Myelin is an insulating substance that wraps around axons, enabling the fast and efficient transmission of electrical impulses in the nervous system. Upon damage, myelin sheath can be functionally restored through a regenerative process known as remyelination. However, in demyelinating diseases, such as multiple sclerosis (MS), remyelination fails. The Translational Regenerative Neurobiology Group (TReN) aims to study how remyelination works and to explore why it fails during MS. Our final goal is to design and develop regenerative therapies for the treatment of demyelinating diseases.