The EISG 2024 Meeting will start in the morning of June 18th and end at lunch on June 20th. Detailed program will be announced closer to the Meeting.

8:00 AM Registration desk opens

Day 1 - Theme: Human islet development and its defects

9:00   Session 1: Islet development and stem cell islets

Chair: Diego Balboa

Timo Otonkoski & Diego Balboa: Opening words & welcome
9:05   Maike Sander: Understanding and treating diabetes with stem cell islets - Keynote talk
9:40   Malgorzata Borowiak: Shaping It Up: Mechanosignaling in the Differentiation and Expansion of Human Pancreatic Beta Cells
10:05 Tom Barsby: Metabolic maturation of stem cell-derived islets
10:30 Christian Honoré: Detailed in vitro and in vivo characterization of off-target cell populations developing during differentiation of human pluripotent stem cells (hPSC) to pancreatic islet-like clusters

10:45-11:15 Coffee break

11:15   Session 2: Genetics of human islet development

Chair: Andrew Hattersley

11:15  Rachel Jennings: A single cell atlas of human pancreas development
11:49  Elisa De Franco: Using genome sequencing to gain novel insights into beta cell biology
12:05  Gérard Gradwohl: Unveiling TOX as a novel regulator of pancreatic beta cell development and function
12:20  Alina Walth-Hummel: The transcription co-factors TBL1 and TBLR1 are novel regulators of β-cell identity
12:35  Annelore Van Mulders: A critical role for iron import through the transferrin receptor in developing ß-cells
12:50  Eliisa Vähäkangas: The effect of mitochondrial metabolism on the function of stem cell derived beta cells

13:05-14:05  Lunch

14:05   Session 3: Signalling and crosstalk in the islet

Chair: Patrik Rorsman

14:05  Huixia Ren: Delta-alpha cell-to-cell interactions modulate pancreatic islet Ca2+ oscillation mode and hormone secretion
14:30  Anders Tengholm: Second messenger interplay in islet cells
14:55  Joan Camuna-Soler: Single-cell quantification of β-cell secretory capacity and transcriptome in health and diabetes
15:20  Marta Perez Frances: Life with monotypic pancreatic islets only containing β-cells
15:35  Marie Lallouet: Role of α-cells in β-cell coupling 
15:50  Aharon Helman: Unveiling mTOR as a Negative Feedback Regulator of Insulin Secretion in Pancreatic β-Cells
16:05  Beichen Xie: A Quantitative Study on the Spatiotemporal Dynamics of δ Cell-Secreted Somatostatin in Pancreatic
16:20  Sponsor Presentations by PeptiGrowth and Biorep Diabetes

16:30   Poster session 1

Posters 1 - 55

19:00   Dinner

Day 2 - Theme: What goes wrong in the islets in common forms of diabetes

9:00   Session 4: Metabolic stress

Chair: Guy Rutter

9:00   Miriam Cnop: Unraveling molecular mechanisms of metabolic stress and type 2 diabetes in human islets
9:25   Bengt-Frederik Belgardt: Sphingolipid species differentially regulate proinsulin processing and insulin secretion
9:50   Mireia Molina Van den Bosch: Deciphering the impact of ER-stress on β-cell development and function in MIDY pigs
10:05 Dana Avrahami: Good or bad? - Characterization of senescent beta cells in health and disease
10:20 James Johnson: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

10:35-11:05 Coffee break

11:05   Session 5: The islet in T2D

Chair: Tiinamaija Tuomi

11:05  Keynote: Anna Gloyn: Searching for diamonds in the sand: Human genetics as a tool to identify causal mechanisms for islet-cell dysfunction
11:40  Nils Wierup: Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes
12:05  Piero Marchetti: Rescuing the beta cell in type 2 diabetes: how close are we?
12:30  Efraim Westholm: Insulin-like growth factor binding protein 7 (IGFBP7) is expressed in pancreatic islets and negatively regulates β-cell insulin secretion
12:45  Jones Ofori: Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes

13:00 Group picture

13:15-14:00 Lunch

14:00   Session 6: The islet in T1D

Chair: Decio Eizirik

14:00  Sarah Richardson: Leveraging new knowledge from the human pancreas to advance and improve understanding and treatment of Type 1 diabetes
14:25  Arnaud Zaldumbide: Molecular mechanisms of beta cell immunogenicity
14:50  Yuval Dor: Defects in RNA editing mimic early stage type 1 diabetes
15:15  Malin Flodström Tullberg: A look beyond the usual suspects: Type III Interferons in the Pathogenesis of Type 1 Diabetes
15:40  Chiara Vinci: Pro-inflammatory stimuli induce profound transcriptome and translatome changes in iPSC-derived β cells that mimic type 1 diabetes β cell gene signatures
15:55  Noura Faraj: Beta cell stress following exocrine damage in zebrafish larval pancreas
16:10  Spponsor presentation by Mercodia

16:15   Poster session 2

Posters 56-111

18:30 Social program

18:30  Panorama boat cruise from Hanasaari to Kulosaari
20:00  Dinner at the Kulosaari Casino
22:30  Freeform socialising at the Kulosaari Casino


Day 3 - Theme: Beta-cell regeneration and transplantation

9:00   Session 7: Human Beta cells do (not) proliferate

Chair: Timo Otonkoski

9:00   Andrew Stewart: Development of Safe and EOective Human Beta Cell Regenerative Diabetes Drugs IS Possible
9:20   Raphael Scharfmann: Adult human beta cells do not proliferate (Am I wrong?)
9:40   Discussion
10:00  Burcak Yesildag: A 3D imaging toolbox for islet biology: Utilization of reaggregated uniform islets in 3D high-content confocal microscopy
10:15  Romina Bevacqua: Gene editing in primary human islet cells with ribonucleoprotein-based CRISPR/Cas

10:30-11:00 Coffee break

11:00   Session 8: New strategies for beta-cell replacement

Chair: Heiko Lickert

11:00  Eelco de Koning: Clinical aspects of stem cell-derived islet replacement therapy
11:25  Matthias Hebrok: Designing next-generation beta cells for stem cell therapy
11:50  Santiago Rodriguez-Segui: Pancreatic progenitor-endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in mice and humans
12:00  Eunike Setyono: Generation of designer stem cell-derived islets (SC-islets) to improve safety and efficacy of SC-derived islet replacement therapy
12:15  Jamie Chu: Understanding INS gene activity states and survival in stem cell derived beta-like cells 
12:30  Tamara Casteels: Towards the efficient generation of functional beta cells using CRISPR activation screens
12:45  Nicole Rogers: WNT/planar cell polarity signaling enhances maturation of human stem cell-derived β-cells

13:00 PM Closing of the meeting & poster awards

13:15 Packed lunch and adjourn

Social program

EISG 2024 social program takes us to the Baltic Sea directly from Hanasaari pier. We travel through the Helsinki archipelago towards the East until we dock again in Kulosaari-island of Helsinki, and enjoy a dinner in beautiful Casino until the Sun sets giving its turn to the white summer night.