Our group is focused on indentifying mechanisms that can stabilize or destabilize the vasculature in disease, with the aim to develop these findings towards translational benefit.
Increased capillary leakage and endothelial inflammation can lead to organ failure and shock in sepsis and systemic inflammation. Vascular leakage and new vessel growth (angiogenesis) enhance solid tumor growth and metastasis and impair vision in common ocular diseases including diabetic retinopathy, diabetic macular edema and wet-age related macular degeneration. Drugs targeting the vascular endothelial growth factor (VEGF) have entered in clinical use to block angiogenesis in cancer and neovascular eye disease, whereas tools for vascular stabilization and prevention of capillary leakage in sepsis are scarce (
Our group has interest on Angiopoietin (Angpt or Ang) growth factors that regulate vascular functions, including vessel stability and growth during development and tissue homeostasis (
Integrins couple endothelial cells to the underlying vascular basement membrane, thereby participating in vascular growth and vessel stability. Recent studies by our group have identified signaling interactions between the angiopoeitin-Tie system and integrins that impair endothelial integrity (
Cancer spreads through the vascular systems forming metastasis. We recently discovered how lung capillaries resist metastatic spread by upregulating transcriptional programs regulating reactive capillary endothelial cells in the lung alveolus (
We collaborate with clinician scientists on various aspects of vascular diseases, in order to correlate our preclinical findings with human disease (