
Eliisa Vähäkangas: The effect of mitochondrial metabolism on the function of stem cell derived beta cells

Chair: Andrew Hattersley

13:05   Lunch

14:05   Session 3: Signalling and crosstalk in the islet

Huixia Ren: Delta-alpha cell-to-cell interactions modulate pancreatic islet Ca2+ oscillation mode and hormone secretion
Anders Tengholm: Second messenger interplay in islet cells
Joan Camuna-Soler: Single-cell quantification of β-cell secretory capacity and transcriptome in health and diabetes
Marta Perez Frances: Life with monotypic pancreatic islets only containing β-cells
Aharon Helman: Unveiling mTOR as a Negative Feedback Regulator of Insulin Secretion in Pancreatic β-Cells
Beichen Xie: A Quantitative Study on the Spatiotemporal Dynamics of δ Cell-Secreted Somatostatin in Pancreatic
One short talk TBC

Chair: Patrik Rorsman

16:30   Poster session 1

19:00   Dinner

Day 2 - Theme: What goes wrong in the islets in common forms of diabetes

9:00   Session 4: Metabolic stress

Miriam Cnop: Unraveling molecular mechanisms of metabolic stress and type 2 diabetes in human islets
Bengt-Frederik Belgardt: Sphingolipid species differentially regulate proinsulin processing and insulin secretion
Dana Avrahami: Good or bad? - Characterization of senescent beta cells in health and disease
James Johnson: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
One short talk TBC

Chair: Guy Rutter

11:05   Session 5: The islet in T2D

Anna Gloyn: Searching for diamonds in the sand: Human genetics as a tool to identify causal mechanisms for islet-cell dysfunction
Nils Wierup: Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes
Piero Marchetti: Rescuing the beta cell in type 2 diabetes: how close are we?
Efraim Westholm: Insulin-like growth factor binding protein 7 (IGFBP7) is expressed in pancreatic islets and negatively regulates β-cell insulin secretion
Jones Ofori: Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes

Chair: Tiinamaija Tuomi

14:0   Session 6: The islet in T1D

Sarah Richardson: Leveraging new knowledge from the human pancreas to advance and improve understanding and treatment of Type 1 diabetes
Arnaud Zaldumbide: Molecular mechanisms of beta cell immunogenicity
Yuval Dor: Defects in RNA editing mimic early stage type 1 diabetes
Malin Flodström Tullberg: A look beyond the usual suspects: Type III Interferons in the Pathogenesis of Type 1 Diabetes
Chiara Vinci: Pro-inflammatory stimuli induce profound transcriptome and translatome changes in iPSC-derived β cells that mimic type 1 diabetes β cell gene signatures
Noura Faraj: Beta cell stress following exocrine damage in zebrafish larval pancreas

Chair: Decio Eizirik

16:15   Poster session 2

19:00   Departure to the social program: Cruise to Kulosaari

Day 3 - Theme: Beta-cell regeneration and transplantation

9:00   Session 7: Human Beta cells do (not) proliferate

Debate: Andrew Stewart vs. Raphael Scharfmann
Burcak Yesildag: A 3D imaging toolbox for islet biology: Utilization of reaggregated uniform islets in 3D high-content confocal microscopy
Romina Bevacqua: Gene editing in primary human islet cells with ribonucleoprotein-based CRISPR/Cas9

Chair: Timo Otonkoski

11:00   Session 8: New strategies for beta-cell replacement

Eelco de Koning: Clinical aspects of stem cell-derived islet replacement therapy
Matthias Hebrok: Designing next-generation beta cells for stem cell therapy
Per-Ola Carlsson: Hypoimmune islet  transplantation in type 1  diabetes
Eunike Setyono: Generation of designer stem cell-derived islets (SC-islets) to improve safety and efficacy of SC-derived islet replacement therapy
Tamara Casteels: Towards the efficient generation of functional beta cells using CRISPR activation screens
Nicole Rogers: WNT/planar cell polarity signaling enhances maturation of human stem cell-derived β-cells
One short talk TBC

Chair: Heiko Lickert

13:30 PM Closing of the meeting