SARS-CoV-2 infection of human neurons requires endosomal cell entry and can be blocked by inhibitors of host phosphoinositol-5 kinas

In this , , , and a wonderful team of colleagues from our group and the Neuroscience Center lab of Prof. , found that neurons derived from human pluripotent stem cells are susceptible to the full replication cycle of SARS-CoV-2. To infect neurons, the virus needs to enter the cells and reach lysosomes.

A drug that inhibits endosome maturation blocked infection in vitro. The next step is to validate all of our findings in vivo.

Can it be that a few neurons in our brain are infected for a long time and this causes Long COVID neurological symptoms?

Thank you all for the fantastic collaboration. It's a great start towards understanding what is going on with this virus and our brain!

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