I am a postdoctoral researcher with a strong interest towards cancer genetics. I try to identify genetic defects that would explain cancer susceptibility in family materials. I do this mainly by analyzing high throughput sequencing and genotype data. I also work towards uncovering and characterizing the biological mechanisms by which the genetic defects predispose to tumors. Lately my work has been mostly concentrating on genetic susceptibility to small bowel neuroendocrine tumors, as well as colorectal and small bowel adenocarcinoma.
I am a postdoctoral researcher in cancer biology and genetics. My main project aims to characterize the different genetic subclasses of uterine leiomyoma (UL). In particular, the study aims to uncover distinct features of ULs by investigating chromatin accessibility, genome architecture and transcriptional activity in the 4 main genetic subclasses of the tumor, analyzing both flash-frozen and fresh samples. The techniques I am currently employing are ATAC-seq, ChIP-seq and Hi-C. Beyond this, I exploit CRISPR/Cas9 technique to generate UL cell line derived from myometrium immortalized cells.
I am a postdoctoral researcher with a background in molecular biology and cancer gene therapy. I have a strong interest in translational research and precision medicine. My current work focuses on the development of patient-derived 2D and 3D models of uterine leiomyoma, as predictive preclinical models for drug discovery and drug design. I mainly perform cell culture experiments, genotypic and phenotypic characterization of in vitro-generated models and high-throughput drug sensitivity assays.
My main interest is to further understand the role of retrotransposon insertions in cancer by utilizing whole genome and Nanopore sequencing. My current research focus is the characterization of somatic and germline retrotransposon insertions in 202 whole genome colorectal tumors.
My thesis project dealt with hereditary cancer susceptibility, and my aim has been to identify novel predisposing mutations for various cancer phenotypes. In most of my studies I have utilized the data in the Finnish Cancer Registry and the Population Information System databases to identify cancer patients with a potential genetic predisposition.
My research is focused on the molecular genetic changes in small bowel and colorectal cancers. My current projects include the characterization of both synchronous colorectal cancers and small bowel adenocarcinomas by utilizing exome sequencing.
I am a second year molecular biosciences student. I work as a research assistant. Mainly my work consists of cell culturing and using techniques such as chromatin immunoprecipitation for characterization of different leiomyoma subclasses.
My research is focused on identification and understanding molecular changes, genetic and epigenetic, that are critical for tumor development and progression. Identification of new genotype/phenotype correlations also in other clinical conditions are among my research interests. The work involves analysis and interpretation of next-generation sequencing data, transcriptome and methylation profiling and various cellular works.
I’m a medical student and joined the group in 2019 to work as a research assistant. I’m currently working on updating and improving the group’s custom data management software, the purpose of which is to enable easy and efficient querying of the group’s vast amount of data.
My duties consist mainly of the next-generation sequencing data analysis in various cancer projects, the development/maintenance of the BasePlayer software (https://baseplayer.fi), general bioinformatics assistance. I am particularly useful, when the data analysis concerns DNA alterations in coding or noncoding genome.
I work as a lab technician. My duties include purchasing procedures of goods and services in our laboratory (tendering process). I am also involved in performing all types of experiments carried out in the lab, e.g. DNA\RNA extraction and purification, PCR, qPCR, immunohistochemistry, western blot and others.
My main interest is to identify genetic variants that contribute to the initiation and progression of microsatellite unstable colorectal cancer through large scale sequencing. My current research focuses on utilizing different algorithms to identify the most likely cancer causing genes. I am also interested in the distribution of mutations in the repetitive regions of the genome in microsatellite unstable colorectal cancer.
I am a PhD student in bioinformatics. My work focuses on the genetics of uterine leiomyomas (ULs). During the thesis project, I use e.g. whole-genome sequencing, RNA-seq and whole-genome bisulfite sequencing data to further characterize ULs. Long non-coding RNAs, single-cell transcriptomics and population-level predisposition are among my research interests.
Postdoctoral researcher. I received my PhD in computer science in January 2018, and I joined Aaltonen lab in August 2018. My work mainly focuses on methods for RNA-seq data analysis.
I have worked as a research nurse in Aaltonen lab since Dec 2000. My responsibilities are genealogy work and sample management. I maintain and develop our database and combine cancer data with our sample database. As extra curriculum I am also the groups worry person, I co-arrange our recreational activities and I’m in charge of the safety issues.
I am part of our bioinformatics team. My main responsibilities are all data integrated actions and I try to create an illusion of easiness for our researchers, so that they wouldn't need to worry about their samples. Our data collection is ever increasing and the fluid use of it is a complex puzzle that we are trying solve on a daily basis.
Academy of Finland Postdoctoral Researcher
My research focuses on both benign and malignant uterine smooth muscle tumors. What are the different molecular and genetic mechanisms underlying their growth and development?
I’m currently working at the Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.
I am a senior laboratory technician. My duties principally include experimental planning and research. I troubleshoot and develop better working practices and design protocols for complex samples to facilitate and improve the quality and the quantity of data. I maintain our sample collection, manage the use of DNA stocks and the preparation of samples, including library preps for various downstream applications. I undertake the comparison of data and analysis, including interpretation and evaluation of results. On a general basis I perform various molecular genetic techniques such as DNA isolations, quantification analysis, PCR, fragment analysis, western blots, isolation of RNA and sequencing.
I am a senior staff scientist working both in Aaltonen and Taipale groups. My research is Bioinformatics and Computational Biology from genetics and functional regulatory genomics perspective. I'm involved especially with genetic epidemiology and biobank research related projects and have special interest in functional genomics, gene regulation and functional understanding of non-coding genetic variation.
I’m a second year medical student and I joined the group to work as a research assistant in 2019. My duties consist of laboratory work, which means working with the samples and performing molecular genetic techniques.
I am a research nurse. While my work includes some genealogy and databasing tasks, I also support the lab by being responsible for ordering and compiling patient records as well as collecting and providing patient samples to the researchers such as fresh frozen tissue and FFPE blocks and slides.
I joined the Aaltonen lab as a postdoctoral researcher in 2018. I have a strong background in innate immune signaling and working with primary human blood cells and tissues in translational studies involving complex and familial inflammatory diseases. At the Aaltonen lab, my work will focus on studying the genetics and cellular mechanisms of cancer types strongly associated with inflammation, including colitis-associated colorectal cancer.
I work as a senior scientist / bioinformatican. My duties include basic research and related IT-support and -development. For my research I develop computational methods for processing and analyzing genomic information related to group's interests. In IT-support, I work with others to implement new methods and processes to improve our existing analysis pipelines. I also test new methods and instruct others in the selection and use of bioinformatics tools.
I am a PhD student with M.Sc degree major in human genetics. My project is part of the uterine leiomyoma regulatory genome project. My duties involve both lab work and data analysis of ATAC-seq, ChIP-seq and HiChIP from uterine leiomyomas.
I’m a PhD student in the early phases of my project. My main focus is on studying environmental causes of tumorigenesis by trying to detect patterns of genetic damage in the tumors of patients who have had substantial exposure to carcinogenic agents due to their work environment or lifestyle choices. Finding such patients for study involves utilizing data sets gathered by Finnish national institutes over the past decades. Another branch of my project concerns using the same data to recognize familial cancer clustering that cannot be readily explained by previously known cancer syndromes, the reason behind which we will then study at the genomic level.
My main duties involve genealogy work and databasing. I also have a variety of secretarial and administrative duties which include updating group's webpage, processing an assortment of paperwork, checking invoices, control of supplies, domestic and international travel arrangements as well as submitting travel expenses etc.
I am a PhD student in bioinformatics. My research is focused on retrotransposons in the human genome. I detect somatic and germline transposons from whole-genome sequencing data and study the relationship between cancer and retrotransposition.
I’m a PhD student having my Master’s degree major in genetics and specialty in bioinformatics. My own project is about methylation in colorectal cancer. As a bioinformatican I’m balancing between genetics and computers. My job is to formulate the biological research questions in such a way that computers can understand them. Even though R and shell scripts are pedantic and sometimes frustrating tools they are researcher's best colleagues in this task.
I am junior laboratory manager. My duties include taking care of reagent and supply orders. I also maintain our patient lymphoblastoid cell line collection.
Generally I perform various techniques such as exome library prepping, DNA/RNA isolations, PCR/qPCR, immunohistochemistry, fragment analysis and cell culture.
Postdoctoral researcher. I received my PhD in computer science from the University of Helsinki in 2012. Since then I have continued at Aaltonen lab as a postdoc. My work involves bioinformatics and computational data analysis of the various high-throughput data. My current interests are in statistical inference and data science.
I am the laboratory manager handling most of the techniques and equipment used in the lab. I am responsible for the chemicals and their safety handling, maintenance and service of the equipment and guiding of new members of the lab. In general I do various molecular genetic techniques, for example DNA, RNA and protein extractions, PCR, qPCR, Western blots, immunohistochemistry, cell culture, exome sequencing and bacterial methods, and I maintain the sample collection.