Top publications | Virus Infections and Immunity

Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis

Joona Sarkkinen, Dawit A. Yohannes, Nea Kreivi, Pia Dürnsteiner, Alexandra Elsakova, Jani Huuhtanen, Kirsten Nowlan, Goran Kurdo, Riikka Linden, Mika Saarela, Pentti J. Tienari, Eliisa Kekäläinen, Maria Perdomo, and Sini M. Laakso.

Sci Immunol. 2025 Feb 21;10(104):eadl3604. doi: 10.1126/sciimmunol.adl3604

Individual patient and donor seroprofiles in convalescent plasma treatment of COVID-19 in REMAP-CAP clinical trial

Visa Nurmi, Richard Mayne, Chanice Knight, Hannia L Almonacid-Mendoza, Shannah Secret, Lise Estcourt, Jussi Hepojoki, Tonći Šuštić, Abigail A Lamikanra, Hoi Pat Tsang, David K Menon, Manu Shankar-Hari, C Ellen van der Schoot, Gestur Vidarsson, David J Roberts, Peter Simmonds, Klaus Hedman, Heli Harvala.

J Infect 2025 Feb;90(2):106412. doi: 10.1016/j.jinf.2025.106412

Intra-host genomic diversity and integration landscape of human tissue-resident DNA virome

Lari Pyöriä, Diogo Pratas, Mari Toppinen, Peter Simmonds, Klaus Hedman, Antti Sajantila, Maria F. Perdomo.

Nucleic Acids Research, gkae871, https://doi.org/10.1093/nar/gkae871

Reactivation of a transplant recipient’s inherited human herpesvirus 6 and implications to the graft.

Leo Hannolainen, Lari Pyöriä, Diogo Pratas, Jouko Lohi, Sandra Skuja, Santa Rasa-Dzelzkaleja, Modra Murovska, Klaus Hedman, Timo Jahnukainen, Maria F. Perdomo.

The Journal of Infectious Diseases, 2024; jiae268. https://doi.org/10.1093/infdis/jiae268

Unmasking the tissue-resident eukaryotic DNA Virome in humans.

Pyöriä L, Pratas D, Toppinen M, Hedman K, Sajantila A, Perdomo MF.

Nucl Acids Res 2023;51:3223-3239. DOI: 10.1093/nar/gkad199

Comparison of approaches for IgG avidity calculation and a new highly sensitive and specific method with broad dynamic range.

Nurmi V, Hedman L, Perdomo MF, Weseslindtner L, Hedman K. 2021.

Int J Infect Dis 110:479-487. DOI: 10.1016/j.ijid.2021.05.047

A hybrid pipeline for reconstruction and analysis of viral genomes at multi-organ level.

Pratas D, Toppinen M, Pyöriä L, Hedman K, Sajantila A, Perdomo MF.

GigaScience, 2020 August, 9(8); giaa086. DOI:10.1093/gigascience/giaa086

Extinct type of human parvovirus B19 persists in tonsillar B cells.

Pyöriä L, Toppinen M, Mäntylä E, Hedman L, Aaltonen L-M, Vihinen-Ranta M, Ilmarinen T, Söderlund-Venermo M, Hedman K, Perdomo MF.

Nature Commun 2017;8:14930. DOI: 10.1038/ncomms14930.

17th century Variola Virus reveals the recent history of smallpox.

Duggan AT, Perdomo MF, Piombino-Mascali D, Marciniak S, Poinar D, Emery MV, Buchmann JP, Duchêne S, Jankauskas R, Humphreys M, Golding GB, Southon J, Devault A, Rouillard J-M, Sahl JW, Dutour O, Hedman K, Sajantila A, Smith GL, Holmes EC, Poinar HN.

Curr Biol 2016;26:3407-3412. DOI: 10.1016/j.cub.2016.10.061

Human serum protein enhances HIV-1 replication and up-regulates the transcription factor AP-1.

Perdomo MF, Hosia W, Jejcic A, Corthals G, Vahlne A.

Proc Natl Acad Sci USA 2012 109(43):17639-44. DOI: 10.1073/pnas.1206893109

Neutralization of HIV-1 by redirection of natural antibodies.

Perdomo MF, Levi M, Sällberg M, Vahlne A.

Proc Natl Acad Sci USA 2008;105(34):12515-20. DOI: 10.1073/pnas.0805777105

Serodiagnosis of human bocavirus infection.

Kantola K, Hedman L, Allander T, Jartti T, Lehtinen P, Ruuskanen O, Hedman K, Söderlund-Venermo M.

Clin Infect Dis 2008;46:540-6. DOI: 10.1086/526532

Epstein-Barr viral load and disease prediction in a large cohort of allogeneic stem cell transplant recipients.

Aalto SM, Juvonen E, Tarkkanen J, Volin L, Haario H, Ruutu T, Hedman K.

Clin Infect Dis 2007;45:1305-9. DOI: 10.1086/522531

Bioportfolio: Lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue.

Norja P, Hokynar K, Aaltonen L-M, Chen R, Ranki A, Partio EK, Kiviluoto O, Davidkin I, Leivo T, Eis-Hübinger A-M, Schneider B, Fischer H-P, Tolba R, Vapalahti O, Vaheri A, Söderlund-Venermo M, Hedman K.

Proc Natl Acad Sci USA 2006;103:7450-3. DOI: 10.1073/pnas.0602259103

Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy.

Söderlund M, von Essen R, Haapasaari J, Kiistala U, Kiviluoto O, Hedman K.

The Lancet 1997;349:1063-5. DOI: 10.1016/S0140-6736(96)09110-6

Rapid diagnosis of hantavirus disease with an IgG-avidity assay.

Hedman K, Vaheri A, Brummer-Korvenkontio M.

The Lancet 1991;338:1353-6. DOI: 10.1016/0140-6736(91)92235-T

All publications

For a complete list, please refer to https://researchportal.helsinki.fi/en/organisations/virus-infections-and-immunity/publications/ or to our ORCIDs Maria Perdomo 0000-0002-9031-4251 and Klaus Hedman 0000-0003-1779-7960.