Program

8:00 AM Registration desk opens

Day 1 - Theme: Human islet development and its defects

9:00   Session 1: Islet development and stem cell islets

Chair: Diego Balboa

Timo Otonkoski & Diego Balboa: Opening words & welcome
9:05   Maike Sander: Understanding and treating diabetes with stem cell islets - Keynote talk
9:40   Malgorzata Borowiak: Shaping It Up: Mechanosignaling in the Differentiation and Expansion of Human Pancreatic Beta Cells
10:05 Tom Barsby: Metabolic maturation of stem cell-derived islets
10:30 Christian Honoré: Detailed in vitro and in vivo characterization of off-target cell populations developing during differentiation of human pluripotent stem cells (hPSC) to pancreatic islet-like clusters

10:45-11:15 Coffee break

11:15   Session 2: Genetics of human islet development

Chair: Andrew Hattersley

11:15  Rachel Jennings: A single cell atlas of human pancreas development
11:49  Elisa De Franco: Using genome sequencing to gain novel insights into beta cell biology
12:05  Gérard Gradwohl: Unveiling TOX as a novel regulator of pancreatic beta cell development and function
12:20  Alina Walth-Hummel: The transcription co-factors TBL1 and TBLR1 are novel regulators of β-cell identity
12:35  Annelore Van Mulders: A critical role for iron import through the transferrin receptor in developing ß-cells
12:50  Eliisa Vähäkangas: The effect of mitochondrial metabolism on the function of stem cell derived beta cells

13:05-14:05  Lunch

14:05   Session 3: Signalling and crosstalk in the islet

Chair: Patrik Rorsman

14:05  Huixia Ren: Delta-alpha cell-to-cell interactions modulate pancreatic islet Ca2+ oscillation mode and hormone secretion
14:30  Anders Tengholm: Second messenger interplay in islet cells
14:55  Joan Camuna-Soler: Single-cell quantification of β-cell secretory capacity and transcriptome in health and diabetes
15:20  Marta Perez Frances: Life with monotypic pancreatic islets only containing β-cells
15:35  Marie Lallouet: Role of α-cells in β-cell coupling 
15:50  Aharon Helman: Unveiling mTOR as a Negative Feedback Regulator of Insulin Secretion in Pancreatic β-Cells
16:05  Beichen Xie: A Quantitative Study on the Spatiotemporal Dynamics of δ Cell-Secreted Somatostatin in Pancreatic
16:20  Sponsor Presentations by PeptiGrowth and Biorep Diabetes

16:30   Poster session 1

Posters 1 - 55

19:00   Dinner

Day 2 - Theme: What goes wrong in the islets in common forms of diabetes

9:00   Session 4: Metabolic stress

Chair: Guy Rutter

9:00   Miriam Cnop: Unraveling molecular mechanisms of metabolic stress and type 2 diabetes in human islets
9:25   Bengt-Frederik Belgardt: Sphingolipid species differentially regulate proinsulin processing and insulin secretion
9:50   Mireia Molina Van den Bosch: Deciphering the impact of ER-stress on β-cell development and function in MIDY pigs
10:05 Dana Avrahami: Good or bad? - Characterization of senescent beta cells in health and disease
10:20 James Johnson: Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

10:35-11:05 Coffee break

11:05   Session 5: The islet in T2D

Chair: Tiinamaija Tuomi

11:05  Keynote: Anna Gloyn: Searching for diamonds in the sand: Human genetics as a tool to identify causal mechanisms for islet-cell dysfunction
11:40  Nils Wierup: Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes
12:05  Piero Marchetti: Rescuing the beta cell in type 2 diabetes: how close are we?
12:30  Efraim Westholm: Insulin-like growth factor binding protein 7 (IGFBP7) is expressed in pancreatic islets and negatively regulates β-cell insulin secretion
12:45  Jones Ofori: Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes

13:00 Group picture

13:15-14:00 Lunch

14:00   Session 6: The islet in T1D

Chair: Decio Eizirik

14:00  Sarah Richardson: Leveraging new knowledge from the human pancreas to advance and improve understanding and treatment of Type 1 diabetes
14:25  Arnaud Zaldumbide: Molecular mechanisms of beta cell immunogenicity
14:50  Yuval Dor: Defects in RNA editing mimic early stage type 1 diabetes
15:15  Malin Flodström Tullberg: A look beyond the usual suspects: Type III Interferons in the Pathogenesis of Type 1 Diabetes
15:40  Chiara Vinci: Pro-inflammatory stimuli induce profound transcriptome and translatome changes in iPSC-derived β cells that mimic type 1 diabetes β cell gene signatures
15:55  Noura Faraj: Beta cell stress following exocrine damage in zebrafish larval pancreas
16:10  Spponsor presentation by Mercodia

16:15   Poster session 2

Posters 56-111

18:30 Social program

18:30  Panorama boat cruise from Hanasaari to Kulosaari
20:00  Dinner at the Kulosaari Casino
22:30  Freeform socialising at the Kulosaari Casino

Day 3 - Theme: Beta-cell regeneration and transplantation

9:00   Session 7: Human Beta cells do (not) proliferate

Chair: Timo Otonkoski

Debate: 
9:00   Andrew Stewart: Development of Safe and EOective Human Beta Cell Regenerative Diabetes Drugs IS Possible
9:20   Raphael Scharfmann: Adult human beta cells do not proliferate (Am I wrong?)
9:40   Discussion
10:00  Burcak Yesildag: A 3D imaging toolbox for islet biology: Utilization of reaggregated uniform islets in 3D high-content confocal microscopy
10:15  Romina Bevacqua: Gene editing in primary human islet cells with ribonucleoprotein-based CRISPR/Cas

10:30-11:00 Coffee break

11:00   Session 8: New strategies for beta-cell replacement

Chair: Heiko Lickert

11:00  Eelco de Koning: Clinical aspects of stem cell-derived islet replacement therapy
11:25  Matthias Hebrok: Designing next-generation beta cells for stem cell therapy
11:50  Santiago Rodriguez-Segui: Pancreatic progenitor-endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in mice and humans
12:00  Eunike Setyono: Generation of designer stem cell-derived islets (SC-islets) to improve safety and efficacy of SC-derived islet replacement therapy
12:15  Jamie Chu: Understanding INS gene activity states and survival in stem cell derived beta-like cells 
12:30  Tamara Casteels: Towards the efficient generation of functional beta cells using CRISPR activation screens
12:45  Nicole Rogers: WNT/planar cell polarity signaling enhances maturation of human stem cell-derived β-cells

13:00 PM Closing of the meeting & poster awards

13:15 Packed lunch and adjourn